Based on collision data collected by the BESIII detector at the BEPCII collider at center-of-mass energies from 2.000 to 3.080 GeV, a partial-wave analysis is performed for the process $e^+e^–$→ ...$K^+K^–π^0$. The Born cross section of the process $e^+e^–$→ $K^+K^–π^0$ and its subprocesses $e^+e^–$ → $\phi π^0, K^{*+}$(892)$K^–$ and $K^{*+}_{2}$(1430)$K^–$ are measured. The results for $e^+e^–$→ $K^+K^–π^0$ and $\phi π^0$ are consistent with the BaBar measurements and with improved precision. By analyzing the cross sections of the subprocesses $e^+e^–$ → $K^{*+}$(892)$K^–$ and $K^{*+}_{2}$(1430)$K^–$ a structure with mass $M_R$ = (2190 ± 19 ± 37) MeV/c2 and width $Γ_R$ = (191 ± 28 ± 60) MeV is observed with a combined statistical significance of 7.1σ. The measured resonance parameters suggest it can be identified as the $\phi$(2170), thus the results provide valuable input to understand the internal nature of this state.
We search for the process e+e− → χcJπ+π− (J = 0, 1, 2) and for a charged charmoniumlike state in the χ c J π ± subsystem. The search uses datasets collected with the BESIII detector at the BEPCII ...storage ring at center-of-mass energies between 4.18 GeV and 4.60 GeV. No significant χcJπ+π− signals are observed at any center-of-mass energy, and thus upper limits are provided which also serve as limits for a possible charmoniumlike structure in the invariant χcJπ± mass.
Control of impurities, fuel recycling and hydrogen content by lithium evaporative coatings and real-time lithium powder injection (LPI) in EAST are studied for high performance H-mode discharges of ...up to ∼100 s. The results show that the lithium evaporative coatings significantly reduced both the low-Z impurity carbon and high-Z impurity tungsten as well as molybdenum concentration in the plasmas, and the impurities concentration significantly reduced with the accumulated lithium coatings and maintained well afterwards. Specifically the high-Z tungsten core impurity concentration was maintained between 3 ppm-15 ppm during the 101 s H-mode discharge, which is acceptable for the long pulse operation. In addition, real-time wall conditioning via LPI successfully reduced the core high-Z metal impurities by 50% during ∼35 s long pulse H-mode discharge, exhibiting strong compatibility between real-time LPI with long pulse discharges. In addition, evaporative lithium coatings demonstrated fuel recycling control, with fuel recycling obviously reducing with lithium coatings and maintaining well afterwards. Also, the lithium evaporative coatings reduced the hydrogen minority species content, represented by the density ratio H/(H + D), from ∼50% down to ∼5% with accumulated lithium coatings; low hydrogen fraction improved the ICRF minority heating efficiency. Finally the real-time LPI reduced the recycling coefficient Rglobal from 0.95 to 0.82. With these wall conditionings help, the plasma density controlled well during the 101 s long pulse H-mode discharge. These results provide valuable references on impurities, fuel recycling and hydrogen content control for future longer pulse high performance H-mode operation (≥400 s) in EAST and future fusion devices.
Using 1310.6 x 10(6) J/psi and 448.1 x 10(6) psi(3686) events collected with the BESIII detector, the branching fractions of J/psi decays to Sigma(+)(Sigma) over bar (-) is measured to be (10.61 +/- ...0.04 +/- 0.36) x 10(-4), which is significantly more precise than the current world average. The branching fractions of psi(3686) decays to Sigma(+)(Sigma) over bar (-) is measured to be (2.52 +/- 0.04 +/- 0.09) x 10(-4), which is consistent with the previous measurements. In addition, the ratio of beta(psi(3686) -> Sigma(+)(Sigma) over bar (-)) / beta(J/psi -> Sigma(+)(Sigma) over bar (-)) is determined to be (23.8 +/- 1.1)% which violates the "12% rule".
Esophageal squamous cell carcinoma (ESCC) is a common malignant epithelial tumor in the elderly, and the cause is very complicated. Therefore, the study of the pathogenesis of ESCC is conducive to ...the effective treatment of ESCC. Many studies indicated that lncRNAs were important regulatory factors in tumor formation and disease development. However, the regulatory network of lncRNA in ESCC has not been fully explored.
