This article provides a conceptual map of the debate on ideal and non‐ideal theory. It argues that this debate encompasses a number of different questions, which have not been kept sufficiently ...separate in the literature. In particular, the article distinguishes between the following three interpretations of the ‘ideal vs. non‐ideal theory’ contrast: (i) full compliance vs. partial compliance theory; (ii) utopian vs. realistic theory; (iii) end‐state vs. transitional theory. The article advances critical reflections on each of these sub‐debates, and highlights areas for future research in the field.
Is democracy a requirement of justice or an instrument for realizing it? This article argues that the correct answer to this question depends on the background circumstances against which democracy ...is defended. In the presence of thin reasonable disagreement about justice, we should value democracy only instrumentally (if at all); in the presence of thick reasonable disagreement about justice, we should value it also intrinsically, as a necessary demand of justice. Since the latter type of disagreement is pervasive in real-world politics, the conclusion is that theories of justice designed for our world should be centrally concerned with democracy.
Millions of people in our world are in need of assistance: from the global poor, to refugees, from the victims of natural disasters, to those of violent crimes. What are our responsibilities towards ...them? Christian Barry and Gerhard Øverland's answer is plausible and straightforward: we have enforceable duties to assist others in need whenever we can do so 'at relatively moderate cost to ourselves, and others'. Barry and Øverland defend this answer on the ground that it best fits our intuitions in a variety of hypothetical rescue scenarios. I argue that, although Barry and Øverland's view is intuitively appealing, appeal to intuitive cases is insufficient to vindicate it satisfactorily. Intuitive cases alone do not allow us to establish: (i) what costs count as moderate and (ii) whether assistance-based responsibilities are, in fact, enforceable. These considerations suggest that Barry and Øverland's defence of their preferred answer to the assistance question may be incomplete.
The synthetic polymers used to protect artworks from deterioration process can be colonized by the fungi and bacteria responsible for the biodeterioration process. In this study, the susceptibility ...of synthetic polyacrylics and polyurethane resins to microorganisms (Aspergillus niger ATCC 9642, Aureobasidium pullulans ATCC 15233, Chaetomium globosum ATCC 6205, Cladosporium cladosporioides ATCC 16022, Alternaria alternata BC01, Penicillium citrinum LS1 and Pseudomonas aeruginosa ATCC 9027) was investigated. The microbial attack was simulated alone and with a biocide and the related growth was observed up to 21 days for bacteria and 28 days for fungi. The polyacrylic and polyurethane resins were subjected to microbial attack, regardless of the biocide treatment, with a fungal growth from 60% to the complete coverage of the plate surface. Penicillium citrinum showed the greatest adaptation ability and was found in all the examined resins. P. aeruginosa was visible in all the different resins, regardless of the presence of biocide. An environmental scanning electron microscope (ESEM) revealed the presence of fungal conidia and hyphae in the inoculated resins and the Fourier transform IR spectroscopy (FTIR-ATR) indicated chemical transformations in the IR spectra, particularly the hydrolysis of esters, with some differences between the polyacrylic and polyurethane resins, which were probably due to their different chemical features. Overall, our data stress that the chemical, physical and biological deterioration caused by microorganisms capable of degrading synthetic polymers is still a problem in art restoration and that new strategies must be considered to counteract this phenomenon.
The ancient Duchy of Urbino (Marche and Emilia-Romagna Regions, Italy) is known for its spectacular landscapes linked to a unique geological history. This area owns an unexpected cultural resource, ...which concerns using its landscapes in art. Some great Renaissance artists, including Piero della Francesca, Raphael, and Leonardo, were so impressed by the landscapes that they reproduced them in their most famous paintings. This paper summarizes research concerned with their identification, employing a multidisciplinary method that has enabled the recognition of many morphologies. This contribution provides the scientific community with information on the methodology and regional and national projects developed in this area to enhance its cultural landscapes. Starting from the geological description of the territory, the research focuses on famous works by three great Renaissance artists, providing evidence and morphological details related to the recognition of places: “Nativity” by Piero della Francesca, “Madonna Litta” by Leonardo da Vinci, and “Knight’s Dream” by Raphael. Finally, it is proposed to make these landscapes a timeless resource through their inclusion in UNESCO’s cultural heritage. This contribution is addressed to representatives of the administration, conservation, and enhancement of artistic and landscape heritage to stimulate new perspectives for research, education, and tourism within the cultural heritage of this area.
