When using multiple imputation, users often want to know how many imputations they need. An old answer is that 2–10 imputations usually suffice, but this recommendation only addresses the efficiency ...of point estimates. You may need more imputations if, in addition to efficient point estimates, you also want standard error (SE) estimates that would not change (much) if you imputed the data again. For replicable SE estimates, the required number of imputations increases quadratically with the fraction of missing information (not linearly, as previous studies have suggested). I recommend a two-stage procedure in which you conduct a pilot analysis using a small-to-moderate number of imputations, then use the results to calculate the number of imputations that are needed for a final analysis whose SE estimates will have the desired level of replicability. I implement the two-stage procedure using a new SAS macro called %mi_combine and a new Stata command called how_many_imputations.
Objective
To assess the relative importance of school and nonschool risk factors, this study estimated whether overweight and obesity prevalence grows faster during the school year or during summer ...vacation.
Methods
In the Early Childhood Longitudinal Study, Kindergarten Class of 2010–11, a nationally representative complex random sample of 18,170 U.S. children was followed from the fall of kindergarten in 2010 through the spring of second grade in 2013. Children's weight and heights were measured in schools each fall and spring. A multilevel growth model was used to estimate growth in mean BMI, overweight prevalence, and obesity prevalence during each summer and each school year.
Results
From the fall of kindergarten to the spring of second grade, the prevalence of obesity increased from 8.9% to 11.5%, and the prevalence of overweight increased from 23.3% to 28.7%. All of the increase in prevalence occurred during the two summer vacations; no increase occurred during any of the three school years.
Conclusions
The risk of obesity is higher when children are out of school than when they are in school.
The aim of this paper is to provide a survey of plasma sources at atmospheric pressure used for microbicidal treatment. In order to consider the interdisciplinary character of this topic an ...introduction and definition of basic terms and procedures are given for plasma as well as for microbicidal issues. The list of plasma sources makes no claim to be complete, but to represent the main principles of plasma generation at atmospheric pressure and to give an example of their microbicidal efficiency. The interpretation of the microbicidal results remain difficult due to the non-standardized methods used by different authors and due to the fact that small variations in the setup can change the results dramatically.
When fitting a generalized linear model--such as linear regression, logistic regression, or hierarchical linear modeling--analysts often wonder how to handle missing values of the dependent variable ...Y. If missing values have been filled in using multiple imputation, the usual advice is to use the imputed Y values in analysis. We show, however, that using imputed Ys can add needless noise to the estimates. Better estimates can usually be obtained using a modified strategy that we call multiple imputation, then deletion (MID). Under MID, all cases are used for imputation but, following imputation, cases with imputed Y values are excluded from the analysis. When there is something wrong with the imputed Y values, MID protects the estimates from the problematic imputations. And when the imputed Y values are acceptable, MID usually offers somewhat more efficient estimates than an ordinary MI strategy.
Exercise, heat shock proteins and insulin resistance Archer, Ashley E.; Von Schulze, Alex T.; Geiger, Paige C.
Philosophical transactions of the Royal Society of London. Series B. Biological sciences,
01/2018, Letnik:
373, Številka:
1738
Journal Article
Recenzirano
Odprti dostop
Best known as chaperones, heat shock proteins (HSPs) also have roles in cell signalling and regulation of metabolism. Rodent studies demonstrate that heat treatment, transgenic overexpression and ...pharmacological induction of HSP72 prevent high-fat diet-induced glucose intolerance and skeletal muscle insulin resistance. Overexpression of skeletal muscle HSP72 in mice has been shown to increase endurance running capacity nearly twofold and increase mitochondrial content by 50%. A positive correlation between HSP72 mRNA expression and mitochondrial enzyme activity has been observed in human skeletal muscle, and HSP72 expression is markedly decreased in skeletal muscle of insulin resistant and type 2 diabetic patients. In addition, decreased levels of HSP72 correlate with insulin resistance and non-alcoholic fatty liver disease progression in livers from obese patients. These data suggest the targeted induction of HSPs could be a therapeutic approach for preventing metabolic disease by maintaining the body's natural stress response. Exercise elicits a number of metabolic adaptations and is a powerful tool in the prevention and treatment of insulin resistance. Exercise training is also a stimulus for increased HSP expression. Although the underlying mechanism(s) for exercise-induced HSP expression are currently unknown, the HSP response may be critical for the beneficial metabolic effects of exercise. Exercise-induced extracellular HSP release may also contribute to metabolic homeostasis by actively restoring HSP72 content in insulin resistant tissues containing low endogenous levels of HSPs.
