Resource-based cities are suffering from resource scarcity and environmental deterioration. Spirit, vitality and prosperity are disappearing and cities have moved towards "the valley of death" in ...terms of urban development. This typically appears in environments where it is difficult to maintain sustainable development. Based on empirical analysis, a qualitative analysis method for the selection of evaluation indicators, as well as a quantitative analysis method for index weighting and principal component extraction for constructing a three-level evaluation index system of green development for coal-resource-exhausted cities, was adopted. This study also discussed the life cycle at different development stages of resource-based cities, including mature resource-based and growing resource-based cities. We further argued that the obstacle degree can act as an evaluation basis and make recommendations accordingly to improve the green development of cities. Through star-standard divisions and statistical analysis, it can be explicated that the increase in green development in the first stage is greater than that in the later stage, which is more obvious in cities with lower stars. The results also show the evolution trend and stability coefficient. There is no end in sight for urban green development, and this study can provide a new perspective to relieve the declining trend and promote green sustainable development.
•Basing on the outbreak of COVID-19, the characteristics and potential risk of aerosol transmission of respiratory infectious diseases in indoor environment is discussed.•Standards of indoor ...environmental quality are discussed in this paper.•Lagrangian discrete phase model was adopted to trace the motion of particulate matter to simulate considering unsteady state diffusing process of particulate matter in indoor environment.•A theoretical framework, experiment and numerical model investigation are provided as references for studying on inhalable particles and building environment.
After the outbreak of COVID-19, the indoor environment has become particularly important in closed spaces, being a common concern in environmental science and public health, and of great significance for the building environment. To improve the indoor air quality and control the spread of viruses, the analysis of inhalable particles in indoor environments is critical. In this research, we study standards focused on inhalable particles and indoor environmental quality, as well as analyzing the movement and diffusion of indoor particles. Based on our analysis, we conduct an experimental study to determine the distribution of indoor inhalable particles of different sizes before and after diffusion under the conditions of underfloor air distribution. Furthermore, the mathematical modeling method is adopted to simulate the indoor flow field, particle trajectories, and pollutant dispersion process. The k-ε two-equation model is applied as the turbulence model in the numerical simulation, while the Lagrangian discrete phase model is adopted to trace the motion of particles and analyze the distribution characteristics of indoor particles. The results demonstrate that fine particles (i.e., those with size less than 0.5 μm) have a significant impact on the indoor particle concentration, while coarse particles (i.e., with size above 2.5 μm) have a greater influence on the total mass concentration of indoor particles. Small-sized particles can easily follow the airflow and diffuse to upper parts of the room. Overall, the effects of indoor particles on indoor air quality, including the potential threat of aerosol transmission of respiratory infectious diseases, are non-negligible. Application of the presented research can contribute to improving the health-related aspects of the building environment.
With the rapid development of ports, the port industry continues to focus on the function, service, and value chains. Further accelerating the high-quality development of ports has become crucial to ...promoting urban construction and economic development. Dongjiakou Port is an important shipping and logistics hub in the center of the Bohai Economic Rim and the Northeast Asia economic circle, which has superior deep-water resources. Through active transformation and upgrade, it has become an international trade hub with sustainable practices. This research examined Dongjiakou Port as a case study and employed a grey prediction model to analyze and predict port throughput and to determine the indicators and impact factors for a green port. In addition, the grey model and principal component analysis were used to predict the throughput of Dongjiakou Port from 2021 to 2025, and the effectiveness of the model was verified by comparing the predicted and actual throughput from 2014 to 2020. In addition, this research also provided suggestions for the sustainable development of ports from the aspects of port planning, port cargo structures, and effective port governance and development. The prediction model can provide support for future port planning and port design, to a certain extent, and can also provide references for predicting port throughput and promoting the construction of new ports and sustainable port development.
