In low-disorder, two-dimensional electron systems (2DESs), the fractional quantum Hall states at very small Landau level fillings (ν) terminate in a Wigner solid (WS) phase, where electrons arrange ...themselves in a periodic array. The WS is typically pinned by the residual disorder sites and manifests an insulating behavior, with nonlinear current-voltage (I-V) and noise characteristics. We report here measurements on an ultralow-disorder, dilute 2DES, confined to a GaAs quantum well. In the ν<1/5 range, superimposed on a highly insulating longitudinal resistance, the 2DES exhibits a developing fractional quantum Hall state at ν=1/7, attesting to its exceptional high quality and dominance of electron-electron interaction in the low filling regime. In the nearby insulating phases, we observe remarkable nonlinear I-V and noise characteristics as a function of increasing current, with current thresholds delineating three distinct phases of the WS: a pinned phase (P1) with very small noise, a second phase (P2) in which dV/dI fluctuates between positive and negative values and is accompanied by very high noise, and a third phase (P3) where dV/dI is nearly constant and small, and noise is about an order of magnitude lower than in P2. In the depinned (P2 and P3) phases, the noise spectrum also reveals well-defined peaks at frequencies that vary linearly with the applied current, suggestive of washboard frequencies. We discuss the data in light of a recent theory that proposes different dynamic phases for a driven WS.
Given their importance in predicting clinical outcomes, cardiorespiratory fitness (CRF) and muscle status can be considered new vital signs. However, they are not routinely evaluated in healthcare ...settings. Here, we present a comprehensive review of the epidemiological, mechanistic, and practical bases of the evaluation of CRF and muscle status in adults in primary healthcare settings. We highlight the importance of CRF and muscle status as predictors of morbidity and mortality, focusing on their association with cardiovascular and metabolic outcomes. Notably, adults in the best quartile of CRF and muscle status have as low as one-fourth the risk of developing some of the most common chronic metabolic and cardiovascular diseases than those in the poorest quartile. The physiological mechanisms that underlie these epidemiological associations are addressed. These mechanisms include the fact that both CRF and muscle status reflect an integrative response to the body function. Indeed, muscle plays an active role in the development of many diseases by regulating the body’s metabolic rate and releasing myokines, which modulate metabolic and cardiovascular functions. We also go over the most relevant techniques for assessing peak oxygen uptake as a surrogate of CRF and muscle strength, mass, and quality as surrogates of muscle status in adults. Finally, a clinical case of a middle-aged adult is discussed to integrate and summarize the practical aspects of the information presented throughout. Their clinical importance, the ease with which we can assess CRF and muscle status using affordable techniques, and the availability of reference values, justify their routine evaluation in adults across primary healthcare settings.
Bile acids (BAs) are signalling molecules that mediate various cellular responses in both physiological and pathological processes. Several studies report that BAs can be detected in the brain
, yet ...their physiological role in the central nervous system is still largely unknown. Here we show that postprandial BAs can reach the brain and activate a negative-feedback loop controlling satiety in response to physiological feeding via TGR5, a G-protein-coupled receptor activated by multiple conjugated and unconjugated BAs
and an established regulator of peripheral metabolism
. Notably, peripheral or central administration of a BA mix or a TGR5-specific BA mimetic (INT-777) exerted an anorexigenic effect in wild-type mice, while whole-body, neuron-specific or agouti-related peptide neuronal TGR5 deletion caused a significant increase in food intake. Accordingly, orexigenic peptide expression and secretion were reduced after short-term TGR5 activation. In vitro studies demonstrated that activation of the Rho-ROCK-actin-remodelling pathway decreases orexigenic agouti-related peptide/neuropeptide Y (AgRP/NPY) release in a TGR5-dependent manner. Taken together, these data identify a signalling cascade by which BAs exert acute effects at the transition between fasting and feeding and prime the switch towards satiety, unveiling a previously unrecognized role of physiological feedback mediated by BAs in the central nervous system.
To study the association between health-related quality of life (HRQoL) and all-cause mortality in a healthy middle-aged Mediterranean cohort.
