In the current study, we utilized a person-centered approach to examine the relations of parental psychological control (PPC) and relationship self-efficacy (RSE) to power dynamics in emerging ...adults’ romantic relationships. College student emerging adults (N = 312) completed measures assessing retrospective PPC, RSE, and perceived self and partner power in current relationships. Latent profile analysis uncovered four relationship types based on reported self- and partner-power: balanced-unified, balanced-interchanging, unbalanced–high self, and unbalanced-high partner. Increases in PPC were related to increased odds of being in an unbalanced relationship. Higher levels of RSE were associated with decreased odds of being in an unbalanced relationship. Further, even individuals in the balanced profile who reported average levels of both self and partner power (balanced-interchanging) reported higher levels of PPC and lower levels of RSE compared to those in the balanced group where levels of both self and partner power were low (balanced-unified). These findings suggest using a person-centered approach to relationship power may advance our conceptualization of power distribution in romantic relationships. Further, experienced family dynamics and one’s sense of self may be especially important for young adults’ tendency to form healthy relationships. The current findings encourage future investigation into the mechanisms by which parental factors predict both dominance and submissiveness in romantic relationships. Understanding predictors of power dynamics may contribute to intimate partner violence prevention and intervention.
The Deep Underground Neutrino Experiment (DUNE) will be a premier facility for exploring long-standing questions about the boundaries of the standard model. Acting in concert with the liquid argon ...time projection chambers underpinning the far detector design, the DUNE photon detection system will capture ultraviolet scintillation light in order to provide valuable timing information for event reconstruction. To maximize the active area while maintaining a small photocathode coverage, the experiment will utilize a design based on plastic light guides coated with a wavelength-shifting compound, along with silicon photomultipliers, to collect and record scintillation light from liquid argon. This report presents recent preliminary performance measurements of this baseline design and several alternative designs which promise significant improvements in sensitivity to low-energy interactions.
Background
Recently developed asthma biological therapies have been shown to provide relief for severe asthma patients not controlled by inhaled treatment. Given the relatively high costs of ...biological therapies, cost-effectiveness analyses (CEAs) may be required as a prerequisite for coverage and reimbursement.
Objective
We aimed to systematically review published literature on the economic impact of biological asthma therapies and to identify key drivers that impact cost-effectiveness in order to provide recommendations for future economic evaluations.
Methods
We conducted a systematic literature search in PubMed and Google Scholar. We included studies that assessed the cost-effectiveness of asthma biologics and were published in English between 2000 and 2018. The Quality of Health Economic Studies (QHES) instrument was used to evaluate quality.
Results
Twenty asthma biological CEAs were identified. Nineteen studies analyzed the cost-effectiveness of omalizumab, and one study analyzed mepolizumab. Ten studies concluded that omalizumab was cost-effective in base-case scenarios, four studies concluded omalizumab was not cost-effective, and the remaining studies concluded omalizumab or mepolizumab was cost-effective only when targeted to specific severe subgroups or given considerable price discounts. Key drivers of cost-effectiveness included day-to-day health-related quality of life (HRQoL), asthma-related mortality, acquisition price of the biological therapy, and time horizon.
Conclusions
Most studies recommended carefully targeting biological therapy to specific populations such as responders or discounting acquisition price in order to further improve value. The quality of the studies was generally satisfactory, but improved evidence is needed linking HRQoL to utilities as well as understanding interventions’ impact on asthma-related mortality. Key recommendations from this review may allow for greater comparability across future cost-effectiveness studies.
A better understanding of household water use in developing countries is necessary to manage and expand water systems more effectively. Several meta-analyzes have examined the determinants of ...household water demand in industrialized countries, but little effort has been made to synthesize the growing body of literature evaluating household water demand in developing countries. This article reviews what is known and what is missing from that literature thus far. Analysis of demand for water in developing countries is complicated by abundant evidence that, contrary to what is observed in most developed countries, households in developing countries have access to, and may use more than one of several types of, water sources. The authors describe the different modeling strategies that researchers have adopted to estimate water demand in developing countries and discuss issues related to data collection. The findings from the literature on the main determinants of water demand in these countries suggest that, despite heterogeneity in the places and time periods studied, most estimates of own-price elasticity of water from private connections are in the range from −0.3 to −0.6, close to what is usually reported for industrialized countries. The empirical findings on decisions relating to household water sources are much less robust and should be a high priority for future research.
