Abstract
High-glucose microenvironment in the diabetic foot ulcer (DFU) causes excessive glycation and induces chronic inflammation, leading to the difficulty of DFU healing. Hydrogen-rich water bath ...can promote the healing of DFU in clinic by virtue of the anti-inflammatory effect of hydrogen molecules, but the long-term daily soaking counts against the formation of a scab and cannot change the high-glucose microenvironment, limiting the outcome of DFU therapy. In this work, photocatalytic therapy of diabetic wound is proposed for sustainable hydrogen generation and local glucose depletion by utilizing glucose in the high-glucose microenvironment as a sacrificial agent. Hydrogen-incorporated titanium oxide nanorods are developed to realize efficient visible light (VIS)-responsive photocatalysis for glucose depletion and hydrogen generation, achieving a high efficacy of diabetic wound healing. Mechanistically, local glucose depletion and hydrogen generation jointly attenuate the apoptosis of skin cells and promote their proliferation and migration by inhibiting the synthesis of advanced glycation end products and the expression of their receptors, respectively. The proposed VIS-photocatalytic strategy provides a solution for facile, safe and efficient treatment of DFU.
Insect herbivory during the Pennsylvanian–Permian transition interval (late Gzhelian) was estimated from the Williamson Drive locality of north-central Texas, USA. We investigated vegetational ...composition and the response of host plants to herbivores by characterization of insect-damage patterns. The bulk flora consists of four major plant groups: lycophytes, sphenophytes, pteridophytes, and pteridosperms, as well as unaffiliated morphotypes. Forty-six distinctive damage types (DTs) were recognized from 17 herbivorized plant-host taxa that were categorized into the five functional feeding groups (FFGs) of external foliage feeding (20 DTs), oviposition (11 DTs), piercing and sucking (9 DTs), galling (5 DTs), and wood boring (1 DT). The distributional patterns of FFGs and DTs on the most herbivorized plant hosts indicate several generalized and specialized patterns and organization into distinctive component communities. The overall herbivory level in the flora is elevated compared to other Cisuralian floras of north-central Texas, based on separate analyses of foliar surface area removed (0.86%) and frequency of herbivorized leaves (19.83%). One ubiquitous plant host, Macroneuropteris scheuchzeri (Hoffmann) Cleal, Shute and Zodrow, is disproportionately consumed, representing 35.75% of all specimens, but contributing 84.38% of the total herbivorized surface area, 60.87% of DT richness, and 55.44% of the DT abundance from all plant species. A notable feature is the abundance of nine piercing-and-sucking DTs on several hosts, representing three of the four new DTs described in this flora and indicating the ecological expansion of this FFG by Paleodictyopteroidea and earliest Hemipteroidea. There is evidence for physical and chemical antiherbivore defense afforded by trichomes and resin ducts of two major host plants, but the absence of seed predation is curious. Analyses of herbivory at Williamson Drive and four younger Cisuralian floras of the region support Feeny's apparency hypothesis. The overwhelming dominance of M. scheuchzeri herbivory at Williamson Drive, absent in earlier, peat-substrated Pennsylvanian floras, is typical of Cisuralian mineral-substrated plants.
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•At Williamson Drive 19.83% of plants and 0.86% of the surface area were herbivorized.•46 insect damage types in 5 functional feeding groups occurred on 17 plant-host taxa.•Seedfern Macroneuropteris scheuchzeri overwhelmingly was the most herbivorized host.•The piercing-and-sucking feeding guild notably expanded during latest Pennsylvanian.•Foliar trichome evidence indicates major antiherbivore defenses from two plant hosts.
► Propose novel sound pressure capture method based on acoustic technology. ► Construct vibration model of gas pipeline leakage by harmonic analysis. ► Position and alarm gas leakage in time by ...acoustic detection method in field test. ► Increase the system ability of small leakage detection.
The acoustic signal of gas pipeline leakage has advantage in short delay time and carries physical information of the leakage, so it can be used for the diagnosis and localization of the pipeline leakage. In the long distance pipeline, collecting vibration signal caused by sound field has important significance to research of acoustic leakage detection technology. In order to get sound signal, first, this paper researches on the phonation principle of the pipeline leakage and the characteristic of the sound source, and the sound field is established on the basis of aero acoustics. Second, the vibration of the pipeline wall is analyzed with the harmonic analysis technology of the ANSYS software when the leak wall bears broadband harmonic sound pressure. Finally, the field experiment demonstrates that this approach can improve detection ability of small leakage with low false alarm rate.
