Heart failure (HF) is an uncommon but serious cardiovascular complication after allogeneic hematopoietic stem cell transplantation (allo-HSCT). Unfortunately, knowledge about early mortality ...prognostic factors in patients with HF after allo-HSCT is limited, and an easy-to-use prognostic model is not available. This study aimed to develop and validate a clinical-biomarker prognostic model capable of predicting HF mortality following allo-HSCT that uses a combination of variables readily available in clinical practice. To investigate this issue, we conducted a retrospective analysis at our center with 154 HF patients who underwent allo-HSCT between 2008 and 2021. The patients were separated according to the time of transplantation, with 100 patients composing the derivation cohort and the other 54 patients composing the external validation cohort. We first calculated the univariable association for each variable with 2-month mortality in the derivation cohort. We then included the variables with a P value <.1 in univariate analysis as candidate predictors in the multivariate analysis using a backward stepwise logistic regression model. Variables remaining in the final model were identified as independent prognostic factors. To predict the prognosis of HF, a scoring system was established, and scores were assigned to the prognostic factors based on the regression coefficient. Finally, 4 strongly significant independent prognostic factors for 2-month mortality from HF were identified using multivariable logistic regression methods with stepwise variable selection: pulmonary infection (P = .005), grade III to IV acute graft-versus-host disease (severe aGVHD; P = .033), lactate dehydrogenase (LDH) >426 U/L (P = .049), and brain natriuretic peptide (BNP) >1799 pg/mL (P = .026). A risk grading model termed the BLIPS score (for BNP, LDH, cardiac troponin I, pulmonary infection, and severe aGVHD) was constructed according to the regression coefficients. The validated internal C-statistic was .870 (95% confidence interval CI, .798 to .942), and the external C-statistic was .882 (95% CI, .791-.973). According to the calibration plots, the model-predicted probability correlated well with the actual observed frequencies. The clinical use of the prognostic model, according to decision curve analysis, could benefit HF patients. The BLIPS model in our study can serve to identify HF patients at higher risk for mortality early, which might aid designing timely targeted therapies and eventually improving patients' survival and prognosis.
The mobility enhancement of organic thin‐film transistors based on poly(3‐hexylthiophene) (P3HT) by incorporating gold nanorods (Au NRs) is reported. Through varying the doping concentration and ...surface modifier of the Au NRs in P3HT matrix, the P3HT/Au composite with 0.5 mg mL−1 pyridine‐capped Au NRs exhibits a hole mobility of 0.059 cm2 V−1 s−1, this value is seven times higher than that of pristine P3HT. This remarkable improvement of mobility originates from the enhanced crystallinity and optimized orientation of P3HT after doping with Au NRs. In addition, the appropriate surface modification can produce more‐efficient hole conduction of Au NRs.
The incorporation of gold nanorods with alkylamino and pyridine ligands into a poly(3‐hexylthiophene) (P3HT) matrix leads to the mobility enhancement of P3HT‐based organic thin‐film transistors. This enhancement is attributed to the improved crystallinity of the P3HT film, and the optimized orientation of P3HT relative to the substrate.
In view of the possible disclosure of personal information in the quantum auction protocol, by using the correlation between entangled particles and quantum teleportation, we propose a secure quantum ...sealed-bid auction (QSBA) protocol based on semi-honest model. In this protocol, by introducing a trusted third party Trent, we separate the registration operation of users from the business function of auction center. Bidders and the auction center can realize quantum identity authentication without information disclosure, so as to reduce the risk of the auction center disclosing the personal information of bidders. With the help of Trent, using the quantum sequences to be the information carrier of bidding, the auction center and bidders can conduct quantum teleportation to obtain each bidding price. When the auction center publishes the bid price and serial number, the registration center also publishes the corresponding winning bidder. Through security analysis, our protocol can guarantee the anonymity of bidders and the integrity of bidding information.
