Formic acid (HCOOH) is one of the most abundant acids in the atmosphere, with an important influence on precipitation chemistry and acidity. Here we employ a chemical transport model (GEOS-Chem CTM) ...to interpret recent airborne and ground-based measurements over the US Southeast in terms of the constraints they provide on HCOOH sources and sinks. Summertime boundary layer concentrations average several parts-per-billion, 2-3 larger than can be explained based on known production and loss pathways. This indicates one or more large missing HCOOH sources, and suggests either a key gap in current understanding of hydrocarbon oxidation or a large, unidentified, direct flux of HCOOH. Model-measurement comparisons implicate biogenic sources (e.g., isoprene oxidation) as the predominant HCOOH source. Resolving the unexplained boundary layer concentrations based (i) solely on isoprene oxidation would require a 3 increase in the model HCOOH yield, or (ii) solely on direct HCOOH emissions would require approximately a 25 increase in its biogenic flux. However, neither of these can explain the high HCOOH amounts seen in anthropogenic air masses and in the free troposphere. The overall indication is of a large biogenic source combined with ubiquitous chemical production of HCOOH across a range of precursors. Laboratory work is needed to better quantify the rates and mechanisms of carboxylic acid production from isoprene and other prevalent organics. Stabilized Criegee intermediates (SCIs) provide a large model source of HCOOH, while acetaldehyde tautomerization accounts for ~ 15% of the simulated global burden. Because carboxylic acids also react with SCIs and catalyze the reverse tautomerization reaction, HCOOH buffers against its own production by both of these pathways. Based on recent laboratory results, reaction between CH3O2 and OH could provide a major source of atmospheric HCOOH; however, including this chemistry degrades the model simulation of CH3OOH and NOx : CH3OOH. Developing better constraints on SCI and RO2 + OH chemistry is a high priority for future work. The model neither captures the large diurnal amplitude in HCOOH seen in surface air, nor its inverted vertical gradient at night. This implies a substantial bias in our current representation of deposition as modulated by boundary layer dynamics, and may indicate an HCOOH sink underestimate and thus an even larger missing source. A more robust treatment of surface deposition is a key need for improving simulations of HCOOH and related trace gases, and our understanding of their budgets.
Far-infrared images and photometry are presented for 201 Luminous and Ultraluminous Infrared Galaxies LIRGs: log (L sub(IR)/L sub(middot in circle)) = 11.00-11.99, ULIRGs: log (L sub(IR)/L sub(middot ...in circle)) = 12.00-12.99, in the Great Observatories All-Sky LIRG Survey (GOALS), based on observations with the Herschel Space Observatory Photodetector Array Camera and Spectrometer (PACS) and the Spectral and Photometric Imaging Receiver (SPIRE) instruments. The image atlas displays each GOALS target in the three PACS bands (70, 100, and 160 mu m) and the three SPIRE bands (250, 350, and 500 mu m), optimized to reveal structures at both high and low surface brightness levels, with images scaled to simplify comparison of structures in the same physical areas of ~100 x 100 kpc super(2). Flux densities of companion galaxies in merging systems are provided where possible, depending on their angular separation and the spatial resolution in each passband, along with integrated system fluxes (sum of components). This data set constitutes the imaging and photometric component of the GOALS Herschel OT1 observing program, and is complementary to atlases presented for the Hubble Space Telescope, Spitzer Space Telescope, and Chandra X-ray Observatory. Collectively, these data will enable a wide range of detailed studies of active galactic nucleus and starburst activity within the most luminous infrared galaxies in the local universe.
Despite their crucial role in health and disease, our knowledge of immune cells within human tissues remains limited. We surveyed the immune compartment of 16 tissues from 12 adult donors by ...single-cell RNA sequencing and VDJ sequencing generating a dataset of ~360,000 cells. To systematically resolve immune cell heterogeneity across tissues, we developed CellTypist, a machine learning tool for rapid and precise cell type annotation. Using this approach, combined with detailed curation, we determined the tissue distribution of finely phenotyped immune cell types, revealing hitherto unappreciated tissue-specific features and clonal architecture of T and B cells. Our multitissue approach lays the foundation for identifying highly resolved immune cell types by leveraging a common reference dataset, tissue-integrated expression analysis, and antigen receptor sequencing.
Divertor detachment offers a promising solution to the challenge of plasma-wall interactions for steady-state operation of fusion reactors. Here, we demonstrate the excellent compatibility of ...actively controlled full divertor detachment with a high-performance (β
~ 3, H
~ 1.5) core plasma, using high-β
(poloidal beta, β
> 2) scenario characterized by a sustained core internal transport barrier (ITB) and a modest edge transport barrier (ETB) in DIII-D tokamak. The high-β
high-confinement scenario facilitates divertor detachment which, in turn, promotes the development of an even stronger ITB at large radius with a weaker ETB. This self-organized synergy between ITB and ETB, leads to a net gain in energy confinement, in contrast to the net confinement loss caused by divertor detachment in standard H-modes. These results show the potential of integrating excellent core plasma performance with an efficient divertor solution, an essential step towards steady-state operation of reactor-grade plasmas.
