Based on the fundamentals of electromagnetics, this clear and concise text explains basic and applied principles of transformer and inductor design for power electronic applications. It details both ...the theory and practice of inductors and transformers employed to filter currents, store electromagnetic energy, provide physical isolation between circuits, and perform stepping up and down of DC and AC voltages.The authors present a broad range of applications from modern power conversion systems. They provide rigorous design guidelines based on a robust methodology for inductor and transformer design. They offer real design examples, informed by proven and working field examples.Key features include:emphasis on high frequency design, including optimisation of the winding layout and treatment of non-sinusoidal waveformsa chapter on planar magnetic with analytical models and descriptions of the processing technologiesanalysis of the role of variable inductors, and their applications for power factor correction and solar powerunique coverage on the measurements of inductance and transformer capacitance, as well as tests for core losses at high frequencyworked examples in MATLAB, end-of-chapter problems, and an accompanying website containing solutions, a full set of instructors’ presentations, and copies of all the figures.Covering the basics of the magnetic components of power electronic converters, this book is a comprehensive reference for students and professional engineers dealing with specialised inductor and transformer design. It is especially useful for senior undergraduate and graduate students in electrical engineering and electrical energy systems, and engineers working with power supplies and energy conversion systems who want to update their knowledge on a field that has progressed considerably in recent years.
The insulin-like growth factor (IGF) axis mediates growth, differentiation and developmental processes, and is also involved in control of metabolic activities. Deregulation of IGF axis expression ...and action is linked to a number of pathologies, ranging from metabolic disorders to growth deficits and cancer development. Activation of the IGF signaling pathway is a crucial prerequisite for malignant transformation. In addition, overexpression of the IGF-1 receptor (IGF-1R) constitutes a typical hallmark of most types of cancer. A series of tumor suppressors have been identified whose mechanisms of action involve transcriptional suppression of the IGF-1R gene. These tumor suppressors include the p53/p63/p73 family, breast cancer gene-1, von-Hippel Lindau protein, Wilms' tumor-1 and others. Comprehensive analyses have identified a complex bidirectional interplay between the IGF and tumor-suppressor signaling pathways. These interactions are of major importance in terms of cancer development and may also predict responsiveness to IGF-1R-targeted therapies. Furthermore, the insulin/IGF system has a pivotal role in the regulation of cancer cell metabolism. Deregulation of IGF axis components by mutated tumor-suppressor proteins may lead to metabolic perturbations, with ensuing pathological consequences.
Brave new world: service robots in the frontline Wirtz, Jochen; Patterson, Paul G; Kunz, Werner H ...
International journal of service industry management,
11/2018, Letnik:
29, Številka:
5
Journal Article
Recenzirano
Odprti dostop
Purpose
The service sector is at an inflection point with regard to productivity gains and service industrialization similar to the industrial revolution in manufacturing that started in the ...eighteenth century. Robotics in combination with rapidly improving technologies like artificial intelligence (AI), mobile, cloud, big data and biometrics will bring opportunities for a wide range of innovations that have the potential to dramatically change service industries. The purpose of this paper is to explore the potential role service robots will play in the future and to advance a research agenda for service researchers.
Design/methodology/approach
This paper uses a conceptual approach that is rooted in the service, robotics and AI literature.
Findings
The contribution of this paper is threefold. First, it provides a definition of service robots, describes their key attributes, contrasts their features and capabilities with those of frontline employees, and provides an understanding for which types of service tasks robots will dominate and where humans will dominate. Second, this paper examines consumer perceptions, beliefs and behaviors as related to service robots, and advances the service robot acceptance model. Third, it provides an overview of the ethical questions surrounding robot-delivered services at the individual, market and societal level.
Practical implications
This paper helps service organizations and their management, service robot innovators, programmers and developers, and policymakers better understand the implications of a ubiquitous deployment of service robots.
Originality/value
This is the first conceptual paper that systematically examines key dimensions of robot-delivered frontline service and explores how these will differ in the future.
Hybrid metamaterials that exhibit reconfigurable responses under external stimulus, such as electric fields and light radiation, have only recently been demonstrated by combining active media with ...patterned metallic structures. Nevertheless, hybrid terahertz (THz) metamaterials whose spectral performance can be dynamically tuned over a large scale remain rare. Compared with most active media (for instance, silicon) that provide limited activity, vanadium dioxide (VO
), which exhibits an insulator-to-metal transition, has been recently explored to facilitate dynamically tunable metamaterials. More importantly, the phase transition yields a three orders of magnitude increase in THz electrical conductivity, which suggests the potential for creating VO
based hybrid resonators that operate at THz frequencies. Here, we show that an integration of VO
structures and conventional metallic resonating components can enable a class of highly tunable THz metamaterials. Considering the widely studied phase-transition dynamics in VO
, the proposed hybrid metamaterials are capable of offering ultrafast modulation of THz radiation.
Mitochondrial reactive oxygen species (ROS) production and detoxification are tightly balanced. Shifting this balance enables ROS to activate intracellular signaling and/or induce cellular damage and ...cell death. Increased mitochondrial ROS production is observed in a number of pathological conditions characterized by mitochondrial dysfunction. One important hallmark of these diseases is enhanced glycolytic activity and low or impaired oxidative phosphorylation. This suggests that ROS is involved in glycolysis (dys)regulation and vice versa. Here we focus on the bidirectional link between ROS and the regulation of glucose metabolism. To this end, we provide a basic introduction into mitochondrial energy metabolism, ROS generation and redox homeostasis. Next, we discuss the interactions between cellular glucose metabolism and ROS. ROS-stimulated cellular glucose uptake can stimulate both ROS production and scavenging. When glucose-stimulated ROS production, leading to further glucose uptake, is not adequately counterbalanced by (glucose-stimulated) ROS scavenging systems, a toxic cycle is triggered, ultimately leading to cell death. Here we inventoried the various cellular regulatory mechanisms and negative feedback loops that prevent this cycle from occurring. It is concluded that more insight in these processes is required to understand why they are (un)able to prevent excessive ROS production during various pathological conditions in humans.
