Talent attraction has been confirmed to be one of the crucial human resource strategies during the Science Park development. Skilled workers with expertise, knowledge, and innovation are required for ...tenant firms to survive and gain competitive advantages in the increasingly intense information technology (IT) industry. This study aims to contribute to our knowledge of talent attraction management in Science Parks, emphasizing the interaction between universities and research institutes, which are confirmed to be the primary source providing talented individuals. The fundamental logic is that a Science Park's connection to universities may improve innovation capacity, eventually gaining competitive advantages. The data collection comes from 178 senior managers of various IT firms located at two Science Parks in Vietnam, Quang Trung Software City, and Saigon Hi-Tech Park. A partial least squares structural equation modeling approach was used to estimate the measurement and causal relationships. The findings revealed that IT firms should consider two critical elements when enhancing their competitiveness through talent acquisition: the network attractiveness dimension and university-based expertise. Additionally, information gained through firm-university partnerships significantly contributes to both innovation capacity and competitive advantages.
Treatment adherence (TA) is a critical issue and is under-investigated in hemodialysis patients. A multi-center study was conducted from July 2020 to March 2021 on 972 hemodialysis patients in eight ...hospitals in Vietnam to explore the factors associated with TA during the COVID-19 pandemic. Data were collected, including socio-demographics, an End-Stage Renal Disease Adherence Questionnaire (ESRD-AQ), 12-item short-form health literacy questionnaire (HLS-SF12), 4-item digital healthy diet literacy scale (DDL), 10-item hemodialysis dietary knowledge scale (HDK), 7-item fear of COVID-19 scale (FCoV-19S), and suspected COVID-19 symptoms (S-COVID19-S). Bivariate and multivariate linear regression models were used to explore the associations. Higher DDL scores were associated with higher TA scores (regression coefficient, B, 1.35; 95% confidence interval, 95%CI, 0.59, 2.12;
= 0.001). Higher FCoV-19S scores were associated with lower TA scores (B, -1.78; 95%CI, -3.33, -0.24;
= 0.023). In addition, patients aged 60-85 (B, 24.85; 95%CI, 6.61, 43.11;
= 0.008) with "very or fairly easy" medication payment ability (B, 27.92; 95%CI, 5.89, 44.95;
= 0.013) had higher TA scores. Patients who underwent hemodialysis for ≥5 years had a lower TA score than those who received <5 years of hemodialysis (B, -52.87; 95%CI, -70.46, -35.28;
< 0.001). These findings suggested that DDL and FCoV-19S, among other factors, should be considered in future interventions to improve TA in hemodialysis patients.
Osteoporosis is a common bone health disorder in hemodialysis patients that is linked with a higher morbidity and mortality rate. While previous studies have explored the associated factors of ...osteoporosis, there is a lack of studies investigating the impacts of health literacy (HL) and digital healthy diet literacy (DDL) on osteoporosis. Therefore, we aimed to investigate the associations of HL, DDL, and other factors with osteoporosis among hemodialysis patients. From July 2020 to March 2021, a cross-sectional study was conducted on 675 hemodialysis patients in eight hospitals in Vietnam. The data were collected by using the osteoporosis self-assessment tool for Asians (OSTA) and the 12-item short form of the health literacy questionnaire (HLS-SF12) on digital healthy diet literacy (DDL) and hemodialysis dietary knowledge (HDK). In addition, we also collected information about the socio-demographics, the clinical parameters, the biochemical parameters, and physical activity. Unadjusted and adjusted multinomial logistic regression models were utilized in order to investigate the associations. The proportion of patients at low, medium, and high levels of osteoporosis risk was 39.6%, 40.6%, and 19.8%, respectively. In the adjusted models, women had a higher likelihood of osteoporosis risk than men (odds ratio, OR, 3.46; 95% confidence interval, 95% CI, 1.86, 6.44; p < 0.001; and OR, 6.86; 95% CI, 2.96, 15.88; p < 0.001). The patients with rheumatoid arthritis (OR, 4.37; 95% CI, 1.67, 11.52; p = 0.003) and stomach ulcers (OR, 1.95; 95% CI, 1.01, 3.77; p = 0.048) were more likely to have a higher likelihood of osteoporosis risk than those without. The patients who had a higher waist circumference (WC), HL, and DDL were less likely to have a medium level of osteoporosis risk (OR, 0.95; 95% CI, 0.92, 0.98; p = 0.004; OR, 0.92; 95% CI, 0.88, 0.96; p < 0.001; OR, 0.96; 95% CI, 0.93, 0.99; p = 0.017, respectively) and a high level of osteoporosis risk (OR, 0.93; 95% CI, 0.89, 0.97; p = 0.001; OR, 0.89; 95% CI, 0.84, 0.94; p < 0.001; OR, 0.95; 95% CI, 0.91, 0.99; p = 0.008, respectively) compared with a low level of osteoporosis risk and to those with a lower WC, HL, and DDL. In addition, higher levels of hemoglobin (Hb) (OR, 0.79; 95% CI, 0.66, 0.95; p = 0.014), hematocrit (Hct) (OR, 0.95; 95% CI, 0.92, 0.99; p = 0.041), albumin (OR, 0.91; 95% CI, 0.83, 0.99; p = 0.030), and education (OR, 0.37; 95% CI, 0.16, 0.88; p = 0.025) were associated with a lower likelihood of a high level of osteoporosis risk. In conclusion, osteoporosis risk is highly prevalent in hemodialysis patients. Improved HL, DDL, education, WC, albumin, Hb, and Hct levels should be considered in preventing hemodialysis patients from developing osteoporosis.
