Two new discrete cobaloxime based complexes with the general formula ClCo(dioxime)
L (1 and 2), L1 =
-(4-pyridylmethyl)-1,8-naphthalamide, L2 = 4-bromo-
-(4-pyridylmethyl)-1,8-naphthalamide have been ...synthesized and characterized by various spectroscopic techniques such as FT-IR,
H,
C{
H} NMR and PXRD. The molecular structures of both complexes have also been determined using single crystal X-ray crystallography. The solid state molecular structures revealed distorted octahedral geometry around the Co(III) central metal ion with two dioximes in the equatorial plane and axial positions are occupied by chloro and pyridine nitrogen of
-(4-pyridylmethyl)-1,8-naphthalamide ligands. Both complexes exhibit weaker non-covalent interactions (C-H⋯O, C-H⋯Cl and C-H⋯π(Centroid) in complex 1 whereas C-H⋯O and C-H⋯Br in complex 2) resulting in the formation of dimeric and 1D supramolecular structures. Furthermore, these complexes are immobilized onto the surface of activated carbon cloth (CC) and their electrocatalytic performance for the hydrogen evolution reaction (HER) has been investigated in alkaline and acidic media as well as buffer solution. In alkaline medium, we found that complex 2 exhibited impressive electrocatalytic HER activity and produced a current density of -10 mA cm
at an overpotential of 260 mV, whereas complex 1 produced the same current density at an overpotential of 334 mV. An electrochemical impedance spectroscopy (EIS) spectral study revealed the faster charge transfer kinetics of complex 2 than that of complex 1. Similarly, the low Tafel slope (100 mV dec
) for the HER with complex 2 indicates faster HER kinetics compared to complex 1. The chronoamperometric study showed that complex 2 is stable under electrocatalytic HER conditions for 5 h without losing the initial current density and it has also been established that the complex structure is retained after electrocatalysis.
The prominent objective of the present study is to assess the reliability, availability and maintainability of a hot standby database system by analyzing the failure data of the system. This study is ...also helpful in predicting the maintenance schedules and adopting effective maintenance strategies based on repair data recorded for the thirty months of a Database system. The reliability, availability, and maintainability of the system have been evaluated with the help of basic probability arguments. The parameters of well-known probability distributions have been estimated. The statistical analysis, trend and serial correlation, reliability, and maintainability analysis of the primary unit and hot standby unit are performed. It is observed that the database system was available for use at approximately 99.9997628% time. It is observed that no serial and trend correlation present in the failure and repair data. The best fit for the time between failures (TBF) of primary and hot standby units is Weibull Distribution having Anderson–Darling (AD) values 0.486 and 1.161 respectively. Though, best fitted distribution for the TTR of hot standby unit is 3-Parameter Loglogistic Distribution having AD value 1.112 while for primary unit is 3-Parameter Weibull distribution with AD value 1.004. Furthermore, as RAM analysis has been done to increase database system performance, so database designers and managers can use the findings of the present study.
Nowadays, Blockchain-based rating/review systems are gaining popularity as a backbone for recommender systems due to the inherent cryptographically secured decentralised architecture, immutability, ...user anonymity, and inclusion of smart contracts. However, the existing Blockchain-based rating/review systems address resistance to the standard attacks, i.e. collusion attack, user threatening, and unfair rating. Still, they do not present security analyses of smart contracts that may result in substantial threats to the users of the systems. This manuscript presents an in-depth study of twelve publicly available security analysis tools and standard vulnerabilities in smart contracts and reviews. The experimental setup uses a two-step approach for selecting the security analysis tool. The first step identifies the seven tools their proposers or independent researchers have compared, and the second step proposes a new method for selecting tools based on continuous improvement. Our experimental results show security issues in 51.72% of the analysed smart contracts of four Blockchain-based rating/review systems. 6.67% of vulnerable smart contracts exhibit high-level severity threats that raise an alarming condition for the current state of system developments.
