Abstract— Covid -19, a virus strain and a member of family with known member as Severe Acute Respiratory Disease (SARS) or Middle East Respiratory Syndrome (MERS), but having a potentially lethal ...differences in not readily recognized by our immunity. Classified as betacoronavirus, with incubation period up to 14 days, the sign and symptoms can be highly variable, from asymptomatic to mild to criticalin the form of severe pneumonia. Almost half the persons infected did not show any symptoms, but in cases of people with comorbidities such as advanced age, pregnancy, obesity or other certain diseases, could increase the likelihood of morbidity and even potentially fatal. Covid-19 has spread globally, including Indonesia, with a potentially increased number of cases, prevention in covid-19 protocol is a necessity. Keywords: Covid-19, SARS, symptoms, variable, prevention
Abstrak— Covid-19, yang sebelumnya dikenal sebagai virus strain dari kelompok family yang sama dengan Severe Acute Respiratory Disease (SARS) atau Middle East Respiratory Syndrome (MERS), tapi memiliki fatalitas yang secara potensial lebih tinggi, karena bersiafat novel bagi sistem imunitas kita. Termasuk betacoronavirus, dengan masa inkubasi sampai dengan 14 hari, tanda dan gejala penyakit bisa sangat bervariasi, mulai dari asimtomatik, ringan sampai berat, dalam bentuk pneumonia berat. Hamper separuh penderita yang terinfeksi tidak menunjukkan gejala sama sekali, tapi pada penderita dengan komorbiditas seperti usia lanjut, kehamilan, obesitas atau penyakit kronis tertentu, resiko moribiditas dan mortalitas dapat meningkat. Covid-19 saat ini sudah menyebar ke seluruh dunia, termasuk Indonesia, dengan adanya potensi kenaikan kasus lebih banyak, pencegahan dalam bentuk protocol covid-19 bersifat mutlak diperlukan. Kata kunci: Covid-19, SARS, gejala, bervariasi, pencegahan
Background
Providing proper antibiotics is undoubtedly crucial to prevent infections during surgery.
Objective
This study set out to evaluate the medication administration in antibiotic prophylaxis ...using both quantitative and qualitative methods.
Setting
The study employed a retrospective design and observed patients who underwent surgical procedures during hospitalization at a private hospital in Indonesia within the period of January–June 2019.
Methods
The data obtained were evaluated quantitatively and qualitatively; and analyzed descriptively. The quantitative evaluation used the defined daily dose (DDD) per 100 bed-days. The qualitative evaluation was expressed as the percentage of antibiotic suitability based on antibiotic administration, i.e. (1) type; (2) timing; (3) dosage; (4) duration; and (5) route.
Main outcome measure
Suitability of antibiotic prophylaxis in a hospital setting.
Results
There were 164 prescriptions recorded from 20 types of surgical procedures, of which the most common was cholecystectomy (23 patients, 14%). Most antibiotics were administered 61–120 min before the incision time (55 patients, 37%), and had a duration of more than 24 h (119 patients, 80%). The total DDD per 100 bed-days for pre-, on-, and post-surgery antibiotic use were 44.2, 33.3, and 66.7 respectively. The suitability profiles of the antibiotics used according to the Antibiotic Use Guideline for Hospital (2018) were as follows: 26.3% right type, 52.9% right time, 24.8% right dosage, 19.1% right duration, 91.8% right route, while according to American Society of Health-System Pharmacists Therapeutic Guidelines (2014) there were 17.6% right type, 53.4% right time, 16.4% right dosage, 19.1% right duration, and 96.6% right route.
Conclusion
Ceftriaxone was the first-choice prophylactic antibiotic administered in this Indonesian hospital. The data indicate a considerable non-compliance with local and international guidelines.
Diabetic ulcers can progress into tissue death, or gangrene, which create a risk for amputation. Measures for preventing other complications and accelerating wound healing in diabetic ulcers include ...blood sugar level control, diet adjustment, wound care, antidiabetic drug administration, and comorbid therapy. This leads to the use of various drugs that can potentially trigger drug interactions. This study aimed to identify possible drug interactions in the therapeutic management of diabetic ulcer patients treated in Husada Utama Hospital Surabaya, Indonesia, from January 2020–June 2022. This was a descriptive observational study using retrospective data from medical records. Results showed that 103 types of drugs were administered to 48 research samples with 41 of them experienced drug interactions (n=263 cases). Based on the severity of drug interactions, 31 cases were categorized as major cases (11.79%), with drug-class antibiotic-antiemetic interactions as the most frequent interactions. This study proves that it is essential for doctors and pharmacists.
