By analyzing a data sample corresponding to an integrated luminosity of 2.93 fb−1 collected at a center-of-mass energy of 3.773 GeV with the BESIII detector, we measure for the first time the ...absolute branching fraction of the D+ → ημ+νμ decay to be BD+→ημ+νμ = ( 10.4 ± 1.0stat ± 0.5syst) × 10−4. Using the world averaged value of BD+ → ηe+νe, the ratio of the two branching fractions is determined to be BD+ → ημ+νμ/BD+ → ηe+νe = 0.91 ± 0.13(stat+syst), which agrees with the theoretical expectation of lepton flavor universality within uncertainty. By studying the differential decay rates in five four-momentum transfer intervals, we obtain the product of the hadronic form factor f+η(0) and the c → d Cabibbo-Kobayashi-Maskawa matrix element |Vcd| to be fη+(0) |Vcd| = 0.087 ± 0.008stat ± 0.002syst. Taking the input of |Vcd| from the global fit in the standard model, we determine fη+(0) = 0.39 ± 0.04stat ± 0.01syst. On the other hand, using the value of fη+(0) calculated in theory, we find |Vcd| = 0.242 ± 0.022stat ± 0.00 6 syst ± 0.033theory.
Using a 3.19 fb^{-1} data sample collected at an e^{+}e^{-} center-of-mass energy of E_{cm}=4.178 GeV with the BESIII detector, we measure the branching fraction of the leptonic decay ...D_{s}^{+}→μ^{+}ν_{μ} to be B_{D_{s}^{+}→μ^{+}ν_{μ}}=(5.49±0.16_{stat}±0.15_{syst})×10^{-3}. Combining our branching fraction with the masses of the D_{s}^{+} and μ^{+} and the lifetime of the D_{s}^{+}, we determine f_{D_{s}^{+}}|V_{cs}|=246.2±3.6_{stat}±3.5_{syst} MeV. Using the c→s quark mixing matrix element |V_{cs}| determined from a global standard model fit, we evaluate the D_{s}^{+} decay constant f_{D_{s}^{+}}=252.9±3.7_{stat}±3.6_{syst} MeV. Alternatively, using the value of f_{D_{s}^{+}} calculated by lattice quantum chromodynamics, we find |V_{cs}|=0.985±0.014_{stat}±0.014_{syst}. These values of B_{D_{s}^{+}→μ^{+}ν_{μ}}, f_{D_{s}^{+}}|V_{cs}|, f_{D_{s}^{+}} and |V_{cs}| are each the most precise results to date.
Using a data sample of e^{+}e^{-} collisions corresponding to an integrated luminosity of 567 pb^{-1} collected at a center-of-mass energy of sqrts=4.6 GeV with the BESIII detector, we measure the ...absolute branching fraction of the inclusive semileptonic Λ_{c}^{+} decay with a double-tag method. We obtain B(Λ_{c}^{+}→Xe^{+}ν_{e})=(3.95±0.34±0.09)%, where the first uncertainty is statistical and the second systematic. Using the known Λ_{c}^{+} lifetime and the charge-averaged semileptonic decay width of nonstrange charmed mesons (D^{0} and D^{+}), we obtain the ratio of the inclusive semileptonic decay widths Γ(Λ_{c}^{+}→Xe^{+}ν_{e})/Γover ¯(D→Xe^{+}ν_{e})=1.26±0.12.
We study the process e+ e- →(D* D*)± π∓ at a center-of-mass energy of 4.26 GeV using a 827 pb(-1) data sample obtained with the BESIII detector at the Beijing Electron Positron Collider. Based on a ...partial reconstruction technique, the Born cross section is measured to be (137±9±15) pb. We observe a structure near the (D* D*)± threshold in the π∓ recoil mass spectrum, which we denote as the Zc±(4025). The measured mass and width of the structure are (4026.3±2.6±3.7) MeV/c2 and (24.8±5.6±7.7) MeV, respectively. Its production ratio σ(e+ e- → Zc±(4025)π∓ → (D* D*)± π∓)/σ(e+ e- → (D* D*)± π∓) is determined to be 0.65±0.09±0.06. The first uncertainties are statistical and the second are systematic.
An ultrahigh resolution probe technique for charactering nanoscale Seebeck coefficient was developed based on a modified conductive AFM probe with local heating function. The heated AFM conductive ...tip realizes nanoscale thermal contact between the AFM tip and the thermoelectric samples and successfully excites nanoscale thermoelectric signal. Excellent agreement was found between nanoscale Seebeck coefficient values and their corresponding macroscopy measurements in thermoelectric bulk and thin films. Such AFM-based thermoelectric probe technique provides a very convenient and promising tool for measuring nanoscale thermoelectric parameters with ultrahigh resolution up to 15 nm.
