Objective
To evaluate the shaping ability of three thermally-treated rotary nickel-titanium (NiTi) systems including ProTaper Next (PTN), HyFlex™ CM (HFCM) and HyFlex™ EDM (HFEDM) during root canal ...preparation in simulated root canals.
Methods
A total of 45 simulated root canals were divided into three groups (n = 15) and prepared with PTN, HFCM or HFEDM files up to size 25. Microcomputed tomography (microCT) was used to scan the specimens before and after instrumentation. Volume and diameter changes, transportations and centring ratios at 11 levels of the simulated root canals were measured and compared.
Results
HFEDM caused significantly greater volume increases than HFCM and PTN in the entire root canal and in the apical and middle thirds. HFCM removed the least amount of resin in the coronal third compared with HFEDM and PTN. Overall, HFCM caused significantly less transportation in the apical 2 mm and was better centred than PTN in the apical 3 mm.
Conclusion
Under the conditions of this study, all systems prepared curved canals without significant shaping errors and instrument fracture. PTN and HFCM cut less resin than HFEDM. HFCM stayed centred apically and cut the least material coronally.
•Dual network porous Si/Al9FeSi3/Fe2O3 composite is prepared by dealloying method.•Huge volume change during cycling is accommodated by the dual network structure.•Low theoretical capacity materials ...mixed with Si relieve internal stress of anodes.•The material shows good Li storage performance as an anode for Li-ion battery.
Silicon (Si) is regarded as the most prominent anode material for lithium ion batteries (LIBs) because of its high theoretical specific capacity. However, Si-based anodes suffer from fast capacity degradation caused by drastic volume expansion/contraction during repeated charge/discharge process and accompanying internal mechanical strain. Herein, we report a new dealloying strategy to synthesize a dual network porous Si/Al9FeSi3/Fe2O3 composite, which can release the internal stress and accommodate the volume changes of the anode during cycling. The anode presents a high Li storage capability, revealing an excellent reversible capacity of 1100 mAh g − 1 at 200 mA g − 1 for 150 cycles and 378 mAh g − 1 at 4000 mA g − 1 for 500 cycles. Such outstanding Li storage properties can be attributed to the special dual network porous structure and compositing the materials with high and low theoretical capacities. The work provides a new route to design and prepare low-price and high-performance Si-based anodes, which opens new avenues for the technical progress in dealloying preparation and the development of advanced high performance anode materials.
Rhabdomyosarcoma (RMS) is a common soft tissue sarcoma in children with high malignancy. The prognosis of refractory recurrent RMS is extremely poor, and the 5-year survival rate is less than 20%.
We ...reported a 2-year-old male patient with RMS who underwent 3 operations and 2 recurrences while being treated with regular multidisciplinary therapy.
A diagnosis of embryonal rhabdomyosarcoma with primary bladder (IIIa, TNM stage 2, and medium risk group) was made.
After repeated recurrence, the patient was treated with chimeric antigen receptor T (CAR-T) cells, which had a safety mechanism and specifically bound the CD56 antigen in the fourth generation.
The process of CAR-T cell transfusion was smooth, and there were no significant cytokine release syndrome manifestations after reinfusion. The patient was in complete remission at last follow-up visit after 3.5 years.
CD56-CAR-T cell therapy is a safe and effective approach and may be an option for children with solid tumors who are nonresponsive to conventional radiotherapy and chemotherapy, or are unsuitable for hematopoietic stem cell transplantation.
Epidermal growth factor receptor (EGFR) is one of the most studied drug targets for the treatment of non-small-cell lung cancer (NSCLC). Here, we report the identification, structure optimization, ...and structure–activity relationship studies of quinazoline derivatives as novel selective EGFR L858R/T790M inhibitors. The most promising compound, 28f, exhibited strong inhibitory activity against EGFR L858R/T790M (IC50 = 3.5 nM) and greater than 368-fold selectivity over EGFR WT (IC50 = 1290 nM), a 6.7-fold improvement over osimertinib. Furthermore, 28f effectively inhibited downstream signaling pathways and induced apoptosis in mutant cells. In the H1975 xenograft in vivo model, 28f exhibited a good tumor suppressive effect. Furthermore, the combination of 28f with the ACK1 inhibitor dasatinib produced synergistic antiproliferative efficacy with 28f in 28f-resistant cells and in vivo. In conclusion,28f could become a candidate drug for the treatment of NSCLC, and the combination of 28f and dasatinib is expected to overcome EGFR resistance.