Background. Since the first outbreak of COVID-19, most hospitals restricted patients’ family support accompaniment during medical treatment of infectious transmission. On the other hand, ...accompaniment has also been recognized as an essential part of the treatment. Therefore, this study aims to determine the effect of family presence accompanying COVID-19 patients during hospitalization on the recovery rate and survival time. Objective: this study was conducted in a private hospital designated as a referral hospital for COVID-19 cases in Surabaya, East Java province, Indonesia. Materials and Methods. There were 541 COVID-19 patients included in the study, consisting of 251 women and 290 men. The requirements set as a sample are patients treated between January 1st 2021 and March 31st 2021. This study used a survival analysis study design. The data used is secondary data and uses total sampling. Results. The result of this study is that patients who get support from their families can survive longer than patients who do not get family support. Among the 251 female samples, only 34 were accompanied by their families, with 29.411% fatalities recorded. Among 290 male patients, 25.71% fatalities were recorded in 35 accompanying family presence. Furthermore, female patients have a probability of better outcomes than males (P<0.001). Conclusions. Based on these results, family presence has the benefit of improving outcomes and recovery. So, the authorities are expected to reconsider the restrictions on family presence by maintaining proper safety protocols of isolation and quarantine.
The clinical manifestations associated with COVID-19 disease is mainly due to a dysregulated host response related to the overexpression of inflammatory markers. Until recently, only remdesivir had ...gained FDA approval for COVID-19 hospitalized patients and there are currently no evidence-based therapeutic options or options for prevention of complications that have been established. Some medical treatments such as antivirals, antibacterials, antithrombotics, antipyretics, corticosteroids, interleukin inhibitors, monoclonal antibodies, convalescent plasma, immunostimulants, and vitamin supplements have been utilized. However, there are limited data to support their effectiveness. Hence, this study was attempted to identify and evaluate the effectiveness of antibacterials and antivirals used for COVID-19 using a retrospective cross-sectional approach based on the medical records of adult patients in four hospitals. The number of antibacterials was calculated in defined daily dose (DDD) per 100 bed-days unit. Both mixed-logit regression and analysis of covariance were used to determine the effectiveness of the aforementioned agents in relation to COVID-19 outcome and patients' length of stay. The model was weighed accordingly and covariates (e.g., age) were considered in the model. Heart disease was found to be the most common pre-existing condition of COVID-19 hospitalized patients in this study. Azithromycin, an antibacterial in the Watch category list, was used extensively (33-65 DDD per 100 bed-days). Oseltamivir, an antiviral approved by the FDA for influenza was the most prescribed antiviral. In addition, favipiravir was found to be a significant factor in improving patients' COVID-19 outcomes and decreasing their length of stay. This study strongly suggests that COVID-19 patients' received polypharmacy for their treatment. However, most of the drugs used did not reach statistical significance in improving the patients' condition or decreasing the length of stay. Further studies to support drug use are needed.
Collaborative practice in healthcare has been recommended to improve the quality of antimicrobial stewardship interventions, a behavioral change in antimicrobial use. Insufficient knowledge regarding ...antibiotic resistance, the fear of complications from infections, and how providers perceive antibiotic use and resistance are likely to influence prescribing behavior. This study's objective was to identify the knowledge and belief healthcare professionals' differences about antibiotic stewardship.
This cross-sectional survey study of three hospitals in the East Java province, Indonesia utilized a 43-item questionnaire to assess antimicrobial stewardship knowledge and belief. There were 12 knowledge questions (total possible score: 12) and 31 belief questions (total possible score: 155). The Kuder Richardson 20 (KR-20) and Cronbach alpha values of the questionnaire were 0.54 and 0.92, respectively.
Out of the 257 respondents, 19% (48/257) had a low scores of knowledge, and 39% (101/257) had low scores on belief about antibiotic stewardship (101/257). Most midwives had a low scores on knowledge (25/61) and low scores on belief (46/61). Respondents with high scores on belief were 17% (10/59) physicians, 15% (4/27) pharmacists, 8% (5/65) nurses, and 3% (2/61) midwives.
Among healthcare professionals, knowledge and belief differences concerning antibiotic stewardship vary widely. These differences will affect their capability, behavior, and contribution to the healthcare team collaboration and performance. Further studies are needed to evaluate the correlation between the level of inter-professional collaboration and the quality of the antibiotic stewardship implementation.
