Alzheimer's disease (AD) is associated not only with regional gray matter damages, but also with abnormalities in functional integration between brain regions. Here, we employed resting-state ...functional magnetic resonance imaging data and voxel-based graph-theory analysis to systematically investigate intrinsic functional connectivity patterns of whole-brain networks in 32 AD patients and 38 healthy controls (HCs). We found that AD selectively targeted highly connected hub regions (in terms of nodal functional connectivity strength) of brain networks, involving the medial and lateral prefrontal and parietal cortices, insula, and thalamus. This impairment was connectivity distance-dependent (Euclidean), with the most prominent disruptions appearing in the long-range connections (e.g., 100-130 mm). Moreover, AD also disrupted functional connections within the default-mode, salience and executive-control modules, and connections between the salience and executive-control modules. These disruptions of hub connectivity and modular integrity significantly correlated with the patients' cognitive performance. Finally, the nodal connectivity strength in the posteromedial cortex exhibited a highly discriminative power in distinguishing individuals with AD from HCs. Taken together, our results emphasize AD-related degeneration of specific brain hubs, thus providing novel insights into the pathophysiological mechanisms of connectivity dysfunction in AD and suggesting the potential of using network hub connectivity as a diagnostic biomarker.
In the field of information and communication technology, the Internet of Things is regarded as a brand-new and important technology. The introduction of new protocols in this area is caused by the ...presence of devices in these networks with constrained resources and relatively low computing power. One of the most well-known routing protocols for low-power devices is the RPL protocol. This algorithm cannot take into account all of the required routing goals at once. This article introduces a proposed data-oriented RPL algorithm that divides data during routing according to their content. This can decrease the amount of duplicate data transferred through the network, shorten the communication system's delay, conserve the node's limited energy, and prolong the network's lifespan. The effectiveness of RPL can be increased by selecting the best route utilizing the Binary Gray Wolf Optimization. The best parent node in the routing procedure is chosen using an objective function during the tree construction phase. This objective function is built using fuzzy logic and the Binary Gray Wolf Optimization in the suggested technique. The results of Matlab 2022a and OMNET environment tests have shown that the proposed method has increased the efficiency of energy consumption and reduced the period of instability and end-to-end delay. that the ratio of the instability period in the proposed method is much less than the other three methods, so that the ratio of the instability period is 57% for the proposed method in the ORPL and Qos RPL methods, it is equal to 80%, and in the RPL method it is equal to 89%. This problem shows that the proposed method is more stable, or, in other words, it has been active for a longer period of time with the maximum number of nodes.
Mild cognitive impairment (MCI) is the transitional, heterogeneous continuum from healthy elderly to Alzheimer's disease (AD). Previous studies have shown that brain functional activity in the ...default mode network (DMN) is impaired in AD patients. However, altering DMN activity patterns in MCI patients remains largely unclear. The present study utilized resting-state functional magnetic resonance imaging (fMRI) and an independent component analysis (ICA) approach to investigate DMN activity in 14 amnestic MCI (aMCI) patients and 14 healthy elderly. Compared to the aMCI patients, the healthy elderly exhibited increased functional activity in the DMN regions, including the bilateral precuneus/posterior cingulate cortex, right inferior parietal lobule, and left fusiform gyrus, as well as a trend towards increased right medial temporal lobe activity. The aMCI patients exhibited increased activity in the left prefrontal cortex, inferior parietal lobule, and middle temporal gyrus compared to the healthy elderly. Increased frontal–parietal activity may indicate compensatory processes in the aMCI patients. These findings suggest that abnormal DMN activity could be useful as an imaging-based biomarker for the diagnosis and monitoring of aMCI patients.