During the COVID-19 pandemic, it is essential to evaluate hemodialysis patients’ dietary knowledge, especially among those with COVID-19 related symptoms, in order to identify appropriate strategies ...in managing their mental health. The study’s purposes were to test the psychometric properties of the hemodialysis dietary knowledge (HDK) scale, and to investigate the modifying impact of HDK on the associations of suspected COVID-19 symptoms (S-COVID-19-S) with anxiety and depression among hemodialysis patients. A cross-sectional study was conducted from July 2020 to March 2021 at eight hospitals across Vietnam. Data of 875 hemodialysis patients were analyzed, including socio-demographic, anxiety (the generalized anxiety disorder scale, GAD-7), depression (the patient health questionnaire, PHQ-9), S-COVID-19-S, HDK, health literacy, and digital healthy diet literacy. Confirmatory factor analysis (CFA) and logistic regression models were used to analyze the data. The HDK scale demonstrates the satisfactory construct validity with good model fit (Goodness of Fit Index, GFI = 0.96; Adjusted Goodness of Fit Index, AGFI = 0.90; Standardized Root Mean Square Residual, SRMR = 0.05; Root Mean Square Error of Approximation, RMSEA = 0.09; Normed Fit Index, NFI = 0.96; Comparative Fit Index, CFI = 0.96, and Parsimony goodness of Fit Index, PGFI = 0.43), criterion validity (as correlated with HL (r = 0.22, p < 0.01) and DDL (r = 0.19, p < 0.01), and reliability (Cronbach alpha = 0.70)). In the multivariate analysis, S-COVID-19-S was associated with a higher likelihood of anxiety (odds ratio, OR, 20.76; 95% confidence interval, 95%CI, 8.85, 48.70; p < 0.001) and depression (OR, 12.95; 95%CI, 6.67, 25.14, p < 0.001). A higher HDK score was associated with a lower likelihood of anxiety (OR, 0.70; 95%CI, 0.64, 0.77; p < 0.001) and depression (OR, 0.72; 95%CI, 0.66, 0.79; p < 0.001). In the interaction analysis, the negative impacts of S-COVID-19-S on anxiety and depression were mitigated by higher HDK scores (p < 0.001). In conclusion, HDK is a valid and reliable tool to measure dietary knowledge in hemodialysis patients. Higher HDK scores potentially protect patients with S-COVID-19-S from anxiety and depression during the pandemic.
