Gaia Data Release 2 Bastian, U.; Babusiaux, C.; Breddels, M. A. ...
Astronomy and astrophysics (Berlin),
08/2018, Letnik:
616, Številka:
A12
Journal Article, Web Resource
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Context.
Aims.
The goal of this paper is to demonstrate the outstanding quality of the second data release of the
Gaia
mission and its power for constraining many different aspects of the dynamics of ...the satellites of the Milky Way. We focus here on determining the proper motions of 75 Galactic globular clusters, nine dwarf spheroidal galaxies, one ultra-faint system, and the Large and Small Magellanic Clouds.
Methods.
Using data extracted from the
Gaia
archive, we derived the proper motions and parallaxes for these systems, as well as their uncertainties. We demonstrate that the errors, statistical and systematic, are relatively well understood. We integrated the orbits of these objects in three different Galactic potentials, and characterised their properties. We present the derived proper motions, space velocities, and characteristic orbital parameters in various tables to facilitate their use by the astronomical community.
Results.
Our limited and straightforward analyses have allowed us for example to (
i
) determine absolute and very precise proper motions for globular clusters; (
ii
) detect clear rotation signatures in the proper motions of at least five globular clusters; (
iii
) show that the satellites of the Milky Way are all on high-inclination orbits, but that they do not share a single plane of motion; (
iv
) derive a lower limit for the mass of the Milky Way of 9.1
-2.6
+6.2
× 10
11
M
⊙
based on the assumption that the Leo I dwarf spheroidal is bound; (
v
) derive a rotation curve for the Large Magellanic Cloud based solely on proper motions that is competitive with line-of-sight velocity curves, now using many orders of magnitude more sources; and (
vi
) unveil the dynamical effect of the bar on the motions of stars in the Large Magellanic Cloud.
Conclusions.
All these results highlight the incredible power of the
Gaia
astrometric mission, and in particular of its second data release.
In order to exploit the capabilities of Computational Fluid Dynamics in aerodynamic design, the cost should be reduced without compromising accuracy and consistency. In this direction a hybrid ...methodology is formulated within the context of domain decomposition. The strategy is to choose in each sub-domain the best performing method. Close to solid boundaries a grid-based Eulerian flow solver is used while in the far field the flow is described in Lagrangian coordinates using particle approximations. Aiming at consistently including compressible effects, particles carry mass, dilatation, vorticity and energy and the complete set of conservation laws is solved in Lagrangian coordinates. At software level, the URANS solver MaPFlow is coupled to the vortex code GENUVP. In the present paper the two dimensional formulation is given alongside with validation tests around airfoils in steady and inherently unsteady conditions. It is verified that: purely Eulerian and hybrid simulations are equivalent; the Eulerian domain in the hybrid solver can be effectively restricted to a layer 1.5 chord lengths wide; significant cost reduction reaching up to 1:3 ratio is achieved.
Allogeneic hematopoietic cell transplantation (allo-HCT) is offered to selected patients after chimeric antigen receptor–modified T-cell (CAR-T) therapy. Lymphodepleting chemotherapy and CAR-T ...therapy have immunosuppressive and immunomodulatory effects that could alter the safety profile of subsequent allo-HCT. We reviewed our experience with 32 adults (acute lymphoblastic leukemia ALL, n = 19; B-cell non-Hodgkin lymphoma NHL/chronic lymphocytic leukemia CLL, n = 13) who received an allo-HCT after CAR-T therapy, with a focus on posttransplant toxicities. Myeloablative conditioning (MAC) was used in 74% of ALL patients and 39% of NHL/CLL patients. The median time from CAR-T therapy to allo-HCT was 72 days in ALL patients and 122 days in NHL/CLL patients. Cumulative incidences of grade 3-4 acute graft-versus-host disease (GVHD) and chronic GVHD were 25% and 10%, respectively. All patients had neutrophil recovery (median, 18.5 days) and all but 3 had platelet recovery (median, 12 days). Twenty-two percent had viral or systemic fungal infection within 100 days after allo-HCT. The 100-day and 1-year cumulative incidences of NRM were 16% and 21%, respectively, for ALL patients and 15% and 33%, respectively, for NHL/CLL patients. In ALL patients, later utilization of allo-HCT after CAR-T therapy was associated with higher mortality. In NHL/CLL patients, MAC was associated with higher mortality. Toxicities did not exceed the expected incidences in this high-risk population.
