The SARS-CoV-2-infected disease (COVID-19) outbreak is a major threat to human beings. Previous studies mainly focused on Wuhan and typical symptoms. We analysed 74 confirmed COVID-19 cases with GI ...symptoms in the Zhejiang province to determine epidemiological, clinical and virological characteristics.
COVID-19 hospital patients were admitted in the Zhejiang province from 17 January 2020 to 8 February 2020. Epidemiological, demographic, clinical, laboratory, management and outcome data of patients with GI symptoms were analysed using multivariate analysis for risk of severe/critical type. Bioinformatics were used to analyse features of SARS-CoV-2 from Zhejiang province.
Among enrolled 651 patients, 74 (11.4%) presented with at least one GI symptom (nausea, vomiting or diarrhoea), average age of 46.14 years, 4-day incubation period and 10.8% had pre-existing liver disease. Of patients with COVID-19 with GI symptoms, 17 (22.97%) and 23 (31.08%) had severe/critical types and family clustering, respectively, significantly higher than those without GI symptoms, 47 (8.14%) and 118 (20.45%). Of patients with COVID-19 with GI symptoms, 29 (39.19%), 23 (31.08%), 8 (10.81%) and 16 (21.62%) had significantly higher rates of fever >38.5°C, fatigue, shortness of breath and headache, respectively. Low-dose glucocorticoids and antibiotics were administered to 14.86% and 41.89% of patients, respectively. Sputum production and increased lactate dehydrogenase/glucose levels were risk factors for severe/critical type. Bioinformatics showed sequence mutation of SARS-CoV-2 with m
A methylation and changed binding capacity with ACE2.
We report COVID-19 cases with GI symptoms with novel features outside Wuhan. Attention to patients with COVID-19 with non-classic symptoms should increase to protect health providers.
This article presents a robust adaptive neural control algorithm for the wing-sail-assisted vehicle to track the desired waypoint-based route, where the event-triggered mechanism is with the ...multiport form. The main features of the proposed algorithm are three-fold: 1) the communication burden, in the channel from the sensor to the controller as well as the actuator, has been reduced for the merits of the multiport event-triggered approach. The feedback error signals and the control input will be updated only on the event-triggered time point; 2) for the wing-sail-assisted vehicle, the thrust force is provided by devices with the propeller and the sail. From this consideration, the proper sail force compensation is derived on the basis of information about the current heading angle and the wind direction. The corresponding control law can guarantee the energy-saving for the propeller; and 3) in the algorithm, the system uncertainties are remodeled by the neural-network approximator. Furthermore, by fusion of the robust neural damping and dynamic surface control (DSC) techniques, the corresponding gain-related adaptive law is developed to address constraints of the gain uncertainty and the environmental disturbances. Through the Lyapunov theorem, all signals of the closed-loop control system have been proved to be with the semiglobal uniform ultimate bounded (SGUUB) stability, including the triggered time point and the intermediate triggered interval. Finally, the numerical simulation and the practical experiment are illustrated to verify the effectiveness of the proposed strategy.
Canker caused by ascomycetous Valsa species are among the most destructive diseases of woody plants worldwide. These pathogens are distinct from other pathogens because they only effectively attack ...tree bark in the field. To unravel the potential adaptation mechanism of bark colonization, we examined the genomes of Valsa mali and Valsa pyri that preferentially infect apple and pear, respectively. We reported the 44.7 and 35.7 Mb genomes of V. mali and V. pyri, respectively. We also identified the potential genomic determinants of wood colonization by comparing them with related cereal pathogens. Both genomes encode a plethora of pathogenicity‐related genes involved in plant cell wall degradation and secondary metabolite biosynthesis. In order to adapt to the nutrient limitation and low pH environment in bark, they seem to employ membrane transporters associated with nitrogen uptake and secrete proteases predominantly with acidic pH optima. Remarkably, both Valsa genomes are especially suited for pectin decomposition, but are limited in lignocellulose and cutin degradation. Besides many similarities, the two genomes show distinct variations in many secondary metabolism gene clusters. Our results show a potential adaptation of Valsa canker pathogens to colonize woody bark. Secondary metabolism gene clusters are probably responsible for this host specificity.
Phosphatases are known to play important roles in the regulation of various cellular processes in eukaryotes. However, systematic characterization of the phosphatome has not been reported in ...phytopathogenic fungi.