This article is part of the theme issue ‘Heat shock proteins as modulators and therapeutic targets of chronic disease: an integrated perspective’.
We address the problem of making human motion capture in the wild more practical by using a small set of inertial sensors attached to the body. Since the problem is heavily under‐constrained, ...previous methods either use a large number of sensors, which is intrusive, or they require additional video input. We take a different approach and constrain the problem by: (i) making use of a realistic statistical body model that includes anthropometric constraints and (ii) using a joint optimization framework to fit the model to orientation and acceleration measurements over multiple frames. The resulting tracker Sparse Inertial Poser (SIP) enables motion capture using only 6 sensors (attached to the wrists, lower legs, back and head) and works for arbitrary human motions. Experiments on the recently released TNT15 dataset show that, using the same number of sensors, SIP achieves higher accuracy than the dataset baseline without using any video data. We further demonstrate the effectiveness of SIP on newly recorded challenging motions in outdoor scenarios such as climbing or jumping over a wall.
High-latitude soils store vast amounts of perennially frozen and therefore inert organic matter. With rising global temperatures and consequent permafrost degradation, a part of this carbon stock ...will become available for microbial decay and eventual release to the atmosphere. We have developed a simplified, two-dimensional multi-pool model to estimate the strength and timing of future carbon dioxide (CO2) and methane (CH4) fluxes from newly thawed permafrost carbon (i.e. carbon thawed when temperatures rise above pre-industrial levels). We have especially simulated carbon release from deep deposits in Yedoma regions by describing abrupt thaw under newly formed thermokarst lakes. The computational efficiency of our model allowed us to run large, multi-centennial ensembles under various scenarios of future warming to express uncertainty inherent to simulations of the permafrost carbon feedback. Under moderate warming of the representative concentration pathway (RCP) 2.6 scenario, cumulated CO2 fluxes from newly thawed permafrost carbon amount to 20 to 58 petagrams of carbon (Pg-C) (68% range) by the year 2100 and reach 40 to 98 Pg-C in 2300. The much larger permafrost degradation under strong warming (RCP8.5) results in cumulated CO2 release of 42 to 141 Pg-C and 157 to 313 Pg-C (68% ranges) in the years 2100 and 2300, respectively. Our estimates only consider fluxes from newly thawed permafrost, not from soils already part of the seasonally thawed active layer under pre-industrial climate. Our simulated CH4 fluxes contribute a few percent to total permafrost carbon release yet they can cause up to 40% of total permafrost-affected radiative forcing in the 21st century (upper 68% range). We infer largest CH4 emission rates of about 50 Tg-CH4 per year around the middle of the 21st century when simulated thermokarst lake extent is at its maximum and when abrupt thaw under thermokarst lakes is taken into account. CH4 release from newly thawed carbon in wetland-affected deposits is only discernible in the 22nd and 23rd century because of the absence of abrupt thaw processes. We further show that release from organic matter stored in deep deposits of Yedoma regions crucially affects our simulated circumpolar CH4 fluxes. The additional warming through the release from newly thawed permafrost carbon proved only slightly dependent on the pathway of anthropogenic emission and amounts to about 0.03–0.14 °C (68% ranges) by end of the century. The warming increased further in the 22nd and 23rd century and was most pronounced under the RCP6.0 scenario, adding 0.16 to 0.39 °C (68% range) to simulated global mean surface air temperatures in the year 2300.
