Substrate integrated waveguide (SIW) technology provides an attractive solution to the integration of planar and nonplanar circuits by using a planar circuit fabrication process. However, it is ...usually difficult to implement the negative coupling structure required for the design of compact canonical folded elliptic or quasi-elliptic cross-coupled bandpass filter on the basis of a single-layer SIW. In this paper, a special planar negative coupling scheme including a magnetic coupling post-wall iris and a balanced microstrip line with a pair of metallic via-holes is studied in detail. Two -band fourth-degree cross-coupled bandpass filters without and with source-load coupling using the negative coupling structures are then proposed and designed. The two novel SIW filters having the same center frequency of 20.5 GHz and respective passband width of 700 and 800 MHz are implemented on a single-layer Rogers RT/Duroid 5880 substrate with thickness of 0.508 mm. Measured results of those filters, which exhibit a high selectivity, and a minimum in-band insertion loss of approximately 0.9 and 1.0 dB, respectively, agree well with simulated results.
To investigate the acoustic emission characteristic of rock under different compressive loading rates, a numerical approach using the bonded-particle model (BPM) is adopted in the present study. It ...reveals that under uniaxial compressive test, the physical mechanism and distribution of AE events recorded by the BPM are generally consistent with the phenomena observed from the laboratory experiments. The total crack number, tensile crack number, shear crack number and AE event number increase as the loading rate increases. The increase of loading rates from 0.005m/s to 0.6m/s in the BPM does not have obvious influence on the distribution of AE events.
We report acute antibody responses to SARS-CoV-2 in 285 patients with COVID-19. Within 19 days after symptom onset, 100% of patients tested positive for antiviral immunoglobulin-G (IgG). ...Seroconversion for IgG and IgM occurred simultaneously or sequentially. Both IgG and IgM titers plateaued within 6 days after seroconversion. Serological testing may be helpful for the diagnosis of suspected patients with negative RT-PCR results and for the identification of asymptomatic infections.
With the rapid development of mechanical equipment, the mechanical health monitoring field has entered the era of big data. However, the method of manual feature extraction has the disadvantages of ...low efficiency and poor accuracy, when handling big data. In this study, the research object was the asynchronous motor in the drivetrain diagnostics simulator system. The vibration signals of different fault motors were collected. The raw signal was pretreated using short time Fourier transform （STFT） to obtain the corresponding time-frequency map. Then, the feature of the time-frequency map was adap- tively extracted by using a convolutional neural network （CNN）. The effects of the pretreatment method, and the hyper parameters of network diagnostic accuracy, were investigated experimentally. The experimental results showed that the influence of the preprocessing method is small, and that the batch-size is the main factor affecting accuracy and training efficiency. By investigating feature visualization, it was shown that, in the case of big data, the extracted CNN features can represent complex mapping relationships between signal and health status, and can also overcome the prior knowledge and engineering experience requirement for feature extraction, which is used by tra- ditional diagnosis methods. This paper proposes a new method, based on STFT and CNN, which can complete motor fault diagnosis tasks more intelligently and accurately.
In this paper, synthesis and design techniques of dual- and triple-passband filters with Chebyshev and quasi-elliptic symmetric frequency responses are proposed and demonstrated for the first time on ...the basis of substrate integrated waveguide technology. The inverter coupled resonator section is first investigated, and then a dual-passband Chebyshev filter, a triple-passband Chebyshev filter, and a dual-passband quasi-elliptic filter, which consist of the inverter coupled resonator sections, are synthesized from the generalized low-pass prototypes having Chebyshev or quasi-elliptic responses, respectively. Subsequently, theses filters with a symmetric response are designed and implemented using the substrate integrated waveguide scheme over the -band frequency range. The inverter coupled resonator sections composed of side-by-side horizontally oriented substrate integrated waveguide cavities are coupled, in turn, by post-wall irises. 50-Omega microstrip lines are used to directly excite the filters. Measured results are presented and compared to those simulated by Ansoft's High Frequency Structure Simulator (HFSS) software package. A good agreement between the simulated and measured results is observed, which has also validated the proposed concept of design and synthesis with the substrate integration technology.
To evaluate BPA's potential risk to health, it is important to know human daily intake. This study describes a simple but effective method to estimate the levels of human BPA intake among four ...different populations based on urinary concentration data. Nationally, of the 30 countries examined, the top ten countries for adult intake were Italy, Sweden, Denmark, France, Cyprus, Australia, Israel, Ghana, Jamaica, and Belgium. When the urinary excretion sample size was large enough and over 1000, it was found that the national estimated BPA daily intakes in the child group among countries, showed a good linear relationship with those of their corresponding adult group. Except the infant group with limited data, the global estimated BPA daily intakes for children and pregnant women were 2 and 1.4 times that of the adult group. Although the national and global estimated BPA daily intakes were generally below the temporary tolerable daily intake (tTDI) recommended by the European Food Safety Authority (EFSA), but some normal individuals' daily intakes exceeded the tTDI.