The wheat scab fungus Fusarium graminearum contains 82 putative phosphatases. The biological functions of each phosphatase were investigated in this study.
Although 11 phosphatase genes appeared to be essential, deletion mutants of the other 71 phosphatase genes were obtained and characterized for changes in 15 phenotypes, including vegetative growth, nutrient response and virulence. Overall, the deletion of 63 phosphatase genes resulted in changes in at least one of the phenotypes assayed. Interestingly, the deletion of four genes (Fg06297, Fg03333, Fg03826 and Fg07932) did not dramatically affect hyphal growth, but led to strongly reduced virulence. Western blot analyses showed that three phosphatases (Fg10516, Fg03333 and Fg12867) functioned as negative regulators of the mitogen-activated protein kinase signaling pathways. In addition, we found, for the first time, that FgCdc14 is dispensable for growth, but plays an important role in ribosome biogenesis.
Overall, in this first functional characterization of the fungal phosphatome, phosphatases important for various aspects of hyphal growth, development, plant infection and secondary metabolism were identified in the phytopathogenic fungus F. graminearum.
Zero‐dimensional (0D) organic metal halide hybrids, in which organic and metal halide ions cocrystallize to form neutral species, are a promising platform for the development of multifunctional ...crystalline materials. Herein we report the design, synthesis, and characterization of a ternary 0D organic metal halide hybrid, (HMTA)4PbMn0.69Sn0.31Br8, in which the organic cation N‐benzylhexamethylenetetrammonium (HMTA+, C13H19N4+) cocrystallizes with PbBr42−, MnBr42−, and SnBr42−. The wide band gap of the organic cation and distinct optical characteristics of the three metal bromide anions enabled the single‐crystalline “host–guest” system to exhibit emissions from multiple “guest” metal halide species simultaneously. The combination of these emissions led to near‐perfect white emission with a photoluminescence quantum efficiency of around 73 %. Owing to distinct excitations of the three metal halide species, warm‐ to cool‐white emissions could be generated by controlling the excitation wavelength.
The right white light: The ternary organic metal halide hybrid (HMTA)4PbMn0.69Sn0.31Br8 contains three distinct metal halide species comprising emissions to cover the blue, green, and red spectral regions (the different colors in the picture represent unit cells of single‐component metal halide crystals with HMTA+). The multicomponent single‐crystalline material exhibited warm‐white to cool‐white emissions at appropriate excitation wavelengths.
In this paper, we propose a scheme to design the reconfigurable filtering power divider with arbitrary operating channels based on external quality factor (<inline-formula> <tex-math ...notation="LaTeX">Q_{\mathbf {e}} </tex-math></inline-formula>) control. By using an input feeding line, <inline-formula> <tex-math notation="LaTeX">{n} </tex-math></inline-formula> resonators, and <inline-formula> <tex-math notation="LaTeX">m </tex-math></inline-formula> output feeding lines, the <inline-formula> <tex-math notation="LaTeX">n^{\mathbf {th}} </tex-math></inline-formula>-order <inline-formula> <tex-math notation="LaTeX">m </tex-math></inline-formula>-way filtering power divider topology can be obtained with a simple configuration. A coupled-line output feeding structure loading with multiple PIN diodes is proposed to adjust the output <inline-formula> <tex-math notation="LaTeX">Q_{\mathbf {e}} </tex-math></inline-formula> values. Design theories for obtaining the desired <inline-formula> <tex-math notation="LaTeX">Q_{\mathbf {e}} </tex-math></inline-formula> values are provided. Then, the filtering power divider can be fully reconfigured in the states with one to <inline-formula> <tex-math notation="LaTeX">m </tex-math></inline-formula> operating channels. Good input matching can be achieved without using an additional reconfigurable impedance matching network in all these states, resulting in a size and loss reduction. For verification, a 2nd-order 4-way reconfigurable filtering power divider is designed, fabricated, and measured. As compared to the reported reconfigurable power dividers, the proposed design shows the merits of fully reconfigurable operating channels, favorable filtering responses, low insertion losses, high isolation, and a simple structure.