Antibiotic stewardship; Knowledge; Belief.
Healthcare collaboration intervention: Pre-post study Hikmah, Zahrotul; Yulia, Rika; Setiasih ...
Pharmacy education : an international journal for pharmaceutical education,
07/2024, Letnik:
24, Številka:
3
Journal Article
Recenzirano
Background: Effective interprofessional collaboration between health professionals is correlated with improving the quality of health services and patient safety, for example, Program Pengendalian ...Resistensi Antibiotik (PPRA). Objective: This research aims to determine the effect of educational PPRA on the knowledge and motivation of healthcare professionals in interprofessional collaboration practices. Methods: The research is quasi-experimental, with one group pre-post using a knowledge questionnaire (questionnaire 1) and a motivation questionnaire (questionnaire 2). The respondents were health professionals at Husada Utama Hospital. This research involved 74 respondents: two doctors, three pharmacists, 41 nurses, five midwives, ten pharmacist assistants, and 13 laboratory assistants. Results: The analysis of the effect of providing education on health professionals’ knowledge level showed a significant improvement in good categories before and after education, with 55.4% before and 73% after (Sig. = 0.025, p < 0.05). The analysis of the level of motivation showed that moderate categories grew insignificantly before and after education, with 39.19% before and 47.30% after (Sig = 0.599, p > 0.05). Conclusion: This research concluded that PPRA education's effect on health workers' knowledge and motivation in interprofessional collaboration at Husada Utama Hospital has increased knowledge and motivation.
Background: The quality of services provided by hospitals is the responsibility of a group of multi-professional teams working with different professional backgrounds, resulting in inter-professional ...conflicts that cause losses. To produce quality services, building Interprofessional Collaboration (IPC) among health workers is very important. One of the challenges that prevents the implementation of IPC from working efficiently is the varying opinions of health workers regarding interprofessional collaboration activities. Objective: The goal of this study was to investigate the attitudes of health workers concerning the practice of IPC in hospitals. Method: This research was an observational study employing a cross-sectional strategy. Health workers' impressions of interprofessional cooperation practices were analysed using the Collaborative Practice Assessment Tool for health workers. Result: This study involved 105 health professional respondents. The findings of the questionnaire analysis indicated significant differences in the domain of Relationship among Team Members (p 0.027), Team Relationship with the Community (p 0.012), Leadership (p 0.009), and Mission, Goals, and Objectives (p 0.001). Conclusion: Based on research findings, there are differences in perceptions among health workers because each professional competency domain is different. Therefore, interprofessional education is necessary to illustrate the implementation of collaborative practices across various professions.
Background
Type 2 diabetes mellitus (T2DM) is a metabolic disorder characterized by limited metabolic flexibility in the body. Such limitation implicates the pyruvate dehydrogenase kinase 4 (PDK4) ...gene Poor nutrition, frequently observed among Southeast Asians usually involves excessive intakes of carbohydrates and monosodium glutamate (MSG), that have been frequently linked to an increased risk of T2DM.
Methods
The 14-week study aimed to assess the effects of high-carbohydrate (HC), high-MSG (HMSG), and a combination of high-carbohydrate and high-MSG (HCHMSG) diets on the development of T2DM using male mice. To assess the effects, the male mice were divided into four groups: control (C), HC, HMSG, and HCHMSG for 14 weeks.
Results
After 14 weeks, both the HC and HCHMSG groups showed signs of T2DM (168.83 ± 32.33; 156.42 ± 32.46). The blood samples from the HMSG, HC, and HCHMSG groups (57.67 ± 2.882; 49.22 ± 7.36; 48.9 ± 6.43) as well as skeletal muscle samples from the HMSG, HC, and HCHMSG groups (57.78 ± 8.54; 42.13 ± 7.25; 37.57 ± 10.42) exhibited a gradual hypomethylation. The HC groups particularly displayed significant PDK4 gene expression in skeletal muscle. A progressive overexpression of the PDK4 gene was observed as well in the HMSG, HCHMSG, and HC groups (2.03 ± 3.097; 3.21 ± 2.94; 5.86 ± 2.54).
Conclusions
These findings suggest that T2DM can be induced by high-carbohydrate and high-MSG diets. However, the sole consumption of high MSG did not lead to the development of T2DM. Further research should focus on conducting long-term studies to fully comprehend the impact of a high MSG diet on individuals with pre-existing T2DM.
PDF
