Under the new era of China's high-quality development, the innovation driving of enterprises is shifting from single patent competition to patent portfolio competition, which is of great significance ...for cultivating a more robust domestic market and realizing a higher level of opening-up. This paper puts the firms' patent portfolio index and domestic value-added ratio into a unified analysis framework. It explores the relationship between them by utilizing the Chinese Industrial Database, Chinese Financial Database and China Customs Database from 2000 to 2014. The empirical results suggest that: (1) Domestic patent portfolio plays a significant role in promoting enterprises' export domestic value-added ratio, the suitability of domestic invention and utility model patents is not high in China; (2) Based on the heterogeneity analysis, the domestic patent portfolio of public trading enterprises and high productivity enterprises has a more significant promotion effect on domestic value-added ratio. (3) By examining the mechanism, it shows that price-cost markup and the relative price of intermediate goods are significant intermediate variables of domestic patent portfolio promoting domestic value-added ratio, and patenting abroad is an essential channel of domestic invention patent promoting domestic value-added ratio. This paper made an in-depth analysis of the influence of domestic patent portfolio on domestic value-added ratio, which provides a policy reference value for optimizing the Chinese patent system and enhancing competitive export advantage.
ObjectiveWe aimed to examine trends in overall mortality rates for liver cancer and those within subgroups according to sex, age, aetiological factors and modifiable risk factors in China from 1990 ...to 2019.DesignThe design of this study involved analysing liver cancer mortality rates in China from 1990 to 2019 using joinpoint regression analysis to identify significant changes in mortality rates. Annual percentage changes (APCs) and 95% CIs were used to quantify the magnitude of changes in mortality rates. The study also conducted subgroup analyses based on sex, age, aetiological factors and risk factors to better understand trends in liver cancer mortality rates.ResultsThe age-standardised mortality from liver cancer in China first increased from 28.12 to 31.54 deaths per 100 000 population in 1990–1996 (APC=2.1%, 95% CI: 1.5% to 2.6%), then dropped at varying rates (1996–2000, APC=−3.7%, 95% CI: −5.2% to –2.1%; 2000–2004, APC=−17.4%, 95% CI: −18.7% to –16.1%; 2004–2007, APC=−5.4%, 95% CI: −8.3% to –2.3%; and 2007–2012, APC=−1.4%, 95% CI: −2.3% to –0.4%), and began to increase again after 2012 (APC=1.3%, 95% CI: 0.9% to 1.7%). Hepatitis B and C virus infections accounted for 63% and 18% of liver cancer-related deaths, respectively, in China from 1990 to 2019. Smoking, drug use, alcohol use and elevated body mass index were the four leading risk factors for liver cancer mortality in China during the study period. Notable variations in both liver cancer mortality rates and changes in mortality rates were observed across sexes and age groups.ConclusionsThe age-standardised liver cancer mortality rate in China significantly decreased from 1996 to 2019. The major differences in liver cancer mortality rates and inconsistent changes in mortality rates between 1990 and 2019 merit the attention of researchers and policymakers.
An unusual catalytic double 2 + 2 cycloaddition relay reaction of yne–allenones with unactivated alkenes and alkynes has been achieved, which enabled C–C triple-bond cleavage to access more than 60 ...examples of functionalized phenanthren-9-ols with generally good yields. This reaction provides a regioselective and practical method for the construction of carbocyclic ring systems with a high degree of functional group compatibility. Aside from surveying the scope of this transformation, mechanistic details of this process are provided by conducting systematic theoretical calculations.
Plant health and soil fertility are affected by plant-microbial interactions in soils. Peanut is an important oil crop worldwide and shows considerable adaptability, but growth and yield are ...negatively affected by continuous cropping. In this study, 16S rRNA gene clone library analyses were used to study the succession of soil bacterial communities under continuous peanut cultivation. Six libraries were constructed for peanut over three continuous cropping cycles and during its seedling and pod-maturing growth stages. Cluster analyses indicated that soil bacterial assemblages obtained from the same peanut cropping cycle were similar, regardless of growth period. The diversity of bacterial sequences identified in each growth stage library of the three peanut cropping cycles was high and these sequences were affiliated with 21 bacterial groups. Eight phyla: Acidobacteria, Actinobacteria, Bacteroidetes, Chloroflexi, Gemmatimonadetes, Planctomycetes, Proteobacteria and Verrucomicrobia were dominant. The related bacterial phylotypes dynamic changed during continuous cropping progress of peanut. This study demonstrated that the bacterial populations especially the beneficial populations were positively selected. The simplification of the beneficial microbial communities such as the phylotypes of Alteromonadales, Burkholderiales, Flavobacteriales, Pseudomonadales, Rhizobiales and Rhodospirillales could be important factors contributing to the decline in peanut yield under continuous cropping. The microbial phylotypes that did not successively changed with continuous cropping, such as populations related to Rhizobiales and Rhodospirillales, could potentially resist stress due to continuous cropping and deserve attention. In addition, some phylotypes, such as Acidobacteriales, Chromatiales and Gemmatimonadales, showed a contrary tendency, their abundance or diversity increased with continuous peanut cropping progress. Some bacterial phylotypes including Acidobacteriales, Burkholderiales, Bdellovibrionales, and so on, also were affected by plant age.