Geoheritage is a geotourism resource that could lead to the sustainable development of society, and could contribute to information on geological and geomorphological characteristics, education, ...public awareness on geoconservation, and landscape protection. Understanding this cultural wealth is still limited, since the information available is often specialized. Communication addressed to the emotional sphere can profoundly engage people, and technical information can be transmitted more effectively. For several years, our research group dealt with geoheritage and geotourism in central Italy. This work aimed to investigate different communication methods, such as publications, announcements through social media, conferences, live performances, and field excursions aimed at the emotional involvement of the public. Furthermore, the emotional response of the public was explored through a digital survey. These communication methodologies enabled a broad public reach, without any distinction based on social origin, cultural background, or age. Narrating the landscape through different forms of art creates a personal relationship with the audience. The emotional participation of the people demonstrates the effectiveness of the method in transmitting scientific and cultural themes, such as the origin of the geological landforms, the culture and the traditions that the site generated, and the problems pertaining to its protection and conservation.
Ceterach officinarum Willd is a plant widespread throughout Europe and used in southern Italy as a diuretic. Beliefs in the benefits of C. officinarum aqueous extract in the treatment of calcium ...oxalate kidney stones are widely held. Little is known, however, about the actual mechanism of its antilithiatic action. Our results in this in vitro study corroborate C. officinarum aqueous extract as a good source of antioxidants with a high antioxidant effects. Our results also demonstrate a major impact of C. officinarum aqueous extract on in vitro induced calcium oxalate crystallization kinetics and crystal morphology, showing its critical role in kidney stone formation and/or elimination. We show that progressively increasing doses of C. officinarum aqueous extract cause a sequence of effects. A powerful inhibitory action on calcium oxalate monohydrate (COM) growth and aggregation is first observed. C. officinarum aqueous extract also appears highly effective in stimulating nucleation increasing the number and reducing the size of COM crystals, which become progressively thinner, rounded and concave in a dose-dependent manner. These shape-modified COM crystals are known to be less adherent to renal tubular cells and more easily excreted through the urinary tract preventing kidney stone formation. Further, C. officinarum aqueous extract promotes the formation of calcium oxalate dihydrate (COD) rather than the monohydrate so that, at the highest concentrations used, only COD crystals are observed, in significant greater numbers with a clear reduction in their size, in a dose-dependent manner. Furthermore, AFM analyses allowed us to reveal the presence of C. officinarum component(s) on the surfaces of COD and modified COM crystals. The crystal surface adsorbed component(s) are shown to be similarly active as the total aqueous extract, suggesting a trigger factor which may direct crystal modification towards COD forms. In urolithiasis pathogenesis COD crystals are less dangerous than the COM forms due to their lower affinity for renal tubular cells. Our results are important in understanding the mechanisms which guide the modification induced by C. officinarum on the crystallization process. Based on these data, together with no adverse toxic effect being observed on the in vitro model of human intestinal enterocytes, C. officinarum aqueous extract could represent an attractive natural therapy for the treatment of urolithiasis.
Celotno besedilo
Dostopno za:
DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
This study aims to present a practical method to accurately diagnose ventriculoperitoneal shunt (VPS) malfunction and to detect the exact level at which the system has failed to tailor VPS revision ...at that level only.
A tertiary referral single-center algorithm for diagnosis of VPS malfunction is proposed. Based on clinical symptoms and confirmed ventricular dilatation on computed tomography, the VPS reservoir is punctured; if no cerebrospinal fluid is obtained, ventricular catheter replacement is recommended. Conversely, if cerebrospinal fluid is obtained, a sample is sent for cultural examination and the macroscopic integrity of the whole system is checked via plain radiography in the angiographic suite. Then, through the injection of iodate contrast medium into the reservoir and selective exclusion of the proximal and distal catheters, the patency and correct VPS functioning are investigated.
A total of 102 (56 males) patients (mean age, 41.5 years; range, 1–86 years) underwent a VPS function test from 2012 to 2018: 59 cases of VPS malfunction (57.8%) were diagnosed. Ventricular catheter obstruction/damage/displacement occurred in 12/59 patients (20.3%), valve damage in 11/59 patients (18.6%), distal catheter obstruction/damage/displacement in 17/59 patients (28.8%) and 2-level (valve/proximal catheter or valve/distal catheter) obstruction/damage/displacement in 16/59 patients (27.1%). Subclinical infection was diagnosed in 3 patients (5.1%). VPS revision was performed selectively at the level of failure.
The proposed algorithm is a practical, simple and minimally invasive technique to accurately diagnose VPS malfunction, identifying the exact level of system failure and allowing surgical VPS revision to be tailored, avoiding unnecessary complete system replacement.
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