A new and improved setup of the SF6 retrieval together with a newly calibrated version of MIPAS-ENVISAT level 1b spectra (version 5, ESA data version 5.02/5.06) was used to obtain a new global SF6 ...data set, covering the total observational period of MIPAS from July 2002 to April 2012 for the first time. Monthly and zonally averaged SF6 profiles were converted into mean age of air using a tropospheric SF6-reference curve. The obtained data set of age of air was compared to airborne age of air measurements. The temporal evolution of the mean age of air was then investigated in 10° latitude and 1–2 km altitude bins. A regression model consisting of a constant and a linear trend term, two proxies for the quasi-biennial oscillation variation, sinusoidal terms for the seasonal and semiannual variation and overtones was fitted to the age of air time series. The annual cycle for particular regions in the stratosphere was investigated and compared to other studies. The age of air trend over the total MIPAS period consisting of the linear term was assessed and compared to previous findings of Stiller et al. (2012). While the linear increase of mean age is confirmed to be positive for the northern midlatitudes and southern polar middle stratosphere, differences are found in the northern polar upper stratosphere, where the mean age is now found to increase as well. The magnitude of trends in the northern midlatitude middle stratosphere is slightly lower compared to the previous version and the trends fit remarkably well to the trend derived by Engel et al. (2009). Negative age of air trends found by Stiller et al. (2012) are confirmed for the lowermost tropical stratosphere and lowermost southern midlatitudinal stratosphere. Differences to the previous data versions occur in the middle tropical stratosphere around 25 km, where the trends are now negative. Overall, the new latitude–altitude distribution of trends appears to be less patchy and more coherent than the previous one. The new data provide evidence of an accelerating shallow branch of the Brewer–Dobson circulation, at least in the Southern Hemisphere. Finally the age of air decadal trends are compared to trends calculated with simulated SF6 values by the Karlsruhe Simulation Model of the Middle Atmosphere (KASIMA) and good agreement is found. The hemispheric asymmetry in the trends found in the MIPAS data is also indicated in the trends calculated with simulated SF6 values by the KASIMA model.
Abstract
The Cosmic Ray Isotope Spectrometer (CRIS) on the Advanced Composition Explorer spacecraft has been operating successfully in a halo orbit about the L1 Lagrange point since late 1997. We ...report here the isotopic composition of the Galactic cosmic ray (GCR) elements with 29 ≤
Z
≤ 38 derived from more than 20 years of CRIS data. Using a model of cosmic-ray transport in the Galaxy and the solar system (SS), we have derived from these observations the isotopic composition of the accelerated material at the GCR source (GCRS). Comparison of the isotopic fractions of these elements in the GCRS with corresponding fractions in the solar system gives no indication of GCRS enrichment in
r
-process isotopes. Since a large fraction of core-collapse supernovae (CCSNe) occur in OB associations, the fact that GCRs do not contain enhanced abundances of
r
-process nuclides indicates that CCSNe are not the principal source of lighter (
Z
≤ 38)
r
-process nuclides in the solar system. This conclusion supports recent work that points to binary neutron-star mergers, rather than supernovae, as the principal source of galactic
r
-process isotopes.
Abstract
The 2022 Roadmap is the next update in the series of Plasma Roadmaps published by
Journal of Physics
D with the intent to identify important outstanding challenges in the field of ...low-temperature plasma (LTP) physics and technology. The format of the Roadmap is the same as the previous Roadmaps representing the visions of 41 leading experts representing 21 countries and five continents in the various sub-fields of LTP science and technology. In recognition of the evolution in the field, several new topics have been introduced or given more prominence. These new topics and emphasis highlight increased interests in plasma-enabled additive manufacturing, soft materials, electrification of chemical conversions, plasma propulsion, extreme plasma regimes, plasmas in hypersonics, data-driven plasma science and technology and the contribution of LTP to combat COVID-19. In the last few decades, LTP science and technology has made a tremendously positive impact on our society. It is our hope that this roadmap will help continue this excellent track record over the next 5–10 years.
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