Definitive concurrent chemoradiotherapy (dCCRT) is the gold standard for the treatment of locally advanced esophageal squamous cell carcinoma (ESCC). However, the potential benefits of consolidation ...chemotherapy after dCCRT in patients with esophageal cancer remain debatable. Prospective randomized controlled trials comparing the outcomes of dCCRT with or without consolidation chemotherapy in patients with ESCC are lacking. In this study, we aim to generate evidence regarding consolidation chemotherapy efficacy in patients with locally advanced, inoperable ESCC.
This is a multicenter, prospective, open-label, phase-III randomized controlled trial comparing non-inferiority of dCCRT alone to consolidation chemotherapy following dCCRT. In total, 600 patients will be enrolled and randomly assigned in a 1:1 ratio to receive either consolidation chemotherapy after dCCRT (Arm A) or dCCRT alone (Arm B). Overall survival will be the primary endpoint, whereas progression-free survival, locoregional progression-free survival, distant metastasis-free survival, and treatment-related toxicity will be the secondary endpoints.
This study aid in further understanding the effects of consolidation chemotherapy after dCCRT in patients with locally advanced, inoperable ESCC.
ChiCTR1800017646.
Celotno besedilo
Dostopno za:
DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
The Tibetan Plateau has an abundance of yak milk resources. The complex microbiota found in traditional fermented yak milk produced and sold by local Tibetans endows the yak milk with unique quality ...characteristics such as tissue morphology, flavor, and function. However, the diversity of bacterial flora in traditional fermented yak milk have not been elucidated.
In this study, 15 samples of fermented yak milk were collected for 16S rRNA high-throughput sequencing to analyze the bacterial community composition and function.
After filtering for quality, 792,642 high-quality sequences were obtained, and 13 kinds of different phyla and 82 kinds of different genera were identified, of which the phylum
(98.94%) was the dominant phylum,
(64.73%) and
(28.48%) were identified as the dominant genus, in addition, the bacterial community richness and diversity were higher in Manang Village, followed by Bola Village. Bacterial community richness and diversity in Huage Village were relatively low. Based on the Kyoto Encyclopedia of Genes and Genomes (KEGG) functional classification, the microorganisms in traditional fermented yak milk have rich metabolic functions (77.60%). These findings suggest that a large number of bacteria in traditional fermented yak milk contain abundant metabolic genes and can carry out a variety of growth and metabolic activities. This study established a theoretical foundation for further exploring the microbial flora of traditional fermented yak milk in Gannan.
As the market of the Internet of Things (IoT) increases, great attention has been paid to the development of high-efficient organic photovoltaics (OPVs) utilizing artificial light. However, in a real ...indoor condition, the power density contribution of the artificial light cannot exceed 35% in the combination of indoor and outdoor irradiation, which indicates that the illumination of sunlight cannot be ignored during daytime. Hence, it is urgent to develop high-efficient OPVs in indoor conditions taking into account both sunlight and artificial light. In this work, a novel asymmetric molecule TB-4F was synthesized to trade-off the absorption spectrum that can be applied under both artificial light and sunlight. In conventional bulk-heterojunction (C-BHJ), it was figured out that due to nonoptimal morphology some carriers failed to be efficiently collected. Herein, a sequential deposition bulk-heterojunction (SD-BHJ) as an alternative fabrication method successfully enhanced the performance of OPVs, under both artificial light and sunlight, which was attributed to the favorable microstructure being vertically distributed in the active layer. Notably, the PCE was significantly increased by 25% for SD-BHJ compared to C-BHJ under artificial light, owing to the strong effect of trap-assisted recombination and dark current on PCE in the condition of low carrier density. Our result indicates that an asymmetric molecule with a blue-shifted spectrum fabricated by SD-BHJ can be a promising candidate that can be applied in indoor environments to harvest sunlight and artificial light simultaneously.
