ABSTRACT
A new skin protectant was developed for use on conditions involving partial‐thickness skin loss such as severe incontinence‐associated dermatitis. This new formulation is based on a ...cyanoacrylate chemistry designed to polymerize in situ and create a breathable film able to protect the skin surface from external irritants. This film provides an environment favorable for healing to occur beneath the film. To evaluate the characteristics of the novel chemistry, we devised a preclinical testing strategy comprising three different animal models. The data from all three models was considered collectively to create an overall assessment of effectiveness. A guinea pig model was used to evaluate the barrier efficacy of the new product in protecting intact skin from irritation. A porcine partial‐thickness wound model was used to evaluate the efficacy of the product in helping control minor bleeding and exudate. A similar model was also used to assess the process of reepithelialization in the continued presence of an irritant. In the first model, untreated sites had 8.5 times more irritation than sites covered with the new product (p < 0.001). In the second model, a single application of the new product successfully attached to intact peri‐wound skin and to denuded, weepy skin. It significantly reduced the amount of fluid weeping from the wounds (p ≤ 0.001) and continued to perform throughout a 96 hours experiment. In the third model, the percent of reepithelialization was significantly greater for the wounds covered with the new product than for the control wounds (p = 0.003; on average, 18.3% greater, with a 95% confidence interval of 9.2% to 27.5%). These results suggest that the new skin protectant protects intact and denuded skin from irritants and provides an environment favorable to healing, offering promise for the management of various conditions involving loss of epidermis.
In this paper a general parabolic problem is considered and discretized by the discontinuous Galerkin (DG) method in time and, in general, in space. Optimal
error estimates in space as well as in ...time are derived and applied to the heat equation and to a nonlinear convection-diffusion equation.
A 26-year-old elite male swimmer presented with chronic, isolated, hallux metatarsophalangeal joint varus instability status post previous lateral collateral ligament repair. We report a novel ...surgical technique for revision first metatarsophalangeal joint (MTP-1) lateral collateral ligament reconstruction using soft tissue imbrication and augmentation with a degradable polycaprolactone-based polyurethane urea (PUUR) matrix. There is paucity in the literature describing the surgical management of revision lateral collateral ligament injury in these cases.
Our reconstruction technique using degradable PUUR matrix restores natural soft tissue elasticity, provides a scaffolding for neocollagenesis, is bioinert, and delivers a low-profile reconstruction allowing the patient to return to high level competition with excellent patient outcomes at one year follow up.
Survivors of pelvic cancer treatment live with the ramifications of pelvic radiation for many years after their cure. Several options are available to preserve ovarian function and fertility in ...reproductive age women undergoing pelvic radiation. Laparoscopic ovarian transposition is an under-utilized, yet fairly simple surgical procedure to relocate the ovaries away from the radiation field. Although randomized-controlled trials on the outcomes of ovarian transposition are scarce, there is a growing body of evidence on the risks and benefits of this procedure, in terms of prevention of premature ovarian failure, and potentially preserving fertility. In this review, we summarize the available data on the indications, patient selection and outcomes of ovarian transposition, as well as illustrate the technique of the procedure.
Background:
Due to the need for medical optimization and congested operating room schedules, surgical repair is often performed at night. Studies have shown that work done at night increases ...complications. The primary aim of our study is to compare the rates of complications and 30-day mortality between 2 surgical times of day, daytime group (DTG, 07:00-15:59) and nighttime group (NTG, 16:00-06:59).
Methods:
Retrospective chart review from 2005 through 2010.
Setting:
Level 1 Trauma Center.
Participants:
1443 patients with hip fracture, age ≥50 years with isolated injury and surgical treatment of the fracture.
Main Outcomes and Measures:
Thirty-day mortality and complications: myocardial infarction, cardiac event, stroke, central nervous system event, pneumonia, urinary tract infection, postoperative wound infection, and bleeding requiring transfusion of 3 or more red blood cell units.
Results:
A total of 859 patients met the inclusion criteria; 668 patients in the DTG and 191 patients in the NTG. The 30-day mortality was 7.8%. The complication rate was 28%. No difference was found in 30-day mortality or complication rate based on the time of day the surgery was performed (P = 1.0 and P = .92, respectively). This remained unchanged when controlling for health status and surgical complexity. Age (odds ratio = 1.03/year), Charlson Comorbidity Index (CCI; odds ratio = 1.21), and American Society of Anesthesiologists (ASA; odds ratio = 1.85) score were predictive of adverse outcomes.
Conclusion:
Surgical time of day did not affect 30-day mortality or total number of complications. Age, ASA score, and CCI were associated with adverse outcomes.
Background information. The spatial localization of translation can facilitate the enrichment of proteins at their sites of function while also ensuring that proteins are expressed in the proximity ...of their cognate binding partners. Results. Using human embryonic lung fibroblasts and employing confocal imaging and biochemical fractionation techniques, we show that ribosomes, translation initiation factors and specific RNA-binding proteins localize to nascent focal complexes along the distal edge of migrating lamellipodia. 40S ribosomal subunits appear to associate preferentially with b3 integrin in focal adhesions at the leading edges of spreading cells, with this association strongly augmented by a synergistic effect of cell engagement with a mixture of extracellular matrix proteins. However, both ribosome and initiation factor localizations do not require de novo protein synthesis. Conclusions. Taken together, these findings demonstrate that repression, complex post-transcriptional regulation and modulation of mRNA stability could potentially be taking place along the distal edge of migrating lamellipodia.
Parallel chemical analyses of ribs and femurs from the Middle Woodland Gibson site and the Late Woodland Ledders site show that the elements most closely related to diet (strontium, zinc, magnesium) ...are found in identical proportions in the two bones. Elements associated with soil contamination (iron, aluminum, potassium, manganese) are found in a significantly higher proportion in the rib. The major elements calcium and sodium are found in lower levels in the ribs. Thus the rib is more sensitive to diagenetic processes that alter elemental proportions than is the femur. Conclusions concerning subgroupings by sex or site, derived from the diet-related elements (Sr, Zn, Mg), were found to be essentially the same for the rib and the femur.
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