Receiving hemodialysis treatment makes end-stage renal disease (ESRD) patients highly vulnerable amidst the COVID-19 pandemic. Hence, their kidney disease quality of life (KDQOL) is affected. We ...aimed to examine the association between fear of COVID-19 (FCoV-19) and KDQOL, and the effect modification of Health literacy (HL) on this association.BackgroundReceiving hemodialysis treatment makes end-stage renal disease (ESRD) patients highly vulnerable amidst the COVID-19 pandemic. Hence, their kidney disease quality of life (KDQOL) is affected. We aimed to examine the association between fear of COVID-19 (FCoV-19) and KDQOL, and the effect modification of Health literacy (HL) on this association.A survey was conducted at 8 hospitals from July 2020 to March 2021 on 972 patients. Data collection includes socio-demographic factors, clinical parameters, HL, digital healthy diet literacy (DDL), hemodialysis diet knowledge (HDK), FCoV-19, suspected COVID-19 symptoms (S-COVID-19-S), and KDQOL.Material and MethodsA survey was conducted at 8 hospitals from July 2020 to March 2021 on 972 patients. Data collection includes socio-demographic factors, clinical parameters, HL, digital healthy diet literacy (DDL), hemodialysis diet knowledge (HDK), FCoV-19, suspected COVID-19 symptoms (S-COVID-19-S), and KDQOL.Higher HL scores B = 0.13 (95% CI = 0.06-0.21, p = 0.001) and HDK scores B = 0.58 (95% CI = 0.31-0.85, p = 0.001) were associated with higher KDQOL scores. Whereas, S-COVID-19-S B = -6.12 (95% CI = -7.66 to - 4.58, p = 0.001) and FCoV-19 B = -0.91 (95% CI = -1.03 to - 0.80, p = 0.001) were associated with lower KDQOL scores. Notably, higher HL scores significantly attenuate the negative impact of FCoV-19 on overall KDQOL and the kidney disease component summary.ResultsHigher HL scores B = 0.13 (95% CI = 0.06-0.21, p = 0.001) and HDK scores B = 0.58 (95% CI = 0.31-0.85, p = 0.001) were associated with higher KDQOL scores. Whereas, S-COVID-19-S B = -6.12 (95% CI = -7.66 to - 4.58, p = 0.001) and FCoV-19 B = -0.91 (95% CI = -1.03 to - 0.80, p = 0.001) were associated with lower KDQOL scores. Notably, higher HL scores significantly attenuate the negative impact of FCoV-19 on overall KDQOL and the kidney disease component summary.In hemodialysis patients, FCoV-19 and S-COVID-19-S were associated with a lower KDQOL. Health literacy significantly mitigates the negative impact of FCoV-19 on KDQOL. Strategic public health interventions to improve HL are suggested to protect patient's KDQOL during the pandemic.ConclusionsIn hemodialysis patients, FCoV-19 and S-COVID-19-S were associated with a lower KDQOL. Health literacy significantly mitigates the negative impact of FCoV-19 on KDQOL. Strategic public health interventions to improve HL are suggested to protect patient's KDQOL during the pandemic.
Glyasperin A is a flavonoid that was isolated from the leaves of
Macaranga indica
Wight, Euphorbiaceae, a Vietnamese traditional herbal medicine. This compound has been proven to have potential ...anticancer properties. However, its impact on cancer stem cells has not been identified. In this work, the potential of glyasperin A is described in terms of the cytotoxicity, cell cycle arrest, and apoptosis-inducible activities against the NTERA-2 pluripotent human embryonal carcinoma cell line. The results presented that glyasperin A strongly inhibited NTERA-2 cellular proliferation with a value for the growth inhibition concentration at 50% of 2 ± 0.009 µM and in a dose-dependent manner. Due to approximately 3 times reduction of its IC
50
value, this compound seems to be more sensitive to NTERA-2 cancer stem cells than to the HEK-293A normal kidney embryonic cells (IC
50
6.40 ± 0.09 µM). In addition, the NTERA-2 cell cycle was clearly arrested at the S-phase (56.73%) compared to the untreated control (38.22%). Besides, flow cytometry analysis revealed that glyasperin A induced apoptosis in association with increasing compound concentrations. In addition, significant activation of the caspase-3 apoptotic enzyme under glyasperin A treatment was also recorded (
p
< 0.001). Therefore, glyasperin A demonstrated a potential effectiveness for the treatment of cancer stem cells.
Graphical Abstract
The investigation of safe mud pressure window of horizontal wellbore drilled in the saturated rock by accounting for the combined effect of anisotropy and uncertainty is the main purpose of this ...work. To this aim, the deterministic solution of collapse and fracture initiation pressures are firstly presented in three cases that describe the behavior of wellbore: (1) immediately after drilling (i.e., undrained problem); (2) at long term due to the steady-state fluid flow (permeable boundary case) and (3) by neglecting the variation of initial pore pressure (i.e., impermeable boundary condition case). Based on these deterministic solutions, the key parameters of different sources of anisotropy (initial stress state, poro-elastic and strength properties of rock mass) are highlighted through sensitivity analysis. Then, the famous Monte Carlo Simulation (MCS) is undertaken to quantify the uncertainty effect on the probability of success of safe mud pressure window of the wellbore. We also present an adaptation of the Kriging metamodeling technique to study the stability of wellbore. In comparison with the referent solution of MCS, the Kriging metamodel provides a high accuracy and can be used as a performant tool for the probabilistic assessment of wellbore. The consideration of anisotropy combined with uncertainty, and the hydraulically boundary condition around wellbore in this work allows us to complete the contributions in the literature and confirm their strong effect on the design of wellbore.