With the rapid development of China's "gig economy," the on-call work model has grown increasingly prevalent in China and has attracted a large number of rural migrant workers with its low employment ...threshold. However, this irregular employment mode may negatively impact the mental health of workers.
This paper uses an ordinal logistic regression model to study the relationship between Chinese rural migrant workers' on-call work and their depression.
The results showed that after controlling for relevant variables, the odds ratio of depressive mood among rural migrant workers engaged in on-call work was 1.22 (95% CI 1.04-1.43) compared with rural migrant workers who did not need to be on call. In further heterogeneity research, we found that on-call work is more likely to aggravate the depression risk of rural migrant workers who are highly dependent on the internet and have low-wage incomes.
This research suggests that appropriate measures should be taken to mitigate the negative impact of on-call work on the mental health of rural migrant workers, and more attention needs to be paid to the mental health of lower salaried and gig workers. This paper provides a valuable sample of Chinese rural migrant workers for theoretical research on the relationship between on-call work and mental health and confirms the relationship between the two. These results contribute new ideas to the theory and practice of psychological crisis intervention aimed at Chinese rural migrant workers.
In patients with acute ST-elevation myocardial infarction (STEMI), the preferred intervention is percutaneous coronary intervention (PCI).Whether staged PCI (S-PCI) or one-time complete PCI (MV-PCI) ...is more beneficial and safer in terms of treating the non-culprit vessel during the primary PCI procedure is unclear. We performed a meta-analysis of all randomized and non-randomized controlled trials comparing S-PCI with MV-PCI in patients with acute STEMI and MVD.
Studies of STEMI with multivessel disease receiving primary PCI were searched in PUBMED, EMBASE and The Cochrane Register of Controlled Trials from January 2004 to December 2014. The primary end points were long-term rates of major adverse cardiovascular events and their components-mortality, reinfarction, and target-vessel revascularization. Data were combined using a fixed-effects model.
Of 507 citations, 10 studies (4 randomized, 6 nonrandomized; 820 patients, 562 staged PCI and 347 one-time, complete multi-vessel PCI) were included. S-PCI compared to MV-PCI significantly reduced mortality both long-term (OR 0.44, 95% CI 0.29-0.66, P<0.0001, I2 = 0%) and short-term (OR 0.23, 95% CI 0.1-0.51, P = 0.0003, I2 = 0%). There was a trend toward reduced risk of MACE with s-PCI compared with MV-PCI (OR 0.83, 0.62-1.12, P = 0.22, I2 = 0%). No difference between S-PCI and MV-PCI was observed in reinfarction (OR 0.97, 0.61-1.55, P = 0.91, I2 = 0%), or target vessel revascularization (OR1.17, 95% CI 0.81-1.69, P = 0.40, I2 = 8%).
The staged strategy for non-culprit lesions improved short- and long-term survival and should remain the standard approach to primary PCI in patients with STEMI; one-time complete multivessel PCI may be associated with greater mortality risk. However, additional large, randomized trials are required to confirm the optimal timing of a staged procedure on the non-culprit vessel in STEMI.
Celotno besedilo
Dostopno za:
DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
Abstract
Background
Modification of the gut microbiota has been reported to reduce the incidence of type 1 diabetes mellitus (T1D). We hypothesized that the gut microbiota shifts might also have an ...effect on cognitive functions in T1D. Herein we used a non-absorbable antibiotic vancomycin to modify the gut microbiota in streptozotocin (STZ)-induced T1D mice and studied the impact of microbial changes on cognitive performances in T1D mice and its potential gut-brain neural mechanism.
Results
We found that vancomycin exposure disrupted the gut microbiome, altered host metabolic phenotypes, and facilitated cognitive impairment in T1D mice. Long-term acetate deficiency due to depletion of acetate-producing bacteria resulted in the reduction of synaptophysin (SYP) in the hippocampus as well as learning and memory impairments. Exogenous acetate supplement or fecal microbiota transplant recovered hippocampal SYP level in vancomycin-treated T1D mice, and this effect was attenuated by vagal inhibition or vagotomy.