Celotno besedilo
Dostopno za:
DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
Peanut Fusarium rot, which is widely observed in the main peanut-producing areas in China, has become a significant factor that has limited the yield and quality in recent years. It is highly urgent ...and significant to clarify the regulatory mechanism of peanuts in response to
. In this study, transcriptome and proteome profiling were combined to provide new insights into the molecular mechanisms of peanut stems after
infection. A total of 3746 differentially expressed genes (DEGs) and 305 differentially expressed proteins (DEPs) were screened. The upregulated DEGs and DEPs were primarily enriched in flavonoid biosynthesis, circadian rhythm-plant, and plant-pathogen interaction pathways. Then, qRT-PCR analysis revealed that the expression levels of phenylalanine ammonia-lyase (PAL), chalcone isomerase (CHI), and cinnamic acid-4-hydroxylase (C4H) genes increased after
infection. Moreover, the expressions of these genes varied in different peanut tissues. All the results revealed that many metabolic pathways in peanut were activated by improving key gene expressions and the contents of key enzymes, which play critical roles in preventing fungi infection. Importantly, this research provides the foundation of biological and chemical analysis for peanut disease resistance mechanisms.
Folate and vitamin B12 are two vital regulators in the metabolic process of homocysteine, which is a risk factor of atherothrombotic events. Low folate intake or low plasma folate concentration is ...associated with increased stroke risk. Previous randomized controlled trials presented discordant findings in the effect of folic acid supplementation-based homocysteine lowering on stroke risk. The aim of the present review was to perform a meta-analysis of relevant randomized controlled trials to check the how different folate fortification status might affect the effects of folic acid supplementation in lowering homocysteine and reducing stroke risk.
Relevant randomized controlled trials were identified through formal literature search. Homocysteine reduction was compared in subgroups stratified by folate fortification status. Relative risks with 95 % confidence intervals were used as a measure to assess the association between folic acid supplementation and stroke risk.
The meta-analysis included fourteen randomized controlled trials,
A total of 39 420 patients.
Homocysteine reductions were 26·99 (sd 1·91) %, 18·38 (sd 3·82) % and 21·30 (sd 1·98) %, respectively, in the subgroups without folate fortification, with folate fortification and with partial folate fortification. Significant difference was observed between the subgroups with folate fortification and without folate fortification (P=0·05). The relative risk of stroke was 0·88 (95 % CI 0·77, 1·00, P=0·05) in the subgroup without folate fortification, 0·94 (95 % CI 0·58, 1·54, P=0·82) in the subgroup with folate fortification and 0·91 (95 % CI 0·82, 1·01, P=0·09) in the subgroup with partial folate fortification.
Folic acid supplementation might have a modest benefit on stroke prevention in regions without folate fortification.
Display omitted
Traditional breast cancer (BrCa) bone metastasis models contain many limitations with regards to controllability, reproducibility and flexibility of design. In this study, a novel ...biomimetic bone microenvironment was created by integrating hydroxyapatite (HA) and native bioactive factors deposited by osteogenic induction of human bone marrow mesenchymal stem cells (MSCs) within a cytocompatible chitosan hydrogel. It was found that a 10% nanocrystalline HA (nHA) chitosan scaffold exhibited the highest BrCa adhesion and proliferation when compared to chitosan scaffolds with 20% nHA, 10% and 20% microcrystalline HA as well as amorphous HA. This 3-D tunable bone scaffold can provide a biologically relevant environment, increase cell–cell and cell–matrix interactions as found in native bone, and retain the behavior of BrCa cells with different metastasis potential (i.e. highly metastatic MDA-MB-231, less metastatic MCF-7 and transfected MDA-MB-231). The co-culture of MSCs and MDA-MB-231 in this bone model illustrated that MSCs have the capacity to upregulate the expression of the well-known metastasis-associated gene metadherin within BrCa cells. In summary, this study illustrates the ability of our 3-D bone model to create a biomimetic environment conducive to recapitulating the behavior of metastatic BrCa cells, making it a promising tool for in vitro BrCa cell bone metastasis study and for the discovery of potential therapeutics.
