The underlying aim of this study was to investigate the impact of human resource management (HRM) practices, organizational identity, and brand leadership on employee brand-based equity through the ...mediatory role of brand knowledge dissemination. A questionnaire was adopted to obtain data from 421 employees working in the construction sector of China. The SmartPLS software was used to analyze the data with the help of a structural equation modeling (SEM) technique. The results revealed that HRM practices and organizational identity had a positive and significant relationship with employee brand-based equity, while brand leadership had no direct impact on employee brand-based equity. The results also revealed that brand knowledge dissemination mediated the relationship between independent variables (HRM practices, organizational identity, and brand leadership) and dependent variable (employee brand-based equity). Theoretically, this paper made a valuable contribution by examining the impact of HRM practices, organizational identity, and brand leadership on employee brand-based equity. In terms of practical implications, this study would obviously help the organizations to improve their employee brand-based equity through HRM practices and organizational identity.
A visible‐light‐induced C–H cyanoalkylation of heteroarenes was described, in which cycloketone oximes were readily transformed into carbon‐centered radicals with a terminal cyano‐group via N–O/C–C ...bonds cleavage in one phtochemical step. This reaction protocol displayed a broad substrate scope of heterocycle compounds, and it provided a promising strategy for the installation of cyanoalkyl groups onto heteroarenes.
A visible‐light‐induced C–H cyanoalkylation of heteroarenes was described, in which cycloketone oximes were readily transformed into carbon‐centered radicals with a terminal cyano‐group via N–O/C–C bonds cleavage in one phtochemical step.
RIPK3 amyloid complex plays crucial roles during TNF-induced necroptosis and in response to immune defense in both human and mouse. Here, we have structurally characterized mouse RIPK3 homogeneous ...self-assembly using solid-state NMR, revealing a well-ordered N-shaped amyloid core structure featured with 3 parallel in-register β-sheets. This structure differs from previously published human RIPK1/RIPK3 hetero-amyloid complex structure, which adopted a serpentine fold. Functional studies indicate both RIPK1-RIPK3 binding and RIPK3 amyloid formation are essential but not sufficient for TNF-induced necroptosis. The structural integrity of RIPK3 fibril with three β-strands is necessary for signaling. Molecular dynamics simulations with a mouse RIPK1/RIPK3 model indicate that the hetero-amyloid is less stable when adopting the RIPK3 fibril conformation, suggesting a structural transformation of RIPK3 from RIPK1-RIPK3 binding to RIPK3 amyloid formation. This structural transformation would provide the missing link connecting RIPK1-RIPK3 binding to RIPK3 homo-oligomer formation in the signal transduction.
An organophotoelectrocatalytic method for the C(sp
2
)-H alkylation of heteroarenes with unactivated C(sp
3
)-H compounds through dehydrogenation cross-coupling has been developed. The C(sp
2
)-H ...alkylation combines organic catalysis, photochemistry and electrochemistry, avoiding the need for external metal-reagents, HAT-reagents, and oxidants. This protocol exhibits good substrate tolerance and functional group compatibility, providing a straightforward and powerful pathway to access a variety of alkylated heteroarenes under green conditions.
An organophotoelectrocatalytic method for the C(sp
2
)-H alkylation of heteroarenes with unactivated C(sp
3
)-H compounds
via
dehydrogenation cross-coupling was developed.