Adding mepolizumab to standard treatment with inhaled corticosteroids and controller medications could decrease asthma exacerbations and use of long-term oral steroids in patients with severe disease ...and increased eosinophils; however, mepolizumab is costly and its cost effectiveness is unknown.
To estimate the cost effectiveness of mepolizumab.
A Markov model was used to determine the incremental cost per quality-adjusted life year (QALY) gained for mepolizumab plus standard of care (SoC) and for SoC alone. The population, adults with severe eosinophilic asthma, was modeled for a lifetime time horizon. A responder scenario analysis was conducted to determine the cost effectiveness for a cohort able to achieve and maintain asthma control.
Over a lifetime treatment horizon, 23.96 exacerbations were averted per patient receiving mepolizumab plus SoC. Avoidance of exacerbations and decrease in long-term oral steroid use resulted in more than $18,000 in cost offsets among those receiving mepolizumab, but treatment costs increased by more than $600,000. Treatment with mepolizumab plus SoC vs SoC alone resulted in a cost-effectiveness estimate of $386,000 per QALY. To achieve cost effectiveness of approximately $150,000 per QALY, mepolizumab would require a more than 60% price discount. At current pricing, treating a responder cohort yielded cost-effectiveness estimates near $160,000 per QALY.
The estimated cost effectiveness of mepolizumab exceeds value thresholds. Achieving these thresholds would require significant discounts from the current list price. Alternatively, treatment limited to responders improves the cost effectiveness toward, but remains still slightly above, these thresholds. Payers interested in improving the efficiency of health care resources should consider negotiations of the mepolizumab price and ways to predict and assess the response to mepolizumab.
Results are reported from an improved measurement of ν_{μ}→ν_{e} transitions by the NOvA experiment. Using an exposure equivalent to 6.05×10^{20} protons on target, 33 ν_{e} candidates are observed ...with a background of 8.2±0.8 (syst.). Combined with the latest NOvA ν_{μ} disappearance data and external constraints from reactor experiments on sin^{2}2θ_{13}, the hypothesis of inverted mass hierarchy with θ_{23} in the lower octant is disfavored at greater than 93% C.L. for all values of δ_{CP}.
Until broad vaccination coverage is reached and effective therapeutics are available, controlling population mobility (ie, changes in the spatial location of a population that affect the spread and ...distribution of pathogens) is one of the major interventions used to reduce transmission of SARS-CoV-2. However, population mobility differs across locations, which could reduce the effectiveness of pandemic control measures. Here we assess the extent to which socioeconomic factors are associated with reductions in population mobility during the COVID-19 pandemic, at both the city level in China and at the country level worldwide.
In this retrospective, observational study, we obtained anonymised daily mobile phone location data for 358 Chinese cities from Baidu, and for 121 countries from Google COVID-19 Community Mobility Reports. We assessed the intra-city movement intensity, inflow intensity, and outflow intensity of each Chinese city between Jan 25 (when the national emergency response was implemented) and Feb 18, 2020 (when population mobility was lowest) and compared these data to the corresponding lunar calendar period from the previous year (Feb 5 to March 1, 2019). Chinese cities were classified into four socioeconomic index (SEI) groups (high SEI, high–middle SEI, middle SEI, and low SEI) and the association between socioeconomic factors and changes in population mobility were assessed using univariate and multivariable linear regression. At the country level, we compared six types of mobility (residential, transit stations, workplaces, retail and recreation, parks, and groceries and pharmacies) 35 days after the implementation of the national emergency response in each country and compared these to data from the same day of the week in the baseline period (Jan 3 to Feb 6, 2020). We assessed associations between changes in the six types of mobility and the country's sociodemographic index using univariate and multivariable linear regression.