The fluoritum is used for gynecology frequently and it's for those diseases: kidney yang deficiency, Gong cold sterility, palpitation due to fright, insomnia and dreaminess and cold cough. It's ruled ...in Chinese Pharmacopoeia (1985 edition) that the fluoritum originates from fluorite which belongs to fluoride minerals. Its main content is CaF2. The colors are of differents grades with purple or green. In the market, there are large differences in quality and it has various colors. Besides of the ruled color of purple and green, white and yellow are also common colors. By digging into and analysis the relevant research literature of fluorite which belongs to fluoride minerals, colors and coloration mechanism of fluorite are summarized in this paper.Natural fluorite is the mineral which has the most species of colors in nature. The different colors of fluorite are mainly caused by the impurity elements. At present, there are mainly about the coloration mechanism of fluorite: rare earth ions (4fN ions), color cen
We report solution processed high-kdielectric films with excellent insulating quality (leakage current densities similar to 10 super(-8) A cm super(-2) at 2 MV cm super(-1)), tunable dielectric ...constant (4.7-6.7) and high flexibility. The effects of incorporating different concentrations of barium zirconate (BZ) nanoparticles into poly-4-vinylphenol (PVP) gate dielectrics for flexible organic thin film transistors (OTFTs) were systematically studied. The effect of dielectric composition on the mobilities ( mu ), threshold voltages (V sub(T)), on/off ratios and subthreshold swings (S) has been discussed. The morphologies of dielectric and semiconductor films were investigated and shown to correlate closely with device performances. Two kinds of unipolar inverters based on these transistors have been fabricated and characterized. The depleted load inverter showed large signal gain and sharp switching. The electrical properties under various compressive and tensile strains evidenced the high mechanical stability of the dielectric films, hence the transistors and inverters. These findings will be of value for printable electronic devices on flexible substrates.
We demonstrate air-stable low voltage flexible nonvolatile memory transistors by embedding gold nanoparticles (Au NPs) in poly(methyl methacrylate) (PMMA) as the charge storage element. The solution ...processability of the nanocomposite is suitable for low-cost large area processing on flexible substrates. The memory transistor exhibits a memory window of 2.1 V, long retention time ( > 105 s) with low operating voltage (≤5 V). The memory behavior has been tuned via varying the composition of the fillers (Au NPs), which offers relatively easy processability for different flexible electronics applications. The electrical properties of the memory devices are found to be stable under bending. These findings will be of value for low cost and low voltage advanced flexible electronics.
To investigate the association of the ratio of regulatory and effector T cells with recurrence and chronic graft-versus-host disease (cGVHD) after allogeneic hematopoietic stem cell transplantation ...(allo-HSCT).
Thirty patients with hematological malignancies who underwent allo-HSCT were classified as recurrence with cGVHD (n=4), non-recurrence with cGVHD (n=14), recurrence without cGVHD (n=5) and non-recurrence without cGVHD (n=7). The different percentage of CD4⁺CD25⁻CD69⁺ regulatory T cells in bone marrow and CD4⁺CD25⁺FoxP3⁺ regulatory T cells, Th1 cells and Th17 cells in peripheral blood were analyzed by flow cytometry.