We included 15,390 participants –mean age 42.8 years at ...first HRQoL ascertainment, all university graduates–. HRQoL was assessed with the self-administered Medical Outcomes Study Short Form-36 (SF-36) twice, with a 4-year gap. We used multivariable-adjusted Cox regression models to address the relation between self-reported health and Physical or Mental Component Summary (PCS-36 or MCS-36) and mortality, and their interaction with prior comorbidities or adherence to the Mediterranean diet (MedDiet).
Over 8.7 years of median follow-up time, 266 deaths were identified. Hazard ratio (HR) for the excellent vs. poor/fair category in self-reported health was 0.30 (95 % confidence interval (CI), 0.16–0.57) in the model with repeated measurements of HRQoL. Both the PCS-36 (HRquartile4(Q4)vs.Q1 0.57 95%CI, 0.36–0.90, ptrend < 0.001; HRper+10points: 0.64 95%CI, 0.54–0.75) and the MCS-36 (HRQ4vs.Q1 0.67 95%CI, 0.46–0.97, ptrend = 0.025; HRper+10points: 0.86 95%CI, 0.74–0.99) were inversely associated with mortality in the model with repeated measurements of HRQoL. Previous comorbidities or adherence to the MedDiet did not modify these associations.
Self-reported HRQoL –assessed as self-reported health, PCS-36 and MCS-36– obtained with the Spanish version of the SF-36 were inversely associated with mortality risk, regardless of the presence of previous comorbidities or adherence to the MedDiet.
•The Self-Reported Health may stand as a valid total mortality risk.•Past comorbidities didn't modify the relation between quality of life and mortality.•The Physical Component Summary of the SF-36 was inversely associated with mortality.•The Physical Component Summary was statistically associated to all-cause mortality.•Physical Component Summary scoring <50 progressively increased the mortality risk.
There has been a surge of recent interest in the role of anisotropy in interaction-induced phenomena in two-dimensional (2D) charged carrier systems. A fundamental question is how an anisotropy in ...the energy-band structure of the carriers at zero magnetic field affects the properties of the interacting particles at high fields, in particular of the composite fermions (CFs) and the fractional quantum Hall states (FQHSs). We demonstrate here tunable anisotropy for holes and hole-flux CFs confined to GaAs quantum wells, via applying in situ in-plane strain and measuring their Fermi wave vector anisotropy through commensurability oscillations. For strains on the order of 10^{-4} we observe significant deformations of the shapes of the Fermi contours for both holes and CFs. The measured Fermi contour anisotropy for CFs at high magnetic field (α_{CF}) is less than the anisotropy of their low-field hole (fermion) counterparts (α_{F}), and closely follows the relation α_{CF}=sqrtα_{F}. The energy gap measured for the ν=2/3 FQHS, on the other hand, is nearly unaffected by the Fermi contour anisotropy up to α_{F}∼3.3, the highest anisotropy achieved in our experiments.
Mediterranean diet and depression Sánchez-Villegas, A; Henríquez, P; Bes-Rastrollo, M ...
Public health nutrition,
12/2006, Letnik:
9, Številka:
8A
Journal Article
Recenzirano
Odprti dostop
The adherence to a Mediterranean Dietary Pattern ensures an adequate intake of B vitamins and w-3 fatty acids. A protective role on depression has been suggested for both nutrients.
Cross-sectional ...analysis from the SUN (Seguimiento Universidad de Navarra) prospective cohort study. Data from 9670 participants (4211 men and 5459 women) were analised. Logistic regression analyses were fitted to assess the association between B-vitamins and w-3 fatty acids intake (quintiles) and the prevalence of depression.
Folate intake was inversely associated with depression prevalence among men, especially smokers. Among women, B12 vitamin intake was inversely associated with depression, especially among smokers and physically active women. No significant associations were observed for w-3 fatty acids intake.
The adherence to a Mediterranean Dietary Pattern ensures an adequate intake of fruits, nuts, vegetables, cereals, legumes or fish, important sources of nutrients linked to depression prevention.
