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•An ultrathin MOF nanosheet with cavity structures was fabricated for uranium removal.•It has excellent selectivity for uranium in the presence of multiple coexisting ions.•The ...selectivity coefficient (SU/M) can reach as high as 3.69 × 105.•The MOF nanosheet exhibited extremely high anti-interference capability.•Superb adsorption rate (<20 min) and removal efficiency for uranium (>98 %) were reached in groundwater.
Highly efficient and selective removal of uranium from aqueous media is crucial for the sustained development of nuclear energy. Herein, we utilized the intrinsic advantages of two-dimensional (2D) metal–organic frameworks (MOFs) and developed an ultrathin 2D MOF nanosheet with cavity structure. The preconcentration of the pocket-like cavities on the MOF nanosheet and sufficient interactions with the adsorption sites in the cavity structure realized highly efficient removal of uranium from water. Even in the low concentration range of 0.05–1 ppm, relatively high removal ratios and fast adsorption kinetics still can be achieved. Additionally, the MOF nanosheet exhibited extremely high anti-interference capability, which can efficiently reduce uranium pollution (0.05–1 ppm) in acid groundwater to the safe level (≤30 ppb) recommended by World Health Organization, and the removal performance was comparable to that in deionized water. The adsorption mechanism was thoroughly studied by Fourier transform infrared analysis, X-ray photoelectron spectroscopy, and density functional theory calculations, which revealed that the interactions between uranyl ions and the carboxylate groups dominated uranium adsorption, and the H-bonding interactions in the pocket-like cavities played an important role in uranium extraction.
Acute myeloid leukemia (AML) is an aging-related and heterogeneous hematopoietic malignancy. In this study, a total of 1,474 newly diagnosed AML patients with RNA sequencing data were enrolled, and ...targeted or whole exome sequencing data were obtained in 94% cases. The correlation of aging-related factors including age and clonal hematopoiesis (CH), gender, and genomic/transcriptomic profiles (gene fusions, genetic mutations, and gene expression networks or pathways) was systematically analyzed. Overall, AML patients aged 60 y and older showed an apparently dismal prognosis. Alongside age, the frequency of gene fusions defined in the World Health Organization classification decreased, while the positive rate of gene mutations, especially CH-related ones, increased. Additionally, the number of genetic mutations was higher in gene fusion-negative (GF-) patients than those with GF. Based on the status of CH- and myelodysplastic syndromes (MDS)-related mutations, three mutant subgroups were identified among the GF- AML cohort, namely, CH-AML, CH-MDS-AML, and other GF- AML. Notably, CH-MDS-AML demonstrated a predominance of elderly and male cases, cytopenia, and significantly adverse clinical outcomes. Besides, gene expression networks including
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, platelet factors, and inflammatory responses were most striking features associated with aging and poor prognosis in AML. Our work has thus unraveled the intricate regulatory circuitry of interactions among different age, gender, and molecular groups of AML.
•Ilepcimide (ICM) is structurally similar to lamotrigine (LTG).•Similar to LTG, ICM is a high-potency Na+ channel blocker.•ICM exhibited concentration- and voltage-dependent tonic inhibition of Na+ ...current.•ICM mainly affected inactivated forms of voltage-gated Na+ channels.•ICM slowed the recovery from inactivation of voltage-gated Na+ channels.
