Polyhydroxyalkanoates (PHAs) are biodegradable polymers that can substitute for petroleum-based plastics in a variety of applications. One avenue to commercial PHA production involves coupling ...waste-based synthesis with the use of mixed microbial consortia (MMC). In this regard, production requires maximizing the enrichment of a MMC capable of feast-famine PHA synthesis, with the metabolic response induced through imposition of aerobic-dynamic feeding (ADF) conditions. However, the concept of PHA production in complex matrices remains unrefined; process operational improvements are needed, along with an enhanced understanding of the MMC. Research presented herein investigated the effect of aeration on feast-famine PHA synthesis, with four independent aeration state systems studied; MMC were fed volatile fatty acid (VFA)-rich fermented dairy manure. Regardless of the aeration state, all MMC exhibited a feast-famine response based on observed carbon cycling. Moreover, there was no statistical difference in PHA synthesis rates, with qPHA ranging from 0.10 to 0.19 CmmolPHA gVSS−1 min−1; VFA uptake rates exhibited similar statistical indifferences. PHA production assessments on the enriched MMC resulted in maximum intracellular concentrations ranging from 22.5 to 90.7% (mgPHA mgVSS−1); at maximum concentration, the mean hydroxyvalerate mol content was 73 ± 0.6%. While a typical feast-famine dissolved oxygen (DO) pattern was observed at maximum aeration, less resolution was observed at decreasing aeration rates, suggesting that DO may not be an optimal process monitoring parameter. At lower aeration states, nitrogen cycling patterns, supported by molecular investigations targeting AOBs and NOBs, indicate that NO2 and NO3 sustained feast-famine PHA synthesis. Next-generation sequencing analysis of the respective MMC revealed numerous and diverse genera exhibiting the potential to achieve PHA synthesis, suggesting functional redundancy embedded in the diverse MMC. Ultimately, results demonstrate that aeration can be controlled in waste-based ADF systems to sustain PHA production potential, while enriching for a diverse MMC that exhibits potential functional redundancy. Reduced aeration could also enhance cost competitiveness of waste-based PHA production, with potential further benefits associated with nitrogen treatment.
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•No effect of aeration on feast-famine PHA synthesis by MMC on fermented dairy manure.•Maximum observed intracellular PHA concentration was 90.1% (mgPHA per mgVSS).•At maximum PHA concentration, the mean hydroxyvalerate mol content was 73 ± 0.6%.•NO2 and NO3 appeared to sustain feast-famine PHA synthesis.•Highly diverse culture of putative PHA-producing bacteria.
Background
Rural and remote patients have reduced access to palliative care, often resulting in inter‐hospital transfers and death a long way from home and family. Katherine Hospital (KH), a 50‐bed ...hospital services a population with high Aboriginality who experience this issue.
Aims
To characterise trends in mortality and transfers at a remote hospital in reference to increasing capacity to provide palliative care.
Methods
Retrospective analysis of deaths in patients over 18 years of age, admitted between 2008 and 2018 at KH, Northern Territory. Outcome measures include number of deaths, aeromedical transfers to tertiary facility, palliative care episodes, demographics including Aboriginality, admission data and comorbidity. Statistical analysis included unpaired t‐test, chi‐square test and regression analysis.
Results
The number of deaths in KH increased from 23 (0.88% of inpatient admissions) in 2011 to 52 in 2018 (1.7%). During the same period, the proportion of all deaths classified as palliative increased from 51.4 to 66.0% (P = 0.001), with fewer deaths occurring in the emergency department (17.2–1.4% for the last 3 years, R = 0.75, P = 0.008). The number of aeromedical transfers of patients from KH to tertiary centres decreased from 769 (10.4% of all admissions) in 2011 to 434 (3.4%) in 2018 (P = 0.006).
Conclusions
Increasing the capacity of a remote hospital to provide palliative care allowed more patients to die closer to home and decreased inappropriate aeromedical retrievals. An increased in‐hospital mortality rate should not be misinterpreted as reflecting suboptimal care if palliative intent, patients' wishes and non‐clinical risk factors have not been ascertained.
