To investigate the underlying mechanisms of T2D pathogenesis, we looked for diabetes susceptibility genes that increase the risk of type 2 diabetes (T2D) in a Han Chinese population. A two-stage ...genome-wide association (GWA) study was conducted, in which 995 patients and 894 controls were genotyped using the Illumina HumanHap550-Duo BeadChip for the first genome scan stage. This was further replicated in 1,803 patients and 1,473 controls in stage 2. We found two loci not previously associated with diabetes susceptibility in and around the genes protein tyrosine phosphatase receptor type D (PTPRD) (P = 8.54×10-10; odds ratio OR = 1.57; 95% confidence interval CI = 1.36-1.82), and serine racemase (SRR) (P = 3.06×10-9; OR = 1.28; 95% CI = 1.18-1.39). We also confirmed that variants in KCNQ1 were associated with T2D risk, with the strongest signal at rs2237895 (P = 9.65×10-10; OR = 1.29, 95% CI = 1.19-1.40). By identifying two novel genetic susceptibility loci in a Han Chinese population and confirming the involvement of KCNQ1, which was previously reported to be associated with T2D in Japanese and European descent populations, our results may lead to a better understanding of differences in the molecular pathogenesis of T2D among various populations.
Celotno besedilo
Dostopno za:
DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
New Alkaloids from Annona purpurea Chang, Fang-Rong; Chen, Chung-Yi; Wu, Po-Hsun ...
Journal of natural products (Washington, D.C.),
06/2000, Letnik:
63, Številka:
6
Journal Article
Recenzirano
Three new alkaloids, promucosine (1), romucosine F (2), and romucosine G (3), along with 28 known compounds, were isolated from the MeOH extract of stems of Annona purpurea. The structures of 1−3 ...were determined on the basis of spectral data and chemical evidence.
The purpose of this study attempted to understand the psychological well-being of caregivers of individuals with schizophrenia and factors affecting the caregivers' psychological well-being. More ...specifically, quality of life and psychiatric morbidity were used to represent the psychological well-being. Personal interviews using questionnaires were administrated to 57 caregivers. Data regarding knowledge of schizophrenia, perceived causes of schizophrenia, quality of life and psychiatric morbidity was collected. Psychiatrists assessed the symptoms severity of the schizophrenic patients. Compared with the controls, the psychological well-being of caregivers of patients with schizophrenia was poorer. There was a significant association between the positive symptoms score and the psychological well-being of caregivers. Life quality and psychiatric morbidity were affected by caregivers' knowledge of schizophrenia and beliefs about the cause of schizophrenia. Health care providers should consider the patients and their caregivers as a whole and provide psychoeducaiton to reduce the negative psychological impact of caregivers.
Three new eudesmanolide sesquiterpenes, neolitacumone A−C (1−3), and one new benzylisoquinoline alkaloid, neolitacumonine (5), along with 27 known compounds were isolated from the stem bark of ...Neolitsea acuminatissima. The structures of compounds 1−3 and 5 were established on the basis of spectral and chemical evidence. Compounds 2, 3, and 20 were selectively inhibitory to Hep 2,2,15 cells with IC50 values in the range 0.24−0.04 μg/mL. Compound 20 was marginally cytotoxic to Hep G2 cells.
Abstract Background Parkinson's disease, affecting at least 1% of population older than 65 years, is the most common neurodegenerative movement disorder. Up to now, no evidence has demonstrated that ...biochemical changes in CSF occur preceding the onset of Parkinson's symptoms. In this study, we tested the hypothesis that biochemical changes in CSF precede behavioral deficits in Parkinsonian animals. Methods We infused different doses of 6-OHDA into the MFB of rats bilaterally and examined the animals' movement behaviors, biochemical alterations in CSF, and dopaminergic neuronal number in the SNpc 1 week later. Results Our results indicated that animals with over 70% dopaminergic neuronal loss in the SNpc exhibited behavioral bradykinesia and rigidity, and a decrease of HVA in CSF. In contrast, animals with about 42% dopaminergic neuronal loss in the SNpc showed normal movement behaviors, but displayed a drastic decline of HVA in CSF. Furthermore, the number of dopaminergic neurons in the SNpc was positively correlated with the HVA level in CSF. Conclusions Our findings demonstrate that biochemical alteration in CSF foreruns behavioral deficits and the HVA level in CSF is positively correlated with the number of dopaminergic neurons in the SNpc of Parkinsonian rats induced by 6-OHDA. Our results strongly suggest that additional studies are needed to evaluate usefulness of monitoring the HVA level in CSF for early detection of the loss of dopaminergic neurons in the SNpc that precedes the onset of Parkinsonian symptoms in humans.
The hematocrit and blood viscosity were measured in ovariectomized (Ovx) rats following thyroidectomy or sham operation. Rats were thyroidectomized (Tx) or sham Tx immediately after ovariectomy. ...Three months later, Ovx, Ovx+Tx, and intact rats at proestrus stage were bled. Blood was collected by heart puncture in rats under ether anesthesia and heparinized. One month after the first bleeding, Ovx and Ovx+Tx rats were bled once again. the viscosity of whole blood and plasma was measured at various shear rates at 37 degrees C by means of a Mooney-Ewart viscometer. The hematocrit was determined by a microhematocrit centrifuge. The plasma osmolality was measured by a computerized micro-osmometer. Concentrations of plasma sodium and potassium were measured by a flame photometer. The concentration of plasma thyroid stimulating hormone (TSH) was measured by a radioimmunoassay. In Ovx+Tx rats, the plasma TSH concentration was higher, but the hematocrit and blood viscosity were lower than those in Ovx and proestrus rats. The levels of plasma sodium, osmolality and viscosity were not altered by ovariectomy and thyroidectomy. These results suggest that the lower blood viscosity in thyroidectomized rats is due to a reduction of hematocrit.
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