There were no significant differences in all these T-cell subsets among different groups (P>0.05). While the ratio of CD4⁺CD25⁻CD69⁺ regulatory T cells and Th1 cells (0.211±0.177) in 9 recurrence patients was significant higher than that (0.133±0.160) in 21 non-recurrence patients (P=0.033). The ratio were also significance between recurrence without cGVHD and non-recurrence without cGVHD p
A sensitive rapid method for the simultaneous determination of four major active alkaloids (dehydrocavidine, coptisine, dehydroapocavidine, and tetradehydroscoulerine, in abbreviation thereafter ...called YHL-I, YHL-II, YHL-III, and YHL-IV, respectively) from a Chinese traditional medicine
Corydalis saxicola Bunting. (Yanhuanglian) in rat plasma and urine was established and validated. The assay for these substances in plasma and urine was based on HPLC coupled with tandem mass spectrometry (MS/MS) detection using multiple reaction monitoring mode (MRM) with berberine and clenbuterol as internal standards. The plasma and urine sample were deproteinated by adding methanol prior to liquid chromatography where separation was performed on a Luna column (5
μm, 100
×
2.00
mm) and an Agilent Zorbax SB-C18 guard column (5
μm, 20
×
4
mm). The method was validated with the concentration range 1–1000
ng/mL in plasma and 10–1000
ng/mL in urine for the four test compounds, and the calibration curves were linear with correlation coefficients >0.999. The lowest limits of quantitation for all four substances were 1
ng/mL in 0.1
mL rat plasma and 10
ng/mL in 0.1
mL urine. The intra-assay accuracy and precision in plasma ranged from 88.1 to 115.7% and 1.4 to 10.8%, respectively, while inter-assay accuracy and precision for YHL-I, YHL-II, YHL-III, and YHL-IV ranged from 96.2 to 113.2% and 0.4 to 16.9%, respectively. The intra-assay accuracy and precision for YHL-I, YHL-II, YHL-III, and YHL-IV in rat urine ranged from 96.1 to 112.9% and 1.2 to 8.3%, respectively, while inter-assay accuracy and precision ranged from 95.0 to 106.8% and 2.2 to 10.3%, respectively. The method was further applied to assess pharmacokinetics and urine excretion of the four alkaloids after oral and intravenous administration to rats. Practical utility of this new LC–MS–MS method was confirmed in pilot pharmacokinetic studies in rats following both intravenous and oral administration.
Background: Mountain-cultivated ginseng (MCG) and cultivated ginseng (CG) both belong to Panax ginseng and have similar ingredients. However, their pharmacological activities are different due to ...their significantly different growth environments. Methods: An ultra-performance liquid chromatography/quadrupole time-of-flight mass spectrometry (UPLC-QTOF-MS/MS)-based approach was developed to distinguish MCG and CG. Multivariate statistical methods, such as principal component analysis and supervised orthogonal partial-least-squares discrimination analysis were used to select the influential components. Results: Under optimized UPLC-QTOF-MS/MS conditions, 40 ginsenosides in both MCG and CG were unambiguously identified and tentatively assigned. The results showed that the characteristic components of CG and MCG included ginsenoside Ra3/isomer, gypenoside XVII, quinquenoside R1, ginsenoside Ra7, notoginsenoside Fe, ginsenoside Ra2, ginsenoside Rs6/Rs7, malonyl ginsenoside Rc, malonyl ginsenoside Rb1, malonyl ginsenoside Rb2, palmitoleic acid, and ethyl linoleate. The malony ginsenosides are abundant in CG, but higher levels of the minor ginsenosides were detected in MCG. Conclusion: This is the first time that the differences between CG and MCG have been observed systematically at the chemical level. Our results suggested that using the identified characteristic components as chemical markers to identify different ginseng products is effective and viable.
3D graphene aerogel (GA) integrated with active metal or its derivatives has emerged as a novel class of multifunctional constructs with range of potential applications. However, GA fabricated by ...self‐assembly in the liquid phase still suffers from low conductivity and poor knowledge related to spatial active phase distribution and 3D structure. To address these issues, a facile approach involving in situ integration of 1D silver nanowire (AgNW) during gelation of graphene oxide flakes is presented. AgNWs prevent the restacking of graphene sheets and act as an efficient electron highway and Ag source for deposition of ultrasmall Ag nanocrystals (AgNCs). When applied as the cathodic electrocatalyst in a zinc–air battery, the 3D GA integrated with 0D AgNCs and 1D AgNWs permit ultrahigh discharge rates of up to 300 mA cm−2. Moreover, for the first time, with the help of phase‐contrast X‐ray computed microtomography, the interconnected porous network of millimeter‐sized GA and a full‐field view of the macrodistribution of Ag is delivered, offering the vitally complementary macroscopic structure information, which has been missing in previous reports.
X‐ray computed microtomography (X‐ray μCT) reveals the macrodistribution of active phase (i.e., Ag) and supermacroporous structure in the self‐assembled graphene aerogel for the first time. The interconnected 3D Ag network is the key to achieve high oxygen reduction reaction activity and utrahigh rate performance in Zn–air batteries.