Abstract
With the development of information technology, online and offline blended learning has become a universal learning form. In order to investigate and optimize the online and offline blended ...learning of English in higher vocational colleges, this paper introduces the CoI theory to analyze blended learning. First, design the questionnaire based on the three elements of the CoI theory. After analyzing the results of the questionnaire, conduct related experiments. In order to ensure the accuracy of the results, an experimental group and a control group are set up. After three months, most of the students in the experimental group have improved their performance. The experimental results show that blended learning has a certain positive effect on the improvement of vocational students’ English performance. In addition, it is found through research that there are certain differences in the promoting effect of blended learning on English scores under different scores. Therefore, this article puts forward some suggestions for blended learning.
This paper presents compact 24-35 GHz filtering low noise amplifier (LNA) and filtering switch in 28-nm CMOS technology. A compact mixed magnetic-electric coupling circuit is designed, where a ...transmission zero is introduced out of the passband due to the cancellation of the magnetic and electric couplings. By analyzing the impedance characteristics, this structure can be designed with the impedance conversion function to replace the widely used transformers in integrated circuit designs. It shows the advantages of easy control of coupling coefficient and out-of-band rejection. Then, an LNA employing the magnetic-electric coupling circuits as impedance matching networks is designed. Image rejection can be achieved without increasing the circuit area. Moreover, by loading transistors to this mixed magnetic-electric coupling circuit, the input impedance can be controlled by the parasitic components of the transistor. Subsequently, a filter passband can be switched on and off, realizing a very compact filtering single-pole single-throw (SPST) switch. The fabricated filtering LNA is measured with a 3-dB bandwidth of 24-35 GHz, a noise figure (NF) of 2.4-3.6 dB, a maximum gain of 22 dB, and suppression of better than 25 dBc below 18 GHz. The filtering switch shows a minimum on-state loss of 2.1 dB at 28.6 GHz with better than 12.9 dB rejection below 16 GHz and off-state isolation of higher than 19 dB.
This brief presents a filter-integrated high-efficiency class-F power amplifier (PA). The hybrid cavity-microstrip filtering circuit is employed not only to realize output impedance matching and the ...third-harmonic manipulation but also to provide high-selectivity bandpass responses. To fulfill the requirements of high-efficiency class-F PAs, cavity resonators and microstrip feeding structures are involved, and their benefits are fully exploited. The metal cavity resonator features a high Q value and, thus, low loss in the passband, resulting in high efficiency. Moreover, metal walls of cavities act as heat sink for the transistor. The microstrip feeding structures are used to improve the skirt selectivity and manipulate the third harmonic. Moreover, it features easy integration with the transistor, and thus, the transition between cavity and microstrip lines is eliminated. The hybrid filter is characterized based on filter synthesis theory. Complex impedance conversion analysis is carried out to guide the impedance transformation from 50 Ω to a complex one desired by the transistor. For demonstration, a filtering PA operating at 2.4 GHz is designed and measured. It exhibits both high-selectivity bandpass responses and good PA performance with maximum power-added efficiency of 70.9% at 40.8-dBm output power.
AbstractObjectiveTo study the clinical characteristics of patients in Zhejiang province, China, infected with the 2019 severe acute respiratory syndrome coronavirus 2 (SARS-Cov-2) responsible for ...coronavirus disease 2019 (covid-2019).DesignRetrospective case series.SettingSeven hospitals in Zhejiang province, China.Participants62 patients admitted to hospital with laboratory confirmed SARS-Cov-2 infection. Data were collected from 10 January 2020 to 26 January 2020.Main outcome measuresClinical data, collected using a standardised case report form, such as temperature, history of exposure, incubation period. If information was not clear, the working group in Hangzhou contacted the doctor responsible for treating the patient for clarification.ResultsOf the 62 patients studied (median age 41 years), only one was admitted to an intensive care unit, and no patients died during the study. According to research, none of the infected patients in Zhejiang province were ever exposed to the Huanan seafood market, the original source of the virus; all studied cases were infected by human to human transmission. The most common symptoms at onset of illness were fever in 48 (77%) patients, cough in 50 (81%), expectoration in 35 (56%), headache in 21 (34%), myalgia or fatigue in 32 (52%), diarrhoea in 3 (8%), and haemoptysis in 2 (3%). Only two patients (3%) developed shortness of breath on admission. The median time from exposure to onset of illness was 4 days (interquartile range 3-5 days), and from onset of symptoms to first hospital admission was 2 (1-4) days.ConclusionAs of early February 2020, compared with patients initially infected with SARS-Cov-2 in Wuhan, the symptoms of patients in Zhejiang province are relatively mild.
PDF
