The accelerating and thorough treatment of chronic wounds still represents a major unmet medical need owing to the complex symptoms resulting from metabolic disorder of the wound microenvironment. ...Although numerous strategies and bioactive hydrogels are developed, an effective and widely used method of chronic wound treatment remains a bottleneck. With the aim to accelerate chronic wound healing, many hydrogel dressings with antioxidant functions have emerged and are proven to accelerate wound healing, especially for chronic wound repair. The new strategy in chronic wound treatment brought by antioxidant hydrogels is of great significance to human health. Here, the application of antioxidant hydrogels in the repair of chronic wounds is discussed systematically, aiming to provide an important theoretical reference for the further breakthrough of chronic wound healing.
Antioxidant hydrogel dressings are proved to be effective in accelerating chronic wound healing. Meanwhile, antioxidant hydrogels for chronic wound healing include three main types: 1) antioxidant matrixes constructing hydrogels; 2) hydrogels containing antioxidation drugs; 3) hydrogels containing multifunctional antioxidants.
Mechanofluorochromic or piezochromic fluorescence chemistry involves the switching and tuning of the luminescent properties of solid‐state materials induced by exogenous forces, such as grinding, ...shearing, compression, tension, and so forth. Up until now, most reported mechanochromic systems, including liquid crystals, organic molecules, organometallic compounds, polymers, and dye‐doped polymers, have displayed reversible two‐color changes, which arise from either supramolecular or chemical structure transformations. However, fluorescent materials that undergo mechanically induced multicolor changes remain rare; this Minireview is focused on such materials. Topics are categorized according to the different applied forces that are required to induce the multicolor change, including mechanical control of either the supramolecular structures or the chemical structures, and mechanical control of both the supramolecular structures and chemical structures.
Karma Chameleon: This Minireview focuses on the mechanisms and strategies for constructing fluorescent materials that undergo mechanically induced multicolor changes. The topics are categorized according to the different applied forces that are required to induce the color change, including mechanical control of either the supramolecular structures or the chemical structures, and mechanical control of both the supramolecular structures and chemical structures.
A rhodamine‐based molecule, Rh‐OH, is synthesized. Rh‐OH exhibits a reversible mechanochromic luminescent character but a passivating response to UV light. An elastomeric polymer film based on ...polyurethane with embedded Rh‐OH is prepared via a polycondensation reaction. The film shows mechanochromic and photochromic properties with reversible color change, which originates from the isomerization of the Rh‐OH molecule from a twisted spirolactam in the ring‐closed form to a planarized zwitterionic structure in the ring‐open state.
A fragment‐assembling strategy is used to form oxazoles from aryl acetaldehydes, amines, and molecular oxygen under mild conditions (see scheme). The transformation is highly efficient with the ...removal of six hydrogen atoms, including the cleavage of four C(sp3)H bonds.
Paspaline‐derived indole diterpenes (IDTs) are structurally complex mycotoxins with unique tremorgenic activity. Reported are asymmetric total syntheses of three paspaline‐derived IDTs paspalicine, ...paspalinine and paspalinine‐13‐ene. Our synthesis features a green Achmatowicz rearrangement/bicycloketalization for the efficient construction of FG rings (75 % yield) and a cascade ring‐closing metathesis of dienyne for highly regioselective formation of CD rings (72 % yield). Other highlights include four palladium‐mediated reactions (Stille, aza‐Wacker, Suzuki, and Heck) to forge the BE rings and the installation of two continuous all‐carbon quaternary stereocenters via reductive ring‐opening of cyclopropane and α‐methylation of the conjugate ester. Our new synthetic strategy is expected to be applicable to the chemical synthesis of other paspaline‐derived IDTs and will facilitate the bioactivity studies of these agriculturally and pharmacologically important IDTs.
The asymmetric total synthesis of three paspaline‐derived indole diterpenes paspalicine, paspalinine and paspalinine‐13‐ene is reported. This synthesis features a green Achmatowicz rearrangement/bicycloketalization for the efficient construction of FG rings, a cascade ring‐closing metathesis of dienyne for highly regioselective formation of CD rings, and four palladium‐mediated reactions to forge BE rings.
•Metal elements played an irreplaceable role in regulating and accelerating wound repair.•Based on the dimensionality of metal nanomaterials, we divide the common metal-based nanomaterials into 0D, ...1D, 2D and 3D nanomaterial.•We summarized the advances and impacts of metal-based biomaterials for wound repair.
Wound repair, as one of the most intricate biological mechanisms, is essential to ensure the formation and integrity of the skin barrier. However, multiple factors can cause delays and severe debilitating effects in wound repair, which bring serious challenges. Metal elements such as calcium, copper, iron, and zinc serve irreplaceable roles in various regulatory pathways of the human body and directly or indirectly affect the orderly wound repair process. Biomaterials have proven to be an attractive strategy that can be applied to wound repair and have excellent potential to induce skin regeneration. In recent decades, with in-depth research on the regulatory mechanisms of metal elements involved in wound repair, metal-based biomaterials have been widely reported. Metal-based zero-dimensional (0D) biomaterials such as Ångstrom-scale metallic materials and metal quantum dots, metal-based one-dimensional (1D) biomaterials such as nanorods, nanowires and nanofibers, metal-based two-dimensional (2D) biomaterials such as nanofilms and nanosheets, and metal-based three-dimensional (3D) biomaterials such as nanoframes have achieved remarkable results, which provide great support for accelerated wound repair. In this review, we systematically investigated the advances and impacts of various metal-based biomaterial platforms for wound repair to provide valuable guidance for future breakthroughs in wound treatment.
