A
bstract
We construct the most general single-mode superstrata in 5 dimensions with ambipolar, two centered Gibbons Hawking bases, via dimensional reduction of superstrata in 6 dimensions. ...Previously, asymptotically AdS
3
× 𝕊
2
5-dimensional superstrata have been produced, giving microstate geometries of black strings in 5 dimensions. Our construction produces asymptotically AdS
2
× 𝕊
3
geometries as well, the first instances of superstrata describing the microstate geometries of black holes in 5 dimensions. New examples of superstrata with separable massless wave equations in both 5 and 6 dimensions are uncovered. A ℤ
2
symmetry which identifies distinct 6-dimensional superstrata when reduced to 5 dimensions is found. Finally we use the mathematical structure of the underlying hyper-Kähler bases to produce prepotentials for the superstrata fluxes in 5 dimensions and uplift them to apply in 6 dimensions as well.
Summary
Background
Pulmonary aspiration of gastric contents is a potentially devastating complication of anesthesia.
Aims
This prospective multicenter survey of specialist pediatric centers in the UK ...set out to elucidate the incidence, risk factors, and the outcome of such events. The survey took place over a twelve‐month period via a web‐based secure reporting system.
Results
Over the twelve‐month period, 24 cases of pulmonary aspiration were reported. Over that time period, there were 118 371 cases performed at the eleven pediatric centers. The overall incidence of pulmonary aspiration is therefore 1 in 4932 cases or 2 in 10 000 cases. Over that time period, there were 18 cases during elective surgery and six cases in nonelective/emergency surgery. The incidence of pulmonary aspiration in the elective situation is therefore 1 in 5076 cases or 2.0 per 10 000 cases. The incidence in emergency procedures is 1 in 4498 cases or 2.2 per 10 000 cases.
The timing and severity of deterioration were recorded. In the study period, 8 of 24 cases did not deteriorate, 13 of 24 deteriorated with immediate effect, and the further 3 of 24 deteriorated within the next hour. The deterioration was mild in 11 patients requiring medical management only, and the deterioration was severe in five patients. Those five patients required ventilation for varying durations of time. All patients made a full recovery.
Conclusions
This multicenter survey of specialist pediatric centers in the UK over a one‐year period reveals a low incidence of pulmonary aspiration in both elective and emergency cases. All patients made a full recovery.
Amazonia is an invaluable global asset for all its ecological and cultural significance. Indigenous peoples and their lands are pivotal in safeguarding this unique biodiversity and mitigating global ...climate change. Understanding the causal structure behind variation in the degree of environmental conservation across different indigenous lands-each with varying institutional, legal, and socioenvironmental conditions-is an essential source of information in the struggle for long-term sustainable management of Amazonian ecosystems. Here, we use data from the Instituto Socioambiental for 361 indigenous lands in the Brazilian Amazon coded for environmental integrity, territorial integrity, legal stability, indigenous governance, and threats due to infrastructure projects. Using Bayesian networks to learn the causal structure amongst these variables reveals two causal pathways leading to environmental integrity. One causal pathway starts with territorial integrity and is mediated by infrastructure projects, while the other is directly from legal stability. Hence, safeguarding indigenous lands from exploitation is best accomplished via legal land rights and stricter enforcement instead of placing the onus on indigenous governance, which is also a direct outcome of legal stability.
Celotno besedilo
Dostopno za:
DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
Parkinson’s disease (PD) is associated with the formation of α-synuclein amyloid fibrils. Elucidating the role of these β-sheet-rich fibrils in disease progression is crucial; however, collecting ...detailed structural information on amyloids is inherently difficult because of their insoluble, non-crystalline, and polymorphic nature. Here, we show that Raman spectroscopy is a facile technique for characterizing structural features of α-synuclein fibrils. Combining Raman spectroscopy with aggregation kinetics and transmission electron microscopy, we examined the effects of pH and ionic strength as well as four PD–related mutations (A30P, E46K, G51D, and A53T) on α-synuclein fibrils. Raman spectral differences were observed in the amide-I, amide-III, and fingerprint regions, indicating that secondary structure and tertiary contacts are influenced by pH and to a lesser extent by NaCl. Faster aggregation times appear to facilitate unique fibril structure as determined by the highly reproducible amide-I band widths, linking aggregation propensity and fibril polymorphism. Importantly, Raman spectroscopy revealed molecular-level perturbations of fibril conformation by the PD–related mutations that are not apparent through transmission electron microscopy or limited proteolysis. The amide-III band was found to be particularly sensitive, with G51D exhibiting the most distinctive features, followed by A53T and E46K. Relating to a cellular environment, our data would suggest that fibril polymorphs can be formed in different cellular compartments and potentially result in distinct phenotypes. Our work sets a foundation toward future cellular Raman studies of amyloids.
Faster chemistry at surfaces Walker, Robert A
Nature chemistry,
04/2021, Letnik:
13, Številka:
4
Journal Article
Recenzirano
The physical properties of a liquid at an interface differ from bulk solution limits, but how this affects chemical reactivity is unclear. Now, ultrafast, surface-sensitive vibrational spectroscopy ...has revealed that the light-induced reaction of phenol with water is four orders of magnitude faster at the water surface than in bulk.
