Granitic plutonism is the principal agent of crustal differentiation, but linking granite emplacement to crust formation requires knowledge of the magmatic evolution, which is notoriously difficult ...to reconstruct from bulk rock compositions. We unlocked the plutonic archive through hafnium (Hf) and oxygen (O) isotope analysis of zoned zircon crystals from the classic hornblende-bearing (I-type) granites of eastern Australia. This granite type forms by the reworking of sedimentary materials by mantle-like magmas instead of by remelting ancient metamorphosed igneous rocks as widely believed. I-type magmatism thus drives the coupled growth and differentiation of continental crust.
BACKGROUND:Synovial biomarkers have recently been adopted as diagnostic tools for periprosthetic joint infection (PJI), but their utility is uncertain. The purpose of this systematic review and ...meta-analysis was to synthesize the evidence on the accuracy of the alpha-defensin immunoassay and leukocyte esterase colorimetric strip test for the diagnosis of PJI compared with the Musculoskeletal Infection Society diagnostic criteria.
METHODS:We performed a systematic review to identify diagnostic technique studies evaluating the accuracy of alpha-defensin or leukocyte esterase in the diagnosis of PJI. MEDLINE and Embase on Ovid, ACM, ADS, arXiv, CERN DS (Conseil Européen pour la Recherche Nucléaire Document Server), CrossRef DOI (Digital Object Identifier), DBLP (Digital Bibliography & Library Project), Espacenet, Google Scholar, Gutenberg, HighWire, IEEE Xplore (Institute of Electrical and Electronics Engineers digital library), INSPIRE, JSTOR (Journal Storage), OAlster (Open Archives Initiative Protocol for Metadata Harvesting), Open Content, Pubget, PubMed, and Web of Science were searched for appropriate studies indexed from inception until May 30, 2015, along with unpublished or gray literature. The classification of studies and data extraction were performed independently by 2 reviewers. Data extraction permitted meta-analysis of sensitivity and specificity with construction of receiver operating characteristic curves for each test.
RESULTS:We included 11 eligible studies. The pooled diagnostic sensitivity and specificity of alpha-defensin (6 studies) for PJI were 1.00 (95% confidence interval CI, 0.82 to 1.00) and 0.96 (95% CI, 0.89 to 0.99), respectively. The area under the curve (AUC) for alpha-defensin and PJI was 0.99 (95% CI, 0.98 to 1.00). The pooled diagnostic sensitivity and specificity of leukocyte esterase (5 studies) for PJI were 0.81 (95% CI, 0.49 to 0.95) and 0.97 (95% CI, 0.82 to 0.99), respectively. The AUC for leukocyte esterase and PJI was 0.97 (95% CI, 0.95 to 0.98). There was substantial heterogeneity among studies for both diagnostic tests.
CONCLUSIONS:The diagnostic accuracy for PJI was high for both tests. Given the limited number of studies and the large cost difference between the tests, more independent research on these tests is warranted.
LEVEL OF EVIDENCE:Diagnostic Level II. See Instructions for Authors for a complete description of levels of evidence.
The mountain pine beetle, Dendroctonus ponderosae Hopkins (Coleoptera: Curculionidae: Scolytinae) is the most damaging pest of mature pine (Pinaceae) in western North America. Although mountain pine ...beetles have an obligate dispersal phase during which adults must locate a new host for brood production, dispersal is a poorly understood aspect of its ecology. This flight mill study was designed to test the effects of beetle size, sex, and age on flight capacity. Energy use during flight was assessed through measurements of weight before and after flight and fat content of flown versus control beetles. The mean flight distance achieved by mountain pine beetles varied between 2.12 and 5.95 km over the 23-h bioassay, but the longest total flight of an individual beetle was >24 km. Beetle preflight weight influenced flight initiation, flight distance, and duration. Bigger beetles are more likely to fly and once in flight fly longer and farther than smaller beetles. There was no direct effect of beetle sex on flight capacity. Flight capacity of beetles declined with age postemergence. Although individual flight capacity was variable, flight velocity was relatively constant between 1.55 and 1.93 km/h. Lipids are used to power flight in mountain pine beetles, as lipid content was lower in beetles flown on the flight mills compared with beetles that did not fly. Flight distance was negatively correlated with beetle postflight lipid content. The baseline flight capacity data revealed in this study have implications for understanding the population dynamics of this eruptive forest pest.
The aim of this study was to compare the relative performance of total knee replacement constructs and discern if there is variability in performance in currently commonly used prostheses in the New ...Zealand Joint Registry (NZJR) using a noninferiority analysis.
All patients who underwent a primary total knee replacement (TKR) registered in the NZJR between 1st January 1999 to June 2020 were identified. Using a noninferiority analysis, the performance of total knee replacement prostheses were compared with the best performing contemporary construct. Construct all-cause revision rate was estimated using the 1-Kaplan Meier survival function method to estimate net failure. The difference in all-cause revision rates between the contemporary benchmark and all other constructs was tested.
