We hypothesize that trace amounts of phosphides formed in the mantle are a plausible abiotic source of the Venusian phosphine observed by Greaves et al.
, https://doi.org/10.1038/s41550-020-1174-4 ...(2020). In this hypothesis, small amounts of phosphides (P
bound in metals such as iron), sourced from a deep mantle, are brought to the surface by volcanism. They are then ejected into the atmosphere in the form of volcanic dust by explosive volcanic eruptions, which were invoked by others to explain the episodic changes of sulfur dioxide seen in the atmosphere Esposito,
223, 1072-1074 (1984). There they react with sulfuric acid in the aerosol layer to form phosphine (2 P
+ 3H
SO
= 2PH
+ 3SO
). We take issue with the conclusion of Bains et al. arXiv:2009.06499 (2020) that the volcanic rates for such a mechanism would have to be implausibly high. We consider a mantle with the redox state similar to the Earth, magma originating deep in the mantle-a likely scenario for the origin of plume volcanism on Venus-and episodically high but plausible rates of volcanism on a Venus bereft of plate tectonics. We conclude that volcanism could supply an adequate amount of phosphide to produce phosphine. Our conclusion is supported by remote sensing observations of the Venusian atmosphere and surface that have been interpreted as indicative of currently active volcanism.
In this article, we ask how well Australian households are matched to their neighbourhood social environments. We broadly replicate a previous study of matching and ask to what extent households live ...in communities that are similar in socio-economic status to their characteristics. And, when households move, do they relocate in such a way as to increase similarity to their neighbours? The processes are at the heart of understanding the urban structure, how it changes over time and the links to urban inequality. The article uses data on household incomes from the Household, Income and Labour Dynamic (HILDA) Survey to measure the degree of similarity between households and their neighbours. We study the variation in matching for the population as a whole, and by quintiles of median neighbourhood income. We also measure how individuals that change neighbourhoods increase their similarity to the destination neighbourhood. We find that with respect to matching there is considerable diversity in the levels of matching; and that with respect to residential change, households in general do not make major shifts to increase matching when we control for housing tenure and other household characteristics. There is a need for further replications to understand the nature of matching and the outcomes.
ABSTRACT We present a study of relations between the masses of the central supermassive black holes (SMBHs) and the atmospheric gas temperatures and luminosities measured within a range of radii ...between Re and 5Re, for a sample of 47 early-type galaxies observed by the Chandra X-ray Observatory. We report the discovery of a tight correlation between the atmospheric temperatures of the brightest cluster/group galaxies (BCGs) and their central SMBH masses. Furthermore, our hydrostatic analysis reveals an approximately linear correlation between the total masses of BCGs (Mtot) and their central SMBH masses (MBH). State-of-the-art cosmological simulations show that the SMBH mass could be determined by the binding energy of the halo through radiative feedback during the rapid black hole growth by accretion, while for the most massive galaxies mergers are the chief channel of growth. In the scenario of a simultaneous growth of central SMBHs and their host galaxies through mergers, the observed linear correlation could be a natural consequence of the central limit theorem.
Microhomology-mediated end joining (MMEJ) is a major pathway for Ku-independent alternative nonhomologous end joining, which contributes to chromosomal translocations and telomere fusions, but the ...underlying mechanism of MMEJ in mammalian cells is not well understood. In this study, we demonstrated that, distinct from Ku-dependent classical nonhomologous end joining, MMEJ—even with very limited end resection—requires cyclin-dependent kinase activities and increases significantly when cells enter S phase. We also showed that MMEJ shares the initial end resection step with homologous recombination (HR) by requiring meiotic recombination 11 homolog A (Mre11) nuclease activity, which is needed for subsequent recruitment of Bloom syndrome protein (BLM) and exonuclease 1 (Exo1) to DNA double-strand breaks (DSBs) to promote extended end resection and HR. MMEJ does not require S139-phosphorylated histone H2AX (γ-H2AX), suggesting that initial end resection likely occurs at DSB ends. Using a MMEJ and HR competition repair substrate, we demonstrated that MMEJ with short end resection is used in mammalian cells at the level of 10–20% of HR when both HR and nonhomologous end joining are available. Furthermore, MMEJ is used to repair DSBs generated at collapsed replication forks. These studies suggest that MMEJ not only is a backup repair pathway in mammalian cells, but also has important physiological roles in repairing DSBs to maintain cell viability, especially under genomic stress.
We tested the interest and choice portion of social-cognitive career theory (SCCT; Lent, Brown, & Hackett, 1994) in the context of science, technology, engineering, and mathematics (STEM) domains. ...Data from 143 studies (including 196 independent samples) conducted over a 30-year period (1983 through 2013) were subjected to meta-analytic path analyses. The interest/choice model was found to fit the data well over all samples as well as within samples composed primarily of women and men and racial/ethnic minority and majority persons. The model also accounted for large portions of the variance in interests and choice goals within each path analysis. Despite the general predictive utility of SCCT across gender and racial/ethnic groups, we did find that several parameter estimates differed by group. We present both the group similarities and differences and consider their implications for future research, intervention, and theory refinement.
Public Significance Statement
This meta-analytic study examined theory-based factors that predict involvement in science, technology, engineering, and mathematics (STEM) activities and educational/occupational fields. Combining data from a wide range of student and adult samples, our results suggest that social-cognitive career theory may be a generally helpful framework for understanding STEM-related interests and choices across gender and racial/ethnic groups.
