Studies have shown the indicative role of handgrip strength in health. However, there is limited evidence revealing its potential effect on death events among middle-aged and older adults in China. ...We aimed to prospectively evaluate if lower handgrip strength is associated with the event of death. Among 17,167 middle-aged and older adults between age 45 to 96, handgrip strength was collected by a handheld dynamometer in a Chinese longitudinal study of aging trend (CHARLS) 2011–2018. Using Cox proportional hazard models with exposures, we assessed the association between handgrip strength and death events. Elevated handgrip strength values were independently associated with the decreased death risk. These results illustrate that lower handgrip strength is an independent indicator of death risks among middle-aged and older Chinese, which highlights the significance of related intercessions. The median values of five levels of handgrip strength in the entire cohort were 16.5,23,28,33,42kg at baseline. A linear association existed between the handgrip strength values and the risk of all-cause death within 34.2kg. Handgrip strength can serve as an independent indicator for death risks.
Celotno besedilo
Dostopno za:
DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
Due to the need to repeatedly call a classifier to evaluate individuals in the population, existing evolutionary feature selection algorithms have the disadvantage of high computational cost. In view ...of it, this paper studies a multi-objective feature selection framework based on sample reduction strategy and evolutionary algorithm, significantly reducing the computational cost of algorithm without affecting optimal results. In the framework, a selection strategy of representative samples, called K-means clustering based differential selection, and a ladder-like sample utilization strategy are proposed to reduce the size of samples used in the evolutionary process. Moreover, a fast multi-objective evolutionary feature selection algorithm, called FMABC-FS, is proposed by embedding an improved artificial bee colony algorithm based on the particle update model into the framework. By applying FMABC-FS to several typical UCI datasets, and comparing with three multi-objective feature selection algorithms, experimental results show that the proposed variable sample size strategy is more suitable to FMABC-FS, and FMABC-FS can obtain better feature subsets with much less running time than those comparison algorithms.
•Establishing a multi-objective evolutionary feature selection framework to reduce the computational cost of algorithm without affecting the result of feature selection.•Developing a K-means clustering based differential selection strategy and a ladder-like utilization strategy of samples to select representative samples for evaluating individuals.•Proposing a fast multi-objective feature selection algorithm, called FMABC-FS, by embedding an improved ABC algorithm into the framework.
A
bstract
A light pseudoscalar of the lepton-specific 2HDM can enhance the muon g-2, but suffer from various constraints easily, such as the 125.5 GeV Higgs signals, non-observation of additional ...Higgs at the collider and even
B
s
→
μ
+
μ
−
. In this paper, we take the light CP-even Higgs as the 125.5 GeV Higgs, and examine the implications of those observables on a pseudoscalar with the mass below the half of 125.5 GeV. Also the other relevant theoretical and experimental constraints are considered. We find that the pseudoscalar can be allowed to be as low as 10 GeV, but the corresponding tan
β
, sin(
β
−
α
) and the mass of charged Higgs are strongly constrained. In addition, the surviving samples favor the wrong-sign Yukawa coupling region, namely that the 125.5 GeV Higgs couplings to leptons have opposite sign to the couplings to gauge bosons and quarks.
This article presents an adaptive multi‐surrogate constrained optimization method (AMSCOM) that can automatically determine the appropriate metamodel for each black‐box function in the constrained ...optimization problem (COP) and concurrently find the optimum. In AMSCOM, each black‐box function is approximated initially by several different types of candidate surrogates. Then, as optimization progresses, the poorly performing candidate surrogates of each black‐box function are gradually eliminated until the appropriate surrogate is found. Meanwhile, as more than one candidate surrogate exists for each unknown function in the optimization process, multiple approximate optimization problems (AOPs) can be constructed, and new samples can be obtained by solving these AOPs. Additionally, we employ the genetic operator and the local‐linear approximation–Voronoi method to generate new samples. To verify the effectiveness and investigate several properties of AMSCOM, the proposed method is tested on 12 benchmark COPs and compared with several single surrogate‐based methods. Furthermore, AMSCOM is compared with several published surrogate‐based constrained optimization methods, and the results further prove the superior performance of AMSCOM. The proposed method is then employed to optimize the shaft‐clinching process of wheel‐hub‐bearing units, and a desirable result is achieved.
