ErbB2 is overexpressed in 25-30% of breast and ovarian cancers, correlates with poor prognosis and lower survival and has also been associated with chemoresistance. We have established an isogenic ...pair of human ovarian cells that differ only in the expression of erbB2 protein in order to elucidate the role of the protein in determining cellular sensitivity to various drugs and agents. These included cisplatin and paclitaxel, the main drugs used in the treatment of ovarian cancer, and also various signal transduction inhibitors affecting the ras and P13K pathways. Transfection of erbB2 resulted in cells stably overexpressing the protein and showing increased motility compared to the empty vector control cells. In cells overexpressing erbB2, the most notable effect on chemosensitivity was that of significantly increased (5-fold) sensitivity to the heat shock protein 90 (HSP90) molecular chaperone inhibitor geldanamycin. In contrast, erbB2-overexpressing cells showed statistically significant resistance to cisplatin, the P13K inhibitor LY294002 and the tyrosine kinase inhibitor emodin. No significant difference in growth inhibition was observed after exposure to paclitaxel, two additional HSP90 inhibitors radicicol and 17AAG, the cyclin-dependent kinase inhibitor flavopiridol, the epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor PD153035, the mek inhibitor U0126 or the famesyl transferase inhibitor R115777. Exposure of cells to geldanamycin, 17AAG, emodin, LY294002 and cisplatin led to depletion of erbB2 in the transfected cells. These data suggest that erbB2 status in ovarian cancr may contribute to chemosensitivity, in some cases leading to increased sensitivity (as with geldanamycin) but in other cases leading to resistance (as with cisplatin).
The quasifree
photon beam asymmetry,
, has been measured at photon energies,
, from 390 to 610 MeV, corresponding to center of mass energy from 1.271 to 1.424 GeV, for the first time. The data were ...collected in the A2 hall of the MAMI electron beam facility with the Crystal Ball and TAPS calorimeters covering pion center-of-mass angles from 49
to 148
. In this kinematic region, polarization observables are sensitive to contributions from the
and
(1440) resonances. The extracted values of
have been compared to predictions based on partial-wave analyses (PWAs) of the existing pion photoproduction database. Our comparison includes the SAID, MAID and Bonn-Gatchina analyses; while a revised SAID fit, including the new
measurements, has also been performed. In addition, isospin symmetry is examined as a way to predict
photoproduction observables, based on fits to published data in the channels
,
and
.
The quasifree
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\begin{document}$$\overrightarrow{\gamma } d\rightarrow \pi ^0n(p)$$\end{document}
γ
→
d
→
π
0
n
(
p
)
photon beam asymmetry,
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\begin{document}$$\varSigma $$\end{document}
Σ
, has been measured at photon energies,
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\begin{document}$$E_\gamma $$\end{document}
E
γ
, from 390 to 610 MeV, corresponding to center of mass energy from 1.271 to 1.424 GeV, for the first time. The data were collected in the A2 hall of the MAMI electron beam facility with the Crystal Ball and TAPS calorimeters covering pion center-of-mass angles from 49
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\usepackage{amsmath}
\usepackage{wasysym}
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\begin{document}$$^\circ $$\end{document}
∘
to 148
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\begin{document}$$^\circ $$\end{document}
∘
. In this kinematic region, polarization observables are sensitive to contributions from the
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\usepackage{wasysym}
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\begin{document}$$\varDelta (1232)$$\end{document}
Δ
(
1232
)
and
N
(1440) resonances. The extracted values of
\documentclass12pt{minimal}
\usepackage{amsmath}
\usepackage{wasysym}
\usepackage{amsfonts}
\usepackage{amssymb}
\usepackage{amsbsy}
\usepackage{mathrsfs}
\usepackage{upgreek}
\setlength{\oddsidemargin}{-69pt}
\begin{document}$$\varSigma $$\end{document}
Σ
have been compared to predictions based on partial-wave analyses (PWAs) of the existing pion photoproduction database. Our comparison includes the SAID, MAID and Bonn–Gatchina analyses; while a revised SAID fit, including the new
\documentclass12pt{minimal}
\usepackage{amsmath}
\usepackage{wasysym}
\usepackage{amsfonts}
\usepackage{amssymb}
\usepackage{amsbsy}
\usepackage{mathrsfs}
\usepackage{upgreek}
\setlength{\oddsidemargin}{-69pt}
\begin{document}$$\varSigma $$\end{document}
Σ
measurements, has also been performed. In addition, isospin symmetry is examined as a way to predict
\documentclass12pt{minimal}
\usepackage{amsmath}
\usepackage{wasysym}
\usepackage{amsfonts}
\usepackage{amssymb}
\usepackage{amsbsy}
\usepackage{mathrsfs}
\usepackage{upgreek}
\setlength{\oddsidemargin}{-69pt}
\begin{document}$$\pi ^0n$$\end{document}
π
0
n
photoproduction observables, based on fits to published data in the channels
\documentclass12pt{minimal}
\usepackage{amsmath}
\usepackage{wasysym}
\usepackage{amsfonts}
\usepackage{amssymb}
\usepackage{amsbsy}
\usepackage{mathrsfs}
\usepackage{upgreek}
\setlength{\oddsidemargin}{-69pt}
\begin{document}$$\pi ^0p$$\end{document}
π
0
p
,
\documentclass12pt{minimal}
\usepackage{amsmath}
\usepackage{wasysym}
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\setlength{\oddsidemargin}{-69pt}
\begin{document}$$\pi ^+n$$\end{document}
π
+
n
and
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\begin{document}$$\pi ^-p$$\end{document}
π
-
p
.
The quasifree
γ
→
d
→
π
0
n
(
p
)
photon beam asymmetry,
Σ
, has been measured at photon energies,
E
γ
, from 390 to 610 MeV, corresponding to center of mass energy from 1.271 to 1.424 GeV, for the ...first time. The data were collected in the A2 hall of the MAMI electron beam facility with the Crystal Ball and TAPS calorimeters covering pion center-of-mass angles from 49
∘
to 148
∘
. In this kinematic region, polarization observables are sensitive to contributions from the
Δ
(
1232
)
and
N
(1440) resonances. The extracted values of
Σ
have been compared to predictions based on partial-wave analyses (PWAs) of the existing pion photoproduction database. Our comparison includes the SAID, MAID and Bonn–Gatchina analyses; while a revised SAID fit, including the new
Σ
measurements, has also been performed. In addition, isospin symmetry is examined as a way to predict
π
0
n
photoproduction observables, based on fits to published data in the channels
π
0
p
,
π
+
n
and
π
-
p
.
Analysis of pion photoproduction data Arndt, R. A.; Briscoe, W. J.; Strakovsky, I. I. ...
Physical review. C, Nuclear physics,
11/2002, Letnik:
66, Številka:
5
Journal Article
PDF
