Realizing a long coherence time quantum memory is a major challenge of current quantum technology. Until now, the longest coherence-time of a single qubit was reported as 660 s in a single
Yb
...ion-qubit through the technical developments of sympathetic cooling and dynamical decoupling pulses, which addressed heating-induced detection inefficiency and magnetic field fluctuations. However, it was not clear what prohibited further enhancement. Here, we identify and suppress the limiting factors, which are the remaining magnetic-field fluctuations, frequency instability and leakage of the microwave reference-oscillator. Then, we observe the coherence time of around 5500 s for the
Yb
ion-qubit, which is the time constant of the exponential decay fit from the measurements up to 960 s. We also systematically study the decoherence process of the quantum memory by using quantum process tomography and analyze the results by applying recently developed resource theories of quantum memory and coherence. Our experimental demonstration will accelerate practical applications of quantum memories for various quantum information processing, especially in the noisy-intermediate-scale quantum regime.
Fluorinated aziridines are very important structural motifs, but methods access to such structures are still very rare. In this paper, we report a mild, catalyst‐free and operationally simple ...strategy for the direct aminofluoroalkylation of olefins driven by the noncovalent interaction between N‐allylanilines and fluoroalkyl iodides. This photochemical transformation features synthetic simplicity, mild reaction conditions, without the use of any photoredox catalyst, and high functional group tolerance. Moreover, the structures can be used as important precursors for the synthesis of β‐fluoroalkylated alkylamine derivatives, such as fluorinated amino acids and fluorinated 2‐pyrrolidinones.
We report a new protocol for the fluoroalkylation of alkenes and alkynes by using 2-bromophenol as a catalyst. This reaction can be tailored for different reaction modes by altering the base and ...solvent, which feature a wide substrate scope and excellent functional group tolerance with high chemo- and regioselectivities. We further propose a mechanism involving an electron donor-acceptor (EDA) complex.
A simple, mild and efficient approach for the fluoroalkylation of alkenes and alkynes using 2-bromophenol as a catalyst is presented.
High‐security nanoplatform with enhanced therapy compliance is extremely promising for tumor. Herein, using a simple and high‐efficient self‐assembly method, a novel active‐targeting nanocluster ...probe, namely, Ag2S/chlorin e6 (Ce6)/DOX@DSPE‐mPEG2000‐folate (ACD‐FA) is synthesized. Experiments indicate that ACD‐FA is capable of specifically labeling tumor and guiding targeting ablation of the tumor via precise positioning from fluorescence and photoacoustic imaging. Importantly, the probe is endowed with a photodynamic “on‐off” effect, that is, Ag2S could effectively quench the fluorescence of chlorin e6 (89.5%) and inhibit release of 1O2 (92.7%), which is conducive to avoid unwanted phototoxicity during transhipment in the body, and only after nanocluster endocytosed by tumor cells could release Ce6 to produce 1O2. Moreover, ACD‐FA also achieves excellent acid‐responsive drug release, and exhibits eminent chemo‐photothermal and photodynamic effects upon laser irradiation. Compared with single or two treatment combining modalities, ACD‐FA could provide the best cancer therapeutic effect with a relatively low dose, because it made the most of combined effect from chemo‐photothermal and controlled photodynamic therapy, and significantly improves the drug compliance. Besides, the active‐targeting nanocluster notably reduces nonspecific toxicity of both doxorubicin and chlorin e6. Together, this study demonstrates the potency of a newly designed nanocluster for nonradioactive concomitant therapy with precise tumor‐targeting capability.
A multifunctional nanoprobe Ag2S/Ce6/DOX@DSPE‐mPEG2000‐folate can specifically label tumor via precise positioning from fluorescence and photoacoustic imaging, which guide targeting ablation of tumor combined effect of chemo‐photothermal and controlled photodynamic therapy. In the process, the probe minimizes the administration dose as much as possible while achieving effective therapeutic effect, reducing nonspecific toxicity, and improving drug compliance.
Abstract
We presented a cascade transformation of
N
,
N
‐diallylamines and fluoroalkyl iodides into various functionalized fluoroalkylated pyrrolidines through a visible light‐induced synthetic ...process in the solvent‐free conditions. In this reaction system, the substrate
N, N
‐diallylamine acted both as the base and the electron donor. We further demonstrated the practicality of this protocol by the direct modification of amino acids and pharmaceutical molecules.
