Follow-up, maintenance, and treatment of complications of 81 mandibular subperiosteal implants placed at the University of Southern California Advanced Prosthodontic Clinic were recorded for periods ...up to 21 years. Few patients were lost to follow-up, but a significant number of patients died before termination of the study. A 10-year survival rate of 79% was calculated for 63 patients, and a 15-year survival rate of 60% was calculated for 34 patients. It was found that subperiosteal implants have a low long-term survival rate, and the rate of loss of subperiosteal implants increases over time without reaching a steady state. However, subperiosteal implant therapy did provide function for patients who otherwise could not use dentures.
We examine properties of tt¯ candidate events in lepton+jets final states to establish the helicities of W bosons in t→W+b decays. Our analysis is based on a direct calculation of a probability ...density for each event to correspond to a tt¯ final state, as a function of the helicity of the W boson. Using the 125 events/pb of data collected by the DØ experiment at the Fermilab Tevatron pp¯ Collider at s=1.8 TeV, we obtain a longitudinal helicity fraction F0=0.56±0.31, consistent with the prediction of F0=0.70 from the standard model.
2-4-(tert-Butoxycarbonyl)piperazinylbenzylidene-tert-butanesulfinamides underwent nucleophilic 1,2-addition with different organometallic reagents to give highly diastereomerically enriched adducts. ...X-ray crystallography of the resulting α-branched N-Boc-2-piperazinylbenzyl-tert-butanesulfinamides confirms different mechanisms depending on the organometallic reagent used. Differential deprotection of the N-Boc and the tert-butanesulfinamides was investigated, and the dehydration byproducts have been identified and characterized. To avoid the formation of byproducts in the acidic deprotection step, the N-tert-butanesulfinamide group was converted to the corresponding N-tert-butanesulfonamide (Bus), which allowed for clean orthogonal deprotection. The efficient synthesis and deprotection of the N-Boc-2-piperazinylbenzyl-tert-butanesulfinamides herein described constitutes an attractive method for extensive structure−activity studies in the search for novel ligands of the human melanocortin 4 receptor.
The acrosome of marsupial spermatozoa is a robust structure which, unlike its placental counterpart, resists disruption by detergent or freeze/thawing and does not undergo a calcium ionophore induced ...acrosome reaction. In this study specific fluorescent thiol labels, bromobimanes, were used to detect reactive thiols in the intact marsupial spermatozoon and examine whether disulfides play a role in the stability of the acrosome. Ejaculated brushtail possum (Trichosurus vulpecula) and tammar wallaby (Macropus eugenii) spermatozoa were washed by swim up and incubated with or without dithiothreitol (DTT) in order to reduce disulfides to reactive thiols. Spermatozoa were then washed by centrifugation and treated with monobromobimane (mBBr), a membrane-permeable bromobimane, or with monobromotrimethylammoniobimane (qBBr), a membrane-impermeable bromobimane. Labelled spermatozoa were examined by fluorescence microscopy and sperm proteins (whole sperm proteins and basic nuclear proteins) were analysed by gel electrophoresis. The membrane-permeable agent mBBr lightly labelled the perimeter of the acrosome of non-DTT-treated possum and wallaby spermatozoa, indicating the presence of peri-acrosomal thiol groups. After reduction of sperm disulfides by DTT, mBBr labelled the entire acrosome of both species. The membrane-impermeable agent qBBr did not label any part of the acrosome in non-DTT or DTT-treated wallaby or possum spermatozoa. Thiols and disulfides are thus associated with the marsupial acrosome. They are not found on the overlying plasma membrane but are either in the acrosomal membranes and/or matrix. The sperm midpiece and tail were labelled by mBBr, with increased fluorescence observed in DTT-treated spermatozoa.
Maturation, or meiotic progression, of amphibian oocytes is one of the few physiologically relevant steroid-mediated processes that occurs in the complete absence of transcription from beginning to ...end. As such, frog oocyte maturation has served as a useful model of nongenomic steroid signaling for many years. Earlier work in
Xenopus laevis demonstrated that, although several steroids promoted oocyte maturation in vitro, androgens were the most abundant and potent steroids detected in the serum and ovaries of ovulating frogs. Thus, androgens were likely the primary physiologic regulators of
Xenopus oocyte maturation, mediating their actions at least in part via classical androgen receptors expressed in oocytes. The importance of androgens for
Xenopus oocyte maturation and ovulation has now been confirmed, as inhibition of androgen production in vivo by blocking CYP17 activity reduced hCG-triggered oocyte maturation and delayed ovulation in female frogs. Taking advantage of the absolute transcription-independence of this androgen-mediated response, selective androgen receptor modulators (SARMs) have been characterized that specifically promote genomic versus nongenomic androgen responses. These include androstenediol and estren, which preferentially promote nongenomic signals, as well as R1881 and 19-nortestosterone, which preferentially promote genomic signaling. Interestingly, the SARMs androstenediol and R1881 signal similarly in mouse oocytes, demonstrating the conserved nature of androgen-mediated maturation in vertebrates. These results suggest that SARMs may serve as useful tools for specifically regulating nongenomic androgen signaling both in vitro and in vivo.
This study examined the effect of seating force on the film thickness of new adhesive luting agents. The method was in compliance with American National Standards/American Dental Association ...Specification No. 8 for zinc phosphate cement. The materials tested were zinc phosphate cement, glass ionomer cement, polycarboxylate cement, and a resinous cement with a dentinal bonding agent. All materials were manipulated exactly as described in the manufacturer's instructions, and an electronic gauge with an accuracy of 0.5 micron was used. Each class of material was measured 10 times at six different seating forces. Analysis of variance and multiple comparisons testing disclosed that the seating force and class of material strongly influenced the film thicknesses of luting agents. A mathematical model describing the response of zinc phosphate cement within the range tested was reported.
We report on charged hadron production in deuteron-gold reactions at roots(NN) = 200 GeV. Our measurements in the deuteron direction cover 1.4<eta<2.2, referred to as forward rapidity, and in the ...gold direction -2.0<eta<-1.4, referred to as backward rapidity, and a transverse momentum range p(T)=0.5-4.0 GeV/c. We compare the relative yields for different deuteron-gold collision centrality classes. We observe a suppression relative to binary collision scaling at forward rapidity, sensitive to low momentum fraction (x) partons in the gold nucleus, and an enhancement at backward rapidity, sensitive to high momentum fraction partons in the gold nucleus.
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