Early in 1980, the author anticipated the attraction of restoring posterior teeth with tooth-colored material. He conducted studies and developed the clinical concept of bonded ceramic inlays, at the ...same time raising the issue of the fast fabrication of the ceramic restorations. The author developed plans for in-office computer-aided design/computer-aided manufacturing (CAD/CAM) fabrication of ceramic restorations specifically to enable the dentist to complete one or multiple ceramic restorations chairside, in a single appointment. The initial concept comprised a small mobile CAD/CAM unit integrating a computer, keyboard, trackball, foot pedal and optoelectronic mouth camera as input devices, a monitor and a machining compartment. CEREC 3 (Sirona Dental Systems GmbH, Bensheim, Germany) divided the system into an acquisition/design unit and a separate machining unit. Three-dimensional software makes the handling illustrative and easy both in the office and in the laboratory.
It appears that the CEREC CAD/CAM concept is becoming a significant part of dentistry.
Sound knowledge of adhesive bonding and diligent planning are essential for the successful integration of CAD/CAM into clinical dental offices.
Despite the exotic material properties that have been demonstrated to date, practical examples of versatile metamaterials remain exceedingly rare. The concept of metadevices has been proposed in the ...context of hybrid metamaterial composites: systems in which active materials are introduced to advance tunability, switchability and nonlinearity. In contrast to the successful hybridizations seen at lower frequencies, there has been limited exploration into plasmonic and photonic nanostructures due to the lack of available optical materials with non-trivial activity, together with difficulties in regulating responses to external forces in an integrated manner. Here, by presenting a series of proof-of-concept studies on electrically triggered functionalities, we demonstrate a vanadium dioxide integrated photonic metamaterial as a transformative platform for multifunctional control. The proposed hybrid metamaterial integrated with transition materials represents a major step forward by providing a universal approach to creating self-sufficient and highly versatile nanophotonic systems.
Digitization, artificial intelligence, and service robots carry serious ethical, privacy, and fairness risks. Using the lens of corporate digital responsibility (CDR), we examine these risks and ...their mitigation in service firms and make five contributions. First, we show that CDR is critical in service contexts because of the vast streams of customer data involved and digital service technology’s omnipresence, opacity, and complexity. Second, we synthesize the ethics, privacy, and fairness literature using the CDR data and technology life-cycle perspective to understand better the nature of these risks in a service context. Third, to provide insights on the origins of these risks, we examine the digital service ecosystem and the related flows of money, service, data, insights, and technologies. Fourth, we deduct that the underlying causes of CDR issues are trade-offs between good CDR practices and organizational objectives (e.g., profit opportunities versus CDR risks) and introduce the CDR calculus to capture this. We also conclude that regulation will need to step in when a firm’s CDR calculus becomes so negative that good CDR is unlikely. Finally, we advance a set of strategies, tools, and practices service firms can use to manage these trade-offs and build a strong CDR culture.
Graphical Abstract
CORUM is a database that provides a manually curated repository of experimentally characterized protein complexes from mammalian organisms, mainly human (64%), mouse (16%) and rat (12%). Protein ...complexes are key molecular entities that integrate multiple gene products to perform cellular functions. The new CORUM 2.0 release encompasses 2837 protein complexes offering the largest and most comprehensive publicly available dataset of mammalian protein complexes. The CORUM dataset is built from 3198 different genes, representing ~16% of the protein coding genes in humans. Each protein complex is described by a protein complex name, subunit composition, function as well as the literature reference that characterizes the respective protein complex. Recent developments include mapping of functional annotation to Gene Ontology terms as well as cross-references to Entrez Gene identifiers. In addition, a 'Phylogenetic Conservation' analysis tool was implemented that analyses the potential occurrence of orthologous protein complex subunits in mammals and other selected groups of organisms. This allows one to predict the occurrence of protein complexes in different phylogenetic groups. CORUM is freely accessible at (http://mips.helmholtz-muenchen.de/genre/proj/corum/index.html).
Maternal mortality due to postpartum hemorrhage (PPH) continues to be one of the most important causes of maternal death worldwide. PPH is a significantly underestimated obstetric problem, primarily ...because a lack of definition and diagnosis. The ‘traditional’ definition of primary PPH based on quantification of blood loss has several limitations. Notoriously, blood loss is not measured or is significantly underestimated by visual estimation and there are no generally accepted cut‐offs limits for estimated blood loss. A definition based on hematocrit change is not clinically useful in an emergency such as PPH, as a fall in hematocrit postpartum shows poor correlation with acute blood loss. The need for erythrocyte transfusion alone to define PPH is also of limited value, as the practice of blood transfusion varies widely. Definitions based on symptoms of hemodynamic instability are problematic, as they are late signs of depleted blood volume and commencing failure of compensatory mechanisms threatening the mother's life. There is thus currently no single, satisfactory definition of primary PPH. Proper and timely diagnosis of PPH should above all include accurate estimation of blood loss before vital signs change. Estimation of blood loss by calibrated bags has been shown to be significantly more accurate than visual estimation at vaginal delivery. Careful monitoring of the mother's vital signs, laboratory tests, in particular coagulation testing, and immediate diagnosis of the cause of PPH are important key factors to reduce maternal morbidity and mortality.
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