Photodynamic therapy has become an emerging strategy for the treatment of cancer. This technology relies on the development of photosensitizers (PSs) that convert molecular oxygen to cytotoxic ...reactive oxygen species upon exposure to light. In this study, we have developed a facile and general strategy for obtaining visible light/near-infrared-absorbing PSs by performing a simple sulfur-for-oxygen replacement within existing fluorophores. Thionation of carbonyl groups within existing fluorophore cores leads to an improvement of the singlet oxygen quantum yield and molar absorption coefficient at longer wavelengths (deep to 600-800 nm). Additionally, these thio-based PSs lack dark cytotoxicity but exhibit significant phototoxicity against monolayer cancer cells and 3D multicellular tumor spheroids with IC
50
in the micromolar range. To achieve tumor-specific delivery, we have conjugated these thio-based PSs to an antibody and demonstrated their tumor-specific therapeutic activity.
Thio-based photosensitizer: a general strategy for preparing visible/NIR light absorbing heavy-atom-free photosensitizers was developed by performing a simple sulfur-for-oxygen atom substitution within existing fluorescent molecules.
Recently, wearable devices have been attracting significantly increased interest in human motion detection and human physiological signal monitoring. Currently, it is still a great challenge to ...fabricate strain sensors with high performance and good fit to the human body. In this work, we fabricated a close-fitting and wearable graphene textile strain sensor based on a graphene textile without polymer encapsulation. Graphene oxide acts as a colorant to dye the polyester fabric and is reduced at high temperature, which endows the graphene textile strain sensor with excellent performance. Compared with the previously reported strain sensors, our strain sensor exhibits a distinctive negative resistance variation with increasing strain. In addition, the sensor also demonstrates fascinating performance, including high sensitivity, long-term stability, and great comfort. Based on its superior performance, the graphene textile strain sensor can be knitted on clothing for detecting both subtle and large human motions, showing the tremendous potential for applications in wearable electronics.
The approval of two chimeric antigen receptor-modified T cell types by the US Food and Drug Administration (FDA) for the treatment of hematologic malignancies is a milestone in immunotherapy; ...however, the application of CAR-T cells has been limited by antigen escape and on-target, off-tumor toxicities. Therefore, it may be a potentially effective strategy to select appropriate targets and to combine multi-antigen-targeted CAR-T cells with "OR", "AND" and "NOT" Boolean logic gates. We summarize the current limitations of CAR-T cells as well as the efficacy and safety of logic-gated CAR-T cells in antitumor therapy. This review will help to explore more optimized strategies to expand the CAR-T cell therapeutic window.
AbstractObjectiveTo examine the protective effects of appropriate personal protective equipment for frontline healthcare professionals who provided care for patients with coronavirus disease 2019 ...(covid-19).DesignCross sectional study.SettingFour hospitals in Wuhan, China.Participants420 healthcare professionals (116 doctors and 304 nurses) who were deployed to Wuhan by two affiliated hospitals of Sun Yat-sen University and Nanfang Hospital of Southern Medical University for 6-8 weeks from 24 January to 7 April 2020. These study participants were provided with appropriate personal protective equipment to deliver healthcare to patients admitted to hospital with covid-19 and were involved in aerosol generating procedures. 77 healthcare professionals with no exposure history to covid-19 and 80 patients who had recovered from covid-19 were recruited to verify the accuracy of antibody testing.Main outcome measuresCovid-19 related symptoms (fever, cough, and dyspnoea) and evidence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, defined as a positive test for virus specific nucleic acids in nasopharyngeal swabs, or a positive test for IgM or IgG antibodies in the serum samples.ResultsThe average age of study participants was 35.8 years and 68.1% (286/420) were women. These study participants worked 4-6 hour shifts for an average of 5.4 days a week; they worked an average of 16.2 hours each week in intensive care units. All 420 study participants had direct contact with patients with covid-19 and performed at least one aerosol generating procedure. During the deployment period in Wuhan, none of the study participants reported covid-19 related symptoms. When the participants returned home, they all tested negative for SARS-CoV-2 specific nucleic acids and IgM or IgG antibodies (95% confidence interval 0.0 to 0.7%).ConclusionBefore a safe and effective vaccine becomes available, healthcare professionals remain susceptible to covid-19. Despite being at high risk of exposure, study participants were appropriately protected and did not contract infection or develop protective immunity against SARS-CoV-2. Healthcare systems must give priority to the procurement and distribution of personal protective equipment, and provide adequate training to healthcare professionals in its use.