Ilepcimide (ICM), a clinically effective antiepileptic drug, has been used in China for decades; however, its antiepileptic mechanism remains unclear. ICM is structurally similar to antiepileptic drug lamotrigine (LTG). LTG exerts its anticonvulsant effect by inhibiting voltage-gated Na+ channel (NaV) activity. Thus it is speculated that ICM also exert its antiepileptic activity by inhibiting sodium channel activity. We studied the inhibition of NaV activity by ICM in acutely isolated mouse hippocampal pyramidal neurons. We evaluated ICM-mediated tonic, concentration-dependent, and voltage-dependent inhibition of NaV, and the effects of ICM and LTG on NaV biophysical properties. Na+ currents in hippocampal pyramidal neurons were tonically inhibited by ICM in a concentration- and voltage-dependent manner. The half-maximal inhibitory concentration (IC50) of ICM at a holding potential (Vh) of -90 mV was higher than that at a Vh of -70 mV. Compared with the control groups, in the presence of 10 μM ICM, the current densities of Na+ channels were reduced, the half-maximal availability of the inactivation curve (V1/2) was shifted to more negative potentials, and the recovery from inactivation was delayed. These data can contribute to further investigation of the inhibitory effect of ICM on the sodium channel, suggesting that the main reason for the anticonvulsant effect of ICM is the small influx of sodium ions. ICM can prevent abnormal discharge of neurons, which may prevent epilepsy.
Seedling quality is a prerequisite for successful field performance and therefore influences crop yields. Temperature and illumination are two major factors affecting seedling quality during nursery ...propagation. Suboptimal temperature or light of nurseries generally result in leggy or weak seedlings and great economic loss. However, production of healthy seedlings is challenging due to the lack of knowledge in systemic management of nursery environments. In this study, we have established simulation models to predict how temperature and illumination coordinately influence the growth of tomato and cabbage seedlings. Specifically, correlation between seedling quality characteristics (root-shoot ratio, G value (growth function: defined as ratio of whole plant dry weight to days of seedling), healthy indexes) and TEP (thermal effectiveness and photosynthetically active radiation) were explored to establish the models, which were validated with independent test data. Our results suggested that the curve of healthy index 1 (HI1) and TEP fitted well with high coefficient of determination (R2) in both species, indicating that the model is highly reliable. The HI1 simulation models for tomato and cabbage are HI1=0.0009e0.0308TEP?0.0015 and HI1= 0.0003e0.0671TEP?0.0003, respectively, which can be used for predicting vigors of tomato and cabbage seedlings grown under different temperature and light conditions.
Gastrointestinal bleeding (GIB) is the most common serious bleeding complication of antiplatelet therapy. The bleeding risk score (BRS) of GIB may help to determine the risk of bleeding, and provides ...a reference for the formulation of antiplatelet therapy regimen in clinical practice, but we found that no specific risk scores are available in East Asian patients. This study analyzed patients who were administered antiplatelet therapy from May 2015 to December 2018 in two medical centers. Patient's baseline data were obtained. We assessed four BRSs (New Score, RIETE Score, Cuschieri Score, de Groot Score) and compared them using the area under the receiver operating characteristic curve (AUC). The 4,052 patients enrolled in this study had an average age of 69.6 ± 10.8 years, and 65.9% of them were male. Among the 4,052 patients included, 171 patients experienced GIB within 6 months of follow-up. In the study population, the AUCs for the New, RIETE, Cuschieri, and de Groot scores were 0.673 (95% confidence interval (CI) 0.616-0.729, P < .001), 0.742 (95% CI 0.690-0.794, P < .001), 0.598 (95% CI 0.537-0.659, P = .002), and 0.875 (95% CI 0.839-0.912, P < .001), respectively. After validation, the de Groot Score has better performance. Among the four scores, the de Groot Score might be more suitable for helping Chinese clinicians to predict the risk of GIB in patients taking antiplatelet drugs, and reduce GIB events.