A principal goal of cancer nanomedicine is to deliver therapeutics effectively to cancer cells within solid tumors. However, there are a series of biological barriers that impede nanomedicine from ...reaching target cells. Here, we report a stimuli-responsive clustered nanoparticle to systematically overcome these multiple barriers by sequentially responding to the endogenous attributes of the tumor microenvironment. The smart polymeric clustered nanoparticle (iCluster) has an initial size of ∼100 nm, which is favorable for long blood circulation and high propensity of extravasation through tumor vascular fenestrations. Once iCluster accumulates at tumor sites, the intrinsic tumor extracellular acidity would trigger the discharge of platinum prodrug-conjugated poly(amidoamine) dendrimers (diameter ∼5 nm). Such a structural alteration greatly facilitates tumor penetration and cell internalization of the therapeutics. The internalized dendrimer prodrugs are further reduced intracellularly to release cisplatin to kill cancer cells. The superior in vivo antitumor activities of iCluster are validated in varying intractable tumor models including poorly permeable pancreatic cancer, drug-resistant cancer, and metastatic cancer, demonstrating its versatility and broad applicability.
Fluoroalkylated enaminones, such as trifluridine and 5-trifluoromethyluracil, have widespread applications in pharmaceuticals and agrochemicals. Although these kinds of pharmaceutical agent often ...bear CF3 and perfluoroalkyl motifs in the core structure, access to such analogues typically requires multi-step synthesis. Here, we report a mild, metal-free and operationally simple strategy for the direct perfluoroalkylation of uracils, cytosines and pyridinones through a visible-light induced pathway from perfluoroalkyl iodides. This photochemical transformation features synthetic simplicity, mild reaction conditions without any photoredox catalyst, and high functional group tolerance, providing a facile route for applications in medicinal chemistry.
Microbial fuel cell (MFC) is of great interest as a promising green energy source to harvest electricity from various organic matters. However, low bacterial loading capacity and low extracellular ...electron transfer efficiency between the bacteria and the anode often limit the practical applications of MFC. In this work, a macroporous and monolithic MFC anode based on polyaniline hybridized three-dimensional (3D) graphene is demonstrated. It outperforms the planar carbon electrode because of its abilities to three-dimensionally interface with bacterial biofilm, facilitate electron transfer, and provide multiplexed and highly conductive pathways. This study adds a new dimension to the MFC anode design as well as to the emerging graphene applications.
Applications of artificial intelligence in intelligent manufacturing： a review Li, Bo-hu; Hou, Bao-cun; Yu, Wen-tao ...
Frontiers of Information Technology & Electronic Engineering/Frontiers of Informaion Technology & Electronic Engineering,
2017, 1-2017, 2017-1-00, 20170101, Letnik:
18, Številka:
1
Journal Article
Recenzirano
Odprti dostop
Based on research into the applications of artificial intelligence （AI） technology in the manufacturing industry in recent years, we analyze the rapid development of core technologies in the new era ...of＇Internet plus AI＇, which is triggering a great change in the models, means, and ecosystems of the manufacturing industry, as well as in the development of AI. We then propose new models, means, and forms of intelligent manufacturing, intelligent manufacturing system architecture, and intelligent man- ufactudng technology system, based on the integration of AI technology with information communications, manufacturing, and related product technology. Moreover, from the perspectives of intelligent manufacturing application technology, industry, and application demonstration, the current development in intelligent manufacturing is discussed. Finally, suggestions for the application of AI in intelligent manufacturing in China are presented.
We demonstrate for the first time the construction of a low background electrochemical biosensor with tandem signal amplification for sensitive microRNA assay based on target-activated catalytic ...hairpin assembly (CHA) of heteroduplex-templated copper nanoparticles. This electrochemical biosensor exhibits high sensitivity, good specificity, single-base mismatch discrimination capability, excellent stability and reproducibility, and it can sensitively detect microRNA in cancer cells.
We develop a catalytic hairpin assembly-based electrochemical biosensor with tandem signal amplification for sensitive microRNA assay.
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