Dengue is a vector-borne disease transmitted by the mosquito Aedes aegypti. The incidence of dengue disease shows a clear dependence on seasonal variation. How does the temperature affect the ...incidence? We addressed this question indirectly by estimating the size of the A. aegypti population for different temperatures applying population dynamics theory. In order to achieve this objective we designed temperature-controlled experiments to assess the entomological parameters regarding the mosquito's life-cycle at different temperatures. By obtaining the mortality, transition and oviposition rates for different stages of the life-cycle of the mosquito we were able to calculate the basic offspring number Q0, which is the capacity of vector reproduction and ultimately gives the size of the vector population.
Metabolic processes can influence disease risk and provide therapeutic targets. By conducting genome-wide association studies of 1,091 blood metabolites and 309 metabolite ratios, we identified ...associations with 690 metabolites at 248 loci and associations with 143 metabolite ratios at 69 loci. Integrating metabolite-gene and gene expression information identified 94 effector genes for 109 metabolites and 48 metabolite ratios. Using Mendelian randomization (MR), we identified 22 metabolites and 20 metabolite ratios having estimated causal effect on 12 traits and diseases, including orotate for estimated bone mineral density, α-hydroxyisovalerate for body mass index and ergothioneine for inflammatory bowel disease and asthma. We further measured the orotate level in a separate cohort and demonstrated that, consistent with MR, orotate levels were positively associated with incident hip fractures. This study provides a valuable resource describing the genetic architecture of metabolites and delivers insights into their roles in common diseases, thereby offering opportunities for therapeutic targets.
Net-zero emissions energy systems Davis, Steven J; Lewis, Nathan S; Shaner, Matthew ...
Science,
2018-Jun-29, 2018-06-29, 20180629, Letnik:
360, Številka:
6396
Journal Article
Recenzirano
Odprti dostop
Some energy services and industrial processes-such as long-distance freight transport, air travel, highly reliable electricity, and steel and cement manufacturing-are particularly difficult to ...provide without adding carbon dioxide (CO
) to the atmosphere. Rapidly growing demand for these services, combined with long lead times for technology development and long lifetimes of energy infrastructure, make decarbonization of these services both essential and urgent. We examine barriers and opportunities associated with these difficult-to-decarbonize services and processes, including possible technological solutions and research and development priorities. A range of existing technologies could meet future demands for these services and processes without net addition of CO
to the atmosphere, but their use may depend on a combination of cost reductions via research and innovation, as well as coordinated deployment and integration of operations across currently discrete energy industries.
Understanding how materials that catalyse the oxygen evolution reaction (OER) function is essential for the development of efficient energy-storage technologies. The traditional understanding of the ...OER mechanism on metal oxides involves four concerted proton-electron transfer steps on metal-ion centres at their surface and product oxygen molecules derived from water. Here, using in situ
O isotope labelling mass spectrometry, we provide direct experimental evidence that the O
generated during the OER on some highly active oxides can come from lattice oxygen. The oxides capable of lattice-oxygen oxidation also exhibit pH-dependent OER activity on the reversible hydrogen electrode scale, indicating non-concerted proton-electron transfers in the OER mechanism. Based on our experimental data and density functional theory calculations, we discuss mechanisms that are fundamentally different from the conventional scheme and show that increasing the covalency of metal-oxygen bonds is critical to trigger lattice-oxygen oxidation and enable non-concerted proton-electron transfers during OER.
In this study, we proposed a novel approach to improve centrifugal pump performance with regard to the pump head, pump efficiency, and power. Firstly, to establish constraints, an optimal numerical ...model that accounted for factors such as pump efficiency and the head was considered. The pump was designed, and an artificial intelligence algorithmic approach was applied to the pump before performing experiments. We considered a set of models by selecting the parameters of the centrifugal pump casing section area, the interference of the impeller, the volute tongue length, and the volute tongue angle. The weights of the factors of safety and displacement on the optimization indices were estimated. The matrix of the weights for the optimal process was less than 38% or greater than 62%. This approach guarantees a complicated multi-objective optimization problem. The results show that the centrifugal pump performances were improved.
