Remote deformation management systems (RDMS) have the potential to transform patient care and decision-making in bioethical dilemmas. This study examines the potential of RDMS in enhancing patient ...autonomy and decision-making in bioethical dilemmas. The study used a qualitative research design, including semi-structured interviews with medical professionals and focus group discussions with patients who have experience with RDMS. The data were analyzed using thematic analysis to identify the main themes and patterns in the participants' responses. The study found that RDMS can enhance patient autonomy and decision-making in bioethical dilemmas by providing patients with remote access to their medical data and enabling them to participate in the decision-making process. The study identified several factors that influence the effectiveness of RDMS in enhancing patient autonomy, including the quality of the information provided, the patient's technological literacy, and the availability of support and guidance from medical professionals. The study also highlighted some ethical concerns related to the use of RDMS, such as the risk of information overload, privacy and security issues, and the potential for bias and discrimination. The study concludes that RDMS has the potential to enhance patient autonomy and decision-making in bioethical dilemmas, but its implementation requires careful consideration of the ethical and social implications. Future research could investigate the potential of RDMS in improving patient-centered care and explore the factors that influence its effectiveness in different cultural and organizational contexts.
Exposure of endocrine disrupting chemicals (EDCs) is closely related to induction of obesity, nonalcoholic fatty liver disease (NAFLD) and other lipid-metabolism diseases. Herein, we compared the ...effects of three EDCs exposure (triclosan, bisphenol A and fluorene-9-bisphenol) on lipid metabolism in zebrfish (Danio rerio). The differential lipid-metabolism disorders were analyzed in depth through RNA-Seq and qRT-PCR, as well as assessment of the relationship between lipid disorder and RNA methylation. Histopathological observation along with varying physiological and biochemical indexes all identified that triclosan and bisphenol A induced liver fat accumulation in acute and chronic exposure. RNA-Seq analysis showed that triclosan exposure disrupted multiple physiological processes including drug metabolism, sucrose metabolism, fat metabolism and bile secretion. The dysregulation of lipid-metabolism related genes indicated that liver steatosis in triclosan and BPA-exposed zebrafish resulted from increased fatty acid synthetase, and uptake and suppression of β-oxidation. Besides, the dysregulation of pro-inflammatory genes and endoplasmic reticulum stress showed that triclosan and bisphenol A exposure not only induced occurrence of NAFLD, but also promoted progression of hepatic inflammation. However, no significant effect on lipid metabolism was observed in fluorene-9-bisphenol-exposed treatment although the larval phenotypic malformation was found compared to the control group. Moreover, EDCs exposure led to decreased global m6A level and abnormal expression of m6A modulators in larvae. Especially, the expression of demethylase FTO (fat mass and obesity-associated protein) was significantly increased in triclosan-exposure treatment. These findings are conductive for us to deeply understand the underlying molecular mechanisms regarding the obesity and NAFLD from EDCs exposure.
•Triclosan and bisphenol A exposure results in lipid metabolism disorder in zebrafish.•TCS exposure increases lipogenesis and lipid transport, and inhibits lipid oxidation.•TCS exposure affect drug, fatty acid and sucrose metabolism pathways in zebrafish.•TCS and BPA induce the abnormal expression of ER and inflammation related genes.•Reduced global RNA m6A methylation upon exposure to three endocrine disruptors.
Hollow frame structures are of special interest in the realm of catalysis since they hold only ridges and hollow interiors, enabling the accessibility of active sites to the most extent. Herein, we ...prepared Pd–Pt hollow frame structures composed of double-shell cubes linked by body diagonals as an efficient catalyst toward the oxygen reduction reaction (ORR), inspired by the 4D analogue of a cube, denoted as a tesseract. The etching process involves the selective removal of Pd atoms and the subsequent rearrangement of the remaining Pd and Pt atoms. The successful preparation of Pd–Pt tesseracts via etching lies in the selection of Pd/Pt ratio in the initial Pd–Pt nanocubes. With various ratios of Pd–Pt nanocubes as templates, we obtained Pd–Pt octapods, tesseracts, and nanoframes, respectively. During the ORR, Pd–Pt tesseracts exhibited the highest mass activity of 1.86 A mg–1 Pt among these Pd–Pt nanocrystals. On the basis of mechanistic studies, the high activity of Pd–Pt tesseracts derived from the optimal oxygen adsorption energy due to the facet effect and composition effect.
