This study aims to explore the relationship between organizational innovation climate (OIC) and innovative work behavior (IWB), using psychological safety (PS) and knowledge sharing (KS) as mediating ...variables. Based on the social cognitive theory (SCT), this study proposes a conceptual framework to explore innovative work behavior. The structural model of the extended SCT model was tested using sample data from 446 R&D staff of high-tech enterprises in China. SPSS 25.0 and AMOS 23.0 were used to test the hypothetical model. The results indicated that organizational innovation climate was positively correlated with psychological safety and innovative work behavior. Psychological safety was positively correlated with innovative work behavior. Knowledge sharing was significantly and positively correlated with innovative work behavior. Moreover, Psychological safety and knowledge sharing play a significant mediating role in the relationship between organizational innovation climate and innovative work behavior, and psychological safety further improves individual innovative work behavior by influencing knowledge sharing among research team members. At the end of the study, this study thoroughly discussed the conclusions, practical implications, limitations, and future research directions of the study.
This study delves into the effects of mindfulness on workplace spirituality, work-life balance, and perceived professional benefits among nurses operating in the high-pressure environments of ...hospitals in Jiangxi Province, China. Utilizing a robust sample of 303 valid questionnaires and employing partial least squares (PLS) analysis, the research uncovers a significant positive relationship between mindfulness and workplace spirituality. Furthermore, it demonstrates how both workplace spirituality and work-life balance serve as crucial mediators in enhancing nurses' perception of their professional benefits. The findings illuminate the potential of mindfulness training in substantially elevating job satisfaction and reducing burnout among nurses. The study not only reinforces the value of mindfulness in the healthcare sector but also advocates for its integration into professional development programs and healthcare policies. By doing so, it aims to bolster the overall wellbeing and professional effectiveness of nurses facing the myriad challenges inherent in demanding healthcare environments. This study contributes to the growing discourse on mindfulness in occupational settings, highlighting its pivotal role in enhancing both the personal wellbeing and professional capabilities of healthcare professionals.
Objective
Epstein-Barr virus (EBV) is a virus that is ubiquitous in humans. To investigate the association between EBV infection and lung cancer risk to reveal whether it is involved in the ...development and development of lung cancer. Although there has been discussion of EBV and lung cancer in the past. Through this study, we hope to deepen our understanding of the causes of lung cancer and provide new clues and targets for the prevention, early diagnosis and treatment of lung cancer. This study is also beneficial to the development of medical science and public health. First of all, the research results are expected to be incorporated into lung cancer prevention and treatment strategies and policies, so as to provide better treatment decisions for lung cancer patients and improve the survival rate and quality of life of patients. At the same time, communicating the research results to the public can help raise awareness of lung cancer risk factors. By encouraging healthy lifestyles and screening measures, the public can reduce their risk of lung cancer. In addition, this study also provides an important foundation for subsequent academic research and scientific exploration. It provides valuable information and inspiration for in-depth understanding of lung cancer and other related fields. Overall, this study makes an important contribution to both medical science and public health.
Method
By September 26, 2022, an online database was used to conduct a literature search in English. Random effects models were employed to estimate the prevalence of EBV with 95% confidence intervals (CIs). Additionally, the pooled odds ratio (OR) and 95%CI were calculated from case-control studies to determine the association between EBV and lung cancer.
Results
In this study of 886 patients with lung cancer, the overall prevalence of EBV infection was found to be 44.36% (95%CI: 4.08-16.9). Fourteen studies were included in the analysis, all of which used a case-control design and involved comparisons of tumors with adjacent or non-adjacent normal and non-cancerous controls. There was a significant difference in the prevalence of EBV infection in lung cancer tissues between China and other regions, with an odds ratio (OR) of 9.36 (95% confidence interval: 4.00-21.94, P<0.001, I²=73.5%). This suggests that the association between EBV infection and lung cancer cases is stronger in China than in other regions. Additionally, the prevalence of EBV infection varied across different pathological types of lung cancer, with rates of 81.08% for pulmonary lymphoepithelioma-like carcinoma (LELC),this a rare subtype of non-small cell lung cancer (NSCLC).34.78% for non-small cell lung cancer, and 21.17% for small cell lung cancer. The statistical analysis indicated that EBV infection was most significantly associated with cancer risk in LELC, while non-small cell lung cancer was more strongly associated with EBV than small cell lung cancer.