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A cationic fluorescence nanoparticle efficiently enters plants with high transfection efficacy. Applying a mixture of G2/dsRNA to the model plant,
Arabidopsis
root, leads to significant reduction in ...the expression of important developmental genes and results in apparent phenotypes. This study reports a non-viral gene nanocarrier which triggers gene silencing in plants and leads to systemic phenotypes.
A cationic fluorescence nanoparticle efficiently enters plants with high transfection efficacy.
Native cattle breeds are an important source of genetic variation because they might carry alleles that enable them to adapt to local environment and tough feeding conditions. Jiaxian Red, a Chinese ...native cattle breed, is reported to have originated from crossbreeding between taurine and indicine cattle; their history as a draft and meat animal dates back at least 30 years. Using whole-genome sequencing (WGS) data of 30 animals from the core breeding farm, we investigated the genetic diversity, population structure and genomic regions under selection of Jiaxian Red cattle. Furthermore, we used 131 published genomes of world-wide cattle to characterize the genomic variation of Jiaxian Red cattle.
The population structure analysis revealed that Jiaxian Red cattle harboured the ancestry with East Asian taurine (0.493), Chinese indicine (0.379), European taurine (0.095) and Indian indicine (0.033). Three methods (nucleotide diversity, linkage disequilibrium decay and runs of homozygosity) implied the relatively high genomic diversity in Jiaxian Red cattle. We used θπ, CLR, F
and XP-EHH methods to look for the candidate signatures of positive selection in Jiaxian Red cattle. A total number of 171 (θπ and CLR) and 17 (F
and XP-EHH) shared genes were identified using different detection strategies. Functional annotation analysis revealed that these genes are potentially responsible for growth and feed efficiency (CCSER1), meat quality traits (ROCK2, PPP1R12A, CYB5R4, EYA3, PHACTR1), fertility (RFX4, SRD5A2) and immune system response (SLAMF1, CD84 and SLAMF6).
We provide a comprehensive overview of sequence variations in Jiaxian Red cattle genomes. Selection signatures were detected in genomic regions that are possibly related to economically important traits in Jiaxian Red cattle. We observed a high level of genomic diversity and low inbreeding in Jiaxian Red cattle. These results provide a basis for further resource protection and breeding improvement of this breed.
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Dostopno za:
DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
Adhesives have been widely applied in various fields. However, most industrial adhesives contain organic solvents, which are toxic and difficult to clean after use. Importantly, most adhesives are ...used in a relatively small temperature range (0-50 °C), which is due to the fragmentation of the morphology and properties of supramolecular polymer gels at low temperatures. Most of the supramolecular adhesives need to be heated during the bonding process, which cannot meet the requirements of low-temperature adhesion in daily life and industry. In this study, based on the concept of using deep eutectic solvents (DESs) as a platfonn, cyclodextrin (ß-CD) and carboxyl tenninated hyperbranched polyester (DCHP) were used to prepare solvent-free supramolecular polymer gel (CD-DCHP), which was non-toxic and easy to clean. Due to the joint action of deep eutectic solvent and supramolecular polymer structure, CD-DCHP showed excellent mechanical properties, super strong adhesion (up to 4.55 MPa on glass surface), and excellent low-temperature perfonnance (up to 1.64 MPa at -60 °C). This supramolecular polymer gel also showed excellent tolerance to acids, alkalis, and various organic solvents. It greatly expanded the application of DES and provided a new approach to the development of supramolecular adhesives.
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Dostopno za:
DOBA, IZUM, KILJ, NUK, ODKLJ, PILJ, PNG, SAZU, UILJ, UKNU, UL, UM, UPUK
Cross breeding is an important way to improve livestock performance. As an important livestock and poultry resource in Henan Province of China, Bohuai goat was formed by crossing Boer goat and Huai ...goat. After more than 20 years of breeding, BoHuai goats showed many advantages, such as fast growth, good reproductive performance, and high meat yield. In order to better develop and protect Bohuai goats, we sequenced the whole genomes of 30 BoHuai goats and 5 Huai goats to analyze the genetic diversity, population structure and genomic regions under selection of BoHuai goat. Furthermore, we used 126 published genomes of world-wide goat to characterize the genomic variation of BoHuai goat.
The results showed that the nucleotide diversity of BoHuai goats was lower and the degree of linkage imbalance was higher than that of other breeds. The analysis of population structure showed that BoHuai goats have obvious differences from other goat breeds. In addition, the BoHuai goat is more closely related to the Boer goat than the Huai goat and is highly similar to the Boer goat. Group by selection signal in the BoHuai goat study, we found that one region on chromosome 7 shows a very strong selection signal, which suggests that it could well be the segment region under the intense artificial selection results. Through selective sweeps, we detected some genes related to important traits such as lipid metabolism (LDLR, STAR, ANGPTL8), fertility (STAR), and disease resistance (CD274, DHPS, PDCD1LG2).
In this paper, we elucidated the genomic variation, ancestry composition, and selective signals related to important economic traits in BoHuai goats. Our studies on the genome of BoHuai goats will not only help to understand the characteristics of the crossbred but also provide a basis for the improvement of cross-breeding programs.
Celotno besedilo
Dostopno za:
DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
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