In total 110 183 TKR were recorded and 25 constructs (102 717 procedures) had > 500 procedures at risk at 3 years post-primary of which 5 were inferior by at least 20 % relative risk of which, one was inferior by at least 100 % relative risk. 14 constructs were identified with > 500 procedures at risk at 10 years with 5 inferior by at least 20 %, of which 2 were inferior by > 100 % relative risk.
We discerned that there is great variability in construct performance and at all time points, greater than 25 % of constructs are inferior to the best performing construct by at least 20 %. These results can help inform patients, clinicians and health care funders when considering TKR surgery.
Celotno besedilo
Dostopno za:
DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
Rare earth element (REE) plus yttrium (Y) patterns of modern seawater have characteristic features that can be used as chemical fingerprints. Reliable proxies for marine REE+Y chemistry have been ...demonstrated from a large geological time span, including Archaean banded iron formation (BIF), stromatolitic limestone, Phanerozoic reef carbonate and Holocene microbialite.
Here we present new REE+Y data for two distinct suites of early Archaean (ca. 3.7–3.8 Ga) metamorphosed rocks from southern West Greenland, whose interrelationships, if any, have been much debated in recent literature. The first suite comprises magnetite-quartz BIF, magnetite-carbonate BIF and banded magnetite-rich quartz rock, mostly from the Isua Greenstone Belt (IGB). The REE+Y patterns, particularly diagnostic anomalies (Ce/Ce*, Pr/Pr*), are closely related to those of published seawater proxies. The second suite includes banded quartz-pyroxene-amphibole±garnet rocks with minor magnetite from the so-called Akilia Association enclaves (in early Archaean granitoid gneisses) of the coastal region, some 150 km southwest of the IGB. Rocks of this type from one much publicised and highly debated locality (the island of Akilia) have been identified by some workers Nature 384 (1996) 55; Geochim. Cosmochim. Acta 61 (1997) 2475 as BIF-facies, and their
13C-depleted signature in trace graphite interpreted as a proxy for earliest life on Earth. However, REE+Y patterns of the Akilia Association suite (except for one probably genuine magnetite-rich BIF from Ugpik) are inconsistent with a seawater origin. We agree with published geological and geochemical (including REE) work Science 296 (2002) 1448 that most of the analysed Akilia rocks are not chemical sediments, and that C-isotopes in such rocks therefore cannot be used as biological proxies.
Application of the REE+Y discriminant for the above two rock suites has been facilitated in this study by the use of MC-ICP technique which yields a more complete and precise REE+Y spectrum than was available in many previous studies.
The Adamello intrusive suite is a composite batholith in Northern Italy, with an estimated 2000 km3 volume, assembled incrementally over a time span of 10 to 12 million years. The history of ...crystallization has been studied in detail through laser ablation ICP-MS and SIMS U–Pb geochronology of zircon, which records prolonged crystallization of each of the different intrusive units at mid-crustal levels between 43·47 and 33·16 Ma. The magmas were episodically extracted from this storage area and ascended to the final intrusion level at ∼6 km paleo-depth. Each batch of melt cooled very rapidly down to the ambient temperature of 250°C, evidenced by distinct cooling paths recorded by amphibole, biotite and K-feldspar 40Ar/39Ar dates. The magma source area was moving from SW to NE with time, causing increasing thermal maturity in the mid-crustal reservoir. The resulting temporal trend of higher degrees of crustal assimiliation in the course of the evolution of the magmatic system can be traced through Hf and O isotopes in zircon. Rough estimates of magma emplacement rates (‘magma flux’) yield very low values in the range of 10-4 km3/yr, typical of mid-to-upper crustal plutons and increase with time. Although we cannot discern a decrease of magma flux from our own data, we anticipate that a dramatic decrease of magma flux between 33 and 31 Ma along the northern contact lead to cessation of magma emplacement.
The continental margin of Gondwana preserves a record of long-lived magmatism from the Andean Cordillera to Australia. The crustal blocks of West Antarctica form part of this margin, with ...Palaeozoic–Mesozoic magmatism particularly well preserved in the Antarctic Peninsula and Marie Byrd Land. Magmatic events on the intervening Thurston Island crustal block are poorly defined, which has hindered accurate correlations along the margin. Six samples are dated here using U-Pb geochronology and cover the geological history on Thurston Island. The basement gneisses from Morgan Inlet have a protolith age of 349±2 Ma and correlate closely with the Devonian–Carboniferous magmatism of Marie Byrd Land and New Zealand. Triassic (240–220 Ma) magmatism is identified at two sites on Thurston Island, with Hf isotopes indicating magma extraction from Mesoproterozoic-age lower crust. Several sites on Thurston Island preserve rhyolitic tuffs that have been dated at 182 Ma and are likely to correlate with the successions in the Antarctic Peninsula, particularly given the pre-break-up position of the Thurston Island crustal block. Silicic volcanism was widespread in Patagonia and the Antarctic Peninsula at ~ 183 Ma forming the extensive Chon Aike Province. The most extensive episode of magmatism along the active margin took place during the mid-Cretaceous. This Cordillera ‘flare-up’ event of the Gondwana margin is also developed on Thurston Island with granitoid magmatism dated in the interval 110–100 Ma.