Conclusions
Our results demonstrate the protective role of microbiota metabolite acetate in cognitive functions and suggest long-term acetate deficiency as a risk factor of cognitive decline.
► Propose novel sound pressure capture method based on acoustic technology. ► Position and alarm gas leakage in time by acoustic detection method in experiment and field test. ► Increase the system ...ability of small leakage detection.
Gas leakage from pipeline leads to significant environmental damages and industrial hazards, so small leakage detection for gas pipeline is essential to avoid these serious leakages. However, because of the high frequency component of leakage signal attenuates quickly, traditional detection method which inspects pressure or vibration signal has problem to get effective information from leakage signal. So, a novel detection method based on acoustic wave is proposed. This paper, firstly, researches on the phonation principle of pipeline leakage and the characteristic of sound source, and simulates the leakage acoustic field on the basis of aero acoustics. Secondly, using Wavelet Packet Transform method and Fuzzy Support Vector Machine pattern classification, the laboratory testing for identifying acoustic signal of gas pipeline leakage is presented. Finally, the field application demonstrates that the detection system could identify small gas leakage effectively and avoids false-alarms which caused by running conditions with a good prospect.
Cuproptosis is a recently identified form of regulated cell death that plays a critical role in the onset and progression of various cancers. However, the effects of cuproptosis-related genes (CRGs) ...on hepatocellular carcinoma (HCC) are poorly understood. This study aimed to identify the cuproptosis subtypes and established a novel prognostic signature of HCC.
We collected gene expression data and clinical outcomes from the TCGA, ICGC, and GEO datasets, analysed and identified 16 CRGs and the different subtypes of cuproptosis related to overall survival (OS), and further examined the differences in prognosis and immune infiltration among the subtypes. Subtypes-related differentially expressed genes (DEGs) were employed to build a prognostic signature. The relationship of the signature with the immune landscape as well as the sensitivity to different therapies was explored. Moreover, a nomogram was constructed to predict the outcome based on different clinicopathological characteristics.
Three cuproptosis subtypes were identified on the basis of 16 CRGs, and subtype B had an advanced clinical stage and worse OS. The immune response and function in subtype B were significantly suppressed, which may be an important reason for its poor prognosis. Based on the DEGs among the three subtypes, a prognostic model of five CRGs was constructed in the training set, and its predictive ability was validated in two external validation sets. HCC patients were classified into high and low-risk subgroups according to the risk score, and found that patients in the low-risk group showed significantly higher survival possibilities than those in the high-risk group (
< 0.001). The independent predictive performance of the risk score was assessed and verified by multivariate Cox regression analysis (
< 0.001). We further created an accurate nomogram to improve the clinical applicability of the risk score, showing good predictive ability and calibration. Low- and high-risk patients exhibit distinct immune cell infiltration and immune checkpoint changes. By further analyzing the risk score, patients in the high-risk group were found to be resistant to immunotherapy and a variety of chemotherapy drugs.
Our study identified three cuproptosis subtypes and established a novel prognostic model that provides new insights into HCC subtype prognostic assessment and guides more effective treatment regimens.
Abstract
Wildfires are an important disturbance in the Earth system, and their emissions have regional and even global impacts on radiation, clouds, and climate. The increased frequency and magnitude ...of California wildfires in recent years is altering the terrestrial carbon cycle, undermining the state’s efforts to reduce the Greenhouse Gases (GHGs) to confront climate change. Air quality and public health are also greatly affected by air pollution from wildfires. The severity of wildfire burns is a critical indicator of both their direct and indirect ecological and human impacts. To formulate targeted mitigation strategies, it is imperative to understand the evolving scale, location and timing of wildfire burn severity and emissions. This study analyzed spatial and temporal patterns of burn severity and emissions at 30 m resolution from large wildfires (>404 hectares) burning in California during 1984–2020 from the recently developed Wildfire Burn Severity and Emissions Inventory. Results show vegetation and severity play critical roles in controlling the spatial and seasonal distribution of emissions. California’s annual burned area and emissions increased, notably in early and late parts of what once was the typical fire season, although peak wildfire burned area and emissions continue to occur in mid-Summer. Emissions and areas burned in moderate to high severity were particularly high and increasing in North Coast and Sierra Nevada forests. The 2020 fire year—with the most megafires in California history—had 15 times the annual average emissions that occurred during 1984–2015.
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