The known regional abnormality of the dorsolateral prefrontal cortex (DLPFC) and its role in various neural circuits in mild cognitive impairment (MCI) has given prominence to its importance in ...studies on the disconnection associated with MCI. The purpose of the current study was to examine the DLPFC functional connectivity patterns during rest in MCI patients and the impact of regional grey matter (GM) atrophy on the functional results. Structural and functional MRI data were collected from 14 MCI patients and 14 age, gender-matched healthy controls. We found that both the bilateral DLPFC showed reduced functional connectivity with the inferior parietal lobule (IPL), superior/medial frontal gyrus and sub-cortical regions (e.g., thalamus, putamen) in MCI patients when compared with healthy controls. Moreover, the DLPFC connectivity with the IPL and thalamus significantly correlated with the cognitive performance of patients as measured by mini-mental state examination (MMSE), clock drawing test (CDT), and California verbal learning test (CVLT) scores. When taking GM atrophy as covariates, these results were approximately consistent with those without correction, although there may be a decrease in the statistical power. These results suggest that the DLPFC disconnections may be the substrates of cognitive impairments in MCI patients. In addition, we also found enhanced functional connectivity between the left DLPFC and the right prefrontal cortex in MCI patients. This is consistent with previous findings of MCI-related increased activation during cognitive tasks, and may represent a compensatory mechanism in MCI patients. Together, the present study demonstrated the coexistence of functional disconnection and compensation in MCI patients using DLPFC functional connectivity analysis, and thus might provide insights into biological mechanism of the disease.
Celotno besedilo
Dostopno za:
DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
Objective
Recent research has highlighted the insula as a critical hub in human brain networks and the most susceptible region to subjective cognitive decline (SCD). However, the changes in ...functional connectivity of insular subregions in SCD patients remain poorly understood. The present study aims to clarify the altered functional connectivity patterns within insular subregions in individuals with SCD using resting-state functional magnetic resonance imaging (rs-fMRI).
Methods
In this study, we collected rs-fMRI data from 30 patients with SCD and 28 healthy controls (HCs). By defining three subregions of the insula, we mapped whole-brain resting-state functional connectivity (RSFC). We identified several distinct RSFC patterns of the insular subregions. Specifically, for positive connectivity, three cognitive-related RSFC patterns were identified within the insula, suggesting anterior-to-posterior functional subdivisions: (1) a dorsal anterior zone of the insula that shows RSFC with the executive control network (ECN); (2) a ventral anterior zone of the insula that shows functional connectivity with the salience network (SN); and (3) a posterior zone along the insula that shows functional connectivity with the sensorimotor network (SMN).
Results
Compared to the controls, patients with SCD exhibited increased positive RSFC to the sub-region of the insula, demonstrating compensatory plasticity. Furthermore, these abnormal insular subregion RSFCs are closely correlated with cognitive performance in the SCD patients.
Conclusion
Our findings suggest that different insular subregions exhibit distinct patterns of RSFC with various functional networks, which are affected differently in patients with SCD.
Acupuncture has been used in the therapy of Alzheimer disease (AD); however, its neural mechanisms are still unclear. The aim of this study is to examine the effect of acupuncture on the functional ...connectivity in AD by using resting-state functional magnetic resonance imaging (rs-fMRI). Twenty-eight subjects (14 AD and 14 normal controls) participated in this study. The rs-fMRI data were acquired before and after acupuncture stimulation at the acupoints of Tai chong (Liv3) and Hegu (LI4). During the baseline resting state, by using the amplitude of low-frequency fluctuations (ALFF), we found a significantly decreased or increased ALFF in the AD patients relative to the controls. These regions were located in the right superior frontal gyrus (SFG), left postcentral gyrus, subgenual cingulate cortex (SCC), right middle cingulate cortex (MCC), right inferior frontal gyrus (IFG), right hippocampus and the right inferior temporal gyrus (ITG). Then, we selected these brain regions as seeds to investigate whether regional activity and functional connectivity could be modulated by acupuncture in the AD patients. When compared to the pre-acupuncture stage, several of the above regions showed an increased or decreased ALFF after acupuncture in the AD patients. In addition, the functional connectivity between the hippocampus and the precentral gyrus showed enhancement after acupuncture in the AD patients. Finally, there were close correlations between the functional activity, connectivity and clinical performance in the AD patients. The current study confirmed that acupuncture at Tai chong (Liv3) and He gu (LI4) can modulate functional activity and connectivity of specific cognition-related regions in AD patients.