Conclusion
The study found that EBV infection increases the risk of lung cancer by more than four times, and this risk is associated with the pathological type, lymphatic infiltration, and degree of differentiation of the lung cancer, particularly in the rare subtype of pulmonary lymphoepithelioma in non-small cell lung cancer(NSCLC). Additionally, there are racial and regional differences in the correlation between EBV-infected lung cancer, with the Asian population showing greater susceptibility. The study used normal or abnormal tissue adjacent to the tumor as a control, which is considered a more accurate method for determining the relationship between EBV infection and lung cancer.
Nowadays, many high-tech SMEs have gradually focused on innovation-orientation and have adopted various measures to create an organizational climate, stimulate knowledge workers’ enthusiasm for ...innovation, and promote individual innovation behavior, but met with little success. Based on the stimulus organism response (SOR) model, the objective of this study is to explore the mediating factors that affect knowledge workers’ innovative work behavior, and construct a three-level model of the external environment, psychological factors, and individual behavior. This study selected 575 valid samples from 24 high-tech SMEs in Zhongguancun, which is a technology hub in Haidian District, Beijing, China. Through the convenience sampling method, This study analyze the data and perform structural equation modeling (SEM) using AMOS 23.0. The external environment (i.e., organizational climate, innovation orientation) and psychological factors (i.e., intrinsic motivation, psychological safety) have a significant positive impact on innovative work behavior. Psychological factors have the most significant impact on innovative work behavior. Besides, psychological factors also mediate the relationship between the external environment and innovative work behavior. The findings indicated that high-tech SMEs need to formulate scientific innovation-orientation when implementing strategies, and continue to shape a harmonious and equal organizational climate. Furthermore, high-tech SMEs should encourage knowledge workers to speak the truth, express different voices, and stimulate work enthusiasm to improve psychological safety and intrinsic motivation, thereby enhancing knowledge workers’ innovative work behavior.
The mechanisms underlying the pronociceptive effect of paradoxical sleep deprivation (PSD) are not fully established. The modulation of BDNF signaling-mediated descending facilitation from the ...rostral ventromedial medulla (RVM) of brain stem has been demonstrated in persistent pain models of inflammatory pain, but not in incisional pain model. Recent study has shown that PSD increases the expression of brain-derived neurotrophic factor (BDNF) in the brainstem structure. Therefore, in the current study, we asked whether the BDNF signaling-mediated descending facilitation was involved in the PSD-induced pronociceptive effect on incisional pain and delay the recovery period of postoperative pain in rats. Our results found that a preoperative 24 h PSD significantly aggravated the pain hypersensitivity after incision and prolonged the duration of postoperative pain. The lesions of ipsilateral dorsolateral funiculus partly reversed the PSD-induced pronociceptive effect on incisional pain. Interestingly, the 24 h PSD, but not incision significantly enhanced the levels of BDNF protein expression in the RVM areas of rats. Furthermore, at 1 day or 4 days after incision, intra-RVM microinjection of a BDNF antibody partly reversed the PSD-induced pronociceptive effects in incisional rats, while it did not change the cumulative pain scores and paw withdrawal thresholds in rats receiving only plantar incision. These findings suggest that the preoperative PSD may aggravate and prolong the incision-induced pain hypersensitivity via BDNF signaling-mediated descending facilitation.
Blockade of programmed cell death 1 ligand (PD-L1) has been used to treat triple-negative breast cancer (TNBC), and various strategies are under investigation to improve the treatment response rate. ...Inhibition of glutamine metabolism can reduce the massive consumption of glutamine by tumor cells and meet the demand for glutamine by lymphocytes in tumors, thereby improving the anti-tumor effect on the PD-L1 blockade therapy. Here, molybdenum disulfide (MoS
) was employed to simultaneously deliver anti-PDL1 antibody (aPDL1) and V9302 to boost the anti-tumor immune response in TNBC cells. The characterization results show that MoS
has a dispersed lamellar structure with a size of about 181 nm and a size of 232 nm after poly (L-lysine) (PLL) modification, with high stability and biocompatibility. The loading capacity of aPDL1 and V9302 are 3.84% and 24.76%, respectively. V9302 loaded MoS
(MoS
-V9302) can effectively kill 4T1 cells and significantly reduce glutamine uptake of tumor cells. It slightly increases CD8
cells in the tumor and promotes CD8
cells from the tumor edge into the tumor core. In vivo studies demonstrate that the combination of aPDL1 and V9302 (MoS
-aPDL1-V9302) can strongly inhibit the growth of TNBC 4T1 tumors. Interestingly, after the treatment of MoS
-aPDL1-V9302, glutamine levels in tumor interstitial fluid increased. Subsequently, subtypes of cytotoxic T cells (CD8
) in the tumors were analyzed according to two markers of T cell activation, CD69, and CD25, and the results reveal a marked increase in the proportion of activated T cells. The levels of cytokines in the corresponding tumor interstitial fluid are also significantly increased. Additionally, during the treatment, the body weights of the mice remain stable, the main indicators of liver and kidney function in the blood do not increase significantly, and there are no obvious lesions in the main organs, indicating low systemic toxicity. In conclusion, our study provides new insights into glutamine metabolism in the tumor microenvironment affects immune checkpoint blockade therapy in TNBC, and highlights the potential clinical implications of combining glutamine metabolism inhibition with immune checkpoint blockade in the treatment of TNBC.
