Frequent instances of intervention in current world affairs have threatened the status of nonintervention as a rule of international relations. Gathering evidence from history, law, sociology, and ...political science, R. J. Vincent concludes that the principle of nonintervention can and must remain viable.
The author approaches the question from several angles, seeking to discover why the principle of nonintervention has been asserted as part of the law of nations; whether states in the past and present have conducted their foreign relations according to the principle of nonintervention; and what function the principle performs in the society formed between states.
The author examines the principle of nonintervention through examples taken from contemporary world politics, focusing on its role in the doctrine and practice of the Soviet Union, the United States, and the United Nations. He argues that, despite the erosion of the order of sovereign states, the arrival of nuclear response weapons, all-enveloping ideological conflict, and transnational relationships that diminish the significance of state frontiers, the principle of nonintervention continues to contribute to the international order.
Originally published in 1974.
ThePrinceton Legacy Libraryuses the latest print-on-demand technology to again make available previously out-of-print books from the distinguished backlist of Princeton University Press. These paperback editions preserve the original texts of these important books while presenting them in durable paperback editions. The goal of the Princeton Legacy Library is to vastly increase access to the rich scholarly heritage found in the thousands of books published by Princeton University Press since its founding in 1905.
Obesity is a heritable disorder, with children of obese fathers at higher risk of developing obesity. Environmental factors epigenetically influence somatic tissues, but the contribution of these ...factors to the establishment of epigenetic patterns in human gametes is unknown. Here, we hypothesized that weight loss remodels the epigenetic signature of spermatozoa in human obesity. Comprehensive profiling of the epigenome of sperm from lean and obese men showed similar histone positioning, but small non-coding RNA expression and DNA methylation patterns were markedly different. In a separate cohort of morbidly obese men, surgery-induced weight loss was associated with a dramatic remodeling of sperm DNA methylation, notably at genetic locations implicated in the central control of appetite. Our data provide evidence that the epigenome of human spermatozoa dynamically changes under environmental pressure and offers insight into how obesity may propagate metabolic dysfunction to the next generation.
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•Distinct sncRNA expression and DNA methylation profiles in sperm from obese humans•Differentially methylated genes are related to brain function•The spermatozoal epigenome is dynamically remodeled after bariatric surgery•Differential methylation clusters with known SNPs of obesity
Donkin et al. show that spermatozoa from obese men carry a distinct epigenetic signature compared to lean men, in particular at genes controlling brain development and function. The sperm methylome is dynamically remodeled after gastric-bypass-induced weight loss, notably at gene regions implicated in the central control of appetite.
Polynyas are sections of the polar ocean that remain relatively ice-free during winter, imparting significant physical and biological impact on the region. The North Water polynya (NOW) situated ...between Ellesmere Island and Greenland is the largest recurring Arctic polynya. Historically, the NOW forms every season when Arctic Ocean floes moving southward through Nares Strait become congested and form an ice arch that defines the northern border of the polynya. This blockage usually forms during winter and breaks down in spring. It is conjectured that the polynya is maintained by latent heat of fusion from the continuous formation of new ice as floes are swept southward from the ice arch by wind and ocean currents. Analysis of four decades of satellite imagery indicates a growing instability in the location of the ice arch, challenging previous models of polynya maintenance. A linear trend of the data indicates the number of days of Nares Strait blockage has decreased 2.1 days/year between 1979 and 2019 with wide interannual variations. Prior to 2007, ice arches blocked Nares Strait an average of 177 days/year compared to 128 days/year since that time. The overall trend of reduced ice arch duration is a contributing factor to the dramatic loss of multiyear ice in the Arctic basin.
An enormous amount of research effort has been devoted to biomarker discovery and validation. With the completion of the human genome, proteomics is now playing an increasing role in this search for ...new and better biomarkers. Here, what leads to successful biomarker development is reviewed and how these features may be applied in the context of proteomic biomarker research is considered. The “fit‐for‐purpose” approach to biomarker development suggests that untargeted proteomic approaches may be better suited for early stages of biomarker discovery, while targeted approaches are preferred for validation and implementation. A systematic screening of published biomarker articles using MS‐based proteomics reveals that while both targeted and untargeted technologies are used in proteomic biomarker development, most researchers do not combine these approaches. i) The reasons for this discrepancy, (ii) how proteomic technologies can overcome technical challenges that seem to limit their translation into the clinic, and (iii) how MS can improve, complement, or replace existing clinically important assays in the future are discussed.