•SiQDs and CuNCs are integrated to construct a novel ratiometric fluorescence probe.•Fluorescence of SiQDs can be prominently quenched by CuNCs through a FRET process.•The probe is used to detect ...l-Cys in milk without mediation of intermediate chemicals.•Fluorescence quenching of CuNCs by l-Cys is via PET process based on band-gap theory.•This ratiometric probe offers high selectivity, recovery for assay of l-Cys in milks.
l-cysteine (l-Cys) plays an important role in many physiological processes. The previously reported methodologies for l-Cys detection have many drawbacks, and thus the development of specific/sensitive approaches is crucial for its direct/quick assay in food matrices. Herein, silicon quantum dots (SiQDs) and glutathione-stabilized copper nanoclusters (CuNCs) were successfully synthesized and integrated as a ratiometric fluorescent probe for assay l-Cys assay in milks. The fluorescence of SiQDs was quenched by CuNCs through fluorescence resonance energy-transfer process. Upon addition of l-Cys, the 440-nm fluorescence of SiQDs changed insignificantly, while the 650-nm fluorescence of CuNCs decreased significantly. Ratiometric fluorescence signal was linear in the l-Cys concentration range of 0.25 μM to 2.5 mM with a detection limit of 75 nM and visual color changes from red to blue. The probe can realize rapid and portable detection without the participation of intermediate ions, and has good selectivity and accuracy for l-cysteine in milk samples.
Ion selective separators with the capability of conducting lithium ion and blocking polysulfides are critical and highly desired for high-performance lithium–sulfur (Li–S) batteries. Herein, we ...fabricate an ion selective film of covalent organic framework (denoted as TpPa-SO3Li) onto the commercial Celgard separator. The aligned nanochannels and continuous negatively charged sites in the TpPa-SO3Li layer can effectively facilitate the lithium ion conduction and meanwhile significantly suppress the diffusion of polysulfides via the electrostatic interaction. Consequently, the TpPa-SO3Li layer exhibits excellent ion selectivity with an extremely high lithium ion transference number of 0.88. When using this novel functional layer, the Li–S batteries with a high sulfur loading of 5.4 mg cm–2 can acquire a high initial capacity of 822.9 mA h g–1 and high retention rate of 78% after 100 cycles at 0.2 C. This work provides new insights into developing high-performance Li–S batteries via ion selective separator strategy.
Herein, we synthesized a kind of magnetic covalent organic framework nanohybrids (NiFe2O4@COF), and integrated it with polydimethyl siloxane and silicone rubber curing agent for solid phase ...microextraction (SPME) fiber coating. The fiber coating demonstrated a porous and uniform surface with the BET specific surface of 169.7 m2 g-1. As for seven environmental analytes, the NiFe2O4@COF-based SPME fiber coating gave the higher extraction recoveries for triclosan (TCS) and methyltriclosn (MTCS) than those of fenpropathrin, bifenthrin, permethrin, fenvalerate and deltamethrin. Several operational parameters were rigorously optimized, such as extraction temperature, extraction time, thermal desorption time, solution pH and salt effect. Combined with the GC-ECD detection, the newly developed microextraction method supplied the wide linear range of 0.1–1000 µg L-1 with the correlation coefficients of > 0.9995. The limits of detection (LODs) and limits of quantitation (LOQs) reached as low as 1–7 ng L-1 and 3.3–23 ng L-1, respectively. The intra-day and inter-day precisions in six replicates (n = 6 ) were < 3.55% and < 5.06%, respectively, and the fiber-to-fiber reproducibility (n = 3) was < 7.64%. To evaluate its feasibility in real samples, the fortified recoveries for TCS and MTCS, at low (0.2 µg L-1), middle (2.0 µg L-1) and high (20.0 µg L-1) levels, varied between 81.9% and 119.1% in tap, river and barreled waters as well as male, female and children urine samples. Especially, it is worth mentioning that the NiFe2O4@COF-based SPME coating fiber can be recycled for at least 150 times with nearly unchanged extraction efficiency. Moreover, the extraction recoveries by the as-fabricated fiber coating were much higher than those by three commercial fibers (PDMS, PDMS/DVB and PDMS/DVB/CAR). Overall, the NiFe2O4@COF-based SPME is a convenient, sensitive, efficient and “green” pretreatment method, thereby possessing important application prospects in trace monitoring of TCS-like pollutants in complex liquid matrices.
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•A novel magnetic NiFe2O4@COF-based fiber coating for SPME is successfully fabricated.•NiFe2O4@COF nanohybrid possesses larger surface area and pore size over single COFs.•NiFe2O4@COF based SPME fiber coating provides high extraction selectivity for TCS and MTCS.•Sampling, enrichment, purification and injection are integrated into one solvent-free step.•NiFe2O4@COF-SPME/GC-ECD approach offers low LODs and high repeatability for analytes.