Introduction
To reduce the incidence of hemophilia B (HB) which with no complete cure currently, prenatal diagnosis and preimplantation genetic diagnosis (PGD) are effective and feasible means. ...However, previous studies about genetic diagnosis in HB mostly just focused on the detection of patients and carriers. Here, we established a comprehensive genetic diagnosis strategy for HB and worked it out in Chinese population. The strategy includes the detection of patients and carriers, prenatal diagnosis, and PGD.
Methods
Seven unrelated HB families from Chinese population involved in this study. Firstly, probands and available members were carried out coagulation laboratory assays, and the clinical information has been recorded. Secondly, we used DNA direct sequencing to screen the whole FIX gene of them. The pathogenicity of novel mutations was verified according to 2015 ACMG‐AM guidelines. For prenatal diagnosis, a mix of DNA direct sequencing and STR linkage analysis was employed. To explore a better PGD protocol, Karyomapping was first applied in PGD of HB, comparing with conventional PCR‐based methods.
Results
Six different pathogenic mutations including 1 novel duplication (c.660_661dup ATCA) were identified. The results of prenatal diagnosis were consistent with birth outcomes. In the PGD case, 4 of 11 embryos were confirmed to be normal and one of them was transferred and led to a healthy birth.
Conclusions
The established genetic diagnosis strategy for HB in our study was comprehensive and well applied in clinic practice. Besides, we recommended that DNA direct sequencing combined with Karyomapping was a better PGD protocol.
A
bstract
A search for the hadronic decays of the
h
c
meson to the final states
p
p
¯
π
+
π
−
π
0
,
p
p
¯
η
, and
p
p
¯
π
0
via the process
ψ
(3686) →
π
0
h
c
is performed using (4
.
48
±
0
.
03)
×
...10
8
ψ
(3686) events collected with the BESIII detector. The decay channel
h
c
→
p
p
¯
η
is observed for the first time with a significance greater than 5
σ
and a branching fraction of (6
.
41
±
1
.
74
±
0
.
53
±
1
.
00)
×
10
−
4
, where the uncertainties are statistical, systematic, and that from the branching fraction of
ψ
(3686) →
π
0
h
c
. Strong evidence for the decay
h
c
→
p
p
¯
π
+
π
−
π
0
is found with a significance of 4
.
9
σ
and a branching fraction of (3
.
84
±
0
.
83
±
0
.
69
±
0
.
58)
×
10
−
3
. The significances include systematic uncertainties. No clear signal of the decay
h
c
→
p
p
¯
π
0
is found, and an upper limit of 6
.
59
×
10
−
4
on its branching fraction is set at the 90% confidence level.
Wingless and int homologue (Wnt) family proteins have been shown to have important roles in the decision of cell fate and behavior at multiple stages during the development and tumorigenesis. One of ...the Drosophila segment polarity genes, porcupine (porc) gene, encodes an evolutionarily conserved endoplasmic reticulum membrane protein involving in the post-translational processing of the Wnt family proteins. Here, we report that human homologue of Drosophila porc gene, PPN/MG61, was abundantly expressed in human cancer cell lines, but not in normal cells. We also found that PPN/MG61 was overexpressed in primary lung cancer tissue samples, compared to their matched normal tissue samples. Furthermore, when we used small interfering RNA to knock down PPN/MG61 mRNA in lung cancer cells expressing the gene, we observed apoptosis induction, along with decreased activity of Wnt pathway in those lung cancer cells. These data suggest that PPN/MG61 may be a novel marker for human lung cancer and that post-translational modification of the Wnt signal molecules by PPN/MG61 may be important for the function of Wnt pathway in lung cancer.
Structured packed columns are widely used in the chemical industry for distillation and absorption. However, the understanding of the transfer mechanism behind the counter‐current gas‐liquid flow in ...structured packed columns is still limited. In this work, a three‐dimensional CFD model that considers the local absorption and the local momentum transfer mechanism is developed for a film flow on a small plate with a counter‐current gas flow. The model, based on the Volume of Fluid (VOF) method, is built up on the basis of a pressure drop model and the penetration theory to quantitatively investigate the instantaneous hydrodynamics and mass transfer characteristics of the liquid phase. Simulations and experiments are carried out for a system consisting of propane and toluene. A comparison of the simulation results with the experimental data for the outlet concentrations shows good agreement.
Based on the pressure drop model and the penetration theory, a three‐dimensional, transient CFD model is developed to consider the local drag force and the local mass transfer between the liquid phase and the counter‐current gas phase. The characteristics of the instantaneous hydrodynamics and the concentration profile are investigated in detail.
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