Celotno besedilo
Dostopno za:
DOBA, IJS, IZUM, KILJ, NUK, PILJ, PNG, SAZU, UILJ, UKNU, UL, UM, UPUK
Bio-based polymers are recognized as promising alternatives to fossil-based counterparts. However, the inferior material performance of bio-based polymers is a serious restriction to their ...application fields. Herein, renewable polyethylene-like materials (PLMs) are used as surface coatings for commercial fabrics. First, α,ω-diene monomers were synthesized by the downstream products of sugar and castor oil derivatives. Subsequently, biomass-derived polymers were generated via acyclic diene metathesis (ADMET) (co)polymerization of these monomers followed by exhaustive hydrogenation. The obtained long-chain aliphatic polyesters are considered remarkable polyethylene mimics in that these hydrophobic and semicrystalline materials show unique features such as hydrolysis resistance and recyclability. On the other hand, PLM nanoparticles were prepared by the nanoprecipitation method and then drop-cast on commercial fabric surfaces. Hydrophobically modified fabrics show repellency to various water droplets and the capability of oil/water separation as well as anti-icing and anticorrosive characteristics. Moreover, photoinduced contaminant removal and wettability change are realized by fabrics with a hybrid coating layer composed of PLM and titanium dioxide (TiO2) nanoparticles. These polyethylene-mimetic materials not only meet the requirements of sustainability in terms of renewability and recyclability but also show great prospects in surface functionalization of commercial fabrics and upcycling of waste textiles.
The Asian pitviper genus Ovophis is a group of venomous snakes widely distributed in mid to high elevation mountains in Asia, and presently five species are recognised. However, its systematics, ...species diversity and species distribution boundaries remain poorly understood. We reconstructed the phylogenetic relationships and explored species diversity of Chinese Ovophis based on two mitochondrial fragments (Cyt b and ND4) and four nuclear genes (BACH1, c‐mos, Rag1, NT3) and also conducted a morphological comparison between focal species. Our results indicated that the species diversity had been underestimated within Ovophis and we described a population from southern Yunnan, China, as a new taxon, naming it as Ovophis malhotrae sp. nov. Based on more extensive sampling, we redefined the distribution of O. monticola and O. makazayazaya in China. Divergence date estimation suggested that Ovophis originated at about 16.79 Ma in the middle Miocene.
Thrombocytopenia caused by long-term radiotherapy and chemotherapy exists in cancer treatment. Previous research demonstrates that 5-Hydroxtrayptamine (5-HT) and its receptors induce the formation of ...megakaryocytes (MKs) and platelets. However, the relationships between 5-HT1A receptor (5-HTR1A) and MKs is unclear so far. We screened and investigated the mechanism of vilazodone as a 5-HTR1A partial agonist in promoting MK differentiation and evaluated its therapeutic effect in thrombocytopenia. We employed a drug screening model based on machine learning (ML) to screen the megakaryocytopoiesis activity of Vilazodone (VLZ). The effects of VLZ on megakaryocytopoiesis were verified in HEL and Meg-01 cells. Tg (itga2b: eGFP) zebrafish was performed to analyze the alterations in thrombopoiesis. Moreover, we established a thrombocytopenia mice model to investigate how VLZ administration accelerates platelet recovery and function. We carried out network pharmacology, Western blot, and immunofluorescence to demonstrate the potential targets and pathway of VLZ. VLZ has been predicted to have a potential biological action. Meanwhile, VLZ administration promotes MK differentiation and thrombopoiesis in cells and zebrafish models. Progressive experiments showed that VLZ has a potential therapeutic effect on radiation-induced thrombocytopenia in vivo. The network pharmacology and associated mechanism study indicated that SRC and MAPK signaling are both involved in the processes of megakaryopoiesis facilitated by VLZ. Furthermore, the expression of 5-HTR1A during megakaryocyte differentiation is closely related to the activation of SRC and MAPK. Our findings demonstrated that the expression of 5-HTR1A on MK, VLZ could bind to the 5-HTR1A receptor and further regulate the SRC/MAPK signaling pathway to facilitate megakaryocyte differentiation and platelet production, which provides new insights into the alternative therapeutic options for thrombocytopenia.
Background
The most prevalent sustained arrhythmia in medical practice, atrial fibrillation (AF) is closely associated with a high risk of cardiovascular disease. Nevertheless, the risk of AF ...associated with cardiovascular risk factors has not been well elucidated. We pooled all published studies to provide a better depiction of the relationship among cardiovascular risk factors with AF.
