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•Well-defined microtubular CKF/NiO composite has been prepared.•The as-prepared composites exhibit the maximum capacitance of 575.5Fg−1.•An ASC device of CKF/NiO-400-2//AC shows high ...energy density of 7.5Whkg−1.•This scalable protocol can be used to fabricate other microtubular composites.
Design and fabrication of structurally optimized electrode materials using biomass materials has become one of the hottest subjects in the field of electrochemical energy storage. Hollow tubular carbonized kapok fiber/NiO composites are synthesized by a facile hydrothermal and carbonization procedure using kapok fiber as a low-cost template. Owing to their unique microtubular structure, the as-prepared composites exhibit a high specific capacitance of 575.7Fg−1 at current density of 0.5Ag−1. Furthermore, an asymmetric supercapacitor device also has been fabricated using carbonized kapok fiber/NiO composites and commercial activated carbon as the positive and negative electrodes, respectively. Because of its unique structure, high capacitive performance, and complementary potential window, the asymmetric supercapacitor device can be cycled reversibly at a cell voltage of 1.6V in 1.0M KOH aqueous electrolyte, delivering a high energy density of 7.5Whkg−1 at a power density of 64.6Wkg−1. In addition, the asymmetric supercapacitor device also exhibits a superior long cycle life and the capacitance retention of the initial specific capacitance cannot found clearly degeneration after 4000 cycles. It is worth noting that this scalable protocol also can be employed to prepare other microtubular carbon/metal oxide composites with good electrochemical performances.
The MR/FI bimodal imaging has attracted widely studied due to combining the advantages of MRI and FI can bridge gaps in sensitivity and depth between these two modalities. Herein, a novel MR/FI ...bimodal imaging probe is facile fabricated by coating the Mn-phenolic coordination polymer on the surface of the carbon quantum dots. The structure of the as-prepared nanocomposite probe is carefully validated via SEM, TEM, and XPS. The content of Mn
2+
is calculated through the EDS and TGA. The quantum yield (QY) and emission wavelength of the probe are about 7.24% and 490 nm, respectively. The longitudinal r1 value (2.43 mM
−1
s
−1
) with low r2/r1 (4.45) of the probe is obtained. Subsequently, fluorescence and MR imaging are performed. The metabolic pathways in vivo are inferred by studying the bio-distribution of the probe in major organs. Thus, these results indicate that probe would be an excellent dual-modal imaging probe for enhanced MR imaging and fluorescence imaging.
MR/FI bimodal imaging probe is built via in-situ coated Mn-phenolic coordination polymer on the surface of the carbon quantum dots. The in vitro and vivo image property of the probe is evaluated.
ObjectiveTo explore the influencing factors of survival in intestinal-type gastric adenocarcinoma (IGA) and set up prediction model for the prediction of survival of patients diagnosed with ...IGA.DesignA retrospective cohort study.Setting and participantsA total of 2232 patients with IGA who came from the Surveillance, Epidemiology, and End Results database.Primary and secondary outcome measuresPatients’ overall survival (OS) rate and cancer-specific survival (CSS) at the end of follow-up.ResultsOf the total population, 25.72% survived, 54.93% died of IGA and 19.35% died of other causes. The median survival time of patients was 25 months. The result showed that age, race, stage group, T stage, N stage, M stage, grade, tumour size, radiotherapy, number of lymph nodes removed and gastrectomy were independent prognostic factors of OS risk for patients with IGA; age, race, race, stage group, T stage, N stage, M stage, grade, radiotherapy and gastrectomy were associated with CSS risk for patients with IGA. In view of these prognostic factors, we developed two prediction models for predicting the OS and CSS risk for patients with IGA separately. For the developed OS-related prediction model, the C-index was 0.750 (95% CI: 0.740 to 0.760) in the training set, corresponding to 0.753 (95% CI: 0.736 to 0.770) in the testing set. Likewise, for the developed CSS-related prediction model, the C-index was 0.781 (95% CI: 0.770 to 0.793) in the training set, corresponding to 0.785 (95% CI: 0.766 to 0.803) in the testing set. The calibration curves of the training set and testing set revealed a good agreement between model predictions in the 1-year, 3-year and 5-year survival for patients with IGA and actual observations.ConclusionCombining demographic and clinicopathological features, two prediction models were developed to predict the risk of OS and CSS in patients with IGA, respectively. Both models have good predictive performance.
