Surface deformation relief (SDR) of the contact areas of a hip joint endoprosthesis subjected to wear was studied at different structural levels using laser scanning microscopy. Quantitative ...comparative 3D analysis of the SDR parameters characterizing postimplantation changes in components of the implant was performed. It was found that wear of the kinematic unit was eccentric and heterogeneous. Deep local surface changes were mainly observed at the upper pole of the head and the insert. The bottom segments of the insert remained intact even after long-term use of the tribological pair. The SDR of these segments remained intact.
The article presents the results of a survey of 102 patients with injuries and diseases of the hip sustava.Dana assessment of the quality of life on the SF-36 questionnaire before and 12 months ...after the application of joint replacement. The results: the highest percentage of patients (76.4%) of the age group of 55 to 65 years. There was a high proportion of chronic somatic diseases (4.3 per patient). In assessing the quality of life in patients undergoing hip replacement surgery, a statistically significant increase in the quality of life in all respects as the physical and mental component.
The paper presents the clinical and functional assessment of 97 patients with diseases of the hip. The criteria of severity of psychosocial maladjustment in this pathology were developed. ...Results: the greatest number of patients (75,6%) represented the age group of 55 to 65 years, a high percentage (67,5%) were women. Diagnosed with a high proportion of somatic diseases (4,3 per patient), and pathology of the skeletal system 94,7% (osteoporosis). The expediency of the use of severity psychosocial maladjustment in the preparation of rehabilitation programs in the postoperative period were determined to accelerate the reintegration and quality of life of patients.
The hip arthroplasty in case of destructive - dystrophic affection is considered as the most effective method, which provided social and home reintegration. A modern science development facilitates ...to this technique. However, specialists noted that the rate of endoprosthesis complication increased in the patients after osteosynthesis of proximal femur. The authors compared the results of patient’s treatment that applied hip arthroplasty methods after osteosynthesis of proximal femur. The main group consisted of 38 patients who underwent hip arthroplasty after osteosynthesis of proximal femur. The control group had 43 patients with hip idiopathic osteoarthrosis, who underwent primary arthroplasty. The endoprothesis replacement was associated with increase of the rate of intraoperative and postoperative complications in the main group of patients. According to the results, given group of patients requires a special approach to diagnostics and treatment.
The results of a comparative study (study group included 35 patients after hip arthroplasty, control group - 36 patients) of mineral monitoring in different skeletal segments showed that a deficit in ...bone mineral density is formed in operated limb and is reflected at the system level leading to various forms of suppression of bone homeostasis, which subsequently impairs the quality of life. The efficiency of the use of calcium salts in combination with alfacalcidol, and in conjunction with an active functional rehabilitation after hip arthroplasty based on clinical and radiological monitoring. Such a scheme has a positive effect on treatment outcomes when using this medical technology.
Surgical treatment of destructive and degenerative diseases of the hip arthroplasty technology with the modern development of science, technology and medicine is considered the most effective method ...of providing social and personal reintegration. However, the opinion of experts, arthroplasty increases the complication rate in patients after osteosynthesis and osteotomy of the proximal femur. The purpose of research - to compare patient outcomes Technology hip arthroplasty after-reducing reconstructive interventions at the proximal femur. Material and Methods: The study group comprised 42 patients who underwent hip arthroplasty after-reducing reconstructive interventions at the proximal femur. The control group consisted of 43 patients with idiopathic hip osteoarthritis who underwent primary arthroplasty. Results: conducting joint replacement in patients of the main group was accompanied by an increase in the frequency of intraoperative and postoperative complications. Therefore, this group of patients requires a special approach to diagnosis and treatment.
The matrix (MA) domain of HIV-1 mediates proper Gag localization and membrane binding via interaction with a plasma-membrane (PM)-specific acidic phospholipid, phosphatidylinositol-(4,5)-bisphosphate ...PI(4,5)P2. HIV-1 MA also interacts with RNA, which prevents Gag from binding to membranes containing phosphatidylserine, a prevalent cellular acidic phospholipid. These results suggest that the MA-bound RNA promotes PM-specific localization of HIV-1 Gag by blocking nonspecific interactions with cellular membranes that do not contain PI(4,5)P2. To examine whether PI(4,5)P2 dependence and RNA-mediated inhibition collectively determine MA phenotypes across a broad range of retroviruses and elucidate the significance of their interrelationships, we compared a panel of Gag-leucine zipper constructs (GagLZ) containing MA of different retroviruses. We found that in vitro membrane binding of GagLZ via HIV-1 MA and Rous sarcoma virus (RSV) MA is both PI(4,5)P2 dependent and susceptible to RNA-mediated inhibition. The PM-specific localization and virus-like particle (VLP) release of these GagLZ proteins are severely impaired by overexpression of a PI(4,5)P2-depleting enzyme, polyphosphoinositide 5-phosphatase IV (5ptaseIV). In contrast, membrane binding of GagLZ constructs that contain human T-lymphotropic virus type 1 (HTLV-1) MA, murine leukemia virus (MLV) MA, and human endogenous retrovirus K (HERV-K) MA is PI(4,5)P2 independent and not blocked by RNA. The PM localization and VLP release of these GagLZ chimeras were much less sensitive to 5ptaseIV expression. Notably, single amino acid substitutions that confer a large basic patch rendered HTLV-1 MA susceptible to the RNA-mediated block, suggesting that RNA readily blocks MA containing a large basic patch, such as HIV-1 and RSV MA. Further analyses of these MA mutants suggest a possibility that HIV-1 and RSV MA acquired PI(4,5)P2 dependence to alleviate the membrane binding block imposed by RNA.