Sepsis, a life‐threatening condition stemming from an uncontrolled host immune response to bacterial infections, continues to impose a significant global burden with high morbidity and mortality. ...Addressing the challenges posed by antimicrobial resistance and uncontrollable inflammation remains a challenge in sepsis treatment. Moreover, traditional antibacterial materials have low bacterial trapping efficiency and inevitable prolonged circulation within the bloodstream, resulting in suboptimal antibacterial effects, metabolic complications, and undesirable side effects. In this study, an innovative solution is introduced through the development of Fe3O4@SH@TBTCP‐PMB, an aggregation‐induced emission (AIE) photosensitizer (PS)‐armored magnetic nanoparticles (NPs). It has high reactive oxygen species (ROS) generation efficiency and an exceptional ability to capture Gram‐positive bacteria with over 80% enrichment efficiency within just 1 h, even at low bacterial concentrations. Under white light illumination, 100 µg mL−1 of Fe3O4@SH@TBTCP‐PMB effectively eliminated more than 99.9% of methicillin‐resistant Staphylococcus aureus (MRSA). Furthermore, its magnetic separation properties efficiently prevent systemic blood circulation and associated side effects. Most importantly, Fe3O4@SH@TBTCP‐PMB demonstrates superior anti‐inflammatory effects by regulating cytokines, reducing adhesion molecule expression, and managing oxidative stress levels. This multifunctional approach significantly enhances sepsis survival rates, offering a promising strategy for combating multidrug‐resistant (MDR) bacterial infections in sepsis patients while addressing inflammation‐related complications.
An aggregation‐induced emission photosensitizer‐armored magnetic nanoparticle, Fe3O4@SH@TBTCP‐PMB, that combines high ROS generation efficiency and magnetic trapping and separation character to circumvent the potential toxic side effects associated with prolonged blood circulation and metabolic challenges. It efficiently traps Gram‐positive bacteria, eliminates multidrug‐resistant bacteria, attenuates the inflammatory response, and restores the innate immune defense system to conquer sepsis in mouse model.
The hydrogen evolution reaction (HER) based on water electrolysis is a promising strategy for hydrogen energy production, in which the key point is seeking low-cost, high efficiency and stable ...electrocatalysts. Currently, the most efficient electrocatalysts for the HER are Pt-based catalysts (especially commercial Pt/C), but the low abundance and high cost of Pt hinder their widespread application. Herein, we demonstrate that a cobalt molybdenum phosphide nanocrystal coated by a few-layer N-doped carbon shell (CoMoP@C) is an excellent substitute for the HER. CoMoP@C is prepared by a one-step pyrolysis method on a large scale with polyoxometalate (POM) as a molecular platform. The catalytic activity of CoMoP@C is close to that of commercial 20% Pt/C under pH = 0–1 conditions and superior to that of 20% Pt/C under pH = 2–14 conditions at high overpotential ( e.g. η > 240 mV at pH = 2.2). In real seawater, CoMoP@C exhibits stable HER performance with a high Faradaic efficiency (FE) of 92.5%, while the HER activity of 20% Pt/C dramatically decreases after 4 h. The remarkable HER performance of CoMoP@C should be attributed to the low free energy of H on the central CoMoP crystalline core and the multiple functions of the outer N-doped C shell (especially the strong H + absorption behavior). This work may provide new options for the design and preparation of promising HER electrocatalysts superior to Pt/C, which can be used directly in seawater.
AbstractThis case study presents an investigation on building settlement induced by dewatering for a deep excavation constructed in a deposit in Tianjin, China. The excavation site is located in the ...Tianjin urban center, around which there are many existing buildings. Geological conditions at the site involve a multiaquifer system with one phreatic aquifer over three confined aquifers. To maintain the stability of the bottom of the excavation, a cutoff wall was used to block groundwater seepage with large diameter wells to lower the groundwater level. Field instrumentation was installed during construction to monitor (1) the quantity of withdrawn groundwater, (2) the groundwater head, and (3) the settlement of surrounding buildings. The field observations yielded the following results and implications: (1) pumping of groundwater could lead to large building settlement and a large area of ground settlement; (2) most of the settlement caused by dewatering did not rebound; (3) the cutoff wall played a significant role in reducing the building settlement during dewatering; and (4) the dewatering-on-demand procedure should be implemented during excavation.