Abstract In the modern treatment of Charcot neuroarthropathy, beam screw fixation is an alternative to plate and screw fixation. Exposure is minimized for implantation, and this technique supports ...the longitudinal columns of the foot as a rigid load-sharing construct. A published data review identified a paucity of data regarding metatarsal intramedullary canal morphology relevant to beam screw fixation. The purpose of the present study was to describe metatarsal diaphyseal morphology qualitatively and quantitatively in an effort to provide data that can be used by surgeons when selecting axially based intramedullary fixation. Twenty fresh-frozen cadaveric below-the-knee specimens were obtained. The metatarsals were exposed, cleaned of soft tissue, and axially transected at the point of the narrowest external diameter. Next, a digital caliper was used to measure the size and shape of the diaphysis of the first through fourth metatarsals. The diaphyseal canal shape was categorized as round, oval, triangular, or pear. The widest distance between the endosteal cortical surfaces was measured. Triangular endosteal canals were only found in the first metatarsal, and the remainder of the metatarsal canals were largely round or oval. These data help to approximate the size of fixation needed to achieve maximal screw–endosteal purchase.
Light Field Display Point Rendering Gavane, Ajinkya; Watson, Benjamin
Proceedings of the ACM on computer graphics and interactive techniques,
13/05, Letnik:
7, Številka:
1
Journal Article
Recenzirano
Rendering for light field displays (LFDs) requires rendering of dozens or hundreds of views, which must then be combined into a single image on the display, making real-time LFD rendering extremely ...difficult. We introduce light field display point rendering (LFDPR), which meets these challenges by improving eye-based point rendering Gavane and Watson 2023 with texture-based splatting, which avoids oversampling of triangles mapped to only a few texels; and with LFD-biased sampling, which adjusts horizontal and vertical triangle sampling to match the sampling of the LFD itself. To improve image quality, we introduce multiview mipmapping, which reduces texture aliasing even though compute shaders do not support hardware mipmapping. We also introduce angular supersampling and reconstruction to combat LFD view aliasing and crosstalk. The resulting LFDPR is 2-8x times faster than multiview rendering, with similar comparable quality.
Eye-based point rendering (EPR) can make multiview effects much more practical by adding eye (camera) buffer resolution efficiencies to improved view-independent rendering (iVIR). We demonstrate this ...very successfully by applying EPR to dynamic cube-mapped reflections, sometimes achieving nearly 7× speedups over iVIR and traditional multiview rendering (MVR), with nearly equivalent quality. Our application to omnidirectional soft shadows is less successful, demonstrating that EPR is most effective with larger shader loads and tight eye buffer to off-screen (render target) buffer mappings. This is due to EPR's eye buffer resolution constraints limiting points and shading calculations to the sampling rate of the eye's viewport. In a 2.48 million triangle scene with 50 reflective objects (using 300 off-screen views), EPR renders environment maps with a 49.40ms average frame time on an NVIDIA 1080 Ti GPU. In doing so, EPR generates up to 5x fewer points than iVIR, and regularly performs 50× fewer shading calculations than MVR.
Forests are the most productive terrestrial ecosystems across the world. They can play both a direct and indirect role in global poverty alleviation through their social, economic and environmental ...functions. However, the potential of forests in poverty alleviation is underestimated to a great extent. Sustainability, the most essential advantage and characteristic of forests for poverty alleviation, has not been fully recognized. To that end, we propose the concept of sustainable poverty alleviation through forests (SPAF). This concept shifts the vision of poverty alleviation through forests from a narrow focus on subsistence and livelihood to a sustainable poverty alleviation that promotes all dimensions of human development. There is abundant evidence that forests can at least contribute to sustainable poverty alleviation through a synergy of seven pathways: subsistence materials, health, income, employment, women's empowerment, climate change mitigation and biodiversity, which are highly consistent with the United Nations Sustainable Development Goals. SPAF also faces enormous implementation challenges, so a sustainable global strategy is urgently needed to provide direction for worldwide poverty alleviation at the crossroads of nature and humanity.
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•We propose the concept of sustainable poverty alleviation through forests (SPAF).•The pathways of SPAF include socio-economic and environmental dimensions.•SPAF is a strong contributor to the achievement of the Sustainable Development Goals.•Critical strategies are urgently needed to address the challenges facing SPAF.