MA basic residues in the HIV-1 structural protein Gag interact with phosphatidylinositol-(4,5)-bisphosphate PI(4,5)P2 and RNA. RNA inhibits HIV-1 MA binding to non-PI(4,5)P2 acidic lipids. This inhibition may promote PM specificity of Gag membrane binding, an early essential step in virus assembly. However, whether and how relationships between these interactions have developed among retroviruses are poorly understood. In this study, by comparing diverse retroviral MA domains, we elucidated a strong correlation among PI(4,5)P2 dependence, susceptibility to RNA-mediated inhibition, and cellular behaviors of Gag. Mutagenesis analyses suggest that a large basic patch on MA is sufficient to confer susceptibility to RNA-mediated inhibition but not for PI(4,5)P2-dependent membrane binding. Our findings highlight RNA's role as a general blocker of large basic patches and suggest a possibility that some retroviruses, including HIV-1, have evolved to bind PI(4,5)P2, while others have adopted smaller basic patches on their MA domains, to overcome the RNA-mediated restriction of membrane binding.
The matrix of a photonic crystal was deposited with gold nanoparticles and thin films using MOCVD technique. Nanoparticles were obtained in a pulse pressure MOCVD reactor; Me2Au(thd) ...(thd=2,2,6,6-tetramethyl-3,5-heptanedionato) was used as a precursor. The deposition of thin gold coating was carried out in a stagnant-flow MOCVD reactor, Me2Au(OAc) (OAc=acetate) was used as a precursor. It was demonstrated that deposition conditions affect the morphology of nanoparticles deposited from Me2Au(thd). An increase in the evaporator temperature was found to cause an increase in the concentration of gold nanoparticles on the surface of SiO2 microspheres, whereas their size is almost unchanged. Increasing the deposition temperature results in an increase in the size of the nanoparticles. Using the system of gold nanoparticles – fluorescein, we demonstrated that luminescence is enhanced by a factor of 2 as compared to the pure dye. We performed the deposition of thin gold films onto SiO2 microspheres and demonstrated that the thickness of gold coating is affected by the deposition temperature. Optical characteristics inherent in photonic crystals formed from gold microspheres were studied. The amount of impurities in the films is less than 3%.
•The matrix of a photonic crystal was deposited with gold nanoparticles and thin films using MOCVD technique.•The amount of impurities in the films is less than 3%.•Optical characteristics of gold nanoparticles and photonic crystals formed from gold microspheres have been studied.
The coupled-mode theory is an established and important tool in the electromagnetic theory which describes the exchange of energy between modes of a given system. In the framework of this theory, the ...coupling coefficient is the main parameter that quantifies the intermode interaction strength. In this paper, we introduce practical formulas for calculating the mutual coupling coefficient between two cylindrical dielectric resonators arbitrarily oriented in free space relative to each other. The correctness of the solution is validated against the full-wave numerical simulations performed with the COMSOL Multiphysics electromagnetic solver. In particular, the obtained formulas are suitable to analyze the gain/directivity and transmission/reflection properties of dielectric antennas and metasurfaces consisting of a large but finite number of dielectric resonators.
Celotno besedilo
Dostopno za:
BFBNIB, DOBA, GIS, IJS, IZUM, KILJ, KISLJ, NUK, PILJ, PNG, SAZU, UILJ, UKNU, UL, UM, UPUK
Background
The incidence of atypical pneumonia among immunocompromised patients is not well characterized. Establishing a diagnosis of atypical pneumonia is challenging as positive tests must be ...carefully interpreted. We aimed to assess the test positivity rate and incidence of atypical pneumonia in transplant recipients.
Methods
A retrospective cohort study was conducted at the Yale New Haven Health System in Connecticut. Adults with solid organ transplant, hematopoietic stem cell transplant (HSCT), or chimeric antigen receptor T‐cell, who underwent testing for atypical pathogens of pneumonia (Legionella pneumophilia, Mycoplasma pneumoniae, Chlamydia pneumoniae, and Bordetella pertussis) between January 2016 and August 2022 were included. Positive results were adjudicated in a clinical context using pre‐defined criteria. A cost analysis of diagnostic testing was performed.
Results
Note that, 1021 unique tests for atypical pathogens of pneumonia were performed among 481 transplant recipients. The testing positivity rate was 0.7% (n = 7). After clinical adjudication, there were three cases of proven Legionella and one case of possible Mycoplasma infection. All cases of legionellosis were in transplant recipients within 1‐year post‐transplantation with recently augmented immunosuppression and lymphopenia. The possible case of Mycoplasma infection was in an HSCT recipient with augmented immunosuppression. The cost of all tests ordered was $50,797.73.
Conclusion
The positivity rate of tests for atypical pneumonia was very low in this transplant cohort. An algorithmic approach that targets testing for those with compatible host, clinical, radiographic, and epidemiologic factors, and provides guidance on test selection and test interpretation, may improve the diagnostic yield and lead to substantial cost savings.
The incidence of atypical pneumonia is low in our transplant cohort. An algorithmic testing approach targeting only those with compatible host factors and clinical syndrome may improve diagnostic yield and lead to substantial cost savings.
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