•The toxicity of allo-HCT in patients with prior CAR-T therapy was not higher than what is expected in these high-risk patients.•In ALL patients, there seems to be a benefit from earlier utilization of allo-HCT after CAR-T therapy.
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Gaia Data Release 3 Arenou, F.; Lammers, U. L.; Mignard, F. ...
Astronomy and astrophysics (Berlin),
06/2023, Letnik:
674, Številka:
A1
Journal Article, Web Resource
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Context.
We present the third data release of the European Space Agency’s
Gaia
mission,
Gaia
DR3. This release includes a large variety of new data products, notably a much expanded radial velocity ...survey and a very extensive astrophysical characterisation of
Gaia
sources.
Aims.
We outline the content and the properties of
Gaia
DR3, providing an overview of the main improvements in the data processing in comparison with previous data releases (where applicable) and a brief discussion of the limitations of the data in this release.
Methods.
The
Gaia
DR3 catalogue is the outcome of the processing of raw data collected with the
Gaia
instruments during the first 34 months of the mission by the
Gaia
Data Processing and Analysis Consortium.
Results.
The
Gaia
DR3 catalogue contains the same source list, celestial positions, proper motions, parallaxes, and broad band photometry in the
G
,
G
BP
, and
G
RP
pass-bands already present in the Early Third Data Release,
Gaia
EDR3.
Gaia
DR3 introduces an impressive wealth of new data products. More than 33 million objects in the ranges
G
RVS
< 14 and 3100 <
T
eff
< 14 500, have new determinations of their mean radial velocities based on data collected by
Gaia
. We provide
G
RVS
magnitudes for most sources with radial velocities, and a line broadening parameter is listed for a subset of these. Mean
Gaia
spectra are made available to the community. The
Gaia
DR3 catalogue includes about 1 million mean spectra from the radial velocity spectrometer, and about 220 million low-resolution blue and red prism photometer BP/RP mean spectra. The results of the analysis of epoch photometry are provided for some 10 million sources across 24 variability types.
Gaia
DR3 includes astrophysical parameters and source class probabilities for about 470 million and 1500 million sources, respectively, including stars, galaxies, and quasars. Orbital elements and trend parameters are provided for some 800 000 astrometric, spectroscopic and eclipsing binaries. More than 150 000 Solar System objects, including new discoveries, with preliminary orbital solutions and individual epoch observations are part of this release. Reflectance spectra derived from the epoch BP/RP spectral data are published for about 60 000 asteroids. Finally, an additional data set is provided, namely the
Gaia
Andromeda Photometric Survey, consisting of the photometric time series for all sources located in a 5.5 degree radius field centred on the Andromeda galaxy.
Conclusions.
This data release represents a major advance with respect to
Gaia
DR2 and
Gaia
EDR3 because of the unprecedented quantity, quality, and variety of source astrophysical data. To date this is the largest collection of all-sky spectrophotometry, radial velocities, variables, and astrophysical parameters derived from both low- and high-resolution spectra and includes a spectrophotometric and dynamical survey of SSOs of the highest accuracy. The non-single star content surpasses the existing data by orders of magnitude. The quasar host and galaxy light profile collection is the first such survey that is all sky and space based. The astrophysical information provided in
Gaia
DR3 will unleash the full potential of
Gaia
’s exquisite astrometric, photometric, and radial velocity surveys.
Gaia Early Data Release 3 Brown, A. G. A.; Prusti, T.; Eyer, L. ...
Astronomy and astrophysics (Berlin),
05/2021, Letnik:
649
Journal Article, Web Resource
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Context.