The Eurasian ice sheet complex (EISC) was the third largest ice mass during the Last Glacial Maximum with a span of over 4500 km and responsible for around 20 m of eustatic sea-level lowering. Whilst ...recent terrestrial and marine empirical insights have improved understanding of the chronology, pattern and rates of retreat of this vast ice sheet, a concerted attempt to model the deglaciation of the EISC honouring these new constraints is conspicuously lacking. Here, we apply a first-order, thermomechanical ice sheet model, validated against a diverse suite of empirical data, to investigate the retreat of the EISC after 23 ka BP, directly extending the work of Patton et al. (2016) who modelled the build-up to its maximum extent. Retreat of the ice sheet complex was highly asynchronous, reflecting contrasting regional sensitivities to climate forcing, oceanic influence, and internal dynamics. Most rapid retreat was experienced across the Barents Sea sector after 17.8 ka BP when this marine-based ice sheet disintegrated at a rate of ∼670 gigatonnes per year (Gt a−1) through enhanced calving and interior dynamic thinning, driven by oceanic/atmospheric warming and exacerbated by eustatic sea-level rise. From 14.9 to 12.9 ka BP the EISC lost on average 750 Gt a−1, peaking at rates >3000 Gt a−1, roughly equally partitioned between surface melt and dynamic losses, and potentially contributing up to 2.5 m to global sea-level rise during Meltwater Pulse 1A. Independent glacio-isostatic modelling constrained by an extensive inventory of relative sea-level change corroborates our ice sheet loading history of the Barents Sea sector. Subglacial conditions were predominately temperate during deglaciation, with over 6000 subglacial lakes predicted along with an extensive subglacial drainage network. Moreover, the maximum EISC and its isostatic footprint had a profound impact on the proglacial hydrological network, forming the Fleuve Manche mega-catchment which had an area of ∼2.5 × 106 km2 and drained the present day Vistula, Elbe, Rhine and Thames rivers through the Seine Estuary. During the Bølling/Allerød oscillation after c. 14.6 ka BP, two major proglacial lakes formed in the Baltic and White seas, buffering meltwater pulses from eastern Fennoscandia through to the Younger Dryas when these massive proglacial freshwater lakes flooded into the North Atlantic Ocean. Deglaciation temporarily abated during the Younger Dryas stadial at 12.9 ka BP, when remnant ice across Svalbard, Franz Josef Land, Novaya Zemlya, Fennoscandia and Scotland experienced a short-lived but dynamic re-advance. The final stage of deglaciation converged on present day ice cover around the Scandes mountains and the Barents Sea by 8.7 ka BP, although the phase-lagged isostatic recovery still continues today.
•A new model reconstruction for the EISC deglaciation (23-8 ka BP) is presented.•Ice loading across the High Arctic is tested independently against RSL observations.•The potential locations of >6000 subglacial lakes during the LGM are identified.•The proglacial Fleuve Manche mega-catchment extended >2.5 × 106 km2 across Eurasia.•The EISC contribution to global sea level rise during Meltwater Pulse 1A was ∼2.5 m.
Social living affords primates (including humans) many benefits. Communication has been proposed to be the key mechanism used to bond social connections, which could explain why primates have evolved ...such expressive faces. We assessed whether the facial expressivity of the dominant male (quantified from the coding of anatomically based facial movement) was related to social network properties (based on social proximity and grooming) in nine groups of captive rhesus macaques ( Macaca mulatta ) housed in uniform physical and social environments. More facially expressive dominant male macaques were more socially connected and had more cohesive social groups. These findings show that inter-individual differences in facial expressivity are related to differential social outcomes at both an individual and group level. More expressive individuals occupy more beneficial social positions, which could help explain the selection for complex facial communication in primates.
A strategy is described for evaluating drugs against different phases in the development of an auto allergic disease, experimental allergic encephalomyelitis. It is based on a cell transfer technique ...whereby the disease is passively transferred with lymphoid cells from actively immunized donor rats to normal syngeneic rats = passive recipients. Drugs may be applied in vivo to either the cell donors or the cell recipients or to cells in vitro whilst in transit; their efficiency being determined by the severity of the passive disease (weight loss, paralysis) in the recipients.
Examples are given illustrating the application of these techniques to:
evaluating the lymphocyte-deactivating activity of various nitrogen mustards in vitro;
recognizing drugs, e.g. gold derivatives, clofazimine, etc. that are not conventional immunosuppressant (or cytostatic) agents which, when given to the recipient animals, may prevent the expression of the adopted disease;
comparing some known immunosuppressants for potency, duration of action, etc.;
demonstrating the versatility of cycloleucine, ICI-47,776, etc.
Some merits of the strategy are discussed vis a vis using the local graft-versus-host reaction in rats to search for new drugs.
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