This study aimed to evaluate the effects of different surface preparation techniques on the surface microstructure, the shear bond strength (SBS) between zirconia and an MDP-containing light-cured ...veneer adhesive system, and the adhesive failure mode. Sixty-four zirconia specimens were divided into four groups based on surface preparation methods (n = 16), including zirconia sandblasting (ZSB), zirconia vitrification or glaze-on (ZVG), zirconia surface architecture technique (ZSAT), and ZSAT-ZVG combined technique (ZSATVG) groups. Sixteen lithium disilicate specimens prepared by etching with hydrofluoric acid (HF) were used as a positive control group (LDE). Surface roughness measurement and scanning electron microscopy (SEM) evaluation were performed before and after surface preparation. All specimens were then bonded with an MDP-containing light-cured adhesive system, followed by SBS testing and adhesive failure mode analysis. The ZVG and ZSATVG groups showed the greatest differential roughness value and microscopic irregularities, while the ZSAT and LDE groups had the least surface change but the most micromechanical retentive structures for resin infiltration. SBS values were significantly different among groups (p < 0.001) with the highest SBS observed in the ZSAT group, followed by the ZSB group, LDE group, ZSATVG group, and lastly, the ZVG group. There was a statistically significant difference in failure types among the surface preparation groups (p < 0.001). The ZSAT group had the highest frequency of mixed failure, followed by the ZSB group, LDE group, and the ZSATVG and ZVG groups. Establishing direct micromechanical retention within zirconia itself yields a higher bond strength than indirect micromechanical retention within a glass ceramic layer.
This paper introduces a novel approach to deal with the multi-objective optimization of a two-stage bevel helical gearbox by applying the Taguchi method and Grey Relation Analysis (GRA). The goal of ...the study is to find optimal main design factors that minimize the gearbox volume and maximize the gearbox efficiency. To accomplish this, five main design parameters were selected: the coefficients of wheel face width (CWFW) of the bevel and the helical gear sets, the allowable contact stresses (ACS) of the first and the second stages, and the gear ratio of the first stage. Furthermore, two single targets were investigated: minimum gearbox volumes, and maximum gearbox efficiency. Also, the multi-objective optimization problem is solved through two steps: Step 1 for closing the gap between variable levels and Step 2 for determining the optimal main design factors. The study’s findings were used to introduce the optimum values of five major design parameters for designing a two-stage helical gearbox.
Cancer is among the leading causes of death worldwide, with no effective and safe treatment to date. This study is the first to co-conjugate the natural compound cinchonain Ia, which has promising ...anti-inflammatory activity, and L-asparaginase (ASNase), which has anticancer potential, to manufacture nanoliposomal particles (CALs). The CAL nanoliposomal complex had a mean size of approximately 118.7 nm, a zeta potential of -47.00 mV, and a polydispersity index (PDI) of 0.120. ASNase and cinchonain Ia were encapsulated into liposomes with approximately 93.75% and 98.53% efficiency, respectively. The CAL complex presented strong synergistic anticancer potency, with a combination index (CI) < 0.32 in two-dimensional culture and 0.44 in a three-dimensional model, as tested on NTERA-2 cancer stem cells. Importantly, the CAL nanoparticles demonstrated outstanding antiproliferative efficiency on cell growth in NTERA-2 cell spheroids, with greater than 30- and 2.5-fold increases in cytotoxic activity compared to either cinchonain Ia or ASNase liposomes, respectively. CALs also presented extremely enhanced antitumor effects, reaching approximately 62.49% tumor growth inhibition. Tumorized mice under CALs treatment showed a survival rate of 100%, compared to 31.2% in the untreated control group (
< 0.01), after 28 days of the experiment. Thus, CALs may represent an effective material for anticancer drug development.