Metal-containing nanomaterials have attracted substantial research efforts due to their rich compositional and structural diversity as well as the broad possible applications. However, the most ...metal-containing nanomaterials are normally only used as new delivery vehicles in the field of biomedicine but do not possess biological activity by itself. Herein, we modified dendritic polyethylene glycol on one folate–nickel nanotube to fabricate a new-type of metal-containing nanotube PEG-FA-Ni NTs. We found PEG-FA-Ni NTs have exhibited excellent in vitro and in vivo antitumor activity comparable to the positive drugs doxorubicin and cisplatin. Meanwhile, this study indicates that the PEG-FA-Ni NTs may achieve more optimal antitumor effects by damaging DNA, blocking cell cycle, and ultimately inducing apoptosis. All the results showed that PEG-FA-Ni NTs could be a potent nanomedicine for the further development and application on cancer therapy.
What is the effect of letrozole use in patients undergoing frozen embryo transfer (FET) with normal ovulation? Although the number of FETs is increasing, an optimal protocol for FET (particularly ...vitrified–warmed embryo transfer) is yet to be determined. The aim of this study was to evaluate letrozole use on patients with normal menstrual cycles compared with hormone replacement therapy (HRT) cycles and natural cycles.
The study involved 2849 patients. Patients were divided into three groups: HRT cycle (n = 2115), letrozole cycle (n = 532) and natural cycle (n = 202). Inverse probability of treatment weighting aimed to equate each group according to measured baseline covariates to achieve a comparison with reduced selection bias and live birth rate as main pregnancy outcome was analysed.
In the crude analysis, the letrozole group had a higher live birth rate compared with the HRT cycle (OR 1.18, 95% CI 1.06 to 1.33) and natural cycle (OR 1.24, 95% CI 1.11 to 1.41); after adjusting for confounding factors, live birth rate was consistently higher in the letrozole group. Moreover, the biochemical pregnancy, clinical pregnancy, ongoing pregnancy and full-term delivery rates were higher in the letrozole group.
For infertile women with normal menstrual cycle undergoing FET, mildly stimulated cycles with letrozole present a relatively large advantage compared with HRT cycle and natural cycle, with higher live birth pregnancy, indicating that letrozole administration could improve pregnancy outcomes in this population.
The Oxyfluoride glass ceramics (GCs) containing Na
5
Y
9
F
32
:Ce
3+
/Tb
3+
nanocrystals were synthesized using a high-temperature melting method. The microstructural, luminescent property, energy ...transfer, and thermal stability of the samples were investigated. Under 310 nm excitation, the co-doped GCs exhibited two emissions at blue 380 nm (Ce
3+
: 5
d
→ 4
f
) and green 542 nm (Tb
3+
:
5
D
4
→
7
F
5
). The luminous color can be tuned from blue (0.1966, 0.1512) to yellow–green (0.288, 0.4473) by increasing the content of Tb
3+
ions. Decay curves revealed efficient energy transfer from Ce
3+
to Tb
3+
, with an energy transfer efficiency (ETE) of up to 47.54%. According to the theory of Dexter energy transfer, dipole–dipole interaction was confirmed as the mechanism for energy transfer between Ce
3+
and Tb
3+
. Moreover, the prepared GCs demonstrated good thermal stability even at elevated temperatures. These findings indicate that the Na
5
Y
9
F
32
: Ce
3+
/Tb
3+
GCs can serve as materials for W-LEDs, excited by near-ultraviolet light, to enhance of green light emission.
The complex correlation between regions caused by the externality of air pollution increases the difficulty of its governance. Therefore, analysis of the spatio-temporal network of air pollution ...(STN-AP) holds great significance for the cross-regional coordinated governance of air pollution. Although the spatio-temporal distribution of air pollution has been analyzed, the structural characteristics of the STN-AP still need to be clarified. The STN-AP in the Yangtze River Delta urban agglomeration (YRDUA) is constructed based on the improved gravity model and is visualized by UCINET with data from 2012 to 2019. Then, its overall-individual-clustering characteristics are analyzed through social network analysis (SNA) method. The results show that the STN-AP in the YRDUA was overall stable, and the correlation level gradually improved. The centrality of every individual city is different in the STN-AP, which reveals the different state of their interactive mechanism. The STN-AP could be subdivided into the receptive block, overflow block, bidirectional block and intermediary block. Shanghai, Suzhou, Hangzhou and Wuxi could be key cities with an all above degree centrality, betweenness centrality and closeness centrality and located in the overflow block of the STN-AP. This showed that these cities had a greater impact on the STN-AP and caused a more pronounced air pollution spillovers. The influencing factors of the spatial correlation of air pollution are further determined through the quadratic assignment procedure (QAP) method. Among all factors, geographical proximity has the strongest impact and deserves to be paid attention in order to prevent the cross-regional overflow of air pollution. Furthermore, several suggestions are proposed to promote coordinated governance of air pollution in the YRDUA.
