Sprawozdanie zawiera opis działalności Komisji Badań nad Antykiem Chrześcijańskim TN KUL w roku akademickim 2022/2023. Wymieniono prelegentów poszczególnych posiedzeń oraz streszczono ich tematykę ...poszczególnych spotkań.
Sprawozdanie zawiera opis działalności Komisji Badań nad Antykiem Chrześcijańskim KUL w latach 2017-2022. W ramach sprawozdania zestawiono chronologicznie autorów i ich wystąpienia prezentowane na ...cyklicznych posiedzeniach Komisji.
Praca jest pierwszym tłumaczeniem na jezyk polski drugiej homilii o Dawidzie i Saulu św. Jana Chryzostoma. Przekład został opatrzony komentarzami oraz poprzedzony poglądowym życiorysem św. Jana ...Chryzostoma, jak również został zarysowana kwestia datacji omawianego tu utworu.
Background. A substantial proportion of those infected with COVID-19 are presenting with persistent symptoms, referred to as long COVID-19. Emerging evidence suggests that the presence of ...pre-existing chronic conditions, such as diabetes, may increase the risk of long COVID-19. Objectives. To investigate whether having pre-existing diabetes increases the risk of developing long COVID-19 in the population of middle-aged and older adults (≥50 years old) in Europe, while assessing if this relationship can be accounted for or is modified by the known long COVID-19 and diabetes risk factors (age, sex, hospitalization, pre-existing hypertension, and weight status). Methods. A population-based longitudinal prospective study involving a sample of respondents aged 50 years and older (n=4,004) with probable or confirmed COVID-19 infection from 27 countries that participated in both waves 7 and 8 of the Survey of Health, Ageing and Retirement in Europe and its 2020 and 2021 Corona Surveys. Logistic regression modeling was performed. Results. Overall, 66.8% of the respondents affected by COVID-19 infection reported at least one long COVID-19 symptom; 55.2% were female, and the average age was 64.6 years; 13.2% had pre-existing diabetes. Respondents with pre-existing diabetes had significantly higher odds of developing long COVID-19, compared to those without diabetes (OR=1.37; 95% CI=1.12,1.68). This relationship remained significant (OR=2.00; 98% CI=0.25,1.14) after adjusting for sex (OR=1.64 for females; 95% CI=1.43,1.88), hospitalization for COVID-19 illness (OR=3.19; 95% CI=2.41,4.23), pre-existing hypertension (OR=1.17; 95% CI=1.01,1.36), and overweight (OR=1.31; 95% CI=1.11,1.56) and obese (OR=1.77; 95% CI=1.44,2.19) weight status. The effect of pre-existing diabetes on the risk of long COVID-19 is moderated by age; it was highest at the age of 50 (OR=2.00; 95% CI=1.28,3.14), and then, it declined with age. Conclusions. There is a relationship between pre-existing diabetes and long COVID-19, even after controlling for literature-based confounding factors, with age having a moderating effect on this relationship.
It is the first monograph in which the concertos of all composers active in this field in the Republic of Venice in the years 1695–1740 are methodically discussed. The Venetian instrumental concerto ...from Vivaldi’s time is portrayed here through an extensive and thorough survey of the most complete and representative musical material that allowed for the making of conclusions as to its typology, form, style and technique. The concertos discussed here include 974 works by fifteen composers active in Venice, Brescia, Bergamo and Padua. Such an approach not only gives an exhaustive but also a more objective view on the history of the Baroque concerto in its Venetian variant. It shows Vivaldi’s work in a new and broad context, which allows us to better understand its unique character.
For a little over a decade now, the Macromolecular Crystallography (MX) group at the Helmholtz-Zentrum Berlin (HZB) has been operating three state-of-the-art synchrotron beamlines for MX at the BESSY ...II storage ring in Berlin. The three HZB-MX beamlines, BL14.1, BL14.2 and BL14.3, serve a stable and growing user community of currently more than 100 independent research groups from Berlin, Germany and Europe. Every year, the beamlines provide close to 200 days of MX-beamtime. Over time, the HZB-MX beamlines and endstations, in particular BL14.1, have been continually developed and upgraded and, since 2010, they operate as the most productive MX beamlines in Germany. The environment of the beamlines includes various ancillary equipment as well as additional facilities, such as office space adjacent to the beamlines, a sample preparation laboratory, a safety level 1 biology laboratory (HZB-MX BioLab) and all necessary computing resources. In this paper, the current status of the beamlines as well as the ongoing developments are described.
Glycerol is an organic compound that can be utilized as an alternative source of carbon by various organisms. One of the ways to assimilate glycerol by the cell is the phosphorylative catabolic ...pathway in which its activation is catalyzed by glycerol kinase (GK) and glycerol-3-phosphate (G3P) is formed. To date, several GK crystal structures from bacteria, archaea, and unicellular eukaryotic parasites have been solved. Herein, we present a series of crystal structures of GK from
(CtGK) in apo and glycerol-bound forms. In addition, we show the feasibility of an ADP-dependent glucokinase (ADPGK)-coupled enzymatic assay to measure the CtGK activity. New structures described in our work provide structural insights into the GK catalyzed reaction in the filamentous fungus and set the foundation for understanding the glycerol metabolism in eukaryotes.
Deoxyhypusine synthase (DHS) is a transferase enabling the formation of deoxyhypusine, which is the first, rate-limiting step of a unique post-translational modification: hypusination. DHS catalyses ...the transfer of a 4-aminobutyl moiety of polyamine spermidine to a specific lysine of eukaryotic translation factor 5A (eIF5A) precursor in a nicotinamide adenine dinucleotide (NAD)-dependent manner. This modification occurs exclusively on one protein, eIF5A, and it is essential for cell proliferation. Malfunctions of the hypusination pathway, including those caused by mutations within the DHS encoding gene, are associated with conditions such as cancer or neurodegeneration. Here, we present a series of high-resolution crystal structures of human DHS. Structures were determined as the apoprotein, as well as ligand-bound states at high-resolutions ranging from 1.41 to 1.69 Å. By solving DHS in complex with its natural substrate spermidine (SPD), we identified the mode of substrate recognition. We also observed that other polyamines, namely spermine (SPM) and putrescine, bind DHS in a similar manner as SPD. Moreover, we performed activity assays showing that SPM could to some extent serve as an alternative DHS substrate. In contrast to previous studies, we demonstrate that no conformational changes occur in the DHS structure upon spermidine-binding. By combining mutagenesis and a light-scattering approach, we show that a conserved "ball-and-chain" motif is indispensable to assembling a functional DHS tetramer. Our study substantially advances our knowledge of the substrate recognition mechanism by DHS and may aid the design of pharmacological compounds for potential applications in cancer therapy.
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