We present the early installment of the third
Gaia
data release,
Gaia
EDR3, consisting of astrometry and photometry for 1.8 billion sources brighter than magnitude 21, complemented with the ...list of radial velocities from
Gaia
DR2.
Aims.
A summary of the contents of
Gaia
EDR3 is presented, accompanied by a discussion on the differences with respect to
Gaia
DR2 and an overview of the main limitations which are present in the survey. Recommendations are made on the responsible use of
Gaia
EDR3 results.
Methods.
The raw data collected with the
Gaia
instruments during the first 34 months of the mission have been processed by the
Gaia
Data Processing and Analysis Consortium and turned into this early third data release, which represents a major advance with respect to
Gaia
DR2 in terms of astrometric and photometric precision, accuracy, and homogeneity.
Results. Gaia
EDR3 contains celestial positions and the apparent brightness in
G
for approximately 1.8 billion sources. For 1.5 billion of those sources, parallaxes, proper motions, and the (
G
BP
−
G
RP
) colour are also available. The passbands for
G
,
G
BP
, and
G
RP
are provided as part of the release. For ease of use, the 7 million radial velocities from
Gaia
DR2 are included in this release, after the removal of a small number of spurious values. New radial velocities will appear as part of
Gaia
DR3. Finally,
Gaia
EDR3 represents an updated materialisation of the celestial reference frame (CRF) in the optical, the
Gaia
-CRF3, which is based solely on extragalactic sources. The creation of the source list for
Gaia
EDR3 includes enhancements that make it more robust with respect to high proper motion stars, and the disturbing effects of spurious and partially resolved sources. The source list is largely the same as that for
Gaia
DR2, but it does feature new sources and there are some notable changes. The source list will not change for
Gaia
DR3.
Conclusions. Gaia
EDR3 represents a significant advance over
Gaia
DR2, with parallax precisions increased by 30 per cent, proper motion precisions increased by a factor of 2, and the systematic errors in the astrometry suppressed by 30–40% for the parallaxes and by a factor ~2.5 for the proper motions. The photometry also features increased precision, but above all much better homogeneity across colour, magnitude, and celestial position. A single passband for
G
,
G
BP
, and
G
RP
is valid over the entire magnitude and colour range, with no systematics above the 1% level
Background
Anti‐PD1 checkpoint inhibitors (ICI) represent an established standard‐of‐care for patients with recurrent/metastatic head and neck squamous cell carcinoma (RMHNSCC). Landmark studies ...excluded patients with ECOG performance status (PS) ≥2; the benefit of ICI in this population is therefore unknown.
Methods
We retrospectively reviewed RMHNSCC patients who received 1+ dose of ICI at our institution between 2013 and 2019. Demographic and clinical data were obtained; the latter included objective response (ORR), toxicity, and any unplanned hospitalization (UH). Associations were explored using uni‐ and multivariate analysis. Overall survival (OS) was estimated using a Cox proportional hazards model; ORR, toxicity, and UH were evaluated with logistic regression.
Results
Of the 152 patients, 29 (19%) had an ECOG PS ≥2. Sixty‐six (44%) experienced toxicity; 54 (36%) had a UH. A multivariate model for OS containing PS, smoking status, and HPV status demonstrated a strong association between ECOG ≥2 and shorter OS (p < 0.001; HR = 3.30, CI = 2.01–5.41). An association between OS and former (vs. never) smoking was also seen (p < 0.001; HR = 2.17, CI = 1.41–3.35); current smoking did not reach statistical significance. On univariate analysis, poor PS was associated with inferior ORR (p = 0.03; OR = 0.25, CI = 0.06–0.77) and increased UH (p = 0.04; OR = 2.43, CI = 1.05—5.71). There was no significant association between toxicity and any patient characteristic.
Conclusions
We observed inferior OS, ORR, and rates of UH among ICI‐treated RMHNSCC patients with ECOG 2/3. Our findings help frame discussion of therapeutic options in this poor‐risk population.
