Biomarkers (BMs) are medical signs which can be precisely measured and reproduced. Mainly, BMs provide information on the likely disease which can occur in an individual. On the other hand, BMs also ...signal disease recurrence in patients receiving therapy. The U.S. Food and Drug Administration coupled with the National Institutes of Health and the European Medicines Agency have proposed two distinct procedures to validate BMs. These agencies have elaborated two glossaries to describe the role of BMs. The aim of this study was to investigate medical taxonomies adopted by different governmental agencies for BM validation. Additional goals were to analyze efficiencies of the validated and candidate BMs for thyroid cancers (TCs). Currently, thyroglobulin is validated for monitoring TCs. Sorafenib-tosylate, Doxorubicin-hydrochloride, Vandetanib, Cabozantinib-s-malate, Dabrafenib-mesylate, Trametinib-dimethyl-sulfoxide, Lenvatinib-mesylate, Pralsetinib and Selpercatinib are validated for TC treatment. Among candidate BMs for TC diagnosis, there are molecular combinations including BRAF, RAS, RET/PTC and PAX8-PPARγ mutations. Noteworthy are BRAF and RET/PTC alterations already validated as targets of Dabrafenib-mesylate, Pralsetinib and Selpercatinib. Finally, cellular expressions of c-met in nodal TC metastases have diagnostic imaging applications. On the basis of this analysis, BM taxonomies should have common standards internationally recognized. BMs show different efficiencies depending on their diagnostic or therapeutic use.
In the last decades, a number of infectious viruses have emerged from wildlife or re-emerged, generating serious threats to the global health and to the economy worldwide. Ebola and Marburg ...hemorrhagic fevers, Lassa fever, Dengue fever, Yellow fever, West Nile fever, Zika, and Chikungunya vector-borne diseases, Swine flu, Severe acute respiratory syndrome (SARS), Middle East respiratory syndrome (MERS), and the recent Coronavirus disease 2019 (COVID-19) are examples of zoonoses that have spread throughout the globe with such a significant impact on public health that the scientific community has been called for a rapid intervention in preventing and treating emerging infections. Vaccination is probably the most effective tool in helping the immune system to activate protective responses against pathogens, reducing morbidity and mortality, as proven by historical records. Under health emergency conditions, new and alternative approaches in vaccine design and development are imperative for a rapid and massive vaccination coverage, to manage a disease outbreak and curtail the epidemic spread. This review gives an update on the current vaccination strategies for some of the emerging/re-emerging viruses, and discusses challenges and hurdles to overcome for developing efficacious vaccines against future pathogens.
In recent years, the scientific interest for the economic and landscape impact of wind farms has increased. This paper presents a useful GIS tool that allows for helping policymakers and investors to ...identify promising areas for wind power generation as well as landscape impact and financial and economic sustainability of wind farms. The results of the research carried out for exploring the potential for wind energy in two territorial contexts of Sicily region are presented with the particular look at the possibilities of economic developing, stakeholders’ opportunities and obstacles in the policy, legal, and regulatory framework.
Public housing policy has been proposing plans of public housing (PH) stock alienation or, as an alternative, property enhancement plans, since administrative and financial commitments have become ...too heavy for municipalities. This paper deals with one of the current public housing management policy initiatives, undertaken by the Municipality of Palermo (Italy), which aimed at transferring a significant part of the public housing asset to the current tenants, according to some terms and conditions, and applying a politically fixed price. This policy is described in general, focusing on the amount of the assets involved, reporting the terms and conditions for transferring them at an affordable price, and analysing their concentration/distribution in the urban areas. The main aim of the paper is to provide a valuation pattern for defining the trade-off between the efficiency and fairness of such a tool, recognising the conditions for the consistency between the transfer price established by municipality, the merit of the public housing asset, and the market value. A detailed study on two representative neighbourhoods was carried out in order to measure the value of solidarity of this policy and to propose some corrective rules.
Energy consumption in public buildings increased drastically over the last decade. Significant policy actions towards the promotion of energy efficiency in the building sector have been developed ...involving sustainable low-CO2-emission technologies. This paper presents the results of an economic–environmental valuation of a standard energy retrofit project for a public building in a Mediterranean area, integrating a life-cycle assessment (LCA) into the traditional economic–financial evaluation pattern. The study results show that simple retrofit of sustainable low-CO2-emission strategies such as wooden double-glazed windows, organic external wall insulation systems, and green roofs can reduce energy needs for heating and cooling by 58.5% and 33.4%, respectively. Furthermore, the implementation of an LCA highlights that the use of sustainable materials reduces the building’s carbon footprint index by 54.1% after retrofit compared to standard materials, thus providing an additional increase in the socio-environmental–economic–financial results of 18%. Some proposals are made about the accounting of the replacement costs and the residual value as requested in the logic of life-cycle cost (that is the economic extension of the LCA), namely concerning the method to take into account the replacement costs and the residual value. The economic calculation highlights the fundamental role played by tax benefits supporting the building energy retrofit, also in temperate climate zones, thus allowing the creation of environmental benefits in addition to remarkable cost savings.