Celotno besedilo
Dostopno za:
DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
The interaction of four benzothiazole tethered triazole analogues (MS43, MS70, MS71, and MS78) with human serum albumin (HSA) was investigated using various spectroscopic techniques ...(ultraviolet–visible (UV–vis) light absorption, fluorescence, circular dichroism (CD), molecular docking and density functional theory (DFT) studies). Fluorescence quenching constants (~1012) revealed a static mode of quenching and binding constants (Kb ~104) indicating the strong affinity of these analogues for HSA. Further alteration in the secondary structure of HSA in the presence of these analogues was also confirmed by far UV–CD spectroscopy. The intensity loss in CD studied at 222 nm indicated an increase in random coil/β‐sheet conformations in the protein. Binding energy values (MS71 (−9.3 kcal mol−1), MS78 (−8.02 kcal mol−1), MS70 (−7.16 kcal mol−1) and MS43 (−6.81 kcal mol−1)) obtained from molecular docking revealed binding of these analogues with HSA. Molecular docking and DFT studies validated the experimental results, as these four analogues bind with HSA at site II through hydrogen bonding and hydrophobic interactions.
Background:
The oral cavity is the most common site of cancer in the Indian subcontinent contributing to one-third of all cancers. The prognosis of oral dysplasia and malignant lesions can be ...predicted by both clinicopathological parameters and molecular markers.
Aims and Objectives:
The present study was undertaken to examine and compare the expression profile of cell cycle regulatory proteins p63 and Ki-67 in normal dysplastic and malignant lesions of oral mucosa and its correlation with prognosis.
Settings and Design:
This was a retrospective case–control study in a tertiary referral center.
Materials and Methods:
We evaluated and compared the expression profile of antigens p63 and Ki-67 on 60 cases of histologically proven oral dysplastic and malignant lesions oral squamous cell carcinoma (OSCC – 35 cases), oral epithelial dysplasia (OED – 15 cases), and 10 cases of benign and inflammatory oral lesions.
Statistical Analysis:
Mean and standard deviation were calculated and ANOVA statistical test was used to compare the data.
Results:
The mean labeling index of p63 and KI-67 was higher in OSCC than OED and minimum in inflammatory (controls) groups.
Conclusion:
p63 expression had a positive correlation with Ki-67 expression. Thus, p63 and Ki-67 may be a marker for tumorigenesis and tumor cell proliferation.
Introduction: Postpartum haemorrhage with an atonic uterus is one of the leading causes of maternal mortality during Lower Segment Caesarean Section (LSCS) in nearly 50% of cases. Oxytocin is the ...most commonly administered drug for achieving post-delivery adequate uterine contractions and placenta expulsion, thereby preventing postpartum haemorrhage. Coadministration of phenylephrine during LSCS under spinal anaesthesia inhibits Oxytocin-induced hypotension. Aim: To compare the effectiveness of co-administration of two different doses of phenylephrine with oxytocin in preventing the incidence of Oxytocin-induced hypotension. Materials and Methods: A randomised, double-blinded controlled trial was in the Department of Anaesthesiology, SMS Medical College and Attached Group of Hospitals, Jaipur, Rajasthan, India from August 2021 to July 2022, involving 120 parturients with American Society of Anaesthelsiologists (ASA) grade second undergoing LSCS under subarachnoid block. They were randomised into three groups: Group A received oxytocin 3U with normal saline, Group B received Oxytocin 3U with Phenylephrine 50 mcg, and Group C received Oxytocin 3U with Phenylephrine 75 mcg administered intravenously over five minutes after the baby’s extraction. The incidence of hypotension, requirement for the total rescue dose of Phenylephrine, and side effects were recorded. Statistical analysis was performed using Analysis of Variance (ANOVA) and Chi-square test. Results: Demographic parameters such as age, height, weight, gestational age, and duration of surgery were comparable in all groups. The incidence of hypotension (Group A (Control): 77.5%, Group B (PE50): 47.5%, Group C (PE75): 22.5%, p<0.001), lowest Mean Arterial Pressure (MAP) after Oxytocin infusion (Group A: 67.80±6.16 mmHg, Group B: 68.23±3.96 mmHg, Group C: 72.50±5.87 mmHg, p<0.001), dose of rescue vasopressor requirements (Group A: 75.5±56.61, Group B: 40±50.89, Group C: 17.50±34.99, p<0.001), and incidence of side effects were significantly lower in Group C compared to Group B and Group A. Conclusion: Compared to Phenylephrine 50 mcg, the coadministration of Phenylephrine 75 mcg with Oxytocin 3U reduces the incidence of Oxytocin-induced hypotension and the need for rescue vasopressors during LSCS under subarachnoid block.
