This study employs gray system theory to refine the multiple linear regression model, resulting in the development of the gray multiple linear regression method. Utilizing School A as the primary ...subject, this approach involves gray scaling the intercultural communication skills of college instructors (independent variable) and the effectiveness of Chinese culture dissemination (dependent variable). This transformation aids in resolving the sequence of whitened background values for each variable. This transformation aids in sequencing the whitened background values for each variable. The regression coefficients are then calculated using the Cholesky method to determine the linear correlation between the variables and assess how intercultural communication skills influence cultural dissemination outcomes. The analysis of the influence of college teachers’ intercultural communicative competence on the effect of cultural transmission found that the language competence of college foreign language teachers is related to “attitude toward learning Chinese excellent culture” (0.432) and “whether it is necessary to teach the idea of Chinese excellent culture in the classroom” (0.503) both have significant correlations. The analytical results of this paper provide a reference basis for promoting the wide dissemination of Chinese excellent culture, as well as a direction for improving the cross-cultural communicative competence of foreign language teachers in colleges and universities.
The World Health Organization has declared the outbreak of a novel coronavirus (SARS-CoV-2 or 2019-nCoV) as a global pandemic. However, the mechanisms behind the coronavirus infection are not yet ...fully understood, nor are there any targeted treatments or vaccines. In this study, we identified high-binding-affinity aptamers targeting SARS-CoV-2 RBD, using an ACE2 competition-based aptamer selection strategy and a machine learning screening algorithm. The K d values of the optimized CoV2-RBD-1C and CoV2-RBD-4C aptamers against RBD were 5.8 nM and 19.9 nM, respectively. Simulated interaction modeling, along with competitive experiments, suggests that two aptamers may have partially identical binding sites at ACE2 on SARS-CoV-2 RBD. These aptamers present an opportunity for generating new probes for recognition of SARS-CoV-2 and could provide assistance in the diagnosis and treatment of SARS-CoV-2 while providing a new tool for in-depth study of the mechanisms behind the coronavirus infection.
The COVID‐19 pandemic caused by SARS‐CoV‐2 is threating global health. Inhibiting interaction of the receptor‐binding domain of SARS‐CoV‐2 S protein (SRBD) and human ACE2 receptor is a promising ...treatment strategy. However, SARS‐CoV‐2 neutralizing antibodies are compromised by their risk of antibody‐dependent enhancement (ADE) and unfavorably large size for intranasal delivery. To avoid these limitations, we demonstrated an aptamer blocking strategy by engineering aptamers’ binding to the region on SRBD that directly mediates ACE2 receptor engagement, leading to block SARS‐CoV‐2 infection. With aptamer selection against SRBD and molecular docking, aptamer CoV2‐6 was identified and applied to prevent, compete with, and substitute ACE2 from binding to SRBD. CoV2‐6 was further shortened and engineered as a circular bivalent aptamer CoV2‐6C3 (cb‐CoV2‐6C3) to improve the stability, affinity, and inhibition efficacy. cb‐CoV2‐6C3 is stable in serum for more than 12 h and can be stored at room temperature for more than 14 days. Furthermore, cb‐CoV2‐6C3 binds to SRBD with high affinity (Kd=0.13 nM) and blocks authentic SARS‐CoV‐2 virus with an IC50 of 0.42 nM.
We propose an aptamer blocking strategy to inhibit SARS‐CoV‐2 infection. With the advantages of small size, rapid kinetics, high stability, sophisticated programmability and high security, our aptamers have great potential as prophylactic and therapeutic agents, which could greatly assist in the intervention of prevailing and emerging infectious diseases other than COVID‐19.
In this report, the addition of nab-paclitaxel to standard gemcitabine increased the response rate, progression-free survival, and overall survival among patients with metastatic pancreatic ...adenocarcinoma.
Pancreatic cancer is the fourth leading cause of cancer-related death in Europe and the United States.
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Since 1997, gemcitabine therapy has been the standard first-line treatment for patients with unresectable locally advanced or metastatic pancreatic cancer.
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Among patients with metastatic disease, the 5-year survival rate is only 2%,
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and 1-year survival rates of 17 to 23% have been reported with gemcitabine.
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Numerous phase 2 studies involving patients with advanced pancreatic cancer have shown promising results; however, most subsequent large phase 3 studies have not shown significantly improved survival,
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with the exception of a study involving patients who . . .
This study explored the impact of childhood trauma on adolescent cyberbullying and the mediating roles of emotional intelligence and online social anxiety between them.
The Childhood Trauma Scale, ...Emotional Intelligence Scale, and Chinese Brief Version of the Social Media User Social Anxiety Scale and Cyber Bullying Scale were used to assess 1,046 adolescents boys: 297, girls: 749, average age = 15.79 years from four schools in Shandong Province, China. SPSS 25.0 and AMOS 24.0 were used for statistical analysis.
(1) Childhood trauma was positively associated with adolescents' cyberbullying; (2) Emotional intelligence and online social anxiety played partial mediating roles in the relationship between childhood trauma and cyberbullying; (3) Emotional intelligence and online social anxiety played a chain mediating role in the relationship between childhood trauma and cyberbullying.
