Many new drugs have been discovered in pharmaceutical industry and exposed their surprised potential therapeutic effects. Unfortunately, these drugs possess low absorption and bioavailability since ...their solubility limitation in water. Solid dispersion (SD) is the current technique gaining so many attractions from scientists due to its effect on improving solubility and dissolution rate of poorly water-soluble drugs. A number of patents including the most recent inventions have been undertaken in this review to address various respects of this strategy in solubilization of poorly watersoluble drugs including type of carriers, preparation methods and view of technologies used to detect SD properties and mechanisms with the aim to accomplish a SD not only effective on enhanced bioavailability but also overcome difficulties associated with stability and production. Future prospects are as well discussed with an only hope that many developments and researches in this field will be successfully reached and contributed to commercial use for treatment as much as possible.
The k-anonymity is an efficient model to preserve data privacy. Of late, this model has been applied to the area of privacy-preserving data mining but the state-of-the-arts are still far from ...practical needs. In this paper, we propose a new approach that preserves privacy and maintains data utility in data mining. Concretely, we use a k-anonymity model to preserve privacy while discovering and maintaining association rules through a novel algorithm, M3AR-member migration technique for maintaining association rules. We do not use the existing generalization and suppression techniques to achieve a k-anonymity model. Instead, we propose a member migration technique that is more appropriate for the requirements of maintaining association rules. Experimental results establish the practical value and theoretical analyses of our new technique.
3D heterogeneous integration for analog Samoilov, Arkadii V.; Tran, Khanh; Kerness, Nicole ...
2013 IEEE International Electron Devices Meeting,
12/2013
Conference Proceeding, Journal Article
We illustrate capabilities of 3D integration for analog applications through both wafer-level and packaging technologies. Examples of wafer-level 3D integration include integrated capacitors and ...optical sensors. Integrated Si capacitors demonstrate the highest reported capacitor density of C=1 μF/mm 2 (=1,000 fF/μm 2 ) and the figure of merit (FOM) C*V bd =11 C/m 2 (V bd is the breakdown voltage). Through-Si vias can be used to combine passive and active die into a single stack. Addition of optical layers to the Bipolar CMOS DMOS (BCD) process allows light detection in the visible and infrared range. 3D package-level integration is illustrated by embedding of multiple active and passive components in one package.
The fundamental features of the detection of non-stationary undulatory
perturbations of metrics based on the interference effects are considered. The
advantage of the Aharonov-Bohm effect in ...superconductors for these purposes in
comparison with the ordinary optical interference is demonstrated. Some
circuitries of the interferometric detectors in order to be used with SQUID are
suggested. The possibilities of lowering the noise temperature of the ultraweak
signals detectors based on the analogy between the processes of high-sensitive
measurements and the reversible calculations are discussed.
The fundamental features of the detection of non-stationary undulatory perturbations of metrics based on the interference effects are considered. The advantage of the Aharonov-Bohm effect in ...superconductors for these purposes in comparison with the ordinary optical interference is demonstrated. Some circuitries of the interferometric detectors in order to be used with SQUID are suggested. The possibilities of lowering the noise temperature of the ultraweak signals detectors based on the analogy between the processes of high-sensitive measurements and the reversible calculations are discussed.
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