The reduction in intra-city movement intensity in China was stronger in cities with a higher SEI than in those with a lower SEI (r=–0·47, p<0·0001). However, reductions in inter-city movement flow (both inflow and outflow intensity) were not associated with SEI and were only associated with government control measures. In the country-level analysis, countries with higher sociodemographic and Universal Health Coverage indexes had greater reductions in population mobility (ie, in transit stations, workplaces, and retail and recreation) following national emergency declarations than those with lower sociodemographic and Universal Health Coverage indexes. A higher sociodemographic index showed a greater reduction in mobility in transit stations (r=–0·27, p=0·0028), workplaces (r=–0·34, p=0·0002), and areas retail and recreation (rxs=–0·30, p=0·0012) than those with a lower sociodemographic index.
Although COVID-19 outbreaks are more frequently reported in larger cities, our analysis shows that future policies should prioritise the reduction of risks in areas with a low socioeconomic level—eg, by providing financial assistance and improving public health messaging. However, our study design only allows us to assess associations, and a long-term study is needed to decipher causality.
Chinese Ministry of Science and Technology, Research Council of Norway, Beijing Municipal Science & Technology Commission, Beijing Natural Science Foundation, Beijing Advanced Innovation Program for Land Surface Science, National Natural Science Foundation of China, China Association for Science and Technology.
This paper reports the results of an experiment to directly measure the time-resolved scintillation signal from the passage of cosmic-ray muons through liquid argon. Scintillation light from these ...muons is of value to studies of weakly-interacting particles in neutrino experiments and dark matter searches. The experiment was carried out at the TallBo dewar facility at Fermilab using prototype light guide detectors and electronics developed for the Deep Underground Neutrino Experiment. Two models are presented for the time structure of the scintillation light, a phenomenological model and a composite model. Both models find tau sub(T)= 1.52 mus for the decay time constant of the Ar sub(2) super(*) triplet state. These models also show that the identification of the ''early'' light fraction in the phenomenological model, F sub(E)approximate 25% of the signal, with the total light from singlet decays is an underestimate. The total fraction of singlet light is F sub(S)approximate 36%, where the increase over F sub(E) is from singlet light emitted by the wavelength shifter through processes with long decay constants. The models were further used to compute the experimental particle identification parameter F sub(prompt), the fraction of light coming in a short time window after the trigger compared with the light in the total recorded waveform. The models reproduce quite well the typical experimental value ~0.3 found by dark matter and double beta-decay experiments, which suggests this parameter provides a robust metric for discriminating electrons and muons from more heavily ionizing particles.
Defining reliable demographic models is essential to understand the threats of ongoing environmental change. Yet, in the most remote and threatened areas, models are often based on the survey of a ...single population, assuming stationarity and independence in population responses. This is the case for the Emperor penguin Aptenodytes forsteri, a flagship Antarctic species that may be at high risk continent-wide before 2100. Here, using genome-wide data from the whole Antarctic continent, we reveal that this top-predator is organized as one single global population with a shared demography since the late Quaternary. We refute the view of the local population as a relevant demographic unit, and highlight that (i) robust extinction risk estimations are only possible by including dispersal rates and (ii) colony-scaled population size is rather indicative of local stochastic events, whereas the species' response to global environmental change is likely to follow a shared evolutionary trajectory.
Unwanted pursuit behaviours (UPBs) are behaviours that are often intended to initiate a relationship or restore romantic relationships following a break-up. Research shows relatively high prevalence ...rates of UPBs in college students. In the current study, we tested a conceptual mediation model, where perceived parental warmth would be indirectly related to UPBs via emotional regulation difficulties. College students (n = 314) completed online measures of parental warmth, emotion regulation difficulties, and perpetration of UPBs. We found that perceived parental warmth was significantly negatively related to perpetration of UPBs, and only impulse control difficulties showed a significant indirect effect. Parental warmth was directly associated with UPBs even after accounting for emotion regulation difficulties, suggesting that other factors may also explain the relation. Findings encourage future research into other developmental correlates of UPBs in prevention and intervention efforts.
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