A search for the solar neutrino effective magnetic moment has been performed using data from 1291.5 days exposure during the second phase of the Borexino experiment. No significant deviations from ...the expected shape of the electron recoil spectrum from solar neutrinos have been found, and a new upper limit on the effective neutrino magnetic moment of μνeff<2.8×10−11 μB at 90% C.L. has been set using constraints on the sum of the solar neutrino fluxes implied by the radiochemical gallium experiments. Using the limit for the effective neutrino moment, new limits for the magnetic moments of the neutrino flavor states, and for the elements of the neutrino magnetic moments matrix for Dirac and Majorana neutrinos, are derived.
We report on the search for dark matter weakly interacting massive particles (WIMPs) in the mass range below 10 GeV=c2 from the analysis of the entire dataset acquired with a low-radioactivity argon ...target by the DarkSide-50 experiment at Laboratori Nazionali del Gran Sasso. The new analysis benefits from more accurate calibration of the detector response, improved background model, and better determination of systematic uncertainties, allowing us to accurately model the background rate and spectra down to 0.06 keVer. A 90% C.L. exclusion limit for the spin-independent cross section of 3 GeV=c2 mass WIMP on nucleons is set at 6 × 10-43 cm2, about a factor 10 better than the previous DarkSide-50 limit. This analysis extends the exclusion region for spin-independent dark matter interactions below the current experimental constraints in the 1.2, 3.6 GeV=c2 WIMP mass range.
This paper presents a comprehensive geoneutrino measurement using the Borexino detector, located at Laboratori Nazionali del Gran Sasso (LNGS) in Italy. The analysis is the result of 3262.74 days of ...data between December 2007 and April 2019. The paper describes improved analysis techniques and optimized data selection, which includes enlarged fiducial volume and sophisticated cosmogenic veto. The reported exposure of (1.29±0.05)×1032 protons ×year represents an increase by a factor of two over a previous Borexino analysis reported in 2015. By observing 52.6−8.6+9.4(stat)−2.1+2.7(sys) geoneutrinos (68% interval) from U238 and Th232, a geoneutrino signal of 47.0−7.7+8.4(stat)−1.9+2.4(sys) TNU with −17.2+18.3% total precision was obtained. This result assumes the same Th/U mass ratio as found in chondritic CI meteorites but compatible results were found when contributions from U238 and Th232 were both fit as free parameters. Antineutrino background from reactors is fit unconstrained and found compatible with the expectations. The null-hypothesis of observing a geoneutrino signal from the mantle is excluded at a 99.0% C.L. when exploiting detailed knowledge of the local crust near the experimental site. Measured mantle signal of 21.2−9.0+9.5(stat)−0.9+1.1(sys) TNU corresponds to the production of a radiogenic heat of 24.6−10.4+11.1 TW (68% interval) from U238 and Th232 in the mantle. Assuming 18% contribution of K40 in the mantle and 8.1−1.4+1.9 TW of total radiogenic heat of the lithosphere, the Borexino estimate of the total radiogenic heat of the Earth is 38.2−12.7+13.6 TW, which corresponds to the convective Urey ratio of 0.78−0.28+0.41. These values are compatible with different geological predictions, however there is a ∼2.4σ tension with those Earth models which predict the lowest concentration of heat-producing elements in the mantle. In addition, by constraining the number of expected reactor antineutrino events, the existence of a hypothetical georeactor at the center of the Earth having power greater than 2.4 TW is excluded at 95% C.L. Particular attention is given to the description of all analysis details which should be of interest for the next generation of geoneutrino measurements using liquid scintillator detectors.