Synthetic biology: a new frontier in food production Shi, Shuobo; Wang, Zhihui; Shen, Lirong ...
Trends in biotechnology (Regular ed.),
July 2022, 2022-Jul, 2022-07-00, 20220701, Letnik:
40, Številka:
7
Journal Article
Recenzirano
Concerns regarding food security arise from population growth, global warming, and reduction in arable land. With advances in synthetic biology, food production by microbes is considered to be a ...promising alternative that would allow rapid food production in an environmentally friendly manner. Moreover, synthetic biology can be adopted to the production of healthier or specifically designed food ingredients (e.g., high-value proteins, lipids, and vitamins) and broaden the utilization of feedstocks (e.g., methanol and CO2), thereby offering potential solutions to high-quality food and the greenhouse effect. We first present how synthetic biology can facilitate the microbial production of various food components, and then discuss feedstock availability enabled by synthetic biology. Finally, we illustrate trends and key challenges in synthetic biology-driven food production.
Microbially synthesized food can address challenges in global food security and deliver high-quality food products in an environmentally friendly manner.Synthetic biology is emerging as a powerful approach for engineering microbes to produce macronutrient and micronutrient compounds in food.Recent achievements in synthetic biology have enabled microbes to produce healthier or specifically designed food ingredients.Microbial fermentation from nonfood feedstocks offers the opportunity to alleviate economic, ecologic, and societal problems by recycling resources and greenhouse gases.
Metastasis causes the vast majority of colorectal carcinoma (CRC)-related deaths. However, little is known about the specific traits and underlying mechanisms of metastasis-initiating cells in ...primary CRC. And whether or not circular RNAs (circRNAs) take part in this particular event remain not adequately stated yet.
A screening method based on Transwell assay was first applied to build CRC subgroups with different metastatic potential. High throughput RNA sequencing was used to find out novel metastatic drivers in CRC metastasis-initiating step. A series of in vitro and in vivo assays were further applied to elucidate the functions and underlying molecular mechanisms of circRNAs in CRC metastasis.
A circRNA consisting of exon 8-11 of LONP2, termed as circLONP2, was upregulated in metastasis-initiating CRC subgroups. Aberrant higher expression of circLONP2 was observed in primary CRC tissues with established metastasis, and along the invasive margin in metastatic site. High expression of circLONP2 predicted unfavorable overall survival. Functional studies revealed that circLONP2 could enhance the invasiveness of CRC cells in vitro, and targeting circLONP2 through anti-sense oligonucleotide (ASO) dramatically reduced the penetrance of metastasis to foreign organs in vivo. Mechanically, circLONP2 directly interacted with and promoted the processing of primary microRNA-17 (pri-miR-17), through recruiting DiGeorge syndrome critical region gene 8 (DGCR8) and Drosha complex in DDX1-dependent manner. Meanwhile, upregulated mature miR-17-5p could be assembled into exosomes and internalized by neighboring cells to enhance their aggressiveness.
Our data indicate that circLONP2 acts as key metastasis-initiating molecule during CRC progression through modulating the intracellular maturation and intercellular transfer of miR-17, resulting in dissemination of metastasis-initiating ability in primary site and acceleration of metastasis formation in foreign organs. circLONP2 could serve as an effective prognostic predictor and/or novel anti-metastasis therapeutic target in CRC treatment.
Celotno besedilo
Dostopno za:
DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
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