Relative to those with a performance status of 0‐1, patients with an Eastern Cooperative Oncology Group performance status 2 who received immune checkpoint inhibitors for recurrent/metastatic head and neck cancer have poorer response rates and overall survival as well as increased rates of unplanned hospitalization; no significant difference in toxicity was seen.
The Gaia mission Vallenari, A.; Bailer-Jones, C. A. L.; Milligan, D. J. ...
Astronomy and astrophysics (Berlin),
11/2016, Letnik:
595
Journal Article, Web Resource
Recenzirano
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Gaia is a cornerstone mission in the science programme of the EuropeanSpace Agency (ESA). The spacecraft construction was approved in 2006, following a study in which the original interferometric ...concept was changed to a direct-imaging approach. Both the spacecraft and the payload were built by European industry. The involvement of the scientific community focusses on data processing for which the international Gaia Data Processing and Analysis Consortium (DPAC) was selected in 2007. Gaia was launched on 19 December 2013 and arrived at its operating point, the second Lagrange point of the Sun-Earth-Moon system, a few weeks later. The commissioning of the spacecraft and payload was completed on 19 July 2014. The nominal five-year mission started with four weeks of special, ecliptic-pole scanning and subsequently transferred into full-sky scanning mode. We recall the scientific goals of Gaia and give a description of the as-built spacecraft that is currently (mid-2016) being operated to achieve these goals. We pay special attention to the payload module, the performance of which is closely related to the scientific performance of the mission. We provide a summary of the commissioning activities and findings, followed by a description of the routine operational mode. We summarise scientific performance estimates on the basis of in-orbit operations. Several intermediate Gaia data releases are planned and the data can be retrieved from the Gaia Archive, which is available through the Gaia home page.
The concept of a large (~20MW) multi-rotor wind turbine intended for offshore installations is analysed with respect to its aerodynamic performance. The effect of closely clustering rotors on a ...single actuator disk is estimated using two different modelling approaches: a CFD solver in which the rotors are simulated as distinct actuator disks and a vortex based solver in which the blade geometry is exactly considered. In the present work, a system of 7 rotors is simulated with a centre to centre spacing of 1.05D. At nominal conditions (tip speed ratio=9) both models predict an increase in power of ~3% alongside with an increase in thrust of ~1.5%. The analysis of the flow field indicates that in the 7 rotor system the individual wakes merge into one wake at ~2D and that flow recovery starts at approximately the same downstream distance as in the single rotor case. As regards the dynamic implications of the close spacing of the rotors it was found that there is an increase in the loading amplitude ranging from 0.30-2.13% at blade level in rated conditions.
Urothelial bladder cancer (UBC) is one of the cancers with the highest mortality rate and prevalence worldwide; however, the clinical management of the disease remains challenging. Metabolomics has ...emerged as a powerful tool with beneficial applications in cancer biology and thus can provide new insights on the underlying mechanisms of UBC progression and/or reveal novel diagnostic and therapeutic schemes.
A collection of four human UBC cell lines that critically reflect the different malignancy grades of UBC was employed; RT4 (grade I), RT112 (grade II), T24 (grade III), and TCCSUP (grade IV). They were examined using Nuclear Magnetic Resonance, Mass Spectrometry, and advanced statistical approaches, with the goal of creating new metabolic profiles that are mechanistically associated with UBC progression toward metastasis.
Distinct metabolic profiles were observed for each cell line group, with T24 (grade III) cells exhibiting the most abundant metabolite contents. AMP and creatine phosphate were highly increased in the T24 cell line compared to the RT4 (grade I) cell line, indicating the major energetic transformation to which UBC cells are being subjected during metastasis. Thymosin
4 and
10 were also profiled with grade-specific patterns of expression, strongly suggesting the importance of actin-cytoskeleton dynamics for UBC advancement to metastatic and drug-tolerant forms.
The present study unveils a novel and putatively druggable metabolic signature that holds strong promise for early diagnosis and the successful chemotherapy of UBC disease.
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