Fabry disease (FD) is an X-linked metabolic disease caused by a deficiency in α-galactosidase A (α-Gal A) activity. This causes accumulation of glycosphingolipids, especially globotriaosylceramide ...(Gb3), in different cells and organs. Neuropathic pain and gastrointestinal (GI) symptoms, such as abdominal pain, nausea, diarrhea, constipation, and early satiety, are the most frequent symptoms reported by FD patients and severely affect their quality of life. It is generally accepted that Gb3 and lyso-Gb3 are involved in the symptoms; nevertheless, the origin of these symptoms is complex and multifactorial, and the exact mechanisms of pathogenesis are still poorly understood. Here, we used a murine model of FD, the male α-Gal A (-/0) mouse, to characterize functionality, behavior, and microbiota in an attempt to elucidate the microbiota-gut-brain axis at three different ages. We provided evidence of a diarrhea-like phenotype and visceral hypersensitivity in our FD model together with reduced locomotor activity and anxiety-like behavior. We also showed for the first time that symptomology was associated with early compositional and functional dysbiosis of the gut microbiota, paralleled by alterations in fecal short-chain fatty acid levels, which partly persisted with advancing age. Interestingly, most of the dysbiotic features suggested a disruption of gut homeostasis, possibly contributing to accelerated intestinal transit, visceral hypersensitivity, and impaired communication along the gut-brain axis.
Significantly improved lifetime of micro-channel plate PMTs Lehmann, A.; Britting, A.; Eyrich, W. ...
Nuclear instruments & methods in physics research. Section A, Accelerators, spectrometers, detectors and associated equipment,
08/2013, Letnik:
718
Journal Article
Recenzirano
Odprti dostop
The lifetime of the most recent generation micro-channel plate (MCP) PMTs of BINP, Hamamatsu (R10754X) and PHOTONIS (XP85112) is being studied in a simultaneous measurement. We find that the new ...techniques applied to reduce the aging of the photocathode of the MCP-PMTs has significantly increased the lifetime. Dark count rate, gain and quantum efficiency of the tubes are given as a function of the integrated anode charge. Several times the quantum efficiency was also measured across the surface of the photocathode. At this point of the ongoing measurements the best MCP-PMT turns out to be the XP85112 with its MCP surfaces coated by an atomic layer to reduce the outgassing of the lead glass. This tube shows no aging after an integrated anode charge of 2.1C/cm2 which is more than an order of magnitude better than that of previous generation MCP-PMTs.
For the identification of low momentum charged particles and for event timing purposes a barrel Time-of-Flight (TOF) detector surrounding the interaction point is planned for the PANDA experiment at ...FAIR . Since the boundary conditions in terms of available radial space and radiation length are quite strict the favored layout is a hodoscope composed of several thousand small scintillating tiles (SciTils) read out by silicon photomultipliers (SiPMs). A time resolution of well below 100 ps is aimed for. With the originally proposed 30 x 30 x 5 mm super(3) SciTils read out by two single 3 x 3 mm super(2) SiPMs at the rims of the scintillator the targeted time resolution can be just reached, but with a considerable position dependence across the scintillator surface. In this paper we discuss other design options to further improve the time resolution and its homogeneity. It will be shown that wide scintillating rods (SciRods) with a size of, e.g., 50 x 30 x 5 mm super(3) or longer and read out at opposite sides by a chain of four serially connected SiPMs a time resolution down to 50 ps can be reached without problems. In addition, the position dependence of the time resolution is negligible. These SciRods were tested in the laboratory with electrons of a super(90) Sr source and under real experimental conditions in a particle beam at CERN. The measured time resolutions using fast BC418 or BC420 plastic scintillators wrapped in aluminum foil were consistently between 45 and 75 ps dependent on the SciRod design. This is a significant improvement compared to the original SciTil layout.
The FairRoot framework Al-Turany, M; Bertini, D; Karabowicz, R ...
Journal of physics. Conference series,
01/2012, Letnik:
396, Številka:
2
Journal Article
Recenzirano
Odprti dostop
The FairRoot framework is an object oriented simulation, reconstruction and data analysis framework based on ROOT. It includes core services for detector simulation and offline analysis. The ...framework delivers base classes which enable the users to easily construct their experimental setup in a fast and convenient way. By using the Virtual Monte Carlo concept it is possible to perform the simulations using either Geant3 or Geant4 without changing the user code or the geometry description. Using and extending the task mechanism of ROOT it is possible to implement complex analysis tasks in a convenient way. Moreover, using the FairCuda interface of the framework it is possible to run some of these tasks also on GPU. Data IO, as well as parameter handling and data base connections are also handled by the framework. Since some of the experiments will not have an experimental setup with a conventional trigger system, the framework can handle also free flowing input streams of detector data. For this mode of operation the framework provides classes to create the needed time sorted input streams of detector data out of the event based simulation data. There are also tools to do radiation studies and to visualize the simulated data. A CMake-CDash based building and monitoring system is also part of the FairRoot services which helps to build and test the framework on many different platforms in an automatic way, including also Continuous Integration.