Blackberry polysaccharides with certain molecular weight distribution have good bioactivity. In this research, type 2 diabetes mice were used to investigate the hypoglycemic effect of blackberry ...polysaccharides with three different molecular weights, BBP (603.59 kDa), BBP-8 (408.13 kDa) and BBP-24 (247.62 kDa), through gut microbiota modulation. Blackberry polysaccharides exhibited stronger hypoglycemic activity after degradation, and the FBG of BBP, BBP-8 and BBP-24 was reduced to 20.21 ± 4.17 mmol L −1 , 20.6 ± 7.23 mmol L −1 and 17.32 ± 6.59 mmol L −1 and OGTT-AUC was reduced by 14.76%, 19.80% and 25.04%, respectively, after 8-week intervention. Furthermore, 16S rRNA gene sequencing analysis indicated that BBP, BBP-8 and BBP-24 could reshape the diversity and composition of the gut microbiota. From 0 to 4 weeks, the F/B of BBP, BBP-8 and BBP-24 reduced by 56.44%, 47.19% and 62.04%, reaching 3.39, 6.54, and 3.11 in the 8 th week, respectively, which suggested the faster utilization of BBP-24. Moreover, the intervention the three blackberry polysaccharides increased the relative abundance of the targeted beneficial bacteria Oscillospira and Bacteroidaceae Bacteroides and decreased the relative abundance of the pathogenic bacterium Allobaculum . In general, the result demonstrated that blackberry polysaccharides with a lower molecular weight are more easily fermented, making the theoretical basis for the development of blackberry polysaccharides as a probiotic food to rapidly regulate intestinal flora for type 2 diabetes.
Spinal cord injury (SCI) remains a huge medical problem nowadays as there is no hospital providing the versatile strategies for repairing central nervous system and restoring function. Herein, we ...focused on PC-12 cells as an important research tool and studied the potential role of resveratrol (RSV) in inflammation induced by LPS.
RSV improved inflammatory injury and functional recovery in rat model of SCI. RSV inhibited LPS-induced inflammatory injury in PC-12 cells via increasing viability, decreasing apoptosis, and suppressing IL-1β, IL-6, and TNF-α expression. miR-132 was down-regulated after LPS treatment but up-regulated after RSV administration. miR-132 silence curbed the protective effect of RSV. The results including increase of cell growth, suppression of inflammatory response, and blocking of NF-κB and p38MAPK pathways produced by RSV were all reversed by miR-132 silence.
RSV could up-regulate miR-132 and further ameliorate inflammatory response in PC-12 cells by inhibiting NF-κB and p38MAPK pathways.
Celotno besedilo
Dostopno za:
DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
In this paper, fully bio-based branched unsaturated polyester (BUPE) oligomers were synthesized by one-step solvent-free polycondensation using itaconic acid, isosorbide and glycerol as feedstocks. ...The branched structure was confirmed by Fourier-transform infrared spectroscopy (FTIR) and proton nuclear magnetic resonance spectroscopy (
1
H NMR). The effect of the branched structure on the properties of BUPE UV curing coatings was investigated. The results showed that the introduction of a glycerol branched structure was favorable for UV curing. The BUPE UV curing coatings based on the glycerol branched structure showed higher gel content and crosslink density, which enhanced the hardness, solvent resistance and mechanical properties of the coatings. In addition, the BUPE UV curing coatings possessed extremely low surface roughness, excellent heat resistance and light transmission properties.
To investigate the clinical efficacy and imaging outcomes of unilateral biportal endoscopy (UBE) with unilateral laminotomy for bilateral decompression (ULBD) in the treatment of severe lumbar spinal ...stenosis (SLSS).
We retrospectively analyzed 50 patients with SLSS treated with UBE-ULBD from October 2018 to March 2021. Visual analog scale (VAS) for back and legs pain, Oswestry disability index (ODI), modified Macnab criteria, complications, hospital stay, preoperative and postoperative dural sac cross-sectional area (DSCA) and Schizas grade, mean angle of facetectomy and osseous lateral recess decompression rate were examined.
The mean follow-up period was 10.7 months. The mean hospital stay was 2.76 ± 1.02 days. At the final follow-up, VAS for back pain and legs pain decreased from 7.22 ± 0.95 to 1.26 ± 0.44 and from 7.88 ± 0.69 to 1.18 ± 0.39, respectively; ODI decreased from 69.88 ± 6.32% to 14.96 ± 2.75%. According to the modified Macnab criteria, the results were excellent in 24 (48%), good in 22 (44%), and fair in 4 (8%). Excellent or good results (a satisfactory outcome) were obtained in 92% of the patients. There were 2 cases of complications of dural sac tear. The postoperative DSCA was significantly enlarged compared with that before surgery, from 44.74 ± 9.85 to 126.86 ± 14.81 mm
. According to Schizas grade, the stenosis grade changes from preoperative grade C in 16 cases, grade D in 34 cases, to postoperative grade A in 40 cases, and grade B in 10 cases. The mean angle of facetectomy of the ipsilateral facet joint was 70.87 ± 5.68
, contralateral was 65.07 ± 4.98
. The decompression rate was 70.81 ± 4.43% (ipsilateral side) and 71.22 ± 3.68% (contralateral).