LiCoO2, discovered as a lithium‐ion intercalation material in 1980 by Prof. John B. Goodenough, is still the dominant cathode for lithium‐ion batteries (LIBs) in the portable electronics market due ...to its high compacted density, high energy density, excellent cycle life and reliability. In order to satisfy the increasing energy demand of portable electronics such as smartphones and laptops, the upper cutoff voltage of LiCoO2‐based batteries has been continuously raised for achieving higher energy density. However, several detrimental issues including surface degradation, damages induced by destructive phase transitions, and inhomogeneous reactions could emerge as charging to a high voltage (>4.2 V vs Li/Li+), which leads to the rapid decay of capacity, efficiency, and cycle life. In this review, the history and recent advances of LiCoO2 are introduced, and a significant section is dedicated to the fundamental failure mechanisms of LiCoO2 at high voltages (>4.2 V vs Li/Li+). Meanwhile, the modification strategies and the development of LiCoO2‐based LIBs in industry are also discussed.
In this review, the history of LiCoO2's commercialization and the progress of LiCoO2 after commercialization are summarized. A significant section is dedicated to the fundamental failure mechanisms of LiCoO2 at high voltages (>4.2 V versus Li/Li+) and the corresponding modification strategies. Moreover, the history of LiCoO2‐based lithium ion batteries in industry is also presented.
A series of new hyperbranched aliphatic poly(β-thioether ester)s were prepared by the enzymatic ring-opening polycondensation of 1,4-oxathiepan-7-one (OTO) and AB
/ABB' comonomer with acid-labile ...β-thiopropionate groups. Two kinds of comonomers, methyl 3-((3-hydroxy-2-(hydroxymethyl)propyl)thio)propanoate (HHTP) and methyl 3-((2,3-dihydroxypropyl)thio)propanoate (DHTP), with different primary alcohols and secondary alcohols, were synthesized by thiol-ene click chemistry and thiol-ene Michael addition, respectively. Immobilized lipase B from
(CALB), Novozym 435, was used as the catalyst. The random copolymers were characterized by
H-NMR,
C-NMR, GPC, TGA, and DSC. All branched copolyesters had high molecular weights over 15,000 Da with narrow polydispersities in the range of 1.75-2.01 and were amorphous polymers. Their degradation properties under acidic conditions were also studied in vitro. The polymeric nanoparticles of hyperbranched poly(β-thioether ester)s were successfully obtained and showed good oxidation-responsive properties, indicating their potential for biomedical applications.
Background and Purpose
Increasing evidence has indicated that the high risk of cardiovascular disease in chronic kidney disease (CKD) patients cannot be sufficiently explained by classic risk ...factors.
Experimental Approach
Based on the least absolute shrinkage and selection operator method, we identified significantly altered renal tissue metabolites during progressive CKD in a 5/6 nephrectomized rat model and in CKD patients.
Key Results
Six aryl‐containing metabolites (ACMs) were significantly increased from Week 1 to Week 20. They were associated with the activation of aryl hydrocarbon receptor (AhR) and its target genes including CYP1A1, CYP1A2 and CYP1B1, which were further validated by molecular docking. Our study further demonstrated that AhR signalling could be activated by ACM in patients with idiopathic membranous nephropathy, diabetic nephropathy and IgA nephropathy. Most importantly, 1‐aminopyrene (AP) showed strong positive and negative correlation with serum creatinine and creatinine clearance, respectively. AP significantly up‐regulated the mRNA expressions of AhR and its three target genes in both mice and NRK‐52E cells, while this effect was partially weakened in AhR small hairpin RNA‐treated mice and NRK‐52E cells. Furthermore, dietary flavonoid supplementation ameliorated CKD and renal fibrosis through partially inhibiting the AhR activity via lowering the ACM levels. The antagonistic effect of flavonoids on AhR was deeply influenced by the number and location of hydroxyl and glycosyl groups.
Conclusion and Implications
We uncovered that endogenous AP is a novel mediator of CKD progression via AhR activation; thus, AhR might serve as a promising target for CKD treatment.
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