The expression of miR-574-3p, ZEB2-AS1, and HMGA2 was measured using qRT-PCR. The protein expression of PCNA, Cleaved-caspase3, MMP9, and HMGA2 was detected through Western blot. Cell proliferation or apoptosis of transfected cells was calculated via CKK-8 assay or flow cytometry. Transwell assay was applied to detect cell migration and invasion of ESCC cells. Luciferase reporter assay and RNA pull-down were used to determine the relationship among miR-574-3p, ZEB2-AS1, and HMGA2 in ESCC. Moreover, the regulatory network of ZEB2-AS1 has been verified in vivo in this study.
We found that ZEB2-AS1 was upregulated in ESCC tissues and cells. The knockdown of ZEB2-AS1 could inhibit cell proliferation, invasion, and migration, as well as promoted cell apoptosis in ESCC. Interestingly, miR-574-3p deficiency or HMGA2 promotion could reverse the effects of si-ZEB2-AS1 on ESCC cell progression. Luciferase reporter assay indicated that miR-574-3p was a target miRNA of ZEB2-AS1 and HMGA2 was a target gene of miR-574-3p in ESCC.
In this paper, we first verified the novel regulatory mechanism of lncRNA ZEB2-AS1 in ESCC cellular process. LncRNA ZEB2-AS1 promoted the proliferation, migration, and invasion of ESCC by modulating miR-574-3p/HMGA2 axis, indicating that ZEB2-AS1 played essential roles in cell progression in ESCC and providing a new therapeutic target of ESCC.
Glucocorticoids (GCs) are the most potent anti-inflammatory agents available for allergic diseases including asthma, which are routinely believed to need several hours to take effect through ...regulating gene expression. Our previous report had shown that GCs could inhibit allergic asthma within 10 min, which the classical mechanism could not explain. To confirm the existence and verify the sites of GCs' rapid action, we investigated nongenomic effects of GCs on degranulation of mast cells in allergic asthma. The GCs' rapid action on airway mast cells deregulations was evaluated in the allergic asthma model of guinea pigs by the computer-assisted morphometry. Using whole-cell patch clamp and fluorometric assay, we examined GCs' nongenomic effect on IgE-mediated exocytosis and histamine release of rat basophilic leukaemia-2H3 mast cells. Employing the flash photolysis technique, we studied the role of Ca²⁺ signal in the GCs' nongenomic effect. Inhaled GCs significantly inhibited airway mast cells degranulation in the allergic asthma model of guinea pigs within 10 min. In vitro, GCs could rapidly inhibit IgE-mediated exocytosis and histamine release of mast cells, and neither GC nuclear receptor antagonist nor protein synthesis inhibitor could block the rapid action. We further demonstrated that GCs' nongenomic effect was not through direct action on secretory machinery, but was mediated by a reduction in the Ca²⁺i elevation. The study suggested for the first time that nongenomic pathway was involved in GCs' rapid inhibition on allergic asthma, and raised the possibility of new therapeutic strategies for allergic diseases including asthma.
Using 448.1 x 106 $\psi$(3686) decays collected with the BESIII detector at the BEPCII $e^+e^-$ storage rings, the branching fractions and angular distributions of the decays $χ_{cJ}$ → ...$Ξ^–\overline{Ξ}^+$ and $Ξ^0 \overline{Ξ} ^0$ (J = 0, 1, 2) are measured based on a partial-reconstruction technique. The decays $χ_{c1}$ → $Ξ^0 \overline{Ξ} ^0$ and $χ_{c2}$ → $Ξ^0 \overline{Ξ} ^0$ are observed for the first time with statistical significances of 7σ and 15σ, respectively. The results of this analysis are in good agreement with previous measurements and have significantly improved precision.
Multi-objective optimal controller design of a doubly-fed induction generator (DFIG), wind turbine system using differential evolution (DE) is presented. A detailed mathematical model of DFIG wind ...turbine with a closed-loop vector control system is developed. Based on this, objective functions addressing the steady-state stability and dynamic performance at different operating conditions are implemented to optimise the controller parameters of both the rotor and grid-side converters. A superior 1-constraint method and method of adaptive penalties are applied to handle the multi-objective problem and the constraint with DE, respectively. Eigenvalue analysis and time-domain simulations are performed on a single machine infinite bus system as well as a nine-bus, multi-machine system with two DFIG wind turbines to illustrate the control performance of the DFIG wind turbine with the optimised controller parameters. The electric energy productions of the studied DFIG wind turbine system with and without optimised controller parameters under turbulent wind speed are also demonstrated.
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