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•A simple but effective method to estimate human BPA daily intake is given.•Urinary excretion sample size is an important factor for the estimation.•Global BPA daily intakes among four different populations are presented.•Global BPA daily intake in adult groups showed linear relationship with that of Children group.
Important findings: With the human urinary concentration data, the worldwide daily intakes of BPA were successfully provided.
The occurrence and removal mechanisms of bisphenol A (BPA) and its analogues in municipal WWTPs were critically reviewed in this article. BPA appeared to be the dominant bisphenol, and the removal ...efficiency of bisphenols was in the order of bisphenol AP>bisphenol P>bisphenol F>bisphenol Z>bisphenol C>bisphenol S>bisphenol B>BPA>bisphenol E>bisphenol AF. It was also found that BPA removal showed linear relationships to those of its analogues, which have been proven by BPA vs BPS or BPF. BPA removal performances in different treatment processes ranked from low to high are primary treatment, lagoon process, biological aerated filter, and activated sludge. Lab-scale studies showed that >50% BPA can be removed by sewage sludge estimated with the BPA solid water distribution coefficients, which showed that sludge adsorption played an important role on BPA removal. The theoretically predicted removal of BPA in municipal WWTP showed that it is readily biodegradable, which deviate from its on-site investigations. Existence of BPA conjugates in raw municipal wastewater as well as newly produced BPA degraded or migrated from microplastic materials are possible two main reasons.
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•Removals of BPA and its analogues in municipal WWTPs were summarized and analyzed.•BPA removal differences among different treatment processes were given.•BPA removals by adsorption and biodegradation were discussed.•Factors influencing BPA removals were summarized and discussed.
Cross-species transmission of viruses from wildlife animal reservoirs poses a marked threat to human and animal health
. Bats have been recognized as one of the most important reservoirs for emerging ...viruses and the transmission of a coronavirus that originated in bats to humans via intermediate hosts was responsible for the high-impact emerging zoonosis, severe acute respiratory syndrome (SARS)
. Here we provide virological, epidemiological, evolutionary and experimental evidence that a novel HKU2-related bat coronavirus, swine acute diarrhoea syndrome coronavirus (SADS-CoV), is the aetiological agent that was responsible for a large-scale outbreak of fatal disease in pigs in China that has caused the death of 24,693 piglets across four farms. Notably, the outbreak began in Guangdong province in the vicinity of the origin of the SARS pandemic. Furthermore, we identified SADS-related CoVs with 96-98% sequence identity in 9.8% (58 out of 591) of anal swabs collected from bats in Guangdong province during 2013-2016, predominantly in horseshoe bats (Rhinolophus spp.) that are known reservoirs of SARS-related CoVs. We found that there were striking similarities between the SADS and SARS outbreaks in geographical, temporal, ecological and aetiological settings. This study highlights the importance of identifying coronavirus diversity and distribution in bats to mitigate future outbreaks that could threaten livestock, public health and economic growth.
Obesity and related metabolic diseases are becoming worldwide epidemics that lead to increased death rates and heavy health care costs. Effective treatment options have not been found yet. Here, ...based on the observation that baicalin, a flavonoid from the herbal medicine Scutellaria baicalensis, has unique antisteatosis activity, we performed quantitative chemoproteomic profiling and identified carnitine palmitoyltransferase 1 (CPT1), the controlling enzyme for fatty acid oxidation, as the key target of baicalin. The flavonoid directly activated hepatic CPT1 with isoform selectivity to accelerate the lipid influx into mitochondria for oxidation. Chronic treatment of baicalin ameliorated diet-induced obesity (DIO) and hepatic steatosis and led to systemic improvement of other metabolic disorders. Disruption of the predicted binding site of baicalin on CPT1 completely abolished the beneficial effect of the flavonoid. Our discovery of baicalin as an allosteric CPT1 activator opens new opportunities for pharmacological treatment of DIO and associated sequelae.
A series of neutral cubic nickel(II)-imidazolate Ni8L12X4 cages were prepared by rational choices of substituents and anions with solvothermal subcomponent self-assembly technology. Both substituents ...and halide anions play a critical role in the formation and stabilization of cubic cages. Changing one of the factors in the reaction will switch the final structure to a Ni14L24 rhombic dodecahedral cage. The cubic cage can transform to a large rhombic dodecahedral cage in the presence of methylamine at room temperature accompanied by a color change from purple to light yellow.
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