We report the discovery of two mini-Neptunes in near 2:1 resonance orbits (\(P=7.610303\) d for HIP 113103 b and \(P=14.245651\) d for HIP 113103 c) around the adolescent K-star HIP 113103 (TIC ...121490076). The planet system was first identified from the TESS mission, and was confirmed via additional photometric and spectroscopic observations, including a \(\sim\)17.5 hour observation for the transits of both planets using ESA CHEOPS. We place \(\leq4.5\) min and \(\leq2.5\) min limits on the absence of transit timing variations over the three year photometric baseline, allowing further constraints on the orbital eccentricities of the system beyond that available from the photometric transit duration alone. With a planetary radius of \(R_{p}=1.829^{+0.096}_{-0.067}\,R_{\oplus}\), HIP 113103 b resides within the radius gap, and this might provide invaluable information on the formation disparities between super-Earths and mini-Neptunes. Given the larger radius \(R_{p}=2.40^{+0.10}_{-0.08}\,R_{\oplus}\) for HIP 113103 c, and close proximity of both planets to HIP 113103, it is likely that HIP 113103 b might have lost (or is still losing) its primordial atmosphere. We therefore present simulated atmospheric transmission spectra of both planets using JWST, HST, and Twinkle. It demonstrates a potential metallicity difference (due to differences in their evolution) would be a challenge to detect if the atmospheres are in chemical equilibrium. As one of the brightest multi sub-Neptune planet systems suitable for atmosphere follow up, HIP 113103 b and HIP 113103 c could provide insight on planetary evolution for the sub-Neptune K-star population.
ABSTRACT We present high-resolution observations of a sample of 75 K2 targets from Campaigns 1-3 using speckle interferometry on the Southern Astrophysical Research (SOAR) telescope and adaptive ...optics imaging at the Keck II telescope. The median SOAR I-band and Keck Ks-band detection limits at 1 ″ were Δ m I = 4.4 mag and Δ m K s = 6.1 mag, respectively. This sample includes 37 stars likely to host planets, 32 targets likely to be eclipsing binaries (EBs), and 6 other targets previously labeled as likely planetary false positives. We find nine likely physically bound companion stars within 3 ″ of three candidate transiting exoplanet host stars and six likely EBs. Six of the nine detected companions are new discoveries. One of these new discoveries, EPIC 206061524, is associated with a planet candidate. Among the EB candidates, companions were only found near the shortest period ones ( P < 3 days), which is in line with previous results showing high multiplicity near short-period binary stars. This high-resolution data, including both the detected companions and the limits on potential unseen companions, will be useful in future planet vetting and stellar multiplicity rate studies for planets and binaries.
Objective: The ultrastructure of the nerve profile in women with urinary stress incontinence (USI), who are supposed to have a normal bladder function, is still unknown.
Methods: Bladder biopsy were ...obtained from 11 patients with USI (Age: 55±13 yrs ) and 4 patients ( Age : 58 ±17 yrs) diagnosed with detrusor overactivity /overactive bladder (DO/OAB). Axonal contents of unmyelinated nerve bundles and schwann cells within the suburothelium were studied using electron microscope.
Results: A total of 175 and 63 axons were counted in USI and OAB/DO groups. The mean number of axons/nerve bundle was higher in USI patients in comparison to OAB/DO patients (4.11 vs. 3.15). 4 out of 63 axons (6.35%) in OAB/DO and 3 out of 175 axons (1.71%) in the USI group did not contain small vesicles. The mean number of axons/ nerve bundle without large dense‐cored vesicles in OAB/DO and USI groups was similar (0.55).
Degenerated axons were interestingly observed in both groups of patients. However, the mean number of the degenerated axons/nerve bundle was nearly twice in OAB/DO group in comparison (figure 1) to the USI group (figure 2) (0.55 vs. 0.31).
Degenerated axons with empty appearance were observed in both groups. These changes were observed in 2 out of 63 axons in patients with OAB/DO and 4 out of 175 in USI patients. The regenerated axonal profile was higher in the USI group (7% vs. 3%). Activated schwann cells were observed in both groups of patients (OAB/DO: 30% vs.USI: 45%). The mean short diameter of the nerve bundle was higher in OAB/DO group in comparison to the USI group (3.41 µm vs 1.54 µm).
Conclusion: This study showed ultrastructural changes and nerve degeneration in patients with USI, which has hitherto not been reported.
The profile of axons
OAB/DO patients (n=4)
USI patients (n=11)
Number of biopsies
4
11
Total number of nerve bundle counted
20
53
Total number of axons counted
63
175
Mean number of axons in a nerve bundle
3.15
4.11
Mean number of vesicles per axon
21.03
15.98
Mean number of large dense‐cored vesicles per axon
1.29
1.24
Mean number of number of mitochondria per axon
0.6
0.7
Display omitted
•Develop a computable and standardized reporting specification for clinical genomics.•Use open standards such as Health Level Seven Fast Healthcare Interoperability Resources ...(FHIR®).•Demonstrate feasibility of electronic health record integration for genomics.•Highlight challenges and lessons learned from using the FHIR® standard for genomics.
Structured representation of clinical genetic results is necessary for advancing precision medicine. The Electronic Medical Records and Genomics (eMERGE) Network’s Phase III program initially used a commercially developed XML message format for standardized and structured representation of genetic results for electronic health record (EHR) integration. In a desire to move towards a standard representation, the network created a new standardized format based upon Health Level Seven Fast Healthcare Interoperability Resources (HL7® FHIR®), to represent clinical genomics results. These new standards improve the utility of HL7® FHIR® as an international healthcare interoperability standard for management of genetic data from patients. This work advances the establishment of standards that are being designed for broad adoption in the current health information technology landscape.
Renal-cell carcinoma is the 10th most common cancer in Western countries, with about 30,600 new cases diagnosed and 12,000 deaths from the disease in the United States during 1996.
1
Surgical ...resection of localized disease is the only curative treatment. Approximately one third of patients present with metastatic disease, which is incurable except in a few patients who undergo surgical excision of a solitary soft-tissue metastasis. The median duration of survival of patients with metastatic renal-cell carcinoma is about one year, and only 10 percent survive beyond two years.
2
The results remain poor because of resistance to conventional therapies, such as . . .
We present high-resolution observations of a sample of 75 K2 targets from Campaigns 1-3 using speckle interferometry on the Southern Astrophysical Research (SOAR) telescope and adaptive optics (AO) ...imaging at the Keck II telescope. The median SOAR \(I\)-band and Keck \(K_s\)-band detection limits at 1" were \(\Delta m_{I}=4.4\)~mag and \(\Delta m_{K_s}=6.1\)~mag, respectively. This sample includes 37 stars likely to host planets, 32 targets likely to be eclipsing binaries (EBs), and 6 other targets previously labeled as likely planetary false positives. We find nine likely physically bound companion stars within 3" of three candidate transiting exoplanet host stars and six likely EBs. Six of the nine detected companions are new discoveries; one of the six, EPIC 206061524, is associated with a planet candidate. Among the EB candidates, companions were only found near the shortest period ones (\(P<3\) days), which is in line with previous results showing high multiplicity near short-period binary stars. This high-resolution data, including both the detected companions and the limits on potential unseen companions, will be useful in future planet vetting and stellar multiplicity rate studies for planets and binaries.
PDF
