ABSTRACT We present U336V606J125H160 follow-up Hubble Space Telescope (HST) observations of 16 z ∼ 3 candidate Lyman continuum (LyC) emitters in the HS1549+1919 field. With these data, we obtain high ...spatial-resolution photometric redshifts of all sub-arcsecond components of the LyC candidates in order to eliminate foreground contamination and identify robust candidates for leaking LyC emission. Of the 16 candidates, we find one object with a robust LyC detection that is not due to foreground contamination. This object (MD5) resolves into two components; we refer to the LyC-emitting component as MD5b. MD5b has an observed 1500 to 900 flux-density ratio of , compatible with predictions from stellar population synthesis models. Assuming minimal IGM absorption, this ratio corresponds to a relative (absolute) escape fraction of = 75%-100% ( = 14%-19%). The stellar population fit to MD5b indicates an age of 50 Myr, which is in the youngest 10% of the HST sample and the youngest third of typical z ∼ 3 Lyman break galaxies, and may be a contributing factor to its LyC detection. We obtain a revised, contamination-free estimate for the comoving specific ionizing emissivity at z = 2.85, indicating (with large uncertainties) that star-forming galaxies provide roughly the same contribution as QSOs to the ionizing background at this redshift. Our results show that foreground contamination prevents ground-based LyC studies from obtaining a full understanding of LyC emission from z ∼ 3 star-forming galaxies. Future progress in direct LyC searches is contingent upon the elimination of foreground contaminants through high spatial-resolution observations, and upon acquisition of sufficiently deep LyC imaging to probe ionizing radiation in high-redshift galaxies.
We present results from a survey for z ~ 2.85 Lyman-continuum (LyC) emission in the HS1549+1933 field and place constraints on the amount of ionizing radiation escaping from star-forming galaxies. ...Using a custom narrowband filter (NB3420) tuned to wavelengths just below the Lyman limit at z > or =, slanted 2.82, we probe the LyC spectral region of 49 Lyman break galaxies (LBGs) and 91 Ly alpha emitters (LAEs) spectroscopically confirmed at z > or =, slanted 2.82. Four LBGs and seven LAEs are detected in NB3420. We find (F sub(UV)/F sub(LyC)) sub(LBG) super(corr) = 82 + or - 45 and (F sub(UV)/F sub(LyC)) super(LAE) sub(corr ) = 7.4 + or - 3.6. In order to study the differential properties of galaxies with and without LyC detections, we analyze narrowband Ly alpha imaging and rest-frame near-infrared imaging, finding that while LAEs with Ly alpha detections have lower Ly alpha equivalent widths on average, there is no substantial difference in the rest-frame near-infrared colors of LBGs or LAEs with and without LyC detections.
Plasmodium knowlesi is a zoonotic pathogen, transmitted among macaques and to humans by anopheline mosquitoes. Information on P. knowlesi malaria is lacking in most regions so the first step to ...understand the geographical distribution of disease risk is to define the distributions of the reservoir and vector species.
We used macaque and mosquito species presence data, background data that captured sampling bias in the presence data, a boosted regression tree model and environmental datasets, including annual data for land classes, to predict the distributions of each vector and host species. We then compared the predicted distribution of each species with cover of each land class.
Fine-scale distribution maps were generated for three macaque host species (Macaca fascicularis, M. nemestrina and M. leonina) and two mosquito vector complexes (the Dirus Complex and the Leucosphyrus Complex). The Leucosphyrus Complex was predicted to occur in areas with disturbed, but not intact, forest cover (> 60% tree cover) whereas the Dirus Complex was predicted to occur in areas with 10-100% tree cover as well as vegetation mosaics and cropland. Of the macaque species, M. nemestrina was mainly predicted to occur in forested areas whereas M. fascicularis was predicted to occur in vegetation mosaics, cropland, wetland and urban areas in addition to forested areas.
The predicted M. fascicularis distribution encompassed a wide range of habitats where humans are found. This is of most significance in the northern part of its range where members of the Dirus Complex are the main P. knowlesi vectors because these mosquitoes were also predicted to occur in a wider range of habitats. Our results support the hypothesis that conversion of intact forest into disturbed forest (for example plantations or timber concessions), or the creation of vegetation mosaics, will increase the probability that members of the Leucosphyrus Complex occur at these locations, as well as bringing humans into these areas. An explicit analysis of disease risk itself using infection data is required to explore this further. The species distributions generated here can now be included in future analyses of P. knowlesi infection risk.