In this study, modifying the austenitizing temperature offers a strategically viable way towards creating blocky retained austenite (BRA) with varying sizes and morphologies in nanostructured ...bainitic steel, in strikingly contrast to the conventional method of adjusting the austempering temperature. Dynamic tensile and compressive evaluation at different strain rates of 1 × 103 s−1 and 5 × 103 s−1 were carried out to gain insights into the effect of BRA stability on the dynamic mechanical properties and its intrinsic relationship with high strain rates. Additionally, the phase transformations and the triggered transformation-induced plasticity (TRIP) effects of BRA at different high strain rates were analyzed. The results reveal that during dynamic deformation, most of metastable BRA underwent a two-stage martensitic transformation of γ→εM and εM→α′M, while the filmy retained austenite exhibits minimal phase transformation. BRA dominates the TRIP effect under the extremely short deformation time and adiabatic heating conditioning. Consequently, samples containing more and larger-sized BRA demonstrated superior dynamic mechanical properties, including strength and fracture strain. As the strain rate increases, the TRIP effect induced by less stable BRA contributes to more pronounced enhancement of properties. Besides the deterioration effect originating from the early transformed brittle martensite also gradually intensifies with the strain rate, which is manifested by the appearance of quasi-cleavage facets at the fracture comparable to the BRA size. Nevertheless, during dynamic deformation, the metastable BRA induced TRIP effect significantly enhances the mechanical properties, outweighing its deteriorating effect. Moreover, less stable BRA should be favored at higher the strain rate.
Due to the increasingly tight energy supply situation, thermal insulation mortar is more and more widely used in the exterior wall insulation layer of buildings in various countries. However, the ...existing academic papers have less research on the key properties of thermal insulation mortar such as fire resistance and economic feasibility. Based on the previous research results, this study selected silica fume as an admixture to improve the comprehensive performance of insulation mortar. The goal is to develop a high-performance fireproof insulation mortar. This paper focuses on the fire resistance of the improved insulation mortar. The results show that silica fume mixed into the mortar will play a fine particle filling and hydration gelation cooperation, and the amount of silica fume mixed from 0 to 10% can significantly improve the bond strength and compressive strength of the mortar. For the thermal conductivity and dry density of mortar, there is a certain increase in the range of silica fume dosing from 0 to 4%, while the range of silica fume dosing from 4% to 10% decreases again. Silica fume has a favorable effect on improving the fire resistance of insulating mortar, and the mortar with 10% admixture of silica fume has about 28.30% lower mass loss rate after high temperature and about 14.73% higher relative compressive strength after high temperature after 28 days of maintenance. The final selected optimum admixture of silica fume is 10%, and the best ratio of raw materials is cement: aggregate: water: dispersible emulsion powder: fly ash: diabase rock powder: AOS foaming agent: gelatin: silica fume = 1: 1.67: 2: 0.045: 0.15: 0.225: 0.035: 0.02: 0.138.
A corallivorous nudibranch from the South China Sea reproduced explosively and caused extensive damage to Porites in our aquarium. In this study, morphological and molecular analyses of the ...nudibranch were conducted and described. Morphologically, this nudibranch was nearly consistent with Pinufius rebus in its characteristics intermediate between arminids and aeolids. The only detected difference was that the hook-like denticles on the masticatory border of P. rebus were absent in this nudibranch. In a molecular analysis, phylogenetic results based on the cytochrome oxidase subunit-I, 16S rRNA, and histone H3 gene sequences showed that this nudibranch and P. rebus form a well-supported sister clade under the superfamily Fionoidea, with significant interspecific divergence (0.18). Thus, we presumed that this nudibranch is a new species of Pinufius. Our results extend the distribution of Pinufius to the South China Sea, support the current taxonomic status of Pinufius under the superfamily Fionoidea, and imply that the species composition of Pinufius is more complex than previous records. Moreover, as a corallivorous nudibranch, the potential threat of Pinufius to coral health cannot be neglected.
