The development of polymers that can spontaneously repair themselves after mechanical damage would significantly improve the safety, lifetime, energy efficiency and environmental impact of man-made ...materials. Most approaches to self-healing materials require the input of external energy, healing agents, solvent or plasticizer. Despite intense research in this area, the synthesis of a stiff material with intrinsic self-healing ability remains a key challenge. Here, we show a design of multiphase supramolecular thermoplastic elastomers that combine high modulus and toughness with spontaneous healing capability. The designed hydrogen-bonding brush polymers self-assemble into a hard-soft microphase-separated system, combining the enhanced stiffness and toughness of nanocomposites with the self-healing capability of dynamic supramolecular assemblies. In contrast to previous self-healing polymers, this new system spontaneously self-heals as a single-component solid material at ambient conditions, without the need for any external stimulus, healing agent, plasticizer or solvent.
Although small in size, insects are a quintessential part of terrestrial ecosystems due to their large number and diversity. While captured insects can be thoroughly studied in laboratory conditions, ...their population dynamics and abundance in the wild remain largely unknown due to the lack of accurate methodologies to count them. Here, we present the results of a field experiment where the activity of insects has been monitored continuously over 3 months using an entomological stand-off optical sensor (ESOS). Because its near-infrared laser is imperceptible to insects, the instrument provides an unbiased and absolute measurement of the aerial density (flying insect/m3) with a temporal resolution down to the minute. Multiple clusters of insects are differentiated based on their wingbeat frequency and ratios between wing and body optical cross-sections. The collected data allowed for the study of the circadian rhythm and daily activities as well as the aerial density dynamic over the whole campaign for each cluster individually. These measurements have been compared with traps for validation of this new methodology. We believe that this new type of data can unlock many of the current limitations in the collection of entomological data, especially when studying the population dynamics of insects with large impacts on our society, such as pollinators or vectors of infectious diseases.
Celotno besedilo
Dostopno za:
DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
Abstract
α-Synuclein, a key pathological component of Parkinson's disease, has been implicated in the activation of the innate and adaptive immune system. This immune activation includes ...microgliosis, increased inflammatory cytokines, and the infiltration of T cells into the CNS. More recently, peripherally circulating CD4 and CD8 T cells derived from individuals with Parkinson’s disease have been shown to produce Th1/Th2 cytokines in response to α-synuclein, suggesting there may be a chronic memory T cell response present in Parkinson’s disease. To understand the potential effects of these α-syn associated T cell responses we used an α-synuclein overexpression mouse model, T cell-deficient mice, and a combination of immunohistochemistry and flow cytometry. In this study, we found that α-synuclein overexpression in the midbrain of mice leads to the upregulation of the major histocompatibility complex II (MHCII) protein on CNS myeloid cells as well as the infiltration of IFNγ producing CD4 and CD8 T cells into the CNS. Interestingly, genetic deletion of TCRβ or CD4, as well as the use of the immunosuppressive drug fingolimod, were able to reduce the CNS myeloid MHCII response to α-synuclein. Furthermore, we observed that CD4-deficient mice were protected from the dopaminergic cell loss observed due to α-syn overexpression. These results suggest that T cell responses associated with α-synuclein pathology may be damaging to key areas of the CNS in Parkinson’s disease and that targeting these T cell responses could be an avenue for disease modifying treatments.
Monitoring the dynamics of insect populations is key to assessing the impact of human activities on insect populations. However, traditional methodologies relying on physical traps have inherent ...limitations in accurately monitoring insect abundance. Here, we present findings from a 9-month campaign conducted in New Jersey, USA, utilizing a near-infrared optical sensor known as eBoss. From April to December 2022, the eBoss derived the aerial density (insect/m3) and biomass density (mg/m3) with a 1-min resolution from a total of 302,093 insect observations. The data collected were analyzed in relation to air temperature, relative humidity, and wind speed. The results revealed that the abundance of flying insects exhibited an initial increase from April to June, reaching a peak of 0.094 insect/m3 and 1.34 mg/m3, followed by a subsequent decline towards the end of the year. Our investigation showed a surge in insect abundance above 12.5 °C, with particularly high levels observed between 19 and 31 °C. The impact of relative humidity and wind speed on insect populations was also explored. Overall, this campaign demonstrated the efficacy of photonic sensors in gathering novel and extensive data for the field of entomology, paving the way for improved understanding and management of insect populations.