The femtosecond laser-induced fiber Bragg grating is an effective sensor technology that can be deployed in harsh environments. Depending on the optical fiber chosen and the inscription parameters ...that are used, devices suitable for high temperature, pressure, ionizing radiation and strain sensor applications are possible. Such devices are appropriate for aerospace or energy production applications where there is a need for components, instrumentation and controls that can function in harsh environments. This paper will present a review of some of the more recent developments in this field.
Total hip replacement is a common and highly effective operation. All hip replacements would eventually fail if in situ long enough and it is important that patients understand when this might ...happen. We aimed to answer the question: how long does a hip replacement last?
We did a systematic review and meta-analysis with a search of MEDLINE and Embase from the start of records to Sept 12, 2017. We included articles reporting 15-year survival of primary, conventional total hip replacement constructs in patients with osteoarthritis. We extracted survival and implant data and used all-cause construct survival as the primary outcome. We also reviewed reports of national joint replacement registries, and extracted data for a separate analysis. In the meta-analyses, we weighted each series and calculated a pooled survival estimate for each source of data. This study was registered with PROSPERO (CRD42018085642).
We identified 140 eligible articles reporting 150 series, and included 44 of these series (13 212 total hip placements). National joint replacement registries from Australia and Finland provided data for 92 series (215 676 total hip replacements). The 25-year pooled survival of hip replacements from case series was 77·6% (95% CI 76·0–79·2) and from joint replacement registries was 57·9% (95% CI 57·1–58·7).
Assuming that estimates from national registries are less likely to be biased, patients and surgeons can expect a hip replacement to last 25 years in around 58% of patients.
National Institute for Health Research, National Joint Registry for England, Wales, Northern Ireland and Isle of Man, and The Royal College of Surgeons of England.
Knee replacements are the mainstay of treatment for end-stage osteoarthritis and are effective. Given time, all knee replacements will fail and knowing when this failure might happen is important. We ...aimed to establish how long a knee replacement lasts.
In this systematic review and meta-analysis, we searched MEDLINE and Embase for case series and cohort studies published from database inception until July 21, 2018. Articles reporting 15 year or greater survival of primary total knee replacement (TKR), unicondylar knee replacement (UKR), and patellofemoral replacements in patients with osteoarthritis were included. Articles that reviewed specifically complex primary surgeries or revisions were excluded. Survival and implant data were extracted, with all-cause survival of the knee replacement construct being the primary outcome. We also reviewed national joint replacement registry reports and extracted the data to be analysed separately. In the meta-analysis, we weighted each series and calculated a pooled survival estimate for each data source at 15 years, 20 years, and 25 years, using a fixed-effects model. This study is registered with PROSPERO, number CRD42018105188.
From 4363 references found by our initial search, we identified 33 case series in 30 eligible articles, which reported all-cause survival for 6490 TKRs (26 case series) and 742 UKRs (seven case series). No case series reporting on patellofemoral replacements met our inclusion criteria, and no case series reported 25 year survival for TKR. The estimated 25 year survival for UKR (based on one case series) was 72·0% (95% CI 58·0–95·0). Registries contributed 299 291 TKRs (47 series) and 7714 UKRs (five series). The pooled registry 25 year survival of TKRs (14 registries) was 82·3% (95% CI 81·3–83·2) and of UKRs (four registries) was 69·8% (67·6–72·1).
Our pooled registry data, which we believe to be more accurate than the case series data, shows that approximately 82% of TKRs last 25 years and 70% of UKRs last 25 years. These findings will be of use to patients and health-care providers; further information is required to predict exactly how long specific knee replacements will last.
The National Institute for Health Research, the National Joint Registry for England, Wales, Northern Ireland, and Isle of Man, and the Royal College of Surgeons of England.
Software development can be challenging because of the large information spaces that developers must navigate. Without assistance, developers can become bogged down and spend a disproportionate ...amount of their time seeking information at the expense of other value-producing tasks. Recommendation systems for software engineering (RSSEs) are software tools that can assist developers with a wide range of activities, from reusing code to writing effective bug reports. The authors provide an overview of recommendation systems for software engineering: what they are, what they can do for developers, and what they might do in the future.
The RecQ DNA helicase WRN is a synthetic lethal target for cancer cells with microsatellite instability (MSI), a form of genetic hypermutability that arises from impaired mismatch repair
. Depletion ...of WRN induces widespread DNA double-strand breaks in MSI cells, leading to cell cycle arrest and/or apoptosis. However, the mechanism by which WRN protects MSI-associated cancers from double-strand breaks remains unclear. Here we show that TA-dinucleotide repeats are highly unstable in MSI cells and undergo large-scale expansions, distinct from previously described insertion or deletion mutations of a few nucleotides
. Expanded TA repeats form non-B DNA secondary structures that stall replication forks, activate the ATR checkpoint kinase, and require unwinding by the WRN helicase. In the absence of WRN, the expanded TA-dinucleotide repeats are susceptible to cleavage by the MUS81 nuclease, leading to massive chromosome shattering. These findings identify a distinct biomarker that underlies the synthetic lethal dependence on WRN, and support the development of therapeutic agents that target WRN for MSI-associated cancers.
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