UBE-ULBD has a good clinical effect in the treatment of SLSS, and has achieved satisfactory results in spinal canal enlargement, undercutting of facet joints, and decompression effect. It is a safe and effective surgical for SLSS.
To improve the mechanical behaviour of traditional reinforcement concrete (RC) column, a novel prefabricated engineered cementitious composite (ECC)–reinforced concrete composite (ECC shell–C) column ...was proposed in this study. Subsequently, five prefabricated ECC shell–C columns, as well as one cast–in–place (CIP) RC column and one CIP pure ECC column, were designed and manufactured. Then, axial compression tests were carried out to explore their mechanical behaviour with considering the effect of the ECC shell thickness t and stirrup ratio ρv. On this basis, a numerical analysis method for the composite column was developed and verified. And numerical parametric study was carried out to clarify the influence of the design parameters on the axial compression behaviour of the prefabricated ECC shell–RC columns, including the compressive strength of ECC (fc,ecc) and concrete (fc), as well as the longitudinal reinforcement ratio (ρs). The experimental and numerical results demonstrated that the ECC shell can improve cracking resistance, ductility capacity and energy dissipation capacity of the RC column. The accumulated energy dissipation and ductility coefficient of the prefabricated ECC shell–RC columns with different t was 2.13–2.46 times and 1.14–1.35 times greater than those of the RC column, respectively. The ρv had small influence on the bearing capacity of the prefabricated ECC shell–RC columns, which can be appropriately reduced in practical application. The numerical analysis method considering the confinement effect of ECC shell can provide reliable prediction for the axial compression behaviour of prefabricated ECC shell–RC columns. fc,ecc and fc have the positive influence on the bearing capacity of the prefabricated ECC shell–RC columns but have negative influence on the ductility; meanwhile a moderately lower ρs will not significantly reduce the ductility.
Abstract
The purpose of this study is to improve the properties of the feedstocks and shape retention of debinded parts by the reaction between 17-4PH stainless steel powders. Carboxyl-terminated ...hyperbranched polyester (CTHP) and epoxy-terminated hyperbranched polyester (ETHP) were used to treat the powders, and termed as CTHP-m and ETHP-m with carboxyl and epoxy group, respectively. Comparing with pristine, CTHP-m and ETHP-m, feedstock prepared from equal amount of CTHP-m and ETHP-m (CTHP-m/ETHP-m) possessed more excellent properties. The experimental results showed that the critical solids loading, flexural modulus, density and melt flow index of CTHP-m/ETHP-m feedstock were 63.8 vol.%, 2800 Mpa, 5.06 g cm
−3
and 62 g/10 min, respectively, which were obviously higher than that of others. Also, the shape retention of CTHP-m/ETHP-m debinded parts was the best of all the samples. The improved properties of CTHP-m/ETHP-m feedstock were attributed to the powder interaction between CTHP-m and ETHP-m formed by the chemical reaction between epoxy and carboxyl group.
The seismic performance of a fully fabricated bridge is a key factor limiting its application. In this study, a fiber element model of a fabricated concrete pier with grouting sleeve-prestressed ...tendon composite connections was built and verified. A numerical analysis of three types of continuous girder bridges was conducted with different piers: a cast-in-place reinforced concrete pier, a grouting sleeve-fabricated pier, and a grouting sleeve-prestressed tendon composite fabricated pier. Furthermore, the seismic performance of the composite fabricated pier was investigated. The results show that the OpenSees fiber element model can successfully simulate the hysteresis behavior and failure mode of the grouted sleeve-fabricated pier. Under traditional non-near-fault ground motions, the pier top displacements of the grouting sleeve-fabricated pier and the composite fabricated pier were less than those of the cast-in-place reinforced concrete pier. The composite fabricated pier had a good self-centering capability. In addition, the plastic hinge zones of the grouting sleeve-fabricated pier and the composite fabricated pier shifted to the joint seam and upper edge of the grouting sleeve, respectively. The composite fabricated pier with optimal design parameters has good seismic performance and can be applied in high-intensity seismic areas; however, the influence of pile-soil interaction on its seismic performance should not be ignored.
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