Emotion dysregulation is often considered a core characteristic of individuals with borderline personality disorder (BPD). With the development and strength of a contemporary affective-science model ...that encompasses both healthy emotion regulation (ER) and emotion dysregulation, this model has increasingly been used to understand the affective experiences of people with BPD. In this meta-analysis and review, we systematically review six of the most commonly studied ER strategies and determine their relative endorsement in individuals with elevated symptoms of BPD compared to individuals with low symptoms of BPD and healthy controls, as well as to individuals with other mental disorders. Results from 93 unique studies and 213 different effect-size estimates indicated that symptoms of BPD were associated with less frequent use of ER strategies that would be considered more effective at reducing negative affect (i.e., cognitive reappraisal, problem solving, and acceptance) and more frequent use of ER strategies considered less effective at reducing negative affect (i.e., suppression, rumination, and avoidance). When compared to individuals with other mental disorders, people with BPD endorsed higher rates of rumination and avoidance, and lower rates of problem solving and acceptance. We also review important contributions from studies of ER in BPD that we were unable to incorporate into our meta-analysis. We conclude by discussing how the pattern of using ER strategies in BPD contributes to emotion dysregulation and also the potential reasons for this pattern, integrating both Gross's extended process model of ER and Linehan's updated theoretical account on the development of emotion dysregulation.
Mosquito-borne diseases are a major challenge for Human health as they affect nearly 700 million people every year and result in over 1 million deaths. Reliable information on the evolution of ...population and spatial distribution of key insects species is of major importance in the development of eco-epidemiologic models. This paper reports on the remote characterization of flying mosquitoes using a continuous-wave infrared optical remote sensing system. The system is setup in a controlled environment to mimic long-range lidars, mosquitoes are free flying at a distance of ~ 4 m from the collecting optics. The wing beat frequency is retrieved from the backscattered light from mosquitoes transiting through the laser beam. A total of 427 transit signals have been recorded from three mosquito species, males and females. Since the mosquito species and gender are known a priori, we investigate the use of wing beat frequency as the sole predictor variable for two Bayesian classifications: gender alone (two classes) and species/gender (six classes). The gender of each mosquito is retrieved with a 96.5% accuracy while the species/gender of mosquitoes is retrieved with a 62.3% accuracy. Known to be an efficient mean to identify insect family, we discuss the limitations of using wing beat frequency alone to identify insect species.
A simple, scalable synthesis of mechanically robust and self‐healable superlattice nanocomposites is achieved through self‐assembly of single‐component “sticky” polymer‐grafted nanoparticles. The ...multivalent hydrogen‐bonding interactions between the nanoparticles provide strong cohesive energy, binding the nanoparticles into strong and tough materials. Furthermore, the dynamic hydrogen‐bonding interactions afford the formation of highly dynamic, self‐healing, and mechanochromic nanocomposite materials in the bulk.
This collection of essays offers a critical assessment of Labour in a Single Shot, a groundbreaking documentary video workshop. From 2011 to 2014, curator Antje Ehmann and film- and videomaker Harun ...Farocki produced an art project of truly global proportions. They travelled to fifteen cities around the world to conduct workshops inspired by cinema history’s first film, Workers Leaving the Lumière Factory, shot in 1895 by the Lumière brothers in France. While the workshop videos are in colour and the camera was not required to remain static, Ehmann and Farocki’s students were tasked with honouring the original Lumière film’s basic parameters of theme and style. The fascinating result is a collection of more than 550 short videos that have appeared in international exhibitions and on an open-access website, offering the widest possible audience the opportunity to ponder contemporary labour in multiple contexts around the world.
We constructed an electric multi-rotor autonomous unmanned aerial system (UAS) to perform mosquito control activities. The UAS can be equipped with any of four modules for spraying larvicides, ...dropping larvicide tablets, spreading larvicide granules, and ultra-low volume spraying of adulticides. The larvicide module sprayed 124 mum drops at 591 mL/min over a 14 m swath for a total application rate of 1.6 L/ha. The tablet module was able to repeatedly deliver 40-gram larvicide tablets within 1.1 m of the target site. The granular spreader covered a 6 m swath and treated 0.76 ha in 13 min at an average rate of 1.8 kg/ha. The adulticide module produced 16 mum drops with an average deposition of 2.6 drops/mm.sup.2 . UAS pesticide applications were made at rates prescribed for conventional aircraft, limited only by the payload capacity and flight time. Despite those limitations, this system can deliver pesticides with much greater precision than conventional aircraft, potentially reducing pesticide use. In smaller, congested environments or in programs with limited resources, UAS may be a preferable alternative to conventional aircraft.
Celotno besedilo
Dostopno za:
DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
Insects are major actors in Earth’s ecosystems and their recent decline in abundance and diversity is alarming. The monitoring of insects is paramount to understand the cause of this decline and ...guide conservation policies. In this contribution, an infrared laser-based system is used to remotely monitor the biomass density of flying insects in the wild. By measuring the optical extinction caused by insects crossing the 36-m long laser beam, the Entomological Bistatic Optical Sensor System used in this study can evaluate the mass of each specimen. At the field location, between July and December 2021, the instrument made a total of 262,870 observations of insects for which the average dry mass was 17.1 mg and the median 3.4 mg. The daily average mass of flying insects per meter cube of air at the field location has been retrieved throughout the season and ranged between near 0 to 1.2 mg/m
3
. Thanks to its temporal resolution in the minute range, daily variations of biomass density have been observed as well. These measurements show daily activity patterns changing with the season, as large increases in biomass density were evident around sunset and sunrise during Summer but not during Fall.
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