Abstract
For the increasing attention focused on saving endangered environments, there is a growing need for developing membrane materials able to perform complex functions such as removing ...radioactive pollutants and oil spills from water. A major challenge is the scalable fabrication of membranes with good mechanical and thermal stability, superior resistance to radiation, and excellent recyclability. In this study, we constructed a multifunctional flexible free-standing sodium titanate nanobelt (Na-TNB) membrane that was assembled as advanced radiation-tainted water treatment and oil uptake. We compared the adsorption behavior of
137
Cs
+
and
90
Sr
2+
on Na-TNB membranes under various environmental conditions. The maximum adsorption coefficient value (
K
d
) for Sr
2+
reaches 10
7
mL g
−1
. The structural collapse of the exchange materials were confirmed by XRD, FTIR and XPS spectroscopy as well as Raman analysis. The adsorption mechanism of Na-TNB membrane is clarified by forming a stable solid with the radioactive cations permanently trapped inside. Besides, the engineered multilayer membrane is exceptionally capable in selectively and rapidly adsorbing oils up to 23 times the adsorbent weight when coated with a thin layer of hydrophobic molecules. This multifunctional membrane has exceptional potential as a suitable material for next generation water treatment and separation technologies.
Mother-child interaction is highly dynamic and reciprocal. Switching roles in these back-and-forth interactions serves as a crucial feature of reciprocal behaviors while the underlying neural ...entrainment is still not well-studied. Here, we designed a role-controlled cooperative task with dual EEG recording to explore how differently two brains interact when mothers and children hold different roles. When children were actors and mothers were observers, mother-child interbrain synchrony emerged primarily within the theta oscillations and the frontal lobe, which highly correlated with children's attachment to their mothers (self-reported by mothers). When their roles were reversed, this synchrony was shifted to the alpha oscillations and the central area and associated with mothers' perception of their relationship with their children. The results suggested an observer-actor neural alignment within the actor's oscillations, which was related to the actor-toward-observer emotional bonding. Our findings contribute to the understanding of how interbrain synchrony is established and dynamically changed during mother-child reciprocal interaction.
The construction of sea embankments is an increasingly common approach for controlling the spread of the exotic C4 perennial grass Spartina alterniflora Loisel. in coastal wetlands of eastern China. ...However, the impact of sea embankment reclamation on the soil organic carbon (C) and nitrogen (N) dynamics in salt marshes is not fully understood. In this study, we examined the stocks of the total, labile and recalcitrant organic C and N, the recalcitrant indices of C and N, and the concentrations of water-soluble organic carbon (WSOC), microbial biomass carbon (MBC) and cumulative CO2-C mineralization (MINC) in sea embankment-reclaimed S. alterniflora and Suaeda salsa (Linn.) Pall. salt marshes through comparisons with adjacent unreclaimed S. alterniflora and S. salsa salt marshes in a coastal wetland of eastern China. Sea embankment reclamation significantly decreased plant biomass by 55.34%, soil salinity by 81.71%, soil moisture by 43.16%, soil total organic C by 50.60% and total organic N by 49.99%, and also lowered labile and recalcitrant organic C and N, WSOC, MBC and MINC in the invasive S. alterniflora salt marsh. However, sea embankment reclamation did not significantly affect the stocks of the soil organic total C and N, recalcitrant organic C and N, and soil organic C dynamics in the native S. salsa salt marsh, possibly because the total quantity of S. salsa materials entering the soil, soil salinity, moisture and bulk density were not affected by sea embankment reclamation. Our results suggest that the impact of sea embankment reclamation on soil organic C and N pools is much more profound in S. alterniflora salt marsh than in S. salsa salt marsh. Sea embankment reclamation could greatly weaken the C and N sinks of S. alterniflora salt marsh and potentially affect C and N sinks in the coastal wetlands of eastern China.
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