We present an improved measurement of the carbon-nitrogen-oxygen (CNO) solar neutrino interaction rate at Earth obtained with the complete Borexino Phase-III dataset. The measured rate, ...R_{CNO}=6.7_{-0.8}^{+2.0} counts/(day×100 tonnes), allows us to exclude the absence of the CNO signal with about 7σ C.L. The correspondent CNO neutrino flux is 6.6_{-0.9}^{+2.0}×10^{8} cm^{-2} s^{-1}, taking into account the neutrino flavor conversion. We use the new CNO measurement to evaluate the C and N abundances in the Sun with respect to the H abundance for the first time with solar neutrinos. Our result of N_{CN}=(5.78_{-1.00}^{+1.86})×10^{-4} displays a ∼2σ tension with the "low-metallicity" spectroscopic photospheric measurements. Furthermore, our result used together with the ^{7}Be and ^{8}B solar neutrino fluxes, also measured by Borexino, permits us to disfavor at 3.1σ C.L. the "low-metallicity" standard solar model B16-AGSS09met as an alternative to the "high-metallicity" standard solar model B16-GS98.
In 2014, the national population-based colorectal cancer (CRC) screening program was implemented in the Netherlands. Biennial fecal immunochemical testing (FIT) for hemoglobin (Hb) is used at a ...cut-off of 47 µg Hb per gram feces. The CRC screening program successfully started, with high participation rates and yield of screening. Now that the program has reached a steady state, there is potential to further optimize the program. Previous studies showed that prior fecal Hb (f-Hb) concentrations just below the FIT cut-off are associated with a higher risk for detection of advanced neoplasia (AN) at subsequent screening rounds. We aim to achieve a better balance between the harms and benefits of CRC screening by offering participants tailored invitation intervals based on prior f-Hb concentrations after negative FIT.
This mixed-methods study will be performed within the Dutch national CRC screening program and will consist of: (1) a randomized controlled trial (RCT), (2) focus group studies, and (3) decision modelling. The primary outcome is the yield of AN per screened individual in personalized screening vs. uniform screening. Secondary outcomes are perspectives on, acceptability of and adherence to personalized screening, as well as long-term outcomes of personalized vs. uniform screening. The RCT will include 20,000 participants of the Dutch CRC screening program; 10,000 in the intervention and 10,000 in the control arm. The intervention arm will receive a personalized screening interval based on the prior f-Hb concentration (1, 2 or 3 years). The control arm will receive a screening interval according to current practice (2 years). The focus group studies are designed to understand individuals' perspectives on and acceptability of personalized CRC screening. Results of the RCT will be incorporated into the MISCAN-Colon model to determine long-term benefits, harms, and costs of personalized vs. uniform CRC screening.
The aim of this study is to evaluate the yield, feasibility, acceptability and (cost-) effectiveness of personalized CRC screening through tailored invitation intervals based on prior f-Hb concentrations. This knowledge may be of guidance for health policy makers and may provide evidence for implementing personalized CRC screening in The Netherlands and/or other countries using FIT as screening modality.
ClinicalTrials.gov, NCT05423886, June 21, 2022, https://clinicaltrials.gov/ct2/show/NCT05423886.
Celotno besedilo
Dostopno za:
DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
About 99 per cent of solar energy is produced through sequences of nuclear reactions that convert hydrogen into helium, starting from the fusion of two protons (the pp chain). The neutrinos emitted ...by five of these reactions represent a unique probe of the Sun's internal working and, at the same time, offer an intense natural neutrino beam for fundamental physics. Here we report a complete study of the pp chain. We measure the neutrino-electron elastic-scattering rates for neutrinos produced by four reactions of the chain: the initial proton-proton fusion, the electron-capture decay of beryllium-7, the three-body proton-electron-proton (pep) fusion, here measured with the highest precision so far achieved, and the boron-8 beta decay, measured with the lowest energy threshold. We also set a limit on the neutrino flux produced by the
He-proton fusion (hep). These measurements provide a direct determination of the relative intensity of the two primary terminations of the pp chain (pp-I and pp-II) and an indication that the temperature profile in the Sun is more compatible with solar models that assume high surface metallicity. We also determine the survival probability of solar electron neutrinos at different energies, thus probing simultaneously and with high precision the neutrino flavour-conversion paradigm, both in vacuum and in matter-dominated regimes.
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