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zadetkov: 38
1.
  • Compositional differences b... Compositional differences between Copaxone and Glatopa are reflected in altered immunomodulation ex vivo in a mouse model
    Grossman, Iris; Kolitz, Sarah; Komlosh, Arthur ... Annals of the New York Academy of Sciences, November 2017, Letnik: 1407, Številka: 1
    Journal Article
    Recenzirano
    Odprti dostop

    Copaxone (glatiramer acetate, GA), a structurally and compositionally complex polypeptide nonbiological drug, is an effective treatment for multiple sclerosis, with a well‐established favorable ...
Celotno besedilo
Dostopno za: BFBNIB, FZAB, GIS, IJS, IZUM, KILJ, NLZOH, NUK, OILJ, PILJ, PNG, SAZU, SBCE, SBMB, UL, UM, UPUK

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2.
  • A Selective, Orally Bioavai... A Selective, Orally Bioavailable 1,2,4-Triazolo[1,5-a]pyridine-Based Inhibitor of Janus Kinase 2 for Use in Anticancer Therapy: Discovery of CEP-33779
    Dugan, Benjamin J; Gingrich, Diane E; Mesaros, Eugen F ... Journal of medicinal chemistry, 06/2012, Letnik: 55, Številka: 11
    Journal Article
    Recenzirano

    Members of the JAK family of nonreceptor tyrosine kinases play a critical role in the growth and progression of many cancers and in inflammatory diseases. JAK2 has emerged as a leading therapeutic ...
Celotno besedilo
Dostopno za: PNG, UM
3.
  • Discovery of Clinical Candi... Discovery of Clinical Candidate CEP-37440, a Selective Inhibitor of Focal Adhesion Kinase (FAK) and Anaplastic Lymphoma Kinase (ALK)
    Ott, Gregory R; Cheng, Mangeng; Learn, Keith S ... Journal of medicinal chemistry, 08/2016, Letnik: 59, Številka: 16
    Journal Article
    Recenzirano

    Analogues structurally related to anaplastic lymphoma kinase (ALK) inhibitor 1 were optimized for metabolic stability. The results from this endeavor not only led to improved metabolic stability, ...
Celotno besedilo
Dostopno za: PNG, UM
4.
  • Design, Synthesis, and Anap... Design, Synthesis, and Anaplastic Lymphoma Kinase (ALK) Inhibitory Activity for a Novel Series of 2,4,8,22-Tetraazatetracyclo[14.3.1.13,7.19,13]docosa-1(20),3(22),4,6,9(21),10,12,16,18-nonaene Macrocycles
    Breslin, Henry J; Lane, Brandon M; Ott, Gregory R ... Journal of medicinal chemistry, 01/2012, Letnik: 55, Številka: 1
    Journal Article
    Recenzirano

    A novel set of 2,4,8,22-tetraazatetracyclo­14.3.1.13,7.19,13­docosa-1­(20),3­(22),4,6,9­(21),10,12,16,18-nonaene macrocycles were prepared as potential anaplastic lymphoma kinase (ALK) inhibitors, ...
Celotno besedilo
Dostopno za: PNG, UM
5.
  • 2,7-Pyrrolo[2,1- f][1,2,4]t... 2,7-Pyrrolo[2,1- f][1,2,4]triazines as JAK2 inhibitors: Modification of target structure to minimize reactive metabolite formation
    Weinberg, Linda R.; Albom, Mark S.; Angeles, Thelma S. ... Bioorganic & medicinal chemistry letters, 12/2011, Letnik: 21, Številka: 24
    Journal Article
    Recenzirano

    The JAK2/STAT pathway has important roles in hematopoiesis. With the discovery of the JAK2 V617F mutation and its presence in many patients with myeloproliferative neoplasms, research in the JAK2 ...
Celotno besedilo
Dostopno za: GEOZS, IJS, IMTLJ, KILJ, KISLJ, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UL, UM, UPCLJ, UPUK
6.
  • 2,7-Disubstituted-Pyrrolotr... 2,7-Disubstituted-Pyrrolotriazine Kinase Inhibitors with an Unusually High Degree of Reactive Metabolite Formation
    Wells-Knecht, Kevin J; Ott, Gregory R; Cheng, Mangeng ... Chemical research in toxicology, 11/2011, Letnik: 24, Številka: 11
    Journal Article
    Recenzirano

    There are numerous published studies establishing a link between reactive metabolite formation and toxicity of various drugs. Although the correlation between idiosyncratic reactions and reactive ...
Celotno besedilo
Dostopno za: IJS, KILJ, NUK, PNG, UL, UM
7.
  • Glycation, glycoxidation, a... Glycation, glycoxidation, and cross-linking of collagen by glucose. Kinetics, mechanisms, and inhibition of late stages of the Maillard reaction
    Fu, M X; Wells-Knecht, K J; Blackledge, J A ... Diabetes (New York, N.Y.) 43, Številka: 5
    Journal Article
    Recenzirano

    The Maillard or browning reaction between sugar and protein contributes to the increased chemical modification and cross-linking of long-lived tissue proteins in diabetes. To evaluate the role of ...
Celotno besedilo
Dostopno za: CMK
8.
  • Discovery of an Orally Effi... Discovery of an Orally Efficacious Inhibitor of Anaplastic Lymphoma Kinase
    Gingrich, Diane E; Lisko, Joseph G; Curry, Matthew A ... Journal of medicinal chemistry, 05/2012, Letnik: 55, Številka: 10
    Journal Article
    Recenzirano

    Anaplastic lymphoma kinase (ALK) is a promising therapeutic target for the treatment of cancer, supported by considerable favorable preclinical and clinical activities over the past several years and ...
Celotno besedilo
Dostopno za: PNG, UM
9.
  • 2,4-Diaminopyrimidine inhib... 2,4-Diaminopyrimidine inhibitors of c-Met kinase bearing benzoxazepine anilines
    Zificsak, Craig A.; Theroff, Jay P.; Aimone, Lisa D. ... Bioorganic & medicinal chemistry letters, 01/2011, Letnik: 21, Številka: 2
    Journal Article
    Recenzirano

    Elaboration of the SAR around a series of 2,4-diaminopyrimidines led to a number of c-Met inhibitors in which kinase selectivity was modulated by substituents appended on the C4-aminobenzamide ring ...
Celotno besedilo
Dostopno za: GEOZS, IJS, IMTLJ, KILJ, KISLJ, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UL, UM, UPCLJ, UPUK
10.
  • Modification of CellSensor irf1-bla TF-1 and irf1-bla HEL assays for direct comparison of wild-type JAK2 and JAK2 V617F inhibition
    Mason, Jennifer L; Holskin, Beverly P; Murray, Kristen A ... Assay and drug development technologies 9, Številka: 3
    Journal Article
    Recenzirano

    The Janus kinase (JAK)-signal transducer and activator of transcription pathway is an important therapeutic target because of its role in the regulation of cell growth. Aberrant, constitutive ...
Preverite dostopnost
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zadetkov: 38

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