The advancement in satellite remote sensing technology has revolutionised the approaches to monitoring the Earth’s surface. The development of the Copernicus Programme by the European Space Agency ...(ESA) and the European Union (EU) has contributed to the effective monitoring of the Earth’s surface by producing the Sentinel-2 multispectral products. Sentinel-2 satellites are the second constellation of the ESA Sentinel missions and carry onboard multispectral scanners. The primary objective of the Sentinel-2 mission is to provide high resolution satellite data for land cover/use monitoring, climate change and disaster monitoring, as well as complementing the other satellite missions such as Landsat. Since the launch of Sentinel-2 multispectral instruments in 2015, there have been many studies on land cover/use classification which use Sentinel-2 images. However, no review studies have been dedicated to the application of ESA Sentinel-2 land cover/use monitoring. Therefore, this review focuses on two aspects: (1) assessing the contribution of ESA Sentinel-2 to land cover/use classification, and (2) exploring the performance of Sentinel-2 data in different applications (e.g., forest, urban area and natural hazard monitoring). The present review shows that Sentinel-2 has a positive impact on land cover/use monitoring, specifically in monitoring of crop, forests, urban areas, and water resources. The contemporary high adoption and application of Sentinel-2 can be attributed to the higher spatial resolution (10 m) than other medium spatial resolution images, the high temporal resolution of 5 days and the availability of the red-edge bands with multiple applications. The ability to integrate Sentinel-2 data with other remotely sensed data, as part of data analysis, improves the overall accuracy (OA) when working with Sentinel-2 images. The free access policy drives the increasing use of Sentinel-2 data, especially in developing countries where financial resources for the acquisition of remotely sensed data are limited. The literature also shows that the use of Sentinel-2 data produces high accuracies (>80%) with machine-learning classifiers such as support vector machine (SVM) and Random forest (RF). However, other classifiers such as maximum likelihood analysis are also common. Although Sentinel-2 offers many opportunities for land cover/use classification, there are challenges which include mismatching with Landsat OLI-8 data, a lack of thermal bands, and the differences in spatial resolution among the bands of Sentinel-2. Sentinel-2 data show promise and have the potential to contribute significantly towards land cover/use monitoring.
A significant problem for current quantum computers is noise. While there are many distinct noise channels, the depolarizing noise model often appropriately describes average noise for large circuits ...involving many qubits and gates. We present a method to mitigate the depolarizing noise by first estimating its rate with a noise-estimation circuit and then correcting the output of the target circuit using the estimated rate. The method is experimentally validated on a simulation of the Heisenberg model. We find that our approach in combination with readout-error correction, randomized compiling, and zero-noise extrapolation produces close to exact results even for circuits containing hundreds of CNOT gates. We also show analytically that zero-noise extrapolation is improved when it is applied to the output of our method.
Abstract
In this paper, the convergence of an algorithm for recovering the unknown kinematic viscosity of a two-dimensional incompressible, viscous fluid is studied. The algorithm of interest is a ...recursive feedback control-based algorithm that leverages observations that are received continuously-in-time, then dynamically provides updated values of the viscosity at judicious moments. It is shown that in an idealized setup, convergence to the true value of the viscosity can indeed be achieved under a natural and practically verifiable non-degeneracy condition. This appears to be first such result of its kind for parameter estimation of nonlinear partial differential equations. Analysis for two parameter update rules is provided: one which involves instantaneous evaluation in time and the other, averaging in time. The proof of convergence for either rule exploits sensitivity-type bounds in higher-order Sobolev topologies, while the instantaneous version particularly requires delicate energy estimates involving the time-derivative of the sensitivity-type variable. Indeed, a crucial component in the analysis is the identification of a dissipative structure for the time-derivative of the sensitivity-type variable, which ultimately ensures a favorable dependence on the tuning parameter of the algorithm.
Protection against coastal disasters has been identified as an important service of mangrove ecosystems. Empirical studies on this service have been criticized, however, for using small samples and ...inadequately controlling for confounding factors. We used data on several hundred villages to test the impact of mangroves on human deaths during a 1999 super cyclone that struck Orissa, India. We found that villages with wider mangroves between them and the coast experienced significantly fewer deaths than ones with narrower or no mangroves. This finding was robust to the inclusion of a wide range of other variables to our statistical model, including controls for the historical extent of mangroves. Although mangroves evidently saved fewer lives than an early warning issued by the government, the retention of remaining mangroves in Orissa is economically justified even without considering the many benefits they provide to human society besides storm-protection services.
The properties of warm dark matter haloes Lovell, Mark R; Frenk, Carlos S; Eke, Vincent R ...
Monthly notices of the Royal Astronomical Society,
03/2014, Letnik:
439, Številka:
1
Journal Article
Recenzirano
Odprti dostop
Well-motivated elementary particle candidates for the dark matter, such as the sterile neutrino, behave as warm dark matter (WDM). For particle masses of the order of a keV, free streaming produces a ...cutoff in the linear fluctuation power spectrum at a scale corresponding to dwarf galaxies. We investigate the abundance and structure of WDM haloes and subhaloes on these scales using high resolution cosmological N-body simulations of galactic haloes of mass similar to the Milky Way's. On scales larger than the free-streaming cutoff, the initial conditions have the same power spectrum and phases as one of the cold dark matter (CDM) haloes previously simulated by Springel et al. as part of the Virgo consortium Aquarius project. We have simulated four haloes with WDM particle masses in the range 1.5-2.3 keV and, for one case, we have carried out further simulations at varying resolution. N-body simulations in which the power spectrum cutoff is resolved are known to undergo artificial fragmentation in filaments producing spurious clumps which, for small masses (<107 M in our case) outnumber genuine haloes. We have developed a robust algorithm to identify these spurious objects and remove them from our halo catalogues. We find that the WDM subhalo mass function is suppressed by well over an order magnitude relative to the CDM case for masses <109 M. Requiring that there should be at least as many subhaloes as there are observed satellites in the Milky Way leads to a conservative lower limit to the (thermal equivalent) WDM particle mass of ∼ 1.5 keV. WDM haloes and subhaloes have cuspy density distributions that are well described by Navarro-Frenk-White or Einasto profiles. Their central densities are lower for lower WDM particle masses and none of the models we have considered suffering from the 'too big to fail' problem recently highlighted by Boylan-Kolchin et al.
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