We have grown single-crystal Co ferrite (CoFe2O4) on MgO(001) by oxygen-plasma-assisted molecular beam epitaxy (OPA-MBE), and have characterized the composition, structure, surface morphology, and ...magnetic properties by a number of methods The as-grown OPA-MBE material forms a perfect inverse spinel, in which all Co is in the? formal oxidation state, and occupies octahedral sites within the cation sublattice. The OPA-MBE film surfaces are very flat, with mean roughnesses of only a few A, and exhibit large, stable magnetic domains. The measured moment per unit volume is 250 emu/cm3, and the saturation magnetization for films in the 1000A film thickness range is {approx}60% of that of bulk Co ferrite. The material also exhibits strain-dependent magnetic anisotropy that can be understood by considering the various contributions to the total magnetic energy. The overall quality of epitaxial Co ferrite grown on MgO by OPA-MBE is superior in every respect to that obtained using pulsed laser deposition as the growth method.
A new structural type of kinase inhibitor, containing a benzocarbazole nucleus, has been identified. Members of the series are selective for inhibition of the cyclin dependent kinase family of ...enzymes. Although the cdks are highly homologous, representatives of the series showed intra-cdk selectivities, especially for cdk4. SAR studies elucidated the important features of the molecules for inhibition.
The benzocarbazole
1 and related compounds have been identified as selective inhibitors of CDK4 (CDK4 IC
50=3.6
μM).
We report two low-frequency measurements of the power-law index for the amplitudes of giant radio pulses from the Crab pulsar. The two observations were taken with the Arecibo and Green Bank radio ...telescopes at center frequencies of 327 MHz and 350 MHz, respectively. We find best-fit values for the differential power-law index \(\beta\) (where \(dN/dS \propto S^\beta\) and \(S\) is pulse amplitude) of \(-2.63 \pm 0.05\) and \(-3.6 \pm 0.5\) from the Arecibo and Green Bank data sets, respectively. Both values are broadly consistent with other values previously measured for the Crab pulsar at low radio frequencies. These reported values may be useful in future giant pulse studies of the Crab pulsar.
The avifauna of Indonesia is one of the richest in the world but the taxonomic status of many species remains poorly documented. The sole species of scops owl known from Lombok has long been assigned ...to the widespread Moluccan Scops Owl Otus magicus on the basis of superficial similarities in morphology. Field work in 2003 has shown that the territorial song of the scops owls inhabiting the foothills of Gunung Rinjani differs dramatically from that of O. magicus and is more similar to those of Rufescent Scops Owl O. rufescens and Singapore Scops Owl O. cnephaeus. Detailed comparisons of sound recordings and museum specimens with those of other scops owls in Wallacea and the Indo-Malayan region have confirmed the distinctiveness of the Lombok population. We describe Otus jolandae as a new species, the Rinjani Scops Owl. It is locally common at elevations from 25-1350 m. and occurs within Gunung Rinjani National Park. The new species is known from seven specimens collected by Alfred Everett in 1896. Otus jolandae represents the first endemic bird species from Lombok.
Celotno besedilo
Dostopno za:
DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
Mitochondria undergo fission and fusion to maintain homeostasis, and tumors exhibit the dysregulation of mitochondrial dynamics. We recently demonstrated that ectopic HRasG12V promotes mitochondrial ...fragmentation and tumor growth through Erk phosphorylation of the mitochondrial fission GTPase Dynamin-related protein 1 (Drp1). However, the role of Drp1 in the setting of endogenous oncogenic KRas remains unknown. Here, we show that Drp1 is required for KRas-driven anchorage-independent growth in fibroblasts and patient-derived pancreatic cancer cell lines, and it promotes glycolytic flux, in part through the regulation of hexokinase 2 (HK2). Furthermore, Drp1 deletion imparts a significant survival advantage in a model of KRas-driven pancreatic cancer, and tumors exhibit a strong selective pressure against complete Drp1 deletion. Rare tumors that arise in the absence of Drp1 have restored glycolysis but exhibit defective mitochondrial metabolism. This work demonstrates that Drp1 plays dual roles in KRas-driven tumor growth: supporting both glycolysis and mitochondrial function through independent mechanisms.
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•Drp1 is required for oncogenic KRas-driven transformation•Drp1 promotes KRas-driven glycolysis•Loss of Drp1 inhibits pancreatic tumorigenesis•Loss of Drp1 impairs mitochondrial metabolism in tumor cells
Nagdas et al. find that the mitochondrial fission GTPase Drp1 is required for KRas-driven transformation and pancreatic tumor growth. The inhibition of Drp1 in cells expressing oncogenic KRas leads to impaired glycolytic flux and the eventual loss of mitochondrial metabolic function.
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