CtIP plays an important role in homologous recombination (HR)-mediated DNA double-stranded break (DSB) repair and interacts with Nbs1 and BRCA1, which are linked to Nijmegen breakage syndrome (NBS) ...and familial breast cancer, respectively. We identified new CDK phosphorylation sites on CtIP and found that phosphorylation of these newly identified CDK sites induces association of CtIP with the N-terminus FHA and BRCT domains of Nbs1. We further showed that these CDK-dependent phosphorylation events are a prerequisite for ATM to phosphorylate CtIP upon DNA damage, which is important for end resection to activate HR by promoting recruitment of BLM and Exo1 to DSBs. Most notably, this CDK-dependent CtIP and Nbs1 interaction facilitates ATM to phosphorylate CtIP in a substrate-specific manner. These studies reveal one important mechanism to regulate cell-cycle-dependent activation of HR upon DNA damage by coupling CDK- and ATM-mediated phosphorylation of CtIP through modulating the interaction of CtIP with Nbs1, which significantly helps to understand how DSB repair is regulated in mammalian cells to maintain genome stability.
Celotno besedilo
Dostopno za:
DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
A straightforward method for the undirected trifluoromethylation of unactivated methylene units was developed. The reaction proceeds in aqueous acetonitrile with Grushin’s reagent, bpyCu(CF3)3, ...under broad-spectrum white-light irradiation. The trifluoromethylation tolerates a wide range of functional groups including ketones, esters, nitriles, amides, alcohols, and carboxylic acids. The C–H cleavage step is performed via intermolecular H atom abstraction, and the selectivities across a range of methylene units are reported. Mechanistic studies offer a general reaction coordinate for the overall transformation.
Schlemm's canal is an important structure of the conventional aqueous humor outflow pathway and is critically involved in regulating the intraocular pressure. In this study, we report a novel finding ...that prospero homeobox protein 1 (Prox-1), the master control gene for lymphatic development, is expressed in Schlemm's canal. Moreover, we provide a novel in vivo method of visualizing Schlemm's canal using a transgenic mouse model of Prox-1-green fluorescent protein (GFP). The anatomical location of Prox-1⁺ Schlemm's canal was further confirmed by in vivo gonioscopic examination and ex vivo immunohistochemical analysis. Additionally, we show that the Schlemm's canal is distinguishable from typical lymphatic vessels by lack of lymphatic vessel endothelial hyaluronan receptor (LYVE-1) expression and absence of apparent sprouting reaction when inflammatory lymphangiogenesis occurred in the cornea. Taken together, our findings offer new insights into Schlemm's canal and provide a new experimental model for live imaging of this critical structure to help further our understanding of the aqueous humor outflow. This may lead to new avenues toward the development of novel therapeutic intervention for relevant diseases, most notably glaucoma.
Celotno besedilo
Dostopno za:
DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
Abstract
We analyse the radial pressure profiles, the intracluster medium (ICM) clumping factor and the Sunyaev–Zel'dovich (SZ) scaling relations of a sample of simulated galaxy clusters and groups ...identified in a set of hydrodynamical simulations based on an updated version of the treepm–SPH GADGET-3 code. Three different sets of simulations are performed: the first assumes non-radiative physics, the others include, among other processes, active galactic nucleus (AGN) and/or stellar feedback. Our results are analysed as a function of redshift, ICM physics, cluster mass and cluster cool-coreness or dynamical state. In general, the mean pressure profiles obtained for our sample of groups and clusters show a good agreement with X-ray and SZ observations. Simulated cool-core (CC) and non-cool-core (NCC) clusters also show a good match with real data. We obtain in all cases a small (if any) redshift evolution of the pressure profiles of massive clusters, at least back to z = 1. We find that the clumpiness of gas density and pressure increases with the distance from the cluster centre and with the dynamical activity. The inclusion of AGN feedback in our simulations generates values for the gas clumping ($\sqrt{C}_{\rho }\sim 1.2$ at R200) in good agreement with recent observational estimates. The simulated YSZ–M scaling relations are in good accordance with several observed samples, especially for massive clusters. As for the scatter of these relations, we obtain a clear dependence on the cluster dynamical state, whereas this distinction is not so evident when looking at the subsamples of CC and NCC clusters.
ABSTRACT
Nitrate is an important nitrogen source for plants, but also a signal molecule that controls various aspects of plant development. In the present study the role of nitrate on seed dormancy ...in Arabidopsis was investigated. The effects of either mutations affecting the Arabidopsis nitrate reductase genes or of different nitrate regimes of mother plants on the dormancy of the seeds produced were analysed. Altogether, data show that conditions favouring nitrate accumulation in mother plants and in seeds lead to a lower dormancy of seeds with little other morphological or biochemical differences. Analysis of germination during seed development indicated that nitrate does not prevent the onset of dormancy but rather its maintenance. The effect of an exogenous supply of nitrate on seed germination was tested: nitrate in contrast to glutamine or potassium chloride clearly stimulated the germination of dormant seeds. Data show, moreover, that the Arabidopsis dual affinity nitrate transporter NRT1.1 (CHL1) may be involved in conveying the nitrate signal into seeds. Thus, nitrate provided exogenously or by mother plants to the produced seeds, acts as a signal molecule favouring germination in Arabidopsis. This signalling may involve interaction with the abscisic acid or gibberellin pathway.
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