We report our identification of the optical afterglow and host galaxy of the short-duration gamma-ray burst sGRB 160821B. The spectroscopic redshift of the host is z = 0.162, making it one of the ...lowest redshift short-duration gamma-ray bursts (sGRBs) identified by Swift. Our intensive follow-up campaign using a range of ground-based facilities as well as Hubble Space Telescope, XMM-Newton, and Swift, shows evidence for a late-time excess of optical and near-infrared emission in addition to a complex afterglow. The afterglow light curve at X-ray frequencies reveals a narrow jet, deg, that is refreshed at >1 day post-burst by a slower outflow with significantly more energy than the initial outflow that produced the main GRB. Observations of the 5 GHz radio afterglow shows a reverse shock into a mildly magnetized shell. The optical and near-infrared excess is fainter than AT2017gfo associated with GW170817, and is well explained by a kilonova with dynamic ejecta mass Mdyn = (1.0 0.6) × 10−3 M and a secular (post-merger) ejecta mass with Mpm = (1.0 0.6) × 10−2 M , consistent with a binary neutron star merger resulting in a short-lived massive neutron star. This optical and near-infrared data set provides the best-sampled kilonova light curve without a gravitational wave trigger to date.
The incompressible smoothed particle hydrodynamics (ISPH) method with projection-based pressure correction has been shown to be highly accurate and stable for internal flows and, importantly for many ...problems, the pressure field is virtually noise-free in contrast to the weakly compressible SPH approach (Xu et al., 2009
31). However for almost inviscid fluids instabilities at the free surface occur due to errors associated with the truncated kernels. A new algorithm is presented which remedies this issue, giving stable and accurate solutions to both internal and free-surface flows. Generalising the particle shifting approach of Xu et al. (2009)
31, the algorithm is based upon Fick’s law of diffusion and shifts particles in a manner that prevents highly anisotropic distributions and the onset of numerical instability. The algorithm is validated against analytical solutions for an internal flow at higher Reynolds numbers than previously, the flow due to an impulsively started plate and highly accurate solutions for wet bed dam break problems at zero and small times. The method is then validated for progressive regular waves with paddle motion defined by linear theory. The accurate predictions demonstrate the effectiveness of the algorithm in stabilising solutions and minimising the surface instabilities generated by the inevitable errors associated with truncated kernels. The test cases are thought to provide a more thorough quantitative validation than previously undertaken.
CO2 absorbs and emits radiation, which allows it to act both as radiative forcing and feedback. Recent work has shown CO2’s feedback effect becomes dominant in hothouse climates, giving rise to a ...non‐monotonic climate sensitivity around 310 K. However, CO2’s feedback effect in colder climates is less clear. We use a line‐by‐line model to explore the CO2‐dependence of the longwave clear‐sky feedback and identify a dividing temperature. Above 290 K, feedback increases with CO2 concentration; below 290 K, feedback decreases with CO2 concentration. We explain this dependence in terms of spectral competition under CO2 increases. In hot climates, CO2’s moderate feedback replaces near‐zero feedback from the H2O bands; in cold climates, CO2’s moderate feedback replaces the large feedback from the surface. Given that global mean temperature is currently close to 290 K, our results suggest that feedback CO2‐dependence is weak at present but can be important in past and future climates.
Plain Language Summary
CO2 traps heat, causing warming. But CO2 also emits heat to space, acting as radiative feedback. Recent work has shown CO2’s feedback effect crucially helps to stabilize very hot climates, but how does it affect present‐day Earth? We show that in hot climates, more CO2 increases Earth’s feedback, while in cold climates, more CO2 decreases it. To understand why, we explain that the surface is an effective emitter, CO2 is a moderate emitter, while H2O is a poor emitter. At high temperatures, adding CO2 to the atmosphere thus replaces feedback that would have otherwise come from H2O, increasing the overall feedback; at low temperatures, adding CO2 replaces feedback that would have otherwise come from the surface, decreasing the overall feedback. Currently, Earth’s global‐mean temperature falls between these two temperature regimes, where CO2’s effect on feedback is nearly zero. Our results explain why CO2’s impact on feedback is small now but can be significant in past or future climates.