Celotno besedilo
Dostopno za:
DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
The aim of the study was to investigate the dynamic changes of mycobiota community, and the resultant effects on the antioxidant properties during the Chinese bayberry Jiaosu fermentation. The ...structure and composition of mycobiota during the Chinese bayberry Jiaosu fermentation were significantly changed (
< 0.001) and clearly clustered into two distinct phases (Phase 1: Day 5–20; Phase 2: Day 30–60,
< 0.001). From Phase 1 to Phase 2, the dominant fungi gradually changed from
to
. The antioxidative properties (total polyphenols, 1,1-diphenyl-2-picrylhydrazyl DPPH, superoxide and 2,2′-azino-bis-(3-ethylbenzthiazoline-6-sulphonate) ABTS radical scavenging) of Chinese bayberry Jiaosu were significantly increased by 250.4, 73.9, 25.3 and 40.0% respectively (
< 0.001). Co-occurrence network analysis revealed that
contributed to the increase of antioxidative properties in the Chinese bayberry Jiaosu fermentation. Our research indicates that fermentation into Chinese bayberry Jiaosu is an effective and new method for high-valued utilization of Chinese bayberry.
A series of polyethylene glycol-functionalized imidazolium ionic liquids has been prepared and characterized. These ionic liquids have been successfully applied in the hydrosilylation of alkenes ...catalyzed by rhodium complexes. The effects of the length of the polyether chain, the amount of ionic liquid, and the reaction temperature on the catalytic performance of hydrosilylation have been investigated. Furthermore, the catalytic system has been tested for the hydrosilylation of different alkenes with triethoxysilane. The new catalytic system exhibits both excellent catalytic activity and selectivity under low-temperature conditions. The catalyst system could be recycled five times with slightly deactivation.
A series of polyethylene glycol-functionalized imidazolium ionic liquids has been prepared and characterized. These ionic liquids have been successfully applied in the hydrosilylation of alkenes catalyzed by rhodium complexes. The catalytic system exhibits both excellent catalytic activity and selectivity. The catalytic system could be recycled. Display omitted
•PEG-DIL had been successfully prepared and applied in the hydrosilylation.•PEG-DIL-Rh catalytic system exhibit both excellent catalytic activity and selectivity.•PEG-DIL-Rh catalytic system is stably and could be recycled.
Acquired resistance to 5-fluorouracil (5-FU) frequently occurs in patients with hepatocellular carcinoma (HCC), the underlying molecular mechanisms of which are poorly understood. The aim of this ...study was to identify candidate genes and associated signalling pathways that may play a role in developing drug resistance following repeated 5-FU treatments. In this work, we established 5-FU-resistant cells (HepG2/5-FU) using stepwise increasing concentrations of 5-FU in parental HepG2 cells. Using transcriptome sequencing, we found that the expressions of the Wnt signalling genes, including negative regulators (DKK1, DKK3, ZNRF3, RNF43 and APC2) and positive regulators (FZD10 and DVL1), were significantly downregulated and upregulated in HepG2/5-FU cells, respectively, resulting in increased Wnt signalling. Dishevelled-1 (DVL1) is an essential Wnt signalling pathway component that stabilizes β-catenin and mediates the Wnt pathway. Silencing DVL1 using siDVL1 or other small molecular inhibitors in HepG2/5-FU cells could restore 5-FU responsiveness via reduced cell proliferation and migration, and increased apoptosis. Moreover, DVL1 was found to be upregulated in BEL-7402/5-FU cells when compared to the parental BEL-7402 cells. Collectively, our results provide the first clue towards understanding the contribution of DVL1-mediated acquired resistance to 5-FU in HepG2/5-FU cells, suggesting a promising therapeutic strategy for liver cancer resistant to 5-FU.
Celotno besedilo
Dostopno za:
DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, UILJ, UKNU, UL, UM, UPUK
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