Using quantum mechanical calculations within density functional theory, we provide a comprehensive analysis of infrared-active excitation of water molecules confined in nanocages of a beryl crystal ...lattice. We calculate infrared-active modes including the translational, librational, and mixed-type resonances of regular and heavy water molecules. The results are compared to the experimental spectra measured for the two principal polarizations of the electric field: parallel and perpendicular to the crystallographic c-axis. Good agreement is achieved between calculated and measured isotopic shifts of the normal modes. We analyze the vibrational modes in connection with the structural characteristics and arrangements of water molecules within the beryl crystal. Specific atomic displacements are assigned to each experimentally detected vibrational mode resolving the properties of nano-confined water on scales not accessible by experiments. Our results elucidate the applicability and efficiency of a combined experimental and computational approach for describing and an in-depth understanding of nano-confined water, and pave the way for future studies of more complex systems.
The production of pions and kaons has been measured in 197Au+197Au collisions at beam energies from 0.6 to 1.5A GeV with the kaon spectrometer at SIS/GSI. The K+ meson multiplicity per nucleon is ...enhanced in Au+Au collisions by factors up to 6 relative to C+C reactions, whereas the corresponding pion ratio is reduced. The ratio of the K+ meson excitation functions for Au+Au and C+C collisions increases with decreasing beam energy. This behavior is expected for a soft nuclear equation-of-state.
The FairRoot framework is the standard framework for simulation, reconstruction and data analysis for the FAIR experiments. The framework is designed to optimise the accessibility for beginners and ...developers, to be flexible and to cope with future developments. FairRoot enhances the synergy between the different physics experiments. As a first step toward simulation of free streaming data, the time based simulation was introduced to the framework. The next step is the event source simulation. This is achieved via a client server system. After digitization the so called "samplers" can be started, where sampler can read the data of the corresponding detector from the simulation files and make it available for the reconstruction clients. The system makes it possible to develop and validate the online reconstruction algorithms. In this work, the design and implementation of the new architecture and the communication layer will be described.
Status of the PANDA Barrel DIRC Schwarz, C.; Ali, A.; Belias, A. ...
Journal of instrumentation,
03/2020, Letnik:
15, Številka:
3
Journal Article
Recenzirano
Odprti dostop
The PANDA experiment will use cooled antiproton beams with high intensity stored in the High Energy Storage Ring at FAIR. Reactions on a fixed target producing charmed hadrons will shed light on the ...strong QCD. Three ring imaging Cherenkov counters are used for charged particle identification. The status of the Barrel DIRC (Detection of Internally Reflected Cherenkov light) is described. Its design is robust and its performance validated in experiments with test beams. The PANDA Barrel DIRC has entered the construction phase and will be installed in 2023/2024.
The PANDA experiment at FAIR near Darmstadt, Germany, is under construction, planned to investigate fundamental questions of hadron physics with a fixed proton target by using an antiproton beam ...within a momentum range of 1.5 to 15 GeV/c. A novel Cherenkov detector, the Endcap Disc DIRC (EDD), has been developed to separate π± and K± by at least 3 standard deviation up to 4 GeV/c. It will cover the polar angle range of the forward endcap of the PANDA target spectrometer from 5ˆ to 22ˆ. The EDD uses a 2 cm thick fused silica radiator plate with focusing elements at the outer rim and lifetime-enhanced Microchannel-Plate PMTs (MCP-PMTs) as light sensors. The Cherenkov radiator of the EDD consists of four identical independent quadrants, polished with highest precision in order to conserve the internally reflected Cherenkov angle during light propagation. This manuscript confirms basic functionalities of the EDD design and tests of the prototype with particle beams at CERN in 2018.
Large area triple GEM chambers will be employed in the first two stations of the MuCh system of the CBM experiment at the upcoming Facility for Antiproton and Ion Research FAIR in Darmstadt/Germany. ...The GEM detectors have been designed to take data at an unprecedented interaction rate (up to 10 MHz) in nucleus-nucleus collisions in CBM at FAIR. Real-size trapezoidal modules have been installed in the mCBM experiment and tested in nucleus-nucleus collisions at the SIS18 beamline of GSI as a part of the FAIR Phase-0 program. In this report, we discuss the design, installation, commissioning, and response of these GEM modules in detail. The response has been studied using the self-triggered readout electronics. In free-streaming data, the first attempt on an event building based on the timestamps of hits has been carried out, resulting in the observation of clear spatial correlations between the GEM modules in the mCBM setup for the first time. Accordingly, a time resolution of ∼15 ns have been obtained for the GEM detectors. Gain uniformity & cluster characteristics have also been studied.
PDF