The Industrial Internet of Things (IIoT) refers to the application of the IoT in the industrial field. The development of fifth-generation (5G) communication technology has accelerated the world’s ...entry into the era of the industrial revolution and has also promoted the overall optimization of the IIoT. In the IIoT environment, challenges such as complex operating conditions and diverse data transmission have become increasingly prominent. Therefore, studying how to collect and process a large amount of real-time data from various devices in a timely, efficient, and reasonable manner is a significant problem. To address these issues, we propose a three-level networking model based on distributed sensor self-networking and cloud server platforms for networking. This model can collect monitoring data for a variety of industrial scenarios that require data collection. It enables the processing and storage of key information in a timely manner, reduces data transmission and storage costs, and improves data transmission reliability and efficiency. Additionally, we have designed a feature fusion network to further enhance the amount of feature information and improve the accuracy of industrial data recognition. The system also includes data preprocessing and data visualization capabilities. Finally, we discuss how to further preprocess and visualize the collected dataset and provide a specific algorithm analysis process using a large manipulator dataset as an example.
Celotno besedilo
Dostopno za:
CEKLJ, DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, UILJ, UKNU, UL, UM, UPUK
Complete Coverage Path Planning (CCPP) is a key technology for Unmanned Surface Vehicles (USVs) that require complete coverage on the water surface, such as water sample collection, garbage ...collection, water field patrol, etc. When facing complex and irregular boundaries, the traditional CCPP-based boustrophedon method may encounter many problems and challenges, such as multiple repeated regions, multiple turns, and the easy occurrence of local optima. The traditional genetic algorithm also has some shortcomings. The fixed fitness function, mutation operator and crossover operator are not conducive to the evolution of the population and the production of better offspring. In order to solve the above problems, this paper proposes a CCPP method based on an improved genetic algorithm, including a stretched fitness function, an adaptive mutation operator, and a crossover operator. The algorithm combines the key operators in the fireworks algorithm. Then, the turning and obstacle avoidance during the operation of the Unmanned Surface Vehicle are optimized. Simulation and experiments show that the improved genetic algorithm has higher performance than the exact unit decomposition method and the traditional genetic algorithm, and has more advantages in reducing the coverage path length and repeating the coverage area. This proves that the proposed CCPP method has strong adaptability to the environment and has practical application value in improving the efficiency and quality of USV related operations.
Background Limited data are available regarding the association between serum transferrin saturation (TSAT) levels and heart failure (HF). Methods We utilized data from National Health and Nutrition ...Examination Survey (NHANES) 2017- 2020.03 for analysis. Data on TAST, HF and covariates were extracted and analyzed. Weighted logistic regression and subgroup analysis were used to explore the independent association between TSAT and HF. Furthermore, interaction tests were also carried out to evaluate the strata differences. We subsequently assessed whether there was a non-linear relationship between the 2 using Restricted cubic spline (RCS) and threshold effect models. Result A total of 282 (3.87%) participants were identified to have HF. Among the total population, participants with HF had significantly lower TSAT levels compared to those without HF (24.63 vs. 27.95, P = 0.001). After fully adjusting for potential confounders, weighted multiple logistic regression models revealed a 2.6% reduced in the risk of HF when each unit of TSAT increased. There was also a negative association between elevated TSAT and developed risk of HF in the quartile groups (Q1 OR:1.00; Q2 OR: 0.924 95%CI:0.593,1.440; Q3 OR: 0.515 95%CI:0.298,0.891; Q4 OR:0.411 95%CI:0.201,0.839). The subgroup analysis results remained consistent across strata, with a strong negative correlation between TSAT and HF. Interaction tests showed no dependence on gender, age, Body Mass Index, race, diabetes, hypertension, hyperlipidemia, ratio of family income to poverty and education for this negative association between TSAT and HF (all p for interaction >0.05). The RCS and threshold effect models indicated a linear negative correlation between TSAT and HF, which was more pronounced when TSAT under 40%. Conclusion Overall, these findings suggest a consistent and negative association between TSAT levels and the presence of HF among middle-aged and older adults in the United States.
![Catalytic Double [2 + 2] Cy...](http://api.summon.serialssolutions.com/2.0.0/image/issn/XR4PS5YY4K/1523-7060/small "Catalytic Double [2 + 2] Cycloaddition Relay Enabled C–C Triple Bond Cleavage of Yne–Allenones")
PDF