Friction bounds the lower performance in control applications. Effective product modeling of controlling mechanisms and capturing the nonlinearity imposed by friction always attract the attention of ...researchers. Present work intends to capture the nonlinear dynamic behavior of a mechanical system with control release operation under boundary friction. The system used for this purpose is a second-order mechanical system comprising of rotary inertia element (lever), linear element (targeted mass), and spring element. The mechanical system chosen bears a resemblance to actual systems with control release like actuators, hydraulically operated copy turning machine, flight control mechanism, and robotics. The system dynamics have been captured under the light of two friction models viz. LuGre model and Dahl model. The performance of the system under these two friction models is ascertained for different times taken by the mass to settle, post and pre-zero-crossing time taken by target mass, maximum amplitude, time-period, and amplitude decay. The present work is capable of providing guidelines to simulate systems with control release under friction.
•The present work discusses the dynamics of systems used for control release operations under the nonlinearity imposed by friction.•The system dynamics have been compared for two friction models viz. LuGre model and Dahl model.•The performance is ascertained based on the time taken by the mass to settle, post and pre-zero-crossing time taken by target mass, maximum amplitude, period, and amplitude decay.•The paper is capable of providing guidelines to simulate systems with control release under friction.
This review provides a comprehensive and accessible literature review on the integration of nanoparticles into biolubricants to enhance wear and friction regulation, thus improving the overall ...lubricated system performance. Nanotechnology has significantly impacted various industries, particularly in lubrication. Nanobiolubricants offer promising avenues for enhancing tribological properties. This review focuses on oxide nanoparticles, such as zinc oxide (ZnO), aluminum oxide (Al2O3), copper oxide (CuO), titanium dioxide (TiO2), zirconium dioxide (ZrO2), and graphene oxide (GO) nanoparticles, for their ability to enhance lubricant performance. The impact of nanoparticle concentration on biolubricant properties, including viscosity, viscosity index, flash point temperature, and pour point temperature, is analyzed. The review also addresses potential obstacles and limitations in nanoparticle incorporation, aiming to propose effective strategies for maximizing their benefits. The findings underscore the potential of nanobiolubricants to improve operational efficiency and component lifespan. This review aims to provide valuable insights for researchers, engineers, and professionals in exploring and leveraging nanotechnology’s potential in the lubrication industry. This review paper explores the basics of tribology along with its significance, green principles, mechanisms, and energy savings because of friction, wear, and lubrication. Condition monitoring techniques are also explored to achieve brief knowledge about maintaining reliability and safety of the industrial components. Recent advances in tribology including superconductivity, biotribology, high-temperature tribology, tribological simulation, hybrid polymer composite’s tribology, and cryogenic tribology are investigated, which gives a thorough idea about the subject.
Whole genome sequencing (WGS) of
has been constructive in understanding its evolution, genetic diversity and the mechanisms involved in drug resistance. A large number of sequencing efforts from ...across the globe have revealed genetic diversity among clinical isolates and the genetic determinants for their resistance to anti-tubercular drugs. Considering the high TB burden in India, the availability of WGS studies is limited. Here we present, WGS results of 200 clinical isolates of
from North India which are categorized as sensitive to first-line drugs, mono-resistant, multi-drug resistant and pre-extensively drug resistant isolates. WGS revealed that 20% of the isolates were co-infected with
and non-tuberculous mycobacteria species. We identified 12,802 novel genetic variations in
isolates including 343 novel SNVs in 38 genes which are known to be associated with drug resistance and are not currently used in the diagnostic kits for detection of drug resistant TB. We also identified
lineage 3 to be predominant in the northern region of India. Additionally, several novel SNVs, which may potentially confer drug resistance were found to be enriched in the drug resistant isolates sampled. This study highlights the significance of employing WGS in diagnosis and for monitoring further development of MDR-TB strains.
Telematics technology and its implementation in auto insurance have received great interest due to their potential to transform the insurance sector and promote safer driving practices. By ...implementing telematics technology, insurers may tailor insurance premiums to individual drivers, taking into account their real driving habits and performance, ultimately leading to improved road safety, cost savings, and an empowered driving community. The current study, through bibliometric analysis, carefully identifies and evaluates the existing body of scholarly literature on this subject for the last 21 years, including journal articles, conference papers, and related publications. The analysis uncovers key research studies, influential authors, top publication outlets, top countries with collaborations, and prolific research fields, providing useful insights into the evolution and growth of telematics-based insurance research. Furthermore, thematic mapping, cluster analysis, and critical analysis of top recent studies aided in identifying key research clusters and themes, as well as potential gaps and areas for further exploration, guiding future researchers and policymakers in advancing this transformative technology.
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