Methods
Studies were searched in the MEDLINE, Web of Science, and EMBASE databases since initiation until January 15, 2022. Prospective cohort studies assessing the relationship a minimum of single cardiovascular risk factors to AF incidence were included if they contained adequate data for obtaining relative risks (RR) and 95% confidence intervals (CI). Random-effects models were utilized to perform independent meta-analyses on each cardiovascular risk factor. PROSPERO registry number: CRD42022310882.
Results
A total of 17,098,955 individuals and 738,843 incident cases were reported for data from 101 studies included in the analysis. In all, the risk of AF was 1.39 (95% CI, 1.30–1.49) for obesity, 1.27 (95% CI, 1.22–1.32) per 5 kg/m
2
for increase in body mass index, 1.19 (95% CI, 1.10–1.28) for former smokers, 1.23 (95% CI, 1.09–1.38) for current smokers, 1.31 (95% CI, 1.23–1.39) for diabetes mellitus, 1.68 (95% CI, 1.51–1.87) for hypertension, and 1.12 (95% CI, 0.95–1.32) for dyslipidemia.
Interpretation
Adverse cardiovascular risk factors correlate with an increased risk of AF, yet dyslipidemia does not increase the risk of AF in the general population, potentially providing new insights for AF screening strategies among patients with these risk factors.
Systematic Review Registration
https://www.crd.york.ac.uk/PROSPERO/
, PROSPERO identifier (CRD42022310882).
Objective
To assess the association of baseline anti‐Müllerian hormone (AMH) levels with ovulation, time to ovulation and fertility outcomes in women with polycystic ovary syndrome (PCOS) receiving ...clomiphene citrate (CC) and compare this with placebo.
Design
Secondary analysis of the PCOSAct trial (NCT01573858).
Setting
27 trial centres in mainland China.
Population or sample
1000 infertile women with PCOS receiving either CC or placebo.
Methods
Baseline serum AMH was measured and analysed as a continuous and as a categorical variable. Interaction between AMH and CC was tested. Predictive values of AMH for ovulation, time to ovulation and fertility outcomes were assessed.
Main outcome measures
Ovulation and time to ovulation.
Results
900 baseline AMH data were available for analysis. There were no significant interactions with ovulation or conception for AMH and CC treatment (P = 0.782 and 0.419, respectively). Women in the upper quartile of AMH >15.88 ng/ml had significant lower ovulation (odds ratio OR 0.34, 95% CI 0.20–0.58) and conception rates (OR 0.65, 95% CI 0.42–1.00) compared with women in the lower quartile. Associations of AMH with clinical pregnancy (OR 0.98, 95% CI 0.95–1.01) and live birth (OR 0.98, 95% CI 0.96–1.01) were not significant. Ovulation rate increased until baseline AMH levels ≥7.0 ng/ml in women treated with CC but decreased when AMH increased in women with placebo. When AMH <7.0 ng/ml, an AMH threshold at 4.11 ng/ml predicted ovulation in women receiving CC (area under the curve AUC 0.64, 95% CI 0.42–0.86), with a sensitivity of 64% and a specificity of 62%, whereas prediction was poor for AMH ≥7.0 ng/ml (AUC 0.38, 95% CI 0.28–0.47). Median time to ovulation was 35 days in the lower quartile for women with placebo but this was significantly prolonged up to 98 days in the upper quartile. CC significantly shortened the time to ovulation up to 56 days.
Conclusions
Among women with PCOS, high baseline AMH levels were associated with a 20.1% lower chance of ovulation with a 63‐day longer time to ovulation. AMH can predict ovulation only when the baseline AMH level was <7.0 ng/ml in women with PCOS undergoing ovulation induction with CC.
Tweetable
Ovulation rate increased until baseline AMH levels ≥7.0 ng/ml in women treated with CC; a successful ovulation and time to ovulation was highly associated with baseline AMH level in these women.
Tweetable
Ovulation rate increased until baseline AMH levels ≥7.0 ng/ml in women treated with CC; a successful ovulation and time to ovulation was highly associated with baseline AMH level in these women.
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