Polyacrylonitrile (PAN), a well-known polymer with good stability and mechanical properties, has been widely used in producing carbon nanofibers (CNFs) as these have attracted much recent attention ...due to their excellent characteristics, such as spinnability, environmentally benign nature and commercial viability. Among the various precursors to produce CNFs, PAN has been extensively studied due to its high carbon yield and flexibility for tailoring the structure of the final CNFs as well as the ease of obtaining stabilized products due to the formation of a ladder structure via nitrile polymerization. In view of this, they have applications in areas such as electronics, tissue engineering, membrane filtration and high performance composites. This review presents various combinations of PAN and PAN-based precursors in producing CNFs from the PAN homopolymer or its modified precursors, copolymers, blends and various composites. Various modifications of PAN and their future prospects in different scientific and technological disciplines are addressed.
Familial multiple intestinal atresias is an autosomal recessive disease with or without combined immunodeficiency. In the last year, several reports have described mutations in the gene TTC7A as ...causal to the disease in different populations. However, exact correlation between different genotypes and various phenotypes are not clear. In this study, we report identification of novel compound heterozygous mutations in TTC7A gene in a Malay girl with familial multiple intestinal atresias and severe combined immunodeficiency (MIA‐SCID) by whole exome sequencing. We found two mutations in TTC7A: one that destroyed a putative splicing acceptor at the junction of intron 17/exon 18 and one that introduced a stop codon that would truncate the last two amino acids of the encoded protein. Reviewing the recent reports on TTC7A mutations reveals correlation between the position and nature of the mutations with patient survival and clinical manifestations. Examination of public databases also suggests carrier status for healthy individuals, making a case for population screening on this gene, especially in populations with suspected frequent founder mutations.
The DNA i-motif conformation was discovered in (CCG)•(CGG) n trinucleotide repeats, which are associated with fragile X syndrome, the most widespread inherited cause of mental retardation in humans. ...The DNA i-motif is a four-stranded structure whose strands are held together by proton-bound dimers of cytosine (C+•C). The stronger base-pairing interactions in C+•C proton-bound dimers as compared to Watson–Crick G•C base pairs are the major forces responsible for stabilization of i-motif conformations. Methylation of cytosine results in silencing of the FMR1 gene and causes fragile X syndrome. However, the influence of methylation or other modifications such as halogenation of cytosine on the base-pairing energies (BPEs) in the i-motif remains elusive. To address this, proton-bound heterodimers of cytosine and 5-methylcytosine, 5-fluorocytosine, 5-bromocytosine, and 5-iodocytosine are probed in detail. Experimentally, the BPEs of proton-bound heterodimers of cytosine and modified cytosines are determined using threshold collision-induced dissociation (TCID) techniques. All modifications at the 5-position of cytosine are found to lower the BPE and therefore would tend to destabilize DNA i-motif conformations. However, the BPEs in these proton-bound heterodimers still significantly exceed those of the Watson–Crick G•C and neutral C•C base pairs, suggesting that C+•C mismatches are still energetically favored such that i-motif conformations are preserved. Excellent agreement between TCID measured BPEs and B3LYP calculated values is found with the def2-TZVPPD and 6-311+G(2d,2p) basis sets, suggesting that calculations at these levels of theory can be employed to provide reliable energetic predictions for related systems.
Fundamental understanding of strongly interacting systems necessarily involves collective modes, but their nature and evolution is not generally understood in dynamically disordered and strongly ...interacting systems such as liquids and supercritical fluids. We report the results of extensive molecular dynamics simulations and provide direct evidence that liquids develop a gap in a solidlike transverse spectrum in the reciprocal space, with no propagating modes between zero and a threshold value. In addition to the liquid state, this result importantly applies to the supercritical state of matter. We show that the emerging gap increases with the inverse of liquid relaxation time and discuss how the gap affects properties of liquid and supercritical states.
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