Background Prenatal exposure to omega-3 long-chain polyunsaturated fatty acids (n-3 LC-PUFA) in oily fish may prevent asthma or wheeze in childhood. Objective By limiting n-3 LC-PUFA capsules ...interventions commenced in pregnancy, this systematic review aimed to find more clear evidence on the relationship between the supplement with n-3 LC-PUFA during pregnancy and the risk of asthma/wheeze in offspring and to improve the life satisfaction of children with asthma. Methods The Cochrane library, Embase, Medline, Web of Science, and PubMed were searched from origin to March 2021 in the above-mentioned databases. Studies selection, data of characteristics extraction, and risk of bias assessment were conducted by two authors, independently. A total of 3037 mother-infant pairs from eight randomized controlled trials were ultimately analyzed. The primary outcome was the risk of "asthma and/or wheeze", and the secondary outcome was "Allergic asthma" in this dose-response meta-analysis. Sensitivity analysis and subgroup analysis were conducted. The robust-error meta-regression model was used for dose-response analysis. Results This meta-analysis showed that n-3 LC-PUFA during pregnancy did not obviously reduce the risk of asthma/wheeze (RR 0.93; 95% CI 0.82 to 1.04, p = 0.21) and allergic asthma (RR 0.66, 95% CI 0.24 to 1.86, p = 0.44). The risk of asthma/wheeze in offspring was significantly decreased in the subgroup analysis when:: (1) studies conducted in Europe (RR 0.69; 95% CI 0.53 to 0.89); (2) daily supplementary dose of n-3 LC-PUFA was at least 1200 mg (RR 0.69; 95% CI 0.55 to 0.88); (3) supplementation lasts from pregnancy to lactation period (RR 0.69; 95% CI 0.51 to 0.95). Furthermore, the risk of asthma/wheeze reduce 2% when daily supplemental dose of n-3 LC-PUFA was increased by 100 mg in the linear dose-response analysis model. Conclusions Perinatal supplementation with n-3 LC-PUFA can reduce the incidence of asthma/wheeze and allergic asthma in children under certain conditions, and higher doses indicate better protective effects. Further studies are required to confirm the hypothesis of an association between n-3 LC-PUFA intake and childhood asthma/wheeze prevention. Keywords: Omega-3, Fish oils, Docosahexaenoic acids, Eicosapentaenoic acid, Randomized controlled trial, Prevention, Asthma, Wheeze, Offspring
Chiral nanophotonic devices are promising candidates for chiral molecule sensing, polarization of diverse nanophotonics, and display technologies. Active chiral nanophotonic devices, where the ...optical chirality can be controlled by an external stimulus has triggered great research interest. However, efficient modulation of the optical chirality has been challenging. Here, we demonstrate switching of the extrinsic chirality by applied magnetic fields in a magnetoplasmonic metasurface device based on a magneto-optical oxide material, Ce1Y2Fe5O12 (Ce:YIG). Due to the low optical loss and strong magneto-optical effect of Ce:YIG, we experimentally demonstrated giant and continuous far-field circular dichroism (CD) modulation by applied magnetic fields from −0.6 ± 0.2° to +1.9 ± 0.1° at 950 nm wavelength under glancing incident conditions. The far-field CD modulation is due to both magneto-optical circular dichroism and near-field modulation of the superchiral fields by applied magnetic fields. Finally, we demonstrate magnetic-field-tunable chiral imaging in millimeter-scale magnetoplasmonic metasurfaces fabricated using self-assembly.
As one kind of high nutrition fruits, abandoned Myrica rubra causes great waste due to short storage period. For resource utilization, we herein fabricated the Myrica rubra-based N-doped carbon dots ...(MN-CDs) by a facile/green hydrothermal method. MN-CDs, fabricated from four regions of China, displayed significant differences in their corresponding fluorescence intensities (FIs). Interestingly, different batches of waxberry samples from the same region (Wenzhou, China) exhibited slight differences in their FIs, and also an excellent anti-photobleaching and anti-salt capacity. Based on Fe3+-triggered quenching effect and fluorescent recovery by redox reaction of AA and Fe3+, MN-CDs were employed to construct an “on-off-on” switch probe for sequential detection of Fe3+ and ascorbic acid (AA). Through Zeta potential, UV spectrum, Stern-Volmer equation, and valence-conduction band theory, the Fe3+-triggered quenching belonged to a static quenching process, which resulted from the synergistic contribution of inner filtering effect and photo-induced electron transfer mechanisms. The linear ranges for Fe3+ and AA detections were 1–1000 and 0.1–1000 mM. The limits of detection were 0.3 μM for Fe3+ in environmental waters, and 0.03 μM for AA in pharmaceutical tablets and fruit juice samples. Under 365-nm UV lamp, the color changes of test papers were easily observed from dark blue and bright blue in the presence of Fe3+ and AA, and thus the MN-CDs-based switch probe could be satisfactorily used for visually qualitative detection of Fe3+ and AA outdoor with our naked eyes. To sum up, MN-CDs not only realize resource reutilization of abandoned Myrica rubra, but also offer an convenient outdoor approach for qualitative detection of Fe3+ and AA in complex matrices.
•Myrica rubra-based N-doped carbon dots are fabricated by a green hydrothermal method for recycle of waste resources.•MN-CDs are employed to construct an “on-off-on” switch probe for sequential detection of Fe3+ and AA.•Fluorescence quenching of MN-CDs by Fe3+ belongs to the synergistic mechanisms of IFE and PET.•Colorimetric sensing platform based on the MN-CDs realizes the convenient outdoor detection of Fe3+ and AA.
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