Key Points
An increase in CO2 concentration strengthens Earth’s feedback in hot climates, ∂λ/∂CO2 > 0, but weakens it in colder climates, ∂λ/∂CO2 < 0
Whether feedback CO2‐dependence, ∂λ/∂CO2, is positive or negative primarily depends on the extent of the H2O window
Feedback CO2‐dependence and forcing temperature‐dependence, ∂λ/∂CO2 = −∂F2x/∂Ts, can be important for past or future climates
Jixueteng, the vine of the bush
Dunn., is widely used to treat irregular menstruation and arthralgia. Yinyanghuo, the aboveground part of the plant
Maxim., has the function of warming the kidney to ...invigorate yang. This research aimed to investigate the effects and mechanisms of the Jixueteng and Yinyanghuo herbal pair (JYHP) on cisplatin-induced myelosuppression in a mice model. Firstly, ultra-high performance liquid chromatography quadrupole time-of-flight mass spectrometry (UPLC-Q-TOF/MS) screened 15 effective compounds of JYHP decoction. Network pharmacology enriched 10 genes which may play a role by inhibiting the apoptosis of bone marrow (BM) cells. Then, a myelosuppression C57BL/6 mice model was induced by intraperitoneal (i.p.) injection of cis-Diaminodichloroplatinum (cisplatin, CDDP) and followed by the intragastric (i.g.) administration of JYHP decoction. The efficacy was evaluated by blood cell count, reticulocyte count, and histopathological analysis of bone marrow and spleen. Through the
experiments, we found the timing of JYHP administration affected the effect of drug administration, JYHP had a better therapeutical effect rather than a preventive effect. JYHP obviously recovered the hematopoietic function of bone marrow from the peripheral blood cell test and pathological staining. Flow cytometry data showed JYHP decreased the apoptosis rate of BM cells and the western blotting showed JYHP downregulated the cleaved Caspase-3/Caspase-3 ratios through RAS/MEK/ERK pathway. In conclusion, JYHP alleviated CDDP-induced myelosuppression by inhibiting the apoptosis of BM cells through RAS/MEK/ERK pathway and the optimal timing of JYHP administration was after CDDP administration.
Background:
Chemotherapy-induced adverse effects (CIAEs) remain a challenging problem due to their high incidences and negative impacts on treatment in Chinese colorectal cancer (CRC) patients. We ...aimed to identify risk factors and predictive markers for CIAEs using food/nutrition data in CRC patients receiving post-operative capecitabine-based chemotherapy.
Methods:
Food/nutrition data from 130 Chinese CRC patients were analyzed. Univariate and multivariate analyses were used to identify CIAE-related food/nutrition factors. Prediction models were constructed based on the combination of these factors. The area under the receiver operating characteristic curve (AUROC) was used to evaluate the discrimination ability of models.
Results:
A total of 20 food/nutrition factors associated with CIAEs were identified in the univariate analysis after adjustments for total energy and potential confounding factors. Based on multivariate analysis, we found that, among these factors, dessert, eggs, poultry, and milk were associated with several CIAEs. Most importantly, poultry was an overall protective factor; milk and egg were risk factors for hand-foot syndrome (HFS) and bone marrow suppression (BMS), respectively. Developed multivariate models in predicting grade 1 to 3 CIAEs and grade 2/3 CIAEs both had good discrimination (AUROC values from 0.671 to 0.778, 0.750 to 0.946 respectively), which had potential clinical application value in the early prediction of CIAEs, especially for more severe CIAEs.
Conclusions:
Our findings suggest that patients with high milk and egg intakes should be clinically instructed to control their corresponding dietary intake to reduce the likelihood of developing HFS and BMS during capecitabine-based chemotherapy, respectively.
Trial registration:
ClinicalTrials.gov Identifier: NCT03030508.
Chronic pain is associated with depression. In rodents, pain is often assessed by sensory hypersensitivity, which does not sufficiently measure affective responses. Low-dose ketamine has been used to ...treat both pain and depression, but it is not clear whether ketamine can relieve depression associated with chronic pain and whether this antidepressant effect depends on its antinociceptive properties.
The authors examined whether the spared nerve injury model of neuropathic pain induces depressive behavior in rats, using sucrose preference test and forced swim test, and tested whether a subanesthetic dose of ketamine treats spared nerve injury-induced depression.
Spared nerve injury-treated rats, compared with control rats, showed decreased sucrose preference (0.719 ± 0.068 (mean ± SEM) vs. 0.946 ± 0.010) and enhanced immobility in the forced swim test (107.3 ± 14.6s vs. 56.2 ± 12.5s). Further, sham-operated rats demonstrated depressive behaviors in the acute postoperative period (0.790 ± 0.062 on postoperative day 2). A single subanesthetic dose of ketamine (10 mg/kg) did not alter spared nerve injury-induced hypersensitivity; however, it treated spared nerve injury-associated depression-like behaviors (0.896 ± 0.020 for ketamine vs. 0.663 ± 0.080 for control rats 1 day after administration; 0.858 ± 0.017 for ketamine vs. 0.683 ± 0.077 for control rats 5 days after administration).
Chronic neuropathic pain leads to depression-like behaviors. The postoperative period also confers vulnerability to depression, possibly due to acute pain. Sucrose preference test and forced swim test may be used to compliment sensory tests for assessment of pain in animal studies. Low-dose ketamine can treat depression-like behaviors induced by chronic neuropathic pain.
PDF