In the present work we analyzed seven globular clusters (GCs) selected from their location in the Galactic bulge and with metallicity values in the range −1.30 Fe/H −0.50. The aim of this work is ...first to derive cluster ages assuming single stellar populations and second to identify the stars from first (1G) and second generations (2G) from the main sequence, subgiant, and red giant branches, and to derive their age differences. Based on a combination of UV and optical filters used in this project, we apply the Gaussian mixture models to distinguish the multiple stellar populations. Applying statistical isochrone fitting, we derive self-consistent ages, distances, metallicities, and reddening values for the sample clusters. An average age of 12.3 0.4 Gyr was obtained both using DSED and BaSTI (accounting atomic diffusion effects) isochrones, without a clear distinction between the moderately metal-poor and the more metal-rich bulge clusters, except for NGC 6717 and the inner halo NGC 6362 with ∼13.5 Gyr. We derived a weighted mean age difference between the multiple populations hosted by each GC of 41 170 Myr adopting canonical He abundances; whereas for higher He in 2G stars, this difference reduces to 17 170 Myr, but with individual uncertainties of 500 Myr.
To evaluate how small amounts of astigmatism affect visual acuity and the minimum astigmatism values that should be corrected to achieve maximum visual performance.
Optics Laboratory, University of ...Murcia, Murcia, Spain.
Case series.
A wavefront sensor was used to measure astigmatism and higher-order aberrations (HOAs) in normal young eyes with astigmatism ranging from 0.0 to 0.5 diopter (D). Astigmatism was corrected for natural pupil diameters using a purpose-designed cross-cylinder device. Visual acuity was measured for high-contrast and low-contrast stimuli at best subjective focus with the natural and corrected astigmatism. From the aberrations, optical image-quality metrics were calculated for 3 conditions: natural astigmatism, corrected astigmatism, and astigmatism only (with all HOAs removed).
The study evaluated 54 eyes. There was no significant correlation between the amount of astigmatism and visual acuity. The correction of astigmatism improved visual acuity for only high-contrast letters from 0.3 D, but with a high variability between subjects. Low-contrast visual acuity changed randomly as astigmatism was corrected. The correction of astigmatism increased the mean image-quality values; however, there was no significant correlation with visual performance. The deterioration in image quality given by astigmatism higher than 0.3 D was limited by HOAs.
In most subjects, astigmatism less than 0.5 D did not degrade visual acuity. This suggests that under clinical conditions, the visual benefit of precise correction of astigmatism less than 0.5 D would be limited.
IL-23/Th17 pathway has been identified to sustain inflammatory condition in several autoimmune diseases and therefore being targeted in various therapeutic and effective approaches. Patients affected ...with autoimmune myasthenia gravis exhibit a disease effector tissue, the thymus, that harbors ectopic germinal centers that sustain production of auto-antibodies, targeting proteins located in the neuromuscular junction, cause of the organ-specific chronic autoimmune disease.
The present study aims to investigate the IL-23/Th17 cell pathway in the thymic inflammatory and pathogenic events.
We found that thymuses of MG patients displayed overexpression of Interleukin-17, signature cytokine of activated Th17 cells. This activation was sustained by a higher secretion of Interleukin-23 by TEC, in addition to the increased expression of cytokines involved in Th17 cell development. The overexpression of Interleukin-23 was due to a dysregulation of interferon type I pathway. Besides, Interleukin-17 secreted, and Th17 cells were localized around thymic ectopic germinal centers. These cells expressed podoplanin, a protein involved in B-cell maturation and antibody secretion. Finally, production of Interleukin-23 was also promoted by Interleukin-17 secreted itself by Th17 cells, highlighting a chronic loop of inflammation sustained by thymic cell interaction.
Activation of the IL-23/Th17 pathway in the thymus of autoimmune myasthenia gravis patients creates an unstoppable loop of inflammation that may participate in ectopic germinal center maintenance. To alleviate the physio-pathological events in myasthenia gravis patients, this pathway may be considered as a new therapeutic target.
•In AChR+ MG, Thymic epithelial cells display a significant increased secretion of IL-23.•IL-23 sustained thymic inflammation and consequently thymic auto-antibody production in AChR+ myasthenia gravis.•Blocking IL-23/Th17 may be a promising therapeutic method to prevent/ limit deleterious events affected myasthenia gravis patients.
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