This study reveals the relationship and mediating mechanisms between childhood trauma and cyberbullying. It provides implications for the theory and prevention of cyberbullying.
The requirement of the half-bridge LLC resonant converter with a wide input voltage range is becoming higher in photovoltaic applications because of its simple structure and low switching loss. ...Conventional frequency modulation (FM) requires a wide switching frequency range and a high-quality factor circuit design, leading to reduced efficiency and large component volumes at light loads. To solve the problems, a high-efficiency control strategy using adaptive pulse-width and frequency modulation (APWFM) is proposed. APWFM adjusts the gain by changing the switching frequency and duty cycle simultaneously. When the output power is below the reference value, the switching frequency decreases linearly as the output power decreases, and the duty cycle is simultaneously modulated to achieve constant output voltage, so the switching frequency variation range is smaller than FM. This results in improved light or medium load efficiency in a limited frequency range while keeping a small volume of magnetic components. Also, the proposed control strategy is realized with primary-side regulation (PSR) to eliminate the optocoupler and simplify the control circuit. Experimental results demonstrate a significant improvement in efficiency at medium and light loads compared to FM, and the average efficiency is improved by 5% based on low cost and simple operation.
Sapphire substrates with different crystal orientations are widely used in optoelectronic applications. In this work, focused ion beam (FIB) milling of single-crystal sapphire with A-, C-, and ...M-orientations was performed. The material removal rate (MRR) and surface roughness (Sa) of sapphire with the three crystal orientations after FIB etching were derived. The experimental results show that: The MRR of A-plane sapphire is slightly higher than that of C-plane and M-plane sapphires; the Sa of A-plane sapphire after FIB treatment is the smallest among the three different crystal orientations. These results imply that A-plane sapphire allows easier material removal during FIB milling compared with C-plane and M-plane sapphires. Moreover, the surface quality of A-plane sapphire after FIB milling is better than that of C-plane and M-plane sapphires. The theoretical calculation results show that the removal energy of aluminum ions and oxygen ions per square nanometer on the outermost surface of A-plane sapphire is the smallest. This also implies that material is more easily removed from the surface of A-plane sapphire than the surface of C-plane and M-plane sapphires by FIB milling. In addition, it is also found that higher MRR leads to lower Sa and better surface quality of sapphire for FIB etching.
Transcription factor (TF) is a class of the sequence-specific DNA-binding proteins that modulate the transcription of target genes, and thus regulate their expressions. Variations in TF are the ...crucial determinants for phenotypic traits. Although much progress has been made in the functions of TF genes in wheat, one of the most important staple crops globally, the diversity of TF genes in wheat and its progenitors are not well understood, especially the agronomically promising haplotypes have not yet been characterized. Here, we identified a total of 6,023 TF genes from hexaploid wheat through a genome-search method and classified them into 59 gene families based on the conserved domain. The characteristics and dN/dS values of these genes showed evidently selective effects. Based on re-sequencing data, we found a strong genetic bottleneck among these TF genes on A and D subgenomes while no found in B subgenome during wheat domestication. Combined with selective signals and known QTLs on the whole genome, 21 TF genes were preliminarily found to be associated with yield-related traits. The haplotype frequency of these TF genes was further investigated in bread wheat and its progenitors and 13 major haplotypes were the casual loci related to key traits. Finally, the tissue-specific TF genes were also identified using RNA-seq analysis. This study provided insights into the diversity and evolution of TF genes and the identified TF genes and excellent haplotypes associating with traits will contribute to wheat genetic improvement.
In professional sport, an enormous amount of fine-grain performance data can be generated at near millisecond intervals in the form of vision-based tracking data. One of the first sports to embrace ...this technology has been tennis, where Hawk-Eye technology has been used to both aid umpiring decisions, and to visualize shot trajectories for broadcast purposes. Despite the high-level of accuracy of the tracking systems and the sheer volume of spatiotemporal data they generate, the use of this data for player performance analysis and prediction has been lacking. In this research, we use ball and player tracking data from "Hawk-Eye" to discover unique player styles and predict within-point events. We move beyond current analysis that only incorporates coarse match statistics (i.e., serves, winners, number of shots, and volleys) and use spatial and temporal information which better characterizes the tactics and tendencies of each player. Using a probabilistic graphical model, we are able to model player behaviors which enables us to: 1) find the factors such as location and speed of the incoming shot which are most conducive to a player hitting a winner (i.e., "sweet-spot") or cause an error, and 2) do "live in-point" prediction - based on the shots being played during a rally we estimate the probability of the outcome (e.g., winner, continuation, or error) and the location of the next shot. As player behavior depends on the opponent, we use model adaptation to enhance our prediction. We show the utility of our approach by analyzing the play of Djokovic, Nadal, and Federer at the 2012 Australian Tennis Open.
As its characteristics of huge number of data bits and low energy consumption, optical computing may be used in the applications such as DFT etc. which needs a lot of computation and can be ...implemented in parallel. According to this, DFT implementation methods in full parallel as well as in partial parallel are presented. Based on resources ternary optical computer (TOC), extensive experiments were carried out. Experimental results show that the proposed schemes are correct and feasible. They provide a foundation for further exploration of the applications on TOC that needs a large amount calculation and can be processed in parallel.
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