In his book Multimedia Learning 7, Richard Mayer asserts that viewers learn best from imagery that provides them with cues to help them organize new information into the correct knowledge structures. ...Designers have long been exploiting the Gestalt laws of visual grouping to deliver viewers those cues using visual hierarchy, often communicating structures much more complex than the simple organizations studied in psychological research. Unfortunately, designers are largely practical in their work, and have not paused to build a complex theory of structural communication. If we are to build a tool to help novices create effective and well structured visuals, we need a better understanding of how to create them. Our work takes a first step toward addressing this lack, studying how five of the many grouping cues (proximity, color similarity, common region, connectivity, and alignment) can be effectively combined to communicate structured text and imagery from real world examples. To measure the effectiveness of this structural communication, we applied a digital version of card sorting, a method widely used in anthropology and cognitive science to extract cognitive structures. We then used tree edit distance to measure the difference between perceived and communicated structures. Our most significant findings are: 1) with careful design, complex structure can be communicated clearly; 2) communicating complex structure is best done with multiple reinforcing grouping cues; 3) common region (use of containers such as boxes) is particularly effective at communicating structure; and 4) alignment is a weak structural communicator.
The recent discovery that iconic depictions in caves on the Indonesian island of Sulawesi are more ancient than those from Upper Palaeolithic Europe raises questions as to when such images first ...arose and why the graphic outcomes from the two locations are so similar. In this paper, we show that these questions can be addressed by exploiting the extensive research carried out over the recent past on the psychology of perception and the neuroscience of the visual brain that allows the proper place of iconic depictions in understanding cognitive evolution to be determined.
Category:
Midfoot/Forefoot
Introduction/Purpose:
The average intramedullary diameter of the proximal phalanges of the foot has not been well documented in the literature. This dimension has important ...implications for surgical fixation devices, such as intramedullary screws. By design, intramedullary fixation devices rely on endosteal fit to provide stability. The precise intramedullary diameter is not readily identifiable on plain radiographs. A better understanding of the average diameter of the proximal phalanges of the foot can assist surgeons in surgical planning and appropriate screw diameter selection to provide more satisfactory patient outcomes.
Methods:
Twenty below-knee cadaveric specimens were dissected to expose each proximal phalanx. A sagittal saw was used to transect the diaphysis at its narrowest portion. The dorsal to plantar and medial to lateral diameters were measured using a digital manometer.
Results:
The average diameter dorsal to plantar for each digit was 6.25 ± 2.24 mm, 3.61 ± 1.25 mm, 2.94 ± 0.70 mm, 2.72 ± 0.77 mm, and 2.48 ± 0.80 mm, respectively. The average diameter medial to lateral for each digit was 7.83 ± 2.13 mm, 3.08 ± 0.93 mm, 2.47 ± 0.74 mm, 2.33 ± 0.73 mm, and 2.62 ± 0.69 mm, respectively. The overall average diameter for toes one through five was 7.04 ± 1.95 mm, 3.35 ± 1.04 mm, 2.71 ± 0.66 mm, 2.52 ± 0.71 mm, and 2.55 ± 0.63 mm, respectively.
Conclusion:
Understanding the intramedullary diameters of the proximal phalanges of the foot is a valuable tool when utilizing intramedullary surgical stabilization. The hallux proximal phalanx demonstrated the largest, and most variable, diameter, which could make selection intramedullary fixation difficult. In addition, the hallux proximal phalanx may lend itself better to 2 smaller fixation devices rather than one larger one. The lesser phalanges demonstrated smaller diameters more consistently, which is more amenable to a single smaller (2.5 mm) intramedullary device. This data can provide surgeons with an expected intramedullary diameter during surgical planning.
Am I Playing Better Now? Riahi, Maryam; Watson, Benjamin Allen
Proceedings of the ACM on computer graphics and interactive techniques,
05/2021, Letnik:
4, Številka:
1
Journal Article
Recenzirano
G-SYNC technology matches formerly regular display refreshes to irregular frame updates, improving frame rates and interactive latency. In a previous study of gaming at the 30Hz frame rates common on ...consoles, players of Battlefield 4 were unable to discern when G-SYNC was in use, but scored higher with G-SYNC and were affected emotionally. We build on that study with the first examination of G-SYNC's effects at the 60Hz frame rate more common in PC gaming and on emerging consoles. Though G-SYNC's effects are less at 60Hz than they were at 30Hz, G-SYNC can still improve the performance of veteran players, particularly when games are challenging. G-SYNC's effects on emotion and experience were limited.
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