We present an amplitude analysis of the decay D 0 → K - π + π + π - based on a data sample of 2.93 fb −1 acquired by the BESIII detector at the ψ(3770) resonance. With a nearly background free ...sample of about 16000 events, we investigate the substructure of the decay and determine the relative fractions and the phases among the different intermediate processes. Our amplitude model includes the two-body decays D 0 → ¯K *0 ρ 0 , D 0 → K − a + 1 (1260) and D 0 → K − 1 (1270)π + , the three-body decays D 0 →¯K *0 π + π − and D 0 → K − π + ρ 0 , as well as the four-body nonresonant decay D 0 → K − π + π + π − . The dominant intermediate process is D 0 → K − a + 1 (1260), accounting for a fit fraction of 54.6%.
Using 1310.6 x 10(6) J/psi and 448.1 x 10(6) psi(3686) events collected with the BESIII detector, the branching fractions of J/psi decays to Sigma(+)(Sigma) over bar (-) is measured to be (10.61 +/- ...0.04 +/- 0.36) x 10(-4), which is significantly more precise than the current world average. The branching fractions of psi(3686) decays to Sigma(+)(Sigma) over bar (-) is measured to be (2.52 +/- 0.04 +/- 0.09) x 10(-4), which is consistent with the previous measurements. In addition, the ratio of beta(psi(3686) -> Sigma(+)(Sigma) over bar (-)) / beta(J/psi -> Sigma(+)(Sigma) over bar (-)) is determined to be (23.8 +/- 1.1)% which violates the "12% rule".
To evaluate the effect of autologous hematopoietic stem cell transplantation (ASCT) on the treatment of relapsed/refractory multiple myeloma (RRMM) with chimeric antigen receptor T cell (CAR-T) ...therapy.
A retrospective cohort study. The clinical data of 168 patients with RRMM who underwent CAR-T therapy at the Department of Hematology, Xuzhou Medical University Hospital from 3 January 2020 to 13 September 2022 were analyzed. Patients were classified into a transplantation group (TG;
=47) and non-transplantation group (NTG;
=121) based on whether or not they had undergone ASCT previously. The objective response rate (ORR), progression-free survival (PFS), overall survival (OS) and the levels of CD3, CD4, CD8, CD19, CD56 and natural killer (NK) cells before CAR-T infusion were analyzed by
test, Kaplan-Meier method and independent sample
-test.
Among 168 patients with RRMM, 98 (58.3%) were male. The median age of onset was 57 (range 30-70) years. After CAR-T therapy, the ORR of patients was 89.3% (92/103) in the
The dependency of phosphorous content on the glass forming ability, thermal stability and soft magnetic properties of Fe83.4Si2B14−xPxCu0.5C0.1 (x=0,1,2,3,4) alloys was investigated. The experimental ...results showed that the substitution of B by P increased the glass forming ability in this alloy system. The Fe83.4Si2B10P4Cu0.5C0.1 alloy shows a fully amorphous character. Thermal stability of melt-spun ribbons increases and temperature interval between the first and second crystallization peaks enlarges with the increase of P content. And the saturation magnetic flux density (Bs) shows a slight increase with the increase of P content. The Fe83.4Si2B11P3Cu0.5C0.1 nanocrystalline alloy exhibits a high Bs about 200.6emu/g. The Bs of fully amorphous alloy Fe83.4Si2B10P4Cu0.5C0.1 drops dramatically to 172.1emu/g, which is lower than that of other nanocrystallines. Low material cost and excellent soft magnetic properties make the FeSiBPCuC alloys promise soft magnetic materials for industrial applications.
•Partial substituting B by P helps to improve the glass forming ability of the alloy.•The addition of P content reduces the thermal stability and improves heat treatment temperature region for these alloys.•The Fe83.4Si2B11P3Cu0.5C0.1 nanocrystalline alloy exhibits a high saturation magnetic density of 200.6emu/g.
Abstract
Artificial neural networks (NNs) are trained, based on the numerical database, to predict the no-wall and ideal-wall
β
N
limits, due to onset of the
n
= 1 (
n
is the toroidal mode number) ...ideal external kink instability, for the HL-2M tokamak. The database is constructed by toroidal computations utilizing both the equilibrium code CHEASE (Lütjens
et al
1992
Comput. Phys. Commun.
69
287) and the stability code MARS-F (Liu
et al
2000
Phys. Plasmas
7
3681). The stability results show that (1) the plasma elongation generally enhances both
β
N
limits, for either positive or negative triangularity plasmas; (2) the effect is more pronounced for positive triangularity plasmas; (3) the computed no-wall
β
N
limit linearly scales with the plasma internal inductance, with the proportionality coefficient ranging between 1 and 5 for HL-2M; (4) the no-wall limit substantially decreases with increasing pressure peaking factor. Furthermore, both the NN model and the convolutional neural network (CNN) model are trained and tested, producing consistent results. The trained NNs predict both the no-wall and ideal-wall limits with as high as 95% accuracy, compared to those directly computed by the stability code. Additional test cases, produced by the Tokamak Simulation Code (Jardin
et al
1993
Nucl. Fusion
33
371), also show reasonable performance of the trained NNs, with the relative error being within 10%. The constructed database provides effective references for the future HL-2M operations. The trained NNs can be used as a real-time monitor for disruption prevention in the HL-2M experiments, or serve as part of the integrated modeling tools for ideal kink stability analysis.
BACKGROUND AND PURPOSE HMG‐CoA reductase inhibitors, statins, with lipid‐reducing properties combat against atherosclerosis and diabetes. The favourable modulation of endothelial function may play a ...significant role in this effect. The present study aimed to investigate the cellular mechanisms responsible for the therapeutic benefits of rosuvastatin in ameliorating diabetes‐associated endothelial dysfunction.
EXPERIMENTAL APPROACH Twelve‐week‐old db/db diabetic mice were treated with rosuvastatin at 20 mg·kg−1·day−1 p.o.for 6 weeks. Isometric force was measured in isolated aortae and renal arteries. Protein expressions including angiotensin II type 1 receptor (AT1R), NOX4, p22phox, p67phox, Rac‐1, nitrotyrosine, phospho‐ERK1/2 and phospho‐p38 were determined by Western blotting, while reactive oxygen species (ROS) accumulation in the vascular wall was evaluated by dihydroethidium fluorescence and lucigenin assay.
KEY RESULTS Rosuvastatin treatment of db/db mice reversed the impaired ACh‐induced endothelium‐dependent dilatations in both renal arteries and aortae and prevented the exaggerated contractions to angiotensin II and phenylephrine in db/db mouse renal arteries and aortae. Rosuvastatin reduced the elevated expressions of AT1R, p22phox and p67phox, NOX4, Rac1, nitrotyrosine and phosphorylation of ERK1/2 and p38 MAPK and inhibited ROS production in aortae from db/db mice.
CONCLUSIONS AND IMPLICATIONS The vasoprotective effects of rosuvastatin are attributed to an increase in NO bioavailability, which is probably achieved by its inhibition of ROS production from the AT1R‐NAD(P)H oxidase cascade.
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