Celotno besedilo
Dostopno za:
DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
Our objective is to clarify the effects of acupuncture on hippocampal connectivity in patients with Alzheimer disease (AD) using functional magnetic resonance imaging (fMRI). Twenty-eight ...right-handed subjects (14 AD patients and 14 healthy elders) participated in this study. Clinical and neuropsychological examinations were performed on all subjects. MRI was performed using a SIEMENS verio 3-Tesla scanner. The fMRI study used a single block experimental design. We first acquired baseline resting state data during the initial 3 minutes and then performed acupuncture stimulation on the Tai chong and He gu acupoints for 3 minutes. Last, we acquired fMRI data for another 10 minutes after the needle was withdrawn. The preprocessing and data analysis were performed using statistical parametric mapping (SPM5) software. Two-sample t-tests were performed using data from the two groups in different states. We found that during the resting state, several frontal and temporal regions showed decreased hippocampal connectivity in AD patients relative to control subjects. During the resting state following acupuncture, AD patients showed increased connectivity in most of these hippocampus related regions compared to the first resting state. In conclusion, we investigated the effect of acupuncture on AD patients by combing fMRI and traditional acupuncture. Our fMRI study confirmed that acupuncture at Tai chong and He gu can enhance the hippocampal connectivity in AD patients.
Celotno besedilo
Dostopno za:
DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
Electroencephalography (EEG) signals are crucial for investigating brain function and cognitive processes. This study aims to address the challenges of efficiently recording and analyzing ...high-dimensional EEG signals while listening to music to recognize emotional states. We propose a method combining Bidirectional Long Short-Term Memory (Bi-LSTM) networks with attention mechanisms for EEG signal processing. Using wearable EEG devices, we collected brain activity data from participants listening to music. The data was preprocessed, segmented, and Differential Entropy (DE) features were extracted. We then constructed and trained a Bi-LSTM model to enhance key feature extraction and improve emotion recognition accuracy. Experiments were conducted on the SEED and DEAP datasets. The Bi-LSTM-AttGW model achieved 98.28% accuracy on the SEED dataset and 92.46% on the DEAP dataset in multi-class emotion recognition tasks, significantly outperforming traditional models such as SVM and EEG-Net. This study demonstrates the effectiveness of combining Bi-LSTM with attention mechanisms, providing robust technical support for applications in brain–computer interfaces (BCI) and affective computing. Future work will focus on improving device design, incorporating multimodal data, and further enhancing emotion recognition accuracy, aiming to achieve practical applications in real-world scenarios.
Early recurrence (ER) affects the long-term survival prognosis of patients with hepatocellular carcinoma (HCC). Many previous studies have utilized CT/MRI-based radiomics to predict ER after radical ...treatment, achieving high predictive value. However, the diagnostic performance of radiomics for the preoperative identification of ER remains uncertain. Therefore, we aimed to perform a meta-analysis to investigate the predictive performance of radiomics for ER in HCC.
A systematic literature search was conducted in PubMed, Web of Science (including MEDLINE), EMBASE and the Cochrane Central Register of Controlled Trials to identify studies that utilized radiomics methods to assess ER in HCC. Data were extracted and quality assessed for retrieved studies. Statistical analyses included pooled data, tests for heterogeneity, and publication bias. Meta-regression and subgroup analyses were performed to investigate potential sources of heterogeneity.
The analysis included fifteen studies involving 3,281 patients focusing on preoperative CT/MRI-based radiomics for the prediction of ER in HCC. The combined sensitivity, specificity, and area under the curve (AUC) of the receiver operating characteristic were 75% (95% CI: 65-82), 78% (95% CI: 68-85), and 83% (95% CI: 79-86), respectively. The combined positive likelihood ratio, negative likelihood ratio, diagnostic score, and diagnostic odds ratio were 3.35 (95% CI: 2.41-4.65), 0.33 (95% CI: 0.25-0.43), 2.33 (95% CI: 1.91-2.75), and 10.29 (95% CI: 6.79-15.61), respectively. Substantial heterogeneity was observed among the studies (I²=99%; 95% CI: 99-100). Meta-regression showed imaging equipment contributed to the heterogeneity of specificity in subgroup analysis (
= 0.03).
Preoperative CT/MRI-based radiomics appears to be a promising and non-invasive predictive approach with moderate ER recognition performance.
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