The economic evaluation of the interventions aimed at reducing the seismic risk in the historic centres starting from a minimum risk scenario established by law, namely that provided by the Emergency ...Limit Condition (ELC), and aimed at supporting efficient and effective choices by the public decision-maker pursuing objectives of equity and social well-being, displaying a multidimensional nature. As a result, the evaluation process should integrate more approaches to quantify the different forms of capital involved. The seismic event can pose risks to an individual’s survival or reduce the quality of life. The assessment of the effects of the potential seismic vulnerability reduction plan on the population can be determined on the basis of the value of a statistical life (VSL). Among the possible approaches for its determination, that of the human capital (HC) was chosen for use. A critical review of the HC approach literature has been instrumental in defining an empirical approach that integrates the income-based approach proposed by Jorgenson–Fraumeni for market and non-market assets as well as the approach of Dagum. On the basis of this, the value of the HC for the historic centre of Brisighella was determined. The empirical approach also supported the definition of a model for the quantification of the benefits produced on the population by the plan of interventions to reduce the seismic vulnerability of the historic centre.
Toll-like receptors (TLRs) are transmembrane proteins belonging to the family of pattern-recognition receptors. They function as sensors of invading pathogens through recognition of ...pathogen-associated molecular patterns. After their engagement by microbial ligands, TLRs trigger downstream signaling pathways that culminate into transcriptional upregulation of genes involved in immune defense. Here we provide an updated overview on members of the TLR family and we focus on their role in antiviral response. Understanding of innate sensing and signaling of viruses triggered by these receptors would provide useful knowledge to prompt the development of vaccines able to elicit effective and long-lasting immune responses. We describe the mechanisms developed by viral pathogens to escape from immune surveillance mediated by TLRs and finally discuss how TLR/virus interplay might be exploited to guide the design of innovative vaccine platforms.
Hashimoto's thyroiditis (HT) is a gender autoimmune disease that is manifested by chronic inflammation of the thyroid. Clinical trial studies (CTSs) use molecular biotechnologies (MB) to approach HT ...appearance. The aims of this study were to analyze the applications of MB in CTSs carried out in HT populations (HT-CTSs). Further, to evaluate the role of MB in the context of the hygiene hypothesis (HH). From 75 HT-CTSs found at clinicaltrials.gov web place, forty-five were considered for this investigation. Finally, six HT-CTSs were reported as molecular HT-CTSs (mHT-CTSs) because these were planning to utilize MB. Two of mHT-CTSs were programmed on the French population to isolate DNA viral sequences. Blood, urine, and thyroid tissue biospecimens were analyzed to pick out the parvo and polyoma viruses. Two mHT-CTSs carried out in China aimed to identify oral and fecal microbiotas by measuring PCR sequencing of the 16S rRNA gene. Two mHT-CTSs were programmed in the USA and Greece, respectively, for interception of DNA polymorphisms to associate with genetic susceptibility to HT. In conclusion, MB are mainly employed in HT-CTSs for infective pathogenesis and genetic fingerprinting of HT. Furthermore, MB do not provide evidence of HH; however, they are useful for providing direct evidence of the presence of viruses.
Since the identification of the Human Immunodeficiency Virus type 1 (HIV-1) as the etiologic agent of AIDS (Acquired Immunodeficiency Syndrome), many efforts have been made to stop the AIDS pandemic. ...A major success of medical research has been the development of the highly active antiretroviral therapy and its availability to an increasing number of people worldwide, with a considerable effect on survival. However, a safe and effective vaccine able to prevent and eradicate the HIV pandemic is still lacking. Clinical trials and preclinical proof-of-concept studies in nonhuman primate (NHP) models have provided insights into potential correlates of protection against the HIV-1 infection, which include broadly neutralizing antibodies (bnAbs), non-neutralizing antibodies targeting the variable loops 1 and 2 (V1V2) regions of the HIV-1 envelope (Env), polyfunctional antibody, and Env-specific T-cell responses. In this review, we provide a brief overview of different HIV-1 vaccine approaches and discuss the current understanding of the cellular and humoral correlates of HIV-1 immunity.
Cancer is one of the top life‐threatening dangers to the human survival, accounting for over 10 million deaths per year. Bioactive glasses have developed dramatically since their discovery 50 years ...ago, with applications that include therapeutics as well as diagnostics. A new system within the bioactive glass family, mesoporous bioactive glasses (MBGs), has evolved into a multifunctional platform, thanks to MBGs easy‐to‐functionalize nature and tailorable textural properties—surface area, pore size, and pore volume. Although MBGs have yet to meet their potential in tumor treatment and imaging in practice, recently research has shed light on the distinguished MBGs capabilities as promising theranostic systems for cancer imaging and therapy. This review presents research progress in the field of MBG applications in cancer diagnosis and therapy, including synthesis of MBGs, mechanistic overview of MBGs application in tumor diagnosis and drug monitoring, applications of MBGs in cancer therapy ( particularly, targeted delivery and stimuli‐responsive nanoplatforms), and immunological profile of MBG‐based nanodevices in reference to the development of novel cancer therapeutics.
Cancer targeted therapy for osteosarcoma, utilizes multifunctional mesoporous bioactive glasses (MBG) theranostic systems. It includes 1) administration of MBG through the artery as a multifunctional drug delivery system, 2) tumor targeted delivery and stimuli‐responsive MBG for cancer therapy, 3) tumor diagnosis and drug monitoring, and 4